Ontogeny of human mannan‐binding protein, a lectin of the innate immune system
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Mannan‐binding protein (MBP) is a member of the collectins. These lectins are composed of polypeptide chains which contains a collagen‐like region and a calcium dependent carbohydrate recognition domain (named a C‐type CRD). MBP binds via the CRD to carbohydrate structures on microorganisms. MBP can activate the complement system when bound to carbohydrate. MBP is thus thought to play a role in the defence against microorganisms. The present report describes the ontogeny of MBP. The level of MBP increase during the first 3 months of life, at which time a stable level is reached, comparable to that seen in adults. On average, the level of MBP at term was 37% of the post 3‐month level. Measurements on infants born prematurely showed a 3‐fold increase in MBP concentration from the time of birth at around 30 weeks from conception to the 10th week of life.;
Original language | English |
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Journal | Pediatric Allergy and Immunology |
Volume | 6 |
Issue number | 1 |
Pages (from-to) | 20-23 |
Number of pages | 4 |
ISSN | 0905-6157 |
DOIs | |
Publication status | Published - Feb 1995 |
- children, development, infants, innate immune system, mannan‐binding protein, mannose‐binding protein, ontogeny
Research areas
ID: 328568569