Association between primary care electrocardiogram markers and Alzheimer's disease

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Association between primary care electrocardiogram markers and Alzheimer's disease. / Isaksen, Jonas L; Ghouse, Jonas; Skov, Morten W; Olesen, Morten S; Holst, Anders G; Pietersen, Adrian; Nielsen, Jonas B; Maier, Anja; Graff, Claus; Gerds, Thomas A; Frikke-Schmidt, Ruth; Kanters, Jørgen K.

In: Journal of the Neurological Sciences, Vol. 447, 120581, 2023.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Isaksen, JL, Ghouse, J, Skov, MW, Olesen, MS, Holst, AG, Pietersen, A, Nielsen, JB, Maier, A, Graff, C, Gerds, TA, Frikke-Schmidt, R & Kanters, JK 2023, 'Association between primary care electrocardiogram markers and Alzheimer's disease', Journal of the Neurological Sciences, vol. 447, 120581. https://doi.org/10.1016/j.jns.2023.120581

APA

Isaksen, J. L., Ghouse, J., Skov, M. W., Olesen, M. S., Holst, A. G., Pietersen, A., Nielsen, J. B., Maier, A., Graff, C., Gerds, T. A., Frikke-Schmidt, R., & Kanters, J. K. (2023). Association between primary care electrocardiogram markers and Alzheimer's disease. Journal of the Neurological Sciences, 447, [120581]. https://doi.org/10.1016/j.jns.2023.120581

Vancouver

Isaksen JL, Ghouse J, Skov MW, Olesen MS, Holst AG, Pietersen A et al. Association between primary care electrocardiogram markers and Alzheimer's disease. Journal of the Neurological Sciences. 2023;447. 120581. https://doi.org/10.1016/j.jns.2023.120581

Author

Isaksen, Jonas L ; Ghouse, Jonas ; Skov, Morten W ; Olesen, Morten S ; Holst, Anders G ; Pietersen, Adrian ; Nielsen, Jonas B ; Maier, Anja ; Graff, Claus ; Gerds, Thomas A ; Frikke-Schmidt, Ruth ; Kanters, Jørgen K. / Association between primary care electrocardiogram markers and Alzheimer's disease. In: Journal of the Neurological Sciences. 2023 ; Vol. 447.

Bibtex

@article{32d363b82bba4445b56839ac11848853,

title = "Association between primary care electrocardiogram markers and Alzheimer's disease",

abstract = "OBJECTIVE: The association between common electrocardiogram (ECG) markers and Alzheimer's disease has been scarcely investigated, and it is unknown if ECG markers can improve risk prediction. Thus, we aimed to examine the association between common ECG markers and Alzheimer's disease in a large population.METHODS: We studied the association between ECG markers and Alzheimer's disease using Cox models with adjustment for age, sex, and comorbidities using a large primary care population of patients aged 60 years or more.RESULTS: We followed 172,236 subjects for a median of 7.5 years. Increased PR interval (hazard ratio for PR > 188 ms: 0.76 [95% confidence interval: 0.69-0.83, p < 0.001) and increased QTc interval (hazard ratio for QTc = [426;439]: 0.90 [0.83-0.98], p = 0.02) were associated with a decreased rate of Alzheimer's disease. A positive Sokolow-Lyon index >35 mm (1.22 [1.13-1.33], p < 0.001) and increased T-wave amplitude >4.1 mm (1.15 [1.04-1.27]) were associated with an increased rate of Alzheimer's disease. Upon addition of ECG markers to a reference model, 10-year prediction area under the receiver-operator characteristics curve (AUC) improved by 0.39 [0.06-0.67] %-points. The 10-year absolute risk of Alzheimer's disease was 6.5% and 5.2% for an 82-year old female and a male, respectively, with a favorable ECG, and 12% and 9.2%, respectively, with an unfavorable ECG, almost twice as high.CONCLUSIONS: We identified several common ECG markers which were associated with Alzheimer's disease, and which improved risk prediction for Alzheimer's disease.",

author = "Isaksen, {Jonas L} and Jonas Ghouse and Skov, {Morten W} and Olesen, {Morten S} and Holst, {Anders G} and Adrian Pietersen and Nielsen, {Jonas B} and Anja Maier and Claus Graff and Gerds, {Thomas A} and Ruth Frikke-Schmidt and Kanters, {J{\o}rgen K}",

note = "Copyright {\textcopyright} 2023. Published by Elsevier B.V.",

year = "2023",

doi = "10.1016/j.jns.2023.120581",

language = "English",

volume = "447",

journal = "Journal of the Neurological Sciences",

issn = "0022-510X",

publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Association between primary care electrocardiogram markers and Alzheimer's disease

