Uterine volume and endometrial thickness in healthy girls evaluated by ultrasound (3-dimensional) and magnetic resonance imaging
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Uterine volume and endometrial thickness in healthy girls evaluated by ultrasound (3-dimensional) and magnetic resonance imaging. / Hagen, Casper P; Mouritsen, Annette; Mieritz, Mikkel G; Tinggaard, Jeanette; Wohlfahrt-Veje, Christine; Fallentin, Eva; Brocks, Vibeke; Sundberg, Karin; Jensen, Lisa Neerup; Juul, Anders; Main, Katharina M.
In: Fertility and Sterility, Vol. 104, No. 2, 08.2015, p. 452-9.e2.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Uterine volume and endometrial thickness in healthy girls evaluated by ultrasound (3-dimensional) and magnetic resonance imaging
AU - Hagen, Casper P
AU - Mouritsen, Annette
AU - Mieritz, Mikkel G
AU - Tinggaard, Jeanette
AU - Wohlfahrt-Veje, Christine
AU - Fallentin, Eva
AU - Brocks, Vibeke
AU - Sundberg, Karin
AU - Jensen, Lisa Neerup
AU - Juul, Anders
AU - Main, Katharina M
N1 - Copyright © 2015 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
PY - 2015/8
Y1 - 2015/8
N2 - OBJECTIVE: To report normative data on uterine volume and endometrial thickness in girls, according to pubertal stages; to evaluate factors that affect uterine volume; and to compare transabdominal ultrasound (TAUS) and magnetic resonance imaging (MRI).DESIGN: Cross-sectional study of a nested cohort of girls participating in The Copenhagen Mother-Child Cohort.SETTING: General community.PATIENT(S): One hundred twenty-one healthy girls, aged 9.8-14.7 years.INTERVENTION(S): None.MAIN OUTCOME MEASURE(S): Clinical examination, including pubertal breast stage (Tanner classification: B1-B5). Uterine volume: ellipsoid TAUS (n = 112) and 3-dimensional TAUS (n = 111); ellipsoid MRI (n = 61). Endometrial thickness: TAUS (n = 110) and MRI (n = 60).RESULT(S): Uterine volume and endometrial thickness were positively correlated with pubertal stages; e.g., ellipsoid TAUS: r = 0.753, and endometrium TAUS: 0.648. In multiple regression analyses, uterine volume was associated with the number of large follicles (TAUS >5 mm) (Beta 0.270); estradiol (E2) (Beta 0.504); and height (Beta 0.341). Volumes from ellipsoid vs. 3-dimensional TAUS were strongly correlated (r = 0.931), as were TAUS and MRI: ellipsoid volume (r = 0.891) and endometrial thickness (r = 0.540). Uterine volume was larger in TAUS compared with MRI; mean difference across the measured range: 7.7 (5.2-10.2) cm(3). Agreement was best for small uteri.CONCLUSION(S): Uterine volume and endometrial thickness increased as puberty progressed. Circulating E2 from large follicles was the main contributor to uterine and endometrial growth. The TAUS and MRI assessments of uterus and endometrium were strongly correlated.
AB - OBJECTIVE: To report normative data on uterine volume and endometrial thickness in girls, according to pubertal stages; to evaluate factors that affect uterine volume; and to compare transabdominal ultrasound (TAUS) and magnetic resonance imaging (MRI).DESIGN: Cross-sectional study of a nested cohort of girls participating in The Copenhagen Mother-Child Cohort.SETTING: General community.PATIENT(S): One hundred twenty-one healthy girls, aged 9.8-14.7 years.INTERVENTION(S): None.MAIN OUTCOME MEASURE(S): Clinical examination, including pubertal breast stage (Tanner classification: B1-B5). Uterine volume: ellipsoid TAUS (n = 112) and 3-dimensional TAUS (n = 111); ellipsoid MRI (n = 61). Endometrial thickness: TAUS (n = 110) and MRI (n = 60).RESULT(S): Uterine volume and endometrial thickness were positively correlated with pubertal stages; e.g., ellipsoid TAUS: r = 0.753, and endometrium TAUS: 0.648. In multiple regression analyses, uterine volume was associated with the number of large follicles (TAUS >5 mm) (Beta 0.270); estradiol (E2) (Beta 0.504); and height (Beta 0.341). Volumes from ellipsoid vs. 3-dimensional TAUS were strongly correlated (r = 0.931), as were TAUS and MRI: ellipsoid volume (r = 0.891) and endometrial thickness (r = 0.540). Uterine volume was larger in TAUS compared with MRI; mean difference across the measured range: 7.7 (5.2-10.2) cm(3). Agreement was best for small uteri.CONCLUSION(S): Uterine volume and endometrial thickness increased as puberty progressed. Circulating E2 from large follicles was the main contributor to uterine and endometrial growth. The TAUS and MRI assessments of uterus and endometrium were strongly correlated.
KW - Adolescent
KW - Child
KW - Cohort Studies
KW - Cross-Sectional Studies
KW - Denmark
KW - Endometrium
KW - Female
KW - Humans
KW - Longitudinal Studies
KW - Magnetic Resonance Imaging
KW - Organ Size
KW - Sexual Maturation
KW - Uterus
U2 - 10.1016/j.fertnstert.2015.04.042
DO - 10.1016/j.fertnstert.2015.04.042
M3 - Journal article
C2 - 26051091
VL - 104
SP - 452-9.e2
JO - Sexuality, Reproduction and Menopause
JF - Sexuality, Reproduction and Menopause
SN - 1546-2501
IS - 2
ER -
ID: 160505425