Inducibility of gamma-glutamyltransferase by dexamethasone in rat liver: relationship with the cytochrome P-450 content
Research output: Contribution to journal › Journal article › Research › peer-review
Gamma-glutamyltransferase (GGT) inducibility by dexamethasone (DEX) in rat liver decreased by about 95% within the first 14 days of life, while the liver content of cytochrome P-450 (P-450) increased by about 500%. Cobaltic Protoporphyrin IX (CPP), given on the 9th day of life, caused a temporary depression of the P-450 liver content, with maximal effects 3 and 4 days after the administration of CPP. GGT induction by DEX was significantly higher in CPP-treated rats than in untreated ones, with maximum induction coinciding with the maximal decrease of P-450. These effects were CPP dose-dependent.
| Original language | English |
|---|---|
| Journal | Life Sciences |
| Volume | 52 |
| Issue number | 7 |
| Pages (from-to) | 631-637 |
| Number of pages | 7 |
| ISSN | 0024-3205 |
| DOIs | |
| Publication status | Published - 1993 |
| Externally published | Yes |
- Analysis of Variance, Animals, Cytochrome P-450 Enzyme System/metabolism, Dexamethasone/pharmacology, Enzyme Induction/drug effects, Liver/embryology, Male, Protoporphyrins/pharmacology, Rats, Rats, Sprague-Dawley, gamma-Glutamyltransferase/biosynthesis
Research areas
ID: 257735025