Lipoprotein(a) Levels at Birth and in Early Childhood: The COMPARE Study
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Lipoprotein(a) Levels at Birth and in Early Childhood : The COMPARE Study. / Strandkjær, Nina; Hansen, Malene Kongsgaard; Nielsen, Sofie Taageby; Frikke-Schmidt, Ruth; Tybjærg-Hansen, Anne; Nordestgaard, Børge G.; Tabor, Ann; Bundgaard, Henning; Iversen, Kasper; Kamstrup, Pia R.
In: Journal of Clinical Endocrinology and Metabolism, Vol. 107, No. 2, 2022, p. 324-335.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Lipoprotein(a) Levels at Birth and in Early Childhood
T2 - The COMPARE Study
AU - Strandkjær, Nina
AU - Hansen, Malene Kongsgaard
AU - Nielsen, Sofie Taageby
AU - Frikke-Schmidt, Ruth
AU - Tybjærg-Hansen, Anne
AU - Nordestgaard, Børge G.
AU - Tabor, Ann
AU - Bundgaard, Henning
AU - Iversen, Kasper
AU - Kamstrup, Pia R.
N1 - Publisher Copyright: © 2021 The Author(s) 2021.
PY - 2022
Y1 - 2022
N2 - Background and Objective: High lipoprotein(a) is a genetically determined causal risk factor for cardiovascular disease, and 20% of the adult population has high levels (ie, >42 mg/dL, >88 nmol/L). We investigated whether early life lipoprotein(a) levels measured in cord blood may serve as a proxy for neonatal venous blood levels, whether lipoprotein(a) birth levels (ie, cord or venous) predict levels later in life, and whether early life and parental levels correlate. Methods: The Compare study is a prospective cohort study of newborns (N = 450) from Copenhagen, Denmark, including blood sampling of parents. Plasma lipoprotein(a) was measured in cord blood (N = 402), neonatal venous blood (N = 356), and at 2 (N = 320) and 15 months follow-up (N = 148) of infants, and in parents (N = 705). Results: Mean lipoprotein(a) levels were 2.2 (95% CI, 1.9-2.5), 2.4 (2.0-2.7), 4.1 (3.4-4.9), and 14.6 (11.4-17.9) mg/dL in cord, neonatal venous, and 2- and 15-month venous samples, respectively. Lipoprotein(a) levels in cord blood correlated strongly with neonatal venous blood levels (R2 = 0.95, P < 0.001) and neonatal levels correlated moderately with 2- and 15-month levels (R2 = 0.68 and 0.67, both P < 0.001). Birth levels ≥ 90th percentile predicted lipoprotein(a) > 42 mg/dL at 15 months with positive predictive values of 89% and 85% for neonatal venous and cord blood. Neonatal and infant levels correlated weakly with parental levels, most pronounced at 15 months (R2 = 0.22, P < 0.001). Conclusions: Lipoprotein(a) levels are low in early life, cord blood may serve as a proxy for neonatal venous blood, and birth levels ≥ 90th percentile can identify newborns at risk of developing high levels.
AB - Background and Objective: High lipoprotein(a) is a genetically determined causal risk factor for cardiovascular disease, and 20% of the adult population has high levels (ie, >42 mg/dL, >88 nmol/L). We investigated whether early life lipoprotein(a) levels measured in cord blood may serve as a proxy for neonatal venous blood levels, whether lipoprotein(a) birth levels (ie, cord or venous) predict levels later in life, and whether early life and parental levels correlate. Methods: The Compare study is a prospective cohort study of newborns (N = 450) from Copenhagen, Denmark, including blood sampling of parents. Plasma lipoprotein(a) was measured in cord blood (N = 402), neonatal venous blood (N = 356), and at 2 (N = 320) and 15 months follow-up (N = 148) of infants, and in parents (N = 705). Results: Mean lipoprotein(a) levels were 2.2 (95% CI, 1.9-2.5), 2.4 (2.0-2.7), 4.1 (3.4-4.9), and 14.6 (11.4-17.9) mg/dL in cord, neonatal venous, and 2- and 15-month venous samples, respectively. Lipoprotein(a) levels in cord blood correlated strongly with neonatal venous blood levels (R2 = 0.95, P < 0.001) and neonatal levels correlated moderately with 2- and 15-month levels (R2 = 0.68 and 0.67, both P < 0.001). Birth levels ≥ 90th percentile predicted lipoprotein(a) > 42 mg/dL at 15 months with positive predictive values of 89% and 85% for neonatal venous and cord blood. Neonatal and infant levels correlated weakly with parental levels, most pronounced at 15 months (R2 = 0.22, P < 0.001). Conclusions: Lipoprotein(a) levels are low in early life, cord blood may serve as a proxy for neonatal venous blood, and birth levels ≥ 90th percentile can identify newborns at risk of developing high levels.
KW - cardiovascular disease
KW - children
KW - cholesterol
KW - Lipoprotein(a)
KW - lipoproteins
U2 - 10.1210/clinem/dgab734
DO - 10.1210/clinem/dgab734
M3 - Journal article
C2 - 34618900
AN - SCOPUS:85124917962
VL - 107
SP - 324
EP - 335
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
SN - 0013-7227
IS - 2
ER -
ID: 321464988