The purpose of this study was (1) to evaluate the results following thumb carpometacarpal (CMC) interposition arthroplasties with patient-reported outcomes (PRO) in a large prospective series, (2) to evaluate the correlation between PRO and patient satisfaction following surgery, (3) to evaluate if age, gender, occupational status, sports activities or operative technique correlate with the PRO following surgery. Quick-DASH ranges from 0 to 100 with 100 being the worst score. The mean preoperative Quick-DASH was 49.9. The mean 6 months postoperative Quick-DASH was 25.4 showing an average improvement of 24.6 points. Mixed model analysis revealed a further improvement in Quick-DASH and pain after 6 months. Satisfied patients had significantly lower pain scores and lower Quick-DASH at follow up as compared to dissatisfied patients. Age, gender, hobby activities, occupational status and operative technique do not seem to influence PRO after CMC interposition arthroplasty of the thumb.