Indomethacin lowers optic nerve oxygen tension and reduces the effect of carbonic anhydrase inhibition and carbon dioxide breathing
Research output: Contribution to journal › Journal article › Research › peer-review
Prostaglandins are important in blood flow regulation. Carbon dioxide (CO(2)) breathing and carbonic anhydrase inhibition increase the oxygen tension in the retina and optic nerve. To study the mechanism of this effect and the role of cyclo-oxygenase in the regulation of optic nerve oxygen tension (ONPO(2)), the authors investigated how indomethacin affects ONPO(2) and the ONPO(2) increases caused by CO(2) breathing and carbonic anhydrase inhibition in the pig.
Original language | English |
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Journal | British Journal of Ophthalmology |
Volume | 88 |
Issue number | 8 |
Pages (from-to) | 1088-91 |
Number of pages | 4 |
ISSN | 0007-1161 |
DOIs | |
Publication status | Published - 2004 |
ID: 40148999