Impact of pre-admission depression on mortality following myocardial infarction
Research output: Contribution to journal › Journal article › Research › peer-review
BackgroundThe prognostic impact of previous depression on myocardial infarction survival remains poorly understood.AimsTo examine the association between depression and all-cause mortality following myocardial infarction.MethodUsing Danish medical registries, we conducted a nationwide population-based cohort study. We included all patients with first-time myocardial infarction (1995-2014) and identified previous depression as either a depression diagnosis or use of antidepressants. We used Cox regression to compute adjusted mortality rate ratios (aMRRs) with 95% confidence intervals.ResultsWe identified 170 771 patients with first-time myocardial infarction. Patients with myocardial infarction and a previous depression diagnosis had higher 19-year mortality risks (87% v. 78%). The overall aMRR was 1.11 (95% CI 1.07-1.15) increasing to 1.22 (95% CI 1.17-1.27) when including use of antidepressants in the depression definition.ConclusionsA history of depression was associated with a moderately increased all-cause mortality following myocardial infarction.
Original language | English |
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Journal | The British journal of psychiatry : the journal of mental science |
Volume | 210 |
Issue number | 5 |
Pages (from-to) | 356-361 |
ISSN | 0007-1250 |
DOIs | |
Publication status | Published - 2017 |
- Adult, Aged, Aged, 80 and over, Denmark/epidemiology, Depressive Disorder/complications, Female, Humans, Kaplan-Meier Estimate, Male, Middle Aged, Myocardial Infarction/mortality, Prognosis, Prospective Studies, Risk Factors
Research areas
ID: 196141887