Adenosine derived from Staphylococcus aureus-engulfed macrophages functions as a potent stimulant for the induction of inflammatory cytokines in mast cells

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Adenosine derived from Staphylococcus aureus-engulfed macrophages functions as a potent stimulant for the induction of inflammatory cytokines in mast cells. / Ma, Ying Jie; Kim, Chan-Hee; Ryu, Kyoung-Hwa; Kim, Min-Su; So, Young-In; Lee, Kong-Joo; Garred, Peter; Lee, Bok-Luel.

In: B M B Reports, Vol. 44, No. 5, 2011, p. 335-40.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Ma, YJ, Kim, C-H, Ryu, K-H, Kim, M-S, So, Y-I, Lee, K-J, Garred, P & Lee, B-L 2011, 'Adenosine derived from Staphylococcus aureus-engulfed macrophages functions as a potent stimulant for the induction of inflammatory cytokines in mast cells', B M B Reports, vol. 44, no. 5, pp. 335-40. https://doi.org/10.5483/BMBRep.2011.44.5.335

APA

Ma, Y. J., Kim, C-H., Ryu, K-H., Kim, M-S., So, Y-I., Lee, K-J., Garred, P., & Lee, B-L. (2011). Adenosine derived from Staphylococcus aureus-engulfed macrophages functions as a potent stimulant for the induction of inflammatory cytokines in mast cells. B M B Reports, 44(5), 335-40. https://doi.org/10.5483/BMBRep.2011.44.5.335

Vancouver

Ma YJ, Kim C-H, Ryu K-H, Kim M-S, So Y-I, Lee K-J et al. Adenosine derived from Staphylococcus aureus-engulfed macrophages functions as a potent stimulant for the induction of inflammatory cytokines in mast cells. B M B Reports. 2011;44(5):335-40. https://doi.org/10.5483/BMBRep.2011.44.5.335

Author

Ma, Ying Jie ; Kim, Chan-Hee ; Ryu, Kyoung-Hwa ; Kim, Min-Su ; So, Young-In ; Lee, Kong-Joo ; Garred, Peter ; Lee, Bok-Luel. / Adenosine derived from Staphylococcus aureus-engulfed macrophages functions as a potent stimulant for the induction of inflammatory cytokines in mast cells. In: B M B Reports. 2011 ; Vol. 44, No. 5. pp. 335-40.

Bibtex

@article{3f4059632b93441ab9043f0dc6650ff1,
title = "Adenosine derived from Staphylococcus aureus-engulfed macrophages functions as a potent stimulant for the induction of inflammatory cytokines in mast cells",
abstract = "In this study, we attempted to isolate novel mast cell-stimulating molecules from Staphylococcus aureus. Water-soluble extract of S. aureus cell lysate strongly induced human interleukin- 8 in human mast cell line-1 and mouse interleukin-6 in mouse bone marrow-derived mast cells. The active molecule was purified to homogeneity through a C(18) reverse phase HPLC column. By determination of its structure by MALDITOF and (1)H- and (13)C-NMR, adenosine was revealed to be responsible for the observed cytokine induction activities. Further studies using 8-sulfophenyl theophylline, a selective adenosine receptor blocker, verified that purified adenosine can induce interleukin-8 production via adenosine receptors on mast cells. Moreover, adenosine was purified from S. aureusengulfed RAW264.7 cells, a murine macrophage cell line, used to induce phagocytosis of S. aureus. These results show a novel view of the source of exogenous adenosine in vivo and provide a mechanistic link between inflammatory disease and bacterial infection.",
author = "Ma, {Ying Jie} and Chan-Hee Kim and Kyoung-Hwa Ryu and Min-Su Kim and Young-In So and Kong-Joo Lee and Peter Garred and Bok-Luel Lee",
year = "2011",
doi = "http://dx.doi.org/10.5483/BMBRep.2011.44.5.335",
language = "English",
volume = "44",
pages = "335--40",
journal = "BMB Reports",
issn = "1976-6696",
publisher = "Korean Society for Biochemistry and Molecular Biology",
number = "5",

}

RIS

TY - JOUR

T1 - Adenosine derived from Staphylococcus aureus-engulfed macrophages functions as a potent stimulant for the induction of inflammatory cytokines in mast cells

AU - Ma, Ying Jie

AU - Kim, Chan-Hee

AU - Ryu, Kyoung-Hwa

AU - Kim, Min-Su

AU - So, Young-In

AU - Lee, Kong-Joo

AU - Garred, Peter

AU - Lee, Bok-Luel

PY - 2011

Y1 - 2011

N2 - In this study, we attempted to isolate novel mast cell-stimulating molecules from Staphylococcus aureus. Water-soluble extract of S. aureus cell lysate strongly induced human interleukin- 8 in human mast cell line-1 and mouse interleukin-6 in mouse bone marrow-derived mast cells. The active molecule was purified to homogeneity through a C(18) reverse phase HPLC column. By determination of its structure by MALDITOF and (1)H- and (13)C-NMR, adenosine was revealed to be responsible for the observed cytokine induction activities. Further studies using 8-sulfophenyl theophylline, a selective adenosine receptor blocker, verified that purified adenosine can induce interleukin-8 production via adenosine receptors on mast cells. Moreover, adenosine was purified from S. aureusengulfed RAW264.7 cells, a murine macrophage cell line, used to induce phagocytosis of S. aureus. These results show a novel view of the source of exogenous adenosine in vivo and provide a mechanistic link between inflammatory disease and bacterial infection.

AB - In this study, we attempted to isolate novel mast cell-stimulating molecules from Staphylococcus aureus. Water-soluble extract of S. aureus cell lysate strongly induced human interleukin- 8 in human mast cell line-1 and mouse interleukin-6 in mouse bone marrow-derived mast cells. The active molecule was purified to homogeneity through a C(18) reverse phase HPLC column. By determination of its structure by MALDITOF and (1)H- and (13)C-NMR, adenosine was revealed to be responsible for the observed cytokine induction activities. Further studies using 8-sulfophenyl theophylline, a selective adenosine receptor blocker, verified that purified adenosine can induce interleukin-8 production via adenosine receptors on mast cells. Moreover, adenosine was purified from S. aureusengulfed RAW264.7 cells, a murine macrophage cell line, used to induce phagocytosis of S. aureus. These results show a novel view of the source of exogenous adenosine in vivo and provide a mechanistic link between inflammatory disease and bacterial infection.

U2 - http://dx.doi.org/10.5483/BMBRep.2011.44.5.335

DO - http://dx.doi.org/10.5483/BMBRep.2011.44.5.335

M3 - Journal article

VL - 44

SP - 335

EP - 340

JO - BMB Reports

JF - BMB Reports

SN - 1976-6696

IS - 5

ER -

ID: 40152953