Prevalence of hyperthyroidism and hypothyroidism in liver transplant recipients and associated risk factors

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Prevalence of hyperthyroidism and hypothyroidism in liver transplant recipients and associated risk factors. / Suarez-Zdunek, Moises Alberto; Arentoft, Nicoline Stender; Krohn, Paul Suno; Lauridsen, Emilie Høegholm Ernst; Afzal, Shoaib; Høgh, Julie; Thomsen, Magda Teresa; Knudsen, Andreas Dehlbæk; Nordestgaard, Børge Grønne; Hillingsø, Jens Georg; Villadsen, Gerda Elisabeth; Holland-Fischer, Peter; Rasmussen, Allan; Fialla, Anette Dam; Feldt-Rasmussen, Ulla; Nielsen, Susanne D.

In: Scientific Reports, Vol. 14, No. 1, 7828, 2024.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Suarez-Zdunek, MA, Arentoft, NS, Krohn, PS, Lauridsen, EHE, Afzal, S, Høgh, J, Thomsen, MT, Knudsen, AD, Nordestgaard, BG, Hillingsø, JG, Villadsen, GE, Holland-Fischer, P, Rasmussen, A, Fialla, AD, Feldt-Rasmussen, U & Nielsen, SD 2024, 'Prevalence of hyperthyroidism and hypothyroidism in liver transplant recipients and associated risk factors', Scientific Reports, vol. 14, no. 1, 7828. https://doi.org/10.1038/s41598-024-58544-3

APA

Suarez-Zdunek, M. A., Arentoft, N. S., Krohn, P. S., Lauridsen, E. H. E., Afzal, S., Høgh, J., Thomsen, M. T., Knudsen, A. D., Nordestgaard, B. G., Hillingsø, J. G., Villadsen, G. E., Holland-Fischer, P., Rasmussen, A., Fialla, A. D., Feldt-Rasmussen, U., & Nielsen, S. D. (2024). Prevalence of hyperthyroidism and hypothyroidism in liver transplant recipients and associated risk factors. Scientific Reports, 14(1), [7828]. https://doi.org/10.1038/s41598-024-58544-3

Vancouver

Suarez-Zdunek MA, Arentoft NS, Krohn PS, Lauridsen EHE, Afzal S, Høgh J et al. Prevalence of hyperthyroidism and hypothyroidism in liver transplant recipients and associated risk factors. Scientific Reports. 2024;14(1). 7828. https://doi.org/10.1038/s41598-024-58544-3

Author

Suarez-Zdunek, Moises Alberto ; Arentoft, Nicoline Stender ; Krohn, Paul Suno ; Lauridsen, Emilie Høegholm Ernst ; Afzal, Shoaib ; Høgh, Julie ; Thomsen, Magda Teresa ; Knudsen, Andreas Dehlbæk ; Nordestgaard, Børge Grønne ; Hillingsø, Jens Georg ; Villadsen, Gerda Elisabeth ; Holland-Fischer, Peter ; Rasmussen, Allan ; Fialla, Anette Dam ; Feldt-Rasmussen, Ulla ; Nielsen, Susanne D. / Prevalence of hyperthyroidism and hypothyroidism in liver transplant recipients and associated risk factors. In: Scientific Reports. 2024 ; Vol. 14, No. 1.

Bibtex

@article{ab67b10e79e249b59b4e33ba5d24d3d2,

title = "Prevalence of hyperthyroidism and hypothyroidism in liver transplant recipients and associated risk factors",

abstract = "The prevalence of hyperthyroidism and hypothyroidism and associated risk factors are unknown in liver transplant recipients. We aimed to determine the prevalence of hyperthyroidism and hypothyroidism and associated risk factors in liver transplant recipients and to compare it with controls from the general population. As part of the Danish Comorbidity in Liver Transplant Recipients (DACOLT) Study, all Danish liver transplant recipients over the age of 20 were invited for measurements of concentrations of thyrotropin and thyroid hormones. The prevalence of hyperthyroidism and hypothyroidism was compared to age- and sex-matched controls from the Copenhagen General Population Study. Using logistic regression adjusted for age, sex, smoking, and body-mass index, we investigated potential risk factors. We recruited 489 liver transplant recipients and 1808 controls. Among liver transplant recipients, 14 (2.9%) had hyperthyroidism compared with 21 (1.2%) of controls (adjusted odds ratio [aOR] 2.24, 95% confidence interval [CI] 1.05–4.75, P = 0.04), while 42 (5.7%) had hypothyroidism compared with 139 (7.7%) of controls (aOR 0.68, 95% CI 0.43–1.08, P = 0.10). Female sex, and autoimmune hepatitis and primary sclerosing cholangitis as causes of transplantation were associated with hyperthyroidism after adjustments. Age, female sex, and autoimmune liver diseases as cause of transplantation were associated with hypothyroidism after adjustments. DACOLT is registered in ClinicalTrials.gov (NCT04777032).",

