Initial treatment and survival in Danish patients diagnosed with non-small-cell lung cancer (2005-2015): SCAN-LEAF study

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  • Sørensen, Jens Benn
  • Pia Horvat
  • Mats Rosenlund
  • Anne Mette Kejs
  • Dony Patel
  • Ariadna Juarez-Garcia
  • Laure Lacoin
  • Melinda J. Daumont
  • John R. Penrod
  • John C. O'donnell
  • Odd Terje Brustugun
  • Simon Ekman

Aim: To describe initial treatment patterns and survival of patients diagnosed with non-small-cell lung cancer (NSCLC) in Denmark, before immune checkpoint inhibitor and later-generation tyrosine kinase inhibitor use. Patients & methods: Adults diagnosed with incident NSCLC (2005-2015; follow-up: 2016). Initial treatments and overall survival (OS) are reported. Results: 31,939 NSCLC patients (51.6% stage IV) were included. Increasing use of curative radiotherapy/chemoradiation for stage I, II/IIIA and IIIB NSCLC coincided with improved 2-year OS. Systemic anticancer therapy use increased for patients with stage IV non-squamous NSCLC (53.0-60.6%) but not squamous NSCLC (44.9-47.3%). 1-year OS improved in patients with stage IV non-squamous NSCLC (23-31%) but not squamous NSCLC (22-25%). Conclusion: Trends indicated improved OS as treatments evolved between 2005 and 2015, but the effect was limited to 1-year OS in stage IV disease.

OriginalsprogEngelsk
TidsskriftFuture Oncology
Vol/bind18
Udgave nummer2
Sider (fra-til)205-214
Antal sider10
ISSN1479-6694
DOI
StatusUdgivet - 2022

Bibliografisk note

Funding Information:
This work was supported by Bristol Myers Squibb. IQVIA received funding from Bristol Myers Squibb to perform the data analyses planned in the study protocol. J B Sørensen has received speaker fees from Bristol Myers Squibb. P Horvat, M Rosenlund, A Mette Kejs and D Patel were employees of IQVIA at the time of this study. A Juarez-Garcia, M J Daumont, J R Penrod and J C O’Donnell are employees of Bristol Myers Squibb. A Juarez-Garcia and J R Penrod report stock ownership in Bristol Myers Squibb. L Lacoin is an employee of Epi-Fit and was contracted (paid) as a consultant by Bristol Myers Squibb to support the I-O Optimise initiative. O T Brustugun received honoraria from AstraZeneca, Bristol Myers Squibb, Boehringer Ingelheim, Eli Lilly, MSD, Novartis, Pfizer, Pierre Fabre, Roche and Takeda, and research funding from Pfizer, AstraZeneca, Roche, GlaxoSmithKline and Boehringer Ingelheim. S Ekman is employed by an institution that was remunerated by Bristol Myers Squibb for this study. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. Professional writing and editorial assistance were provided by B Landry of Parexel, funded by Bristol Myers Squibb.

Publisher Copyright:
© 2021 The Authors.

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