Initial treatment and survival in Danish patients diagnosed with non-small-cell lung cancer (2005-2015): SCAN-LEAF study
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Initial treatment and survival in Danish patients diagnosed with non-small-cell lung cancer (2005-2015) : SCAN-LEAF study. / Sørensen, Jens Benn; Horvat, Pia; Rosenlund, Mats; Kejs, Anne Mette; Patel, Dony; Juarez-Garcia, Ariadna; Lacoin, Laure; Daumont, Melinda J.; Penrod, John R.; O'donnell, John C.; Brustugun, Odd Terje; Ekman, Simon.
I: Future Oncology, Bind 18, Nr. 2, 2022, s. 205-214.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Initial treatment and survival in Danish patients diagnosed with non-small-cell lung cancer (2005-2015)
T2 - SCAN-LEAF study
AU - Sørensen, Jens Benn
AU - Horvat, Pia
AU - Rosenlund, Mats
AU - Kejs, Anne Mette
AU - Patel, Dony
AU - Juarez-Garcia, Ariadna
AU - Lacoin, Laure
AU - Daumont, Melinda J.
AU - Penrod, John R.
AU - O'donnell, John C.
AU - Brustugun, Odd Terje
AU - Ekman, Simon
N1 - Publisher Copyright: © 2021 The Authors.
PY - 2022
Y1 - 2022
N2 - Aim: To describe initial treatment patterns and survival of patients diagnosed with non-small-cell lung cancer (NSCLC) in Denmark, before immune checkpoint inhibitor and later-generation tyrosine kinase inhibitor use. Patients & methods: Adults diagnosed with incident NSCLC (2005-2015; follow-up: 2016). Initial treatments and overall survival (OS) are reported. Results: 31,939 NSCLC patients (51.6% stage IV) were included. Increasing use of curative radiotherapy/chemoradiation for stage I, II/IIIA and IIIB NSCLC coincided with improved 2-year OS. Systemic anticancer therapy use increased for patients with stage IV non-squamous NSCLC (53.0-60.6%) but not squamous NSCLC (44.9-47.3%). 1-year OS improved in patients with stage IV non-squamous NSCLC (23-31%) but not squamous NSCLC (22-25%). Conclusion: Trends indicated improved OS as treatments evolved between 2005 and 2015, but the effect was limited to 1-year OS in stage IV disease.
AB - Aim: To describe initial treatment patterns and survival of patients diagnosed with non-small-cell lung cancer (NSCLC) in Denmark, before immune checkpoint inhibitor and later-generation tyrosine kinase inhibitor use. Patients & methods: Adults diagnosed with incident NSCLC (2005-2015; follow-up: 2016). Initial treatments and overall survival (OS) are reported. Results: 31,939 NSCLC patients (51.6% stage IV) were included. Increasing use of curative radiotherapy/chemoradiation for stage I, II/IIIA and IIIB NSCLC coincided with improved 2-year OS. Systemic anticancer therapy use increased for patients with stage IV non-squamous NSCLC (53.0-60.6%) but not squamous NSCLC (44.9-47.3%). 1-year OS improved in patients with stage IV non-squamous NSCLC (23-31%) but not squamous NSCLC (22-25%). Conclusion: Trends indicated improved OS as treatments evolved between 2005 and 2015, but the effect was limited to 1-year OS in stage IV disease.
KW - I-O Optimise initiative
KW - NSCLC
KW - overall survival
KW - registry
KW - SCAN-LEAF
KW - time trends
KW - treatment
UR - http://www.scopus.com/inward/record.url?scp=85121582602&partnerID=8YFLogxK
U2 - 10.2217/fon-2021-0746
DO - 10.2217/fon-2021-0746
M3 - Journal article
C2 - 34784783
AN - SCOPUS:85121582602
VL - 18
SP - 205
EP - 214
JO - Future Oncology
JF - Future Oncology
SN - 1479-6694
IS - 2
ER -
ID: 318201523