High fat in blood and body and increased risk of clinically diagnosed non-alcoholic fatty liver disease in 105,981 individuals

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

High fat in blood and body and increased risk of clinically diagnosed non-alcoholic fatty liver disease in 105,981 individuals. / Kyhl, Lærke Kristine; Nordestgaard, Børge Grønne; Tybjærg-Hansen, Anne; Nielsen, Sune Fallgaard.

In: Atherosclerosis, Vol. 376, 2023, p. 1-10.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Kyhl, LK, Nordestgaard, BG, Tybjærg-Hansen, A & Nielsen, SF 2023, 'High fat in blood and body and increased risk of clinically diagnosed non-alcoholic fatty liver disease in 105,981 individuals', Atherosclerosis, vol. 376, pp. 1-10. https://doi.org/10.1016/j.atherosclerosis.2023.05.015

APA

Kyhl, L. K., Nordestgaard, B. G., Tybjærg-Hansen, A., & Nielsen, S. F. (2023). High fat in blood and body and increased risk of clinically diagnosed non-alcoholic fatty liver disease in 105,981 individuals. Atherosclerosis, 376, 1-10. https://doi.org/10.1016/j.atherosclerosis.2023.05.015

Vancouver

Kyhl LK, Nordestgaard BG, Tybjærg-Hansen A, Nielsen SF. High fat in blood and body and increased risk of clinically diagnosed non-alcoholic fatty liver disease in 105,981 individuals. Atherosclerosis. 2023;376:1-10. https://doi.org/10.1016/j.atherosclerosis.2023.05.015

Author

Kyhl, Lærke Kristine ; Nordestgaard, Børge Grønne ; Tybjærg-Hansen, Anne ; Nielsen, Sune Fallgaard. / High fat in blood and body and increased risk of clinically diagnosed non-alcoholic fatty liver disease in 105,981 individuals. In: Atherosclerosis. 2023 ; Vol. 376. pp. 1-10.

Bibtex

@article{6aaebc46f03548008b6436ed775b4d91,

title = "High fat in blood and body and increased risk of clinically diagnosed non-alcoholic fatty liver disease in 105,981 individuals",

abstract = "Background and aims: High caloric diets rich in fat and carbohydrates lead to increased fat accumulation in adipose tissue and blood. This may lead to increased risk of non-alcoholic fatty liver disease. We hypothesized that baseline high nonfasting plasma triglycerides, body mass index (BMI), and waist circumference, individually and combined, associate with increased risk of clinically diagnosed non-alcoholic fatty liver disease during follow-up. Methods: Cohort of 105,981 white Danish individuals recruited in 2003–2015 with end of follow-up on December 13th, 2018. Mean follow-up was 9.2 years during which time 418 were clinically diagnosed at hospitals with non-alcoholic fatty liver disease. Results: Risk of clinically diagnosed non-alcoholic fatty liver disease increased with higher plasma triglycerides, higher BMI, and with higher waist circumference, continuously and stepwise using multivariable adjusted hazard ratios and cumulative incidences. Combining clinical categories of plasma triglycerides with BMI or waist circumference categories, illustrated an almost additive risk with increasing categories. Compared with plasma triglycerides of <1 mmol/L and BMI <25 kg/m2, the multivariable adjusted hazard ratio was 5.2(95% confidence interval: 1.3–21.6) for individuals with both plasma triglycerides of ≥5 mmol/L and BMI ≥35 kg/m2. The corresponding hazard ratio for individuals with plasma triglycerides ≥5 mmol/L and waist circumference was >88 cm for women and >102 cm for men was 4.8(2.3–9.7). Triglyceride results were more pronounced in women versus men. Conclusions: High fat in blood and body measured by plasma triglycerides, BMI, and waist circumference, individually and especially combined, are associated with up to a 5-fold increased risk of clinically diagnosed non-alcoholic fatty liver disease.",

keywords = "BMI, Fatty liver, Prospective study, Triglycerides, Waist circumference",

author = "Kyhl, {L{\ae}rke Kristine} and Nordestgaard, {B{\o}rge Gr{\o}nne} and Anne Tybj{\ae}rg-Hansen and Nielsen, {Sune Fallgaard}",

note = "Publisher Copyright: {\textcopyright} 2023 Elsevier B.V.",

year = "2023",

doi = "10.1016/j.atherosclerosis.2023.05.015",

language = "English",

volume = "376",

pages = "1--10",

journal = "Journal of atherosclerosis research",

issn = "1567-5688",

publisher = "Elsevier Ireland Ltd",

}

RIS

TY - JOUR

T1 - High fat in blood and body and increased risk of clinically diagnosed non-alcoholic fatty liver disease in 105,981 individuals

