Incidence and time trends of joint surgery in patients with psoriatic arthritis: a register-based time series and cohort study from Denmark
Research output: Contribution to journal › Journal article › Research › peer-review
Objective To investigate time-trends and cumulative incidence of joint surgery among patients with psoriatic arthritis (PsA) compared with the general population. Methods In this nationwide register-based cohort study, The Danish National Patient Registry was used to identify incident PsA patients. The 5-year incidence rates (IR) and incidence rate ratios (IRR) of joint surgery were calculated in four calendar-period defined cohorts. Each patient was matched with ten non-PsA individuals from the general population cohort (GPC). The cumulative incidences of any joint and joint-sacrificing surgery, respectively, were estimated using the Aalen-Johansen method. Results From 1996 to 2017, 11 960 PsA patients (mean age 50 years; 57% female) were registered. The IRR of any joint surgery was twice as high for PsA patients compared with GPCs across all calendar periods. Among patients with PsA, 2, 10 and 29% required joint surgery at 5, 10 and 15 years after diagnosis. The risk of surgery in PsA patients diagnosed at 18-40 years was higher (22%) than in GPC 60+ year old (20%) after 15 years of follow-up. Conclusions The use of joint surgery among PsA patients remained around twofold higher from 1996 to 2012 compared with GPC. After 15 years of follow-up, nearly 30% of the PsA patients had received any surgery, and even a person diagnosed with PsA at the age of 18-40 years had a higher risk of surgery than GPCs of 60+ year old. Thus, the high surgical rates represent an unmet need in the current treatment of PsA.
Original language | English |
---|---|
Journal | Annals of the Rheumatic Diseases |
Volume | 78 |
Issue number | 11 |
Pages (from-to) | 1517-1523 |
Number of pages | 7 |
ISSN | 0003-4967 |
DOIs | |
Publication status | Published - 2019 |
- DMARDS (biologic), epidemiology, orthopaedic surgery, psoriatic arthritis
Research areas
ID: 236266461