Nationwide study of sudden cardiac death in persons aged 1-35 years
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Nationwide study of sudden cardiac death in persons aged 1-35 years. / Winkel, Bo Gregers; Holst, Anders Gaarsdal; Theilade, Juliane; Kristensen, Ingrid Bayer; Thomsen, Jørgen Lange; Ottesen, Gyda Lolk; Bundgaard, Henning; Svendsen, Jesper Hastrup; Haunsø, Stig; Tfelt-Hansen, Jacob.
In: European Heart Journal, Vol. 32, No. 8, 2011, p. 983-90.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Nationwide study of sudden cardiac death in persons aged 1-35 years
AU - Winkel, Bo Gregers
AU - Holst, Anders Gaarsdal
AU - Theilade, Juliane
AU - Kristensen, Ingrid Bayer
AU - Thomsen, Jørgen Lange
AU - Ottesen, Gyda Lolk
AU - Bundgaard, Henning
AU - Svendsen, Jesper Hastrup
AU - Haunsø, Stig
AU - Tfelt-Hansen, Jacob
PY - 2011
Y1 - 2011
N2 - Aims The aim of this investigation was to study the incidence of sudden cardiac death (SCD) in persons aged 1-35 years in a nationwide setting (5.38 million people) by systematic evaluation of all deaths. Methods and results All deaths in persons aged 1-35 years in Denmark in 2000-06 were included. Death certificates were read independently by two physicians. The National Patient Registry was used to retrieve information on prior medical history. All autopsy reports were read and the cause of death was revised based on autopsy findings. We identified 625 cases of sudden unexpected death (10% of all deaths), of which 156 (25%) were not autopsied. Of the 469 autopsied cases, 314 (67%) were SCD. The most common cardiac cause of death was ischaemic heart disease (13%); 29% of autopsied sudden unexpected death cases were unexplained. In 45% of SCD cases, the death was witnessed; 34% died during sleep; 89% were out-of-hospital deaths. Highest possible incidence rate of SCD in the young was 2.8 per 100 000 person-years including non-autopsied cases of sudden unexpected death. Excluding those, the incidence rate declined to 1.9 per 100 000 person-years. Conclusions A total of 7% of all deaths in the young can be attributed to SCD, when including non-autopsied cases (autopsy ratio 75%). The incidence rate of SCD in the young of 2.8 per 100 000 person-years is higher than previously reported.
AB - Aims The aim of this investigation was to study the incidence of sudden cardiac death (SCD) in persons aged 1-35 years in a nationwide setting (5.38 million people) by systematic evaluation of all deaths. Methods and results All deaths in persons aged 1-35 years in Denmark in 2000-06 were included. Death certificates were read independently by two physicians. The National Patient Registry was used to retrieve information on prior medical history. All autopsy reports were read and the cause of death was revised based on autopsy findings. We identified 625 cases of sudden unexpected death (10% of all deaths), of which 156 (25%) were not autopsied. Of the 469 autopsied cases, 314 (67%) were SCD. The most common cardiac cause of death was ischaemic heart disease (13%); 29% of autopsied sudden unexpected death cases were unexplained. In 45% of SCD cases, the death was witnessed; 34% died during sleep; 89% were out-of-hospital deaths. Highest possible incidence rate of SCD in the young was 2.8 per 100 000 person-years including non-autopsied cases of sudden unexpected death. Excluding those, the incidence rate declined to 1.9 per 100 000 person-years. Conclusions A total of 7% of all deaths in the young can be attributed to SCD, when including non-autopsied cases (autopsy ratio 75%). The incidence rate of SCD in the young of 2.8 per 100 000 person-years is higher than previously reported.
U2 - 10.1093/eurheartj/ehq428
DO - 10.1093/eurheartj/ehq428
M3 - Journal article
C2 - 21131293
VL - 32
SP - 983
EP - 990
JO - European Heart Journal
JF - European Heart Journal
SN - 0195-668X
IS - 8
ER -
ID: 32476226