author = "Suarez-Zdunek, {Moises Alberto} and Arentoft, {Nicoline Stender} and Krohn, {Paul Suno} and Lauridsen, {Emilie H{\o}egholm Ernst} and Shoaib Afzal and Julie H{\o}gh and Thomsen, {Magda Teresa} and Knudsen, {Andreas Dehlb{\ae}k} and Nordestgaard, {B{\o}rge Gr{\o}nne} and Hillings{\o}, {Jens Georg} and Villadsen, {Gerda Elisabeth} and Peter Holland-Fischer and Allan Rasmussen and Fialla, {Anette Dam} and Ulla Feldt-Rasmussen and Nielsen, {Susanne D.}",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2024.",

year = "2024",

doi = "10.1038/s41598-024-58544-3",

language = "English",

volume = "14",

journal = "Scientific Reports",

issn = "2045-2322",

publisher = "nature publishing group",

number = "1",

}

RIS

TY - JOUR

T1 - Prevalence of hyperthyroidism and hypothyroidism in liver transplant recipients and associated risk factors

AU - Suarez-Zdunek, Moises Alberto

AU - Arentoft, Nicoline Stender

AU - Krohn, Paul Suno

AU - Lauridsen, Emilie Høegholm Ernst

AU - Afzal, Shoaib

AU - Høgh, Julie

AU - Thomsen, Magda Teresa

AU - Knudsen, Andreas Dehlbæk

AU - Nordestgaard, Børge Grønne

AU - Hillingsø, Jens Georg

AU - Villadsen, Gerda Elisabeth

AU - Holland-Fischer, Peter

AU - Rasmussen, Allan

AU - Fialla, Anette Dam

AU - Feldt-Rasmussen, Ulla

AU - Nielsen, Susanne D.

PY - 2024

Y1 - 2024

N2 - The prevalence of hyperthyroidism and hypothyroidism and associated risk factors are unknown in liver transplant recipients. We aimed to determine the prevalence of hyperthyroidism and hypothyroidism and associated risk factors in liver transplant recipients and to compare it with controls from the general population. As part of the Danish Comorbidity in Liver Transplant Recipients (DACOLT) Study, all Danish liver transplant recipients over the age of 20 were invited for measurements of concentrations of thyrotropin and thyroid hormones. The prevalence of hyperthyroidism and hypothyroidism was compared to age- and sex-matched controls from the Copenhagen General Population Study. Using logistic regression adjusted for age, sex, smoking, and body-mass index, we investigated potential risk factors. We recruited 489 liver transplant recipients and 1808 controls. Among liver transplant recipients, 14 (2.9%) had hyperthyroidism compared with 21 (1.2%) of controls (adjusted odds ratio [aOR] 2.24, 95% confidence interval [CI] 1.05–4.75, P = 0.04), while 42 (5.7%) had hypothyroidism compared with 139 (7.7%) of controls (aOR 0.68, 95% CI 0.43–1.08, P = 0.10). Female sex, and autoimmune hepatitis and primary sclerosing cholangitis as causes of transplantation were associated with hyperthyroidism after adjustments. Age, female sex, and autoimmune liver diseases as cause of transplantation were associated with hypothyroidism after adjustments. DACOLT is registered in ClinicalTrials.gov (NCT04777032).

AB - The prevalence of hyperthyroidism and hypothyroidism and associated risk factors are unknown in liver transplant recipients. We aimed to determine the prevalence of hyperthyroidism and hypothyroidism and associated risk factors in liver transplant recipients and to compare it with controls from the general population. As part of the Danish Comorbidity in Liver Transplant Recipients (DACOLT) Study, all Danish liver transplant recipients over the age of 20 were invited for measurements of concentrations of thyrotropin and thyroid hormones. The prevalence of hyperthyroidism and hypothyroidism was compared to age- and sex-matched controls from the Copenhagen General Population Study. Using logistic regression adjusted for age, sex, smoking, and body-mass index, we investigated potential risk factors. We recruited 489 liver transplant recipients and 1808 controls. Among liver transplant recipients, 14 (2.9%) had hyperthyroidism compared with 21 (1.2%) of controls (adjusted odds ratio [aOR] 2.24, 95% confidence interval [CI] 1.05–4.75, P = 0.04), while 42 (5.7%) had hypothyroidism compared with 139 (7.7%) of controls (aOR 0.68, 95% CI 0.43–1.08, P = 0.10). Female sex, and autoimmune hepatitis and primary sclerosing cholangitis as causes of transplantation were associated with hyperthyroidism after adjustments. Age, female sex, and autoimmune liver diseases as cause of transplantation were associated with hypothyroidism after adjustments. DACOLT is registered in ClinicalTrials.gov (NCT04777032).

U2 - 10.1038/s41598-024-58544-3

DO - 10.1038/s41598-024-58544-3

M3 - Journal article

C2 - 38570629

AN - SCOPUS:85189793367

VL - 14

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

IS - 1

M1 - 7828

ER -

ID: 388944004