AU - Isaksen, Jonas L

AU - Ghouse, Jonas

AU - Skov, Morten W

AU - Olesen, Morten S

AU - Holst, Anders G

AU - Pietersen, Adrian

AU - Nielsen, Jonas B

AU - Maier, Anja

AU - Graff, Claus

AU - Gerds, Thomas A

AU - Frikke-Schmidt, Ruth

AU - Kanters, Jørgen K

PY - 2023

Y1 - 2023

N2 - OBJECTIVE: The association between common electrocardiogram (ECG) markers and Alzheimer's disease has been scarcely investigated, and it is unknown if ECG markers can improve risk prediction. Thus, we aimed to examine the association between common ECG markers and Alzheimer's disease in a large population.METHODS: We studied the association between ECG markers and Alzheimer's disease using Cox models with adjustment for age, sex, and comorbidities using a large primary care population of patients aged 60 years or more.RESULTS: We followed 172,236 subjects for a median of 7.5 years. Increased PR interval (hazard ratio for PR > 188 ms: 0.76 [95% confidence interval: 0.69-0.83, p < 0.001) and increased QTc interval (hazard ratio for QTc = [426;439]: 0.90 [0.83-0.98], p = 0.02) were associated with a decreased rate of Alzheimer's disease. A positive Sokolow-Lyon index >35 mm (1.22 [1.13-1.33], p < 0.001) and increased T-wave amplitude >4.1 mm (1.15 [1.04-1.27]) were associated with an increased rate of Alzheimer's disease. Upon addition of ECG markers to a reference model, 10-year prediction area under the receiver-operator characteristics curve (AUC) improved by 0.39 [0.06-0.67] %-points. The 10-year absolute risk of Alzheimer's disease was 6.5% and 5.2% for an 82-year old female and a male, respectively, with a favorable ECG, and 12% and 9.2%, respectively, with an unfavorable ECG, almost twice as high.CONCLUSIONS: We identified several common ECG markers which were associated with Alzheimer's disease, and which improved risk prediction for Alzheimer's disease.

AB - OBJECTIVE: The association between common electrocardiogram (ECG) markers and Alzheimer's disease has been scarcely investigated, and it is unknown if ECG markers can improve risk prediction. Thus, we aimed to examine the association between common ECG markers and Alzheimer's disease in a large population.METHODS: We studied the association between ECG markers and Alzheimer's disease using Cox models with adjustment for age, sex, and comorbidities using a large primary care population of patients aged 60 years or more.RESULTS: We followed 172,236 subjects for a median of 7.5 years. Increased PR interval (hazard ratio for PR > 188 ms: 0.76 [95% confidence interval: 0.69-0.83, p < 0.001) and increased QTc interval (hazard ratio for QTc = [426;439]: 0.90 [0.83-0.98], p = 0.02) were associated with a decreased rate of Alzheimer's disease. A positive Sokolow-Lyon index >35 mm (1.22 [1.13-1.33], p < 0.001) and increased T-wave amplitude >4.1 mm (1.15 [1.04-1.27]) were associated with an increased rate of Alzheimer's disease. Upon addition of ECG markers to a reference model, 10-year prediction area under the receiver-operator characteristics curve (AUC) improved by 0.39 [0.06-0.67] %-points. The 10-year absolute risk of Alzheimer's disease was 6.5% and 5.2% for an 82-year old female and a male, respectively, with a favorable ECG, and 12% and 9.2%, respectively, with an unfavorable ECG, almost twice as high.CONCLUSIONS: We identified several common ECG markers which were associated with Alzheimer's disease, and which improved risk prediction for Alzheimer's disease.

U2 - 10.1016/j.jns.2023.120581

DO - 10.1016/j.jns.2023.120581

M3 - Journal article

C2 - 36827718

VL - 447

JO - Journal of the Neurological Sciences

JF - Journal of the Neurological Sciences

SN - 0022-510X

M1 - 120581

ER -

ID: 337971858

Department of Clinical Medicine