Peripapillary Hyperreflective Ovoid Mass-like Structures (PHOMS) in Children: The Copenhagen Child Cohort 2000 Eye Study
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Peripapillary Hyperreflective Ovoid Mass-like Structures (PHOMS) in Children : The Copenhagen Child Cohort 2000 Eye Study. / Behrens, Christopher Maximilian; Malmqvist, Lasse; Jørgensen, Morten; Sibony, Patrick A; Munch, Inger Christine; Skovgaard, Anne Mette; Larsen, Michael; Hamann, Steffen.
In: American Journal of Ophthalmology, Vol. 245, 2023, p. 212-221.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Peripapillary Hyperreflective Ovoid Mass-like Structures (PHOMS) in Children
T2 - The Copenhagen Child Cohort 2000 Eye Study
AU - Behrens, Christopher Maximilian
AU - Malmqvist, Lasse
AU - Jørgensen, Morten
AU - Sibony, Patrick A
AU - Munch, Inger Christine
AU - Skovgaard, Anne Mette
AU - Larsen, Michael
AU - Hamann, Steffen
N1 - Copyright © 2022 The Author(s). Published by Elsevier Inc. All rights reserved.
PY - 2023
Y1 - 2023
N2 - PURPOSE: To determine the prevalence of peripapillary hyperreflective ovoid mass-like structures (PHOMS) in a population-based child cohort and to study their association with other optic nerve head features and myopia.DESIGN: Observational, population-based cohort study of 1407 children aged 11-12 years.METHODS: Optical coherence tomography scans of optic nerve heads were graded for PHOMS, disc tilt, prelaminar hyperreflective lines, and scleral canal diameter and investigated for associated prenatal and ocular parameters. Children with optic disc drusen or optic disc edema were excluded.RESULTS: PHOMS were found in 8.9% of children. The location of PHOMS was predominantly in the superonasal section of the optic disc. Myopia and optic nerve head tilt were more common in children with PHOMS than in children without PHOMS (P < .001 and P < .001, respectively). Prelaminar hyperreflective lines were found in 17.9% of children with PHOMS compared to 7.3% of children without PHOMS (P < .001). Prelaminar hyperreflective lines with and without PHOMS were associated with a shorter axial length of the eye (P < .001). There were no prenatal factors associated with PHOMS. Prelaminar hyperreflective lines were associated with higher birth weight and continued maternal smoking during pregnancy (P = .01 and P = .02, respectively).CONCLUSIONS: PHOMS had a prevalence of 8.9% in healthy children without optic disc drusen or optic disc edema and was associated with increasing myopic refraction and the presence of a tilted optic nerve head and prelaminar hyperreflective lines. Given the high prevalence of PHOMS, they should not unreservedly be taken as evidence of optic neuropathy.
AB - PURPOSE: To determine the prevalence of peripapillary hyperreflective ovoid mass-like structures (PHOMS) in a population-based child cohort and to study their association with other optic nerve head features and myopia.DESIGN: Observational, population-based cohort study of 1407 children aged 11-12 years.METHODS: Optical coherence tomography scans of optic nerve heads were graded for PHOMS, disc tilt, prelaminar hyperreflective lines, and scleral canal diameter and investigated for associated prenatal and ocular parameters. Children with optic disc drusen or optic disc edema were excluded.RESULTS: PHOMS were found in 8.9% of children. The location of PHOMS was predominantly in the superonasal section of the optic disc. Myopia and optic nerve head tilt were more common in children with PHOMS than in children without PHOMS (P < .001 and P < .001, respectively). Prelaminar hyperreflective lines were found in 17.9% of children with PHOMS compared to 7.3% of children without PHOMS (P < .001). Prelaminar hyperreflective lines with and without PHOMS were associated with a shorter axial length of the eye (P < .001). There were no prenatal factors associated with PHOMS. Prelaminar hyperreflective lines were associated with higher birth weight and continued maternal smoking during pregnancy (P = .01 and P = .02, respectively).CONCLUSIONS: PHOMS had a prevalence of 8.9% in healthy children without optic disc drusen or optic disc edema and was associated with increasing myopic refraction and the presence of a tilted optic nerve head and prelaminar hyperreflective lines. Given the high prevalence of PHOMS, they should not unreservedly be taken as evidence of optic neuropathy.
KW - Child
KW - Humans
KW - Optic Disk Drusen
KW - Cohort Studies
KW - Papilledema
KW - Optic Disk
KW - Tomography, Optical Coherence/methods
KW - Myopia/diagnosis
U2 - 10.1016/j.ajo.2022.09.003
DO - 10.1016/j.ajo.2022.09.003
M3 - Journal article
C2 - 36108799
VL - 245
SP - 212
EP - 221
JO - American Journal of Ophthalmology
JF - American Journal of Ophthalmology
SN - 0002-9394
ER -
ID: 345683298