AU - Kyhl, Lærke Kristine

AU - Nordestgaard, Børge Grønne

AU - Tybjærg-Hansen, Anne

AU - Nielsen, Sune Fallgaard

PY - 2023

Y1 - 2023

N2 - Background and aims: High caloric diets rich in fat and carbohydrates lead to increased fat accumulation in adipose tissue and blood. This may lead to increased risk of non-alcoholic fatty liver disease. We hypothesized that baseline high nonfasting plasma triglycerides, body mass index (BMI), and waist circumference, individually and combined, associate with increased risk of clinically diagnosed non-alcoholic fatty liver disease during follow-up. Methods: Cohort of 105,981 white Danish individuals recruited in 2003–2015 with end of follow-up on December 13th, 2018. Mean follow-up was 9.2 years during which time 418 were clinically diagnosed at hospitals with non-alcoholic fatty liver disease. Results: Risk of clinically diagnosed non-alcoholic fatty liver disease increased with higher plasma triglycerides, higher BMI, and with higher waist circumference, continuously and stepwise using multivariable adjusted hazard ratios and cumulative incidences. Combining clinical categories of plasma triglycerides with BMI or waist circumference categories, illustrated an almost additive risk with increasing categories. Compared with plasma triglycerides of <1 mmol/L and BMI <25 kg/m2, the multivariable adjusted hazard ratio was 5.2(95% confidence interval: 1.3–21.6) for individuals with both plasma triglycerides of ≥5 mmol/L and BMI ≥35 kg/m2. The corresponding hazard ratio for individuals with plasma triglycerides ≥5 mmol/L and waist circumference was >88 cm for women and >102 cm for men was 4.8(2.3–9.7). Triglyceride results were more pronounced in women versus men. Conclusions: High fat in blood and body measured by plasma triglycerides, BMI, and waist circumference, individually and especially combined, are associated with up to a 5-fold increased risk of clinically diagnosed non-alcoholic fatty liver disease.

AB - Background and aims: High caloric diets rich in fat and carbohydrates lead to increased fat accumulation in adipose tissue and blood. This may lead to increased risk of non-alcoholic fatty liver disease. We hypothesized that baseline high nonfasting plasma triglycerides, body mass index (BMI), and waist circumference, individually and combined, associate with increased risk of clinically diagnosed non-alcoholic fatty liver disease during follow-up. Methods: Cohort of 105,981 white Danish individuals recruited in 2003–2015 with end of follow-up on December 13th, 2018. Mean follow-up was 9.2 years during which time 418 were clinically diagnosed at hospitals with non-alcoholic fatty liver disease. Results: Risk of clinically diagnosed non-alcoholic fatty liver disease increased with higher plasma triglycerides, higher BMI, and with higher waist circumference, continuously and stepwise using multivariable adjusted hazard ratios and cumulative incidences. Combining clinical categories of plasma triglycerides with BMI or waist circumference categories, illustrated an almost additive risk with increasing categories. Compared with plasma triglycerides of <1 mmol/L and BMI <25 kg/m2, the multivariable adjusted hazard ratio was 5.2(95% confidence interval: 1.3–21.6) for individuals with both plasma triglycerides of ≥5 mmol/L and BMI ≥35 kg/m2. The corresponding hazard ratio for individuals with plasma triglycerides ≥5 mmol/L and waist circumference was >88 cm for women and >102 cm for men was 4.8(2.3–9.7). Triglyceride results were more pronounced in women versus men. Conclusions: High fat in blood and body measured by plasma triglycerides, BMI, and waist circumference, individually and especially combined, are associated with up to a 5-fold increased risk of clinically diagnosed non-alcoholic fatty liver disease.

KW - BMI

KW - Fatty liver

KW - Prospective study

KW - Triglycerides

KW - Waist circumference

U2 - 10.1016/j.atherosclerosis.2023.05.015

DO - 10.1016/j.atherosclerosis.2023.05.015

M3 - Journal article

C2 - 37253311

AN - SCOPUS:85160512956

VL - 376

SP - 1

EP - 10

JO - Journal of atherosclerosis research

JF - Journal of atherosclerosis research

SN - 1567-5688

ER -

ID: 360255687