A vital role for complement in heart disease
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A vital role for complement in heart disease. / Lappegård, Knut T; Garred, Peter; Jonasson, Lena; Espevik, Terje; Aukrust, Pål; Yndestad, Arne; Mollnes, Tom E; Hovland, Anders.
In: Molecular Immunology, Vol. 61, No. 2, 2014, p. 126-134.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - A vital role for complement in heart disease
AU - Lappegård, Knut T
AU - Garred, Peter
AU - Jonasson, Lena
AU - Espevik, Terje
AU - Aukrust, Pål
AU - Yndestad, Arne
AU - Mollnes, Tom E
AU - Hovland, Anders
N1 - Copyright © 2014 Elsevier Ltd. All rights reserved.
PY - 2014
Y1 - 2014
N2 - Heart diseases are common and significant contributors to worldwide mortality and morbidity. During recent years complement mediated inflammation has been shown to be an important player in a variety of heart diseases. Despite some negative results from clinical trials using complement inhibitors, emerging evidence points to an association between the complement system and heart diseases. Thus, complement seems to be important in coronary heart disease as well as in heart failure, where several studies underscore the prognostic importance of complement activation. Furthermore, patients with atrial fibrillation often share risk factors both with coronary heart disease and heart failure, and there is some evidence implicating complement activation in atrial fibrillation. Moreover, Chagas heart disease, a protozoal infection, is an important cause of heart failure in Latin America, and the complement system is crucial for the protozoa-host interaction. Thus, complement activation appears to be involved in the pathophysiology of a diverse range of cardiac conditions. Determination of the exact role of complement in the various heart diseases will hopefully help to identify patients that might benefit from therapeutic complement intervention.
AB - Heart diseases are common and significant contributors to worldwide mortality and morbidity. During recent years complement mediated inflammation has been shown to be an important player in a variety of heart diseases. Despite some negative results from clinical trials using complement inhibitors, emerging evidence points to an association between the complement system and heart diseases. Thus, complement seems to be important in coronary heart disease as well as in heart failure, where several studies underscore the prognostic importance of complement activation. Furthermore, patients with atrial fibrillation often share risk factors both with coronary heart disease and heart failure, and there is some evidence implicating complement activation in atrial fibrillation. Moreover, Chagas heart disease, a protozoal infection, is an important cause of heart failure in Latin America, and the complement system is crucial for the protozoa-host interaction. Thus, complement activation appears to be involved in the pathophysiology of a diverse range of cardiac conditions. Determination of the exact role of complement in the various heart diseases will hopefully help to identify patients that might benefit from therapeutic complement intervention.
KW - Animals
KW - Complement System Proteins
KW - Heart Diseases
KW - Humans
U2 - 10.1016/j.molimm.2014.06.036
DO - 10.1016/j.molimm.2014.06.036
M3 - Review
C2 - 25037633
VL - 61
SP - 126
EP - 134
JO - Molecular Immunology
JF - Molecular Immunology
SN - 0161-5890
IS - 2
ER -
ID: 137964997