Vinpocetine improved neuropsychiatric and epileptic outcomes in a patient with a GABRA1 loss-of-function variant
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Vinpocetine is a synthetic derivative of the alkaloid vincamine and has been used as a dietary supplement for decades. Following a positive report of the use of vinpocetine in a patient with a loss-of-function GABRB3 variant, we here describe another patient with a loss-of-function GABRA1 variant (p.(Arg112Gln)) who benefited from vinpocetine treatment. This patient was diagnosed with autism spectrum disorder, psychiatric complications, and therapy-resistant focal epilepsy. Upon add-on treatment with 40 mg vinpocetine daily for 16 months, the patient experienced an overall improved quality of life as well as seizure freedom. Our findings corroborate that vinpocetine can attenuate epilepsy-associated behavioral issues in patients with loss-of-function GABAA receptor gene variants.
Original language | English |
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Journal | Annals of Clinical and Translational Neurology |
Volume | 10 |
Issue number | 8 |
Pages (from-to) | 1493-1498 |
Number of pages | 6 |
ISSN | 2328-9503 |
DOIs | |
Publication status | Published - 2023 |
Bibliographical note
Funding Information:
The Australian National Health & Medical Research Council grant APP1185122 (PKA, VWYL, MC) and the Novo Nordisk foundation grant NNF 0058749 (RSM).
Publisher Copyright:
© 2023 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association.
ID: 386603423