Diagnostic accuracy of a short-form version of the diagnostic criteria for primary hyperhidrosis
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Diagnostic accuracy of a short-form version of the diagnostic criteