Complement related pattern recognition molecules as markers of short-term mortality in intensive care patients
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Complement related pattern recognition molecules as markers of short-term mortality in intensive care patients. / Hansen, Cecilie B.; Bayarri-Olmos, Rafael; Kristensen, Markus K.; Pilely, Katrine; Hellemann, Dorthe; Garred, Peter.
In: Journal of Infection, Vol. 80, No. 4, 2020, p. 378-387.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Complement related pattern recognition molecules as markers of short-term mortality in intensive care patients
AU - Hansen, Cecilie B.
AU - Bayarri-Olmos, Rafael
AU - Kristensen, Markus K.
AU - Pilely, Katrine
AU - Hellemann, Dorthe
AU - Garred, Peter
PY - 2020
Y1 - 2020
N2 - Objectives: To evaluate the complement related pattern recognition molecules (PRMs) PTX3, MBL, CL-11, ficolin-2 and -3, along with the established marker CRP, to predict 28-day mortality and disease severity of sepsis in patients admitted to the intensive care unit (ICU). Methods: In a single-center, prospective, observational study 547 patients were included over a period of 18 months. Blood samples were obtained at admission to the ICU and the following 4 days. Results: PTX3 baseline levels were significantly higher in non-survivors compared to survivors, whereas MBL and ficolin-2 levels were significantly lower in non-survivors compared to survivors. A PTX3 level above the median was independently associated with 28-day mortality in the adjusted analysis including age, sex, chronic disease and immunosuppression (HR 1.87, 95% CI [1.41–2.48], p < 0.0001), while a MBL level above the median was associated with increased chance of survival (HR 0.75, 95% CI [0.57–0.98], p = 0.034). Ficolin-2 was only borderline significant (HR 0.79, 95% CI [0.60–1.03], p = 0.084). In a ROC analysis PTX3 was superior to CRP in predicting septic shock. Conclusions: PTX3, MBL and CRP levels were independently associated with 28-day mortality in ICU patients. PTX3 was a better marker of septic shock compared to CRP.
AB - Objectives: To evaluate the complement related pattern recognition molecules (PRMs) PTX3, MBL, CL-11, ficolin-2 and -3, along with the established marker CRP, to predict 28-day mortality and disease severity of sepsis in patients admitted to the intensive care unit (ICU). Methods: In a single-center, prospective, observational study 547 patients were included over a period of 18 months. Blood samples were obtained at admission to the ICU and the following 4 days. Results: PTX3 baseline levels were significantly higher in non-survivors compared to survivors, whereas MBL and ficolin-2 levels were significantly lower in non-survivors compared to survivors. A PTX3 level above the median was independently associated with 28-day mortality in the adjusted analysis including age, sex, chronic disease and immunosuppression (HR 1.87, 95% CI [1.41–2.48], p < 0.0001), while a MBL level above the median was associated with increased chance of survival (HR 0.75, 95% CI [0.57–0.98], p = 0.034). Ficolin-2 was only borderline significant (HR 0.79, 95% CI [0.60–1.03], p = 0.084). In a ROC analysis PTX3 was superior to CRP in predicting septic shock. Conclusions: PTX3, MBL and CRP levels were independently associated with 28-day mortality in ICU patients. PTX3 was a better marker of septic shock compared to CRP.
KW - Collectin-11
KW - Complement system
KW - Ficolins
KW - Mannose-binding lectin
KW - PTX3
KW - Sepsis
U2 - 10.1016/j.jinf.2020.01.010
DO - 10.1016/j.jinf.2020.01.010
M3 - Journal article
C2 - 31981636
AN - SCOPUS:85078817038
VL - 80
SP - 378
EP - 387
JO - Journal of Infection
JF - Journal of Infection
SN - 0163-4453
IS - 4
ER -
ID: 236722953