Growth hormone (GH) deficiency may be of congenital origin and may present with typical clinical signs and symptoms very early in postnatal life, but may also present later during childhood with growth deceleration. In a short-statured child suspected of GH deficiency, diagnostic procedures include appropriate auxological measurements using updated national growth references, bone age determination, and biochemical evaluation. GH dose is adjusted every three months based on height changes and serum insulin-like growth factor-I concentration. After cessation of linear growth, GH secretion should be re-evaluated during transitional care from a paediatric to an adult endocrinological setting.