Sensitization-based risk for substance abuse in vulnerable individuals with ADHD: Review and re-examination of evidence
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Sensitization-based risk for substance abuse in vulnerable individuals with ADHD : Review and re-examination of evidence. / Ivanov, Iliyan; Bjork, James M.; Blair, James; Newcorn, Jeffrey H.
In: Neuroscience and Biobehavioral Reviews, Vol. 135, 104575, 2022.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Sensitization-based risk for substance abuse in vulnerable individuals with ADHD
T2 - Review and re-examination of evidence
AU - Ivanov, Iliyan
AU - Bjork, James M.
AU - Blair, James
AU - Newcorn, Jeffrey H.
N1 - Publisher Copyright: © 2022
PY - 2022
Y1 - 2022
N2 - Evidence of sensitization following stimulants administration in humans is just emerging, which prevents reaching more definitive conclusions in favor or against a purported protective role of stimulant treatments for ADHD for the development of substance use disorders. Existing evidence from both animal and human research suggest that stimulants produce neurophysiological changes in the brain reward system, some of which could be persistent. This could be relevant in choosing optimal treatments for young patients with ADHD who have additional clinical risk factors for substance abuse (e.g. conduct disorder (CD) and/or familial addictions). Here we stipulate that, while the majority of youth with ADHD greatly benefit from treatments with stimulants, there might be a subpopulation of individuals whose neurobiological profiles may confer risk for heightened vulnerability to the effects of stimulants on the responsiveness of the brain reward system. We propose that focused human research is needed to elucidate the unknown effects of prolonged stimulant exposure on the neurophysiology of the brain reward system in young patients with ADHD.
AB - Evidence of sensitization following stimulants administration in humans is just emerging, which prevents reaching more definitive conclusions in favor or against a purported protective role of stimulant treatments for ADHD for the development of substance use disorders. Existing evidence from both animal and human research suggest that stimulants produce neurophysiological changes in the brain reward system, some of which could be persistent. This could be relevant in choosing optimal treatments for young patients with ADHD who have additional clinical risk factors for substance abuse (e.g. conduct disorder (CD) and/or familial addictions). Here we stipulate that, while the majority of youth with ADHD greatly benefit from treatments with stimulants, there might be a subpopulation of individuals whose neurobiological profiles may confer risk for heightened vulnerability to the effects of stimulants on the responsiveness of the brain reward system. We propose that focused human research is needed to elucidate the unknown effects of prolonged stimulant exposure on the neurophysiology of the brain reward system in young patients with ADHD.
KW - ADHD
KW - Brain reward system
KW - Sensitization
KW - Stimulants
KW - SUD
U2 - 10.1016/j.neubiorev.2022.104575
DO - 10.1016/j.neubiorev.2022.104575
M3 - Review
C2 - 35151770
AN - SCOPUS:85124428631
VL - 135
JO - Neuroscience & Biobehavioral Reviews
JF - Neuroscience & Biobehavioral Reviews
SN - 0149-7634
M1 - 104575
ER -
ID: 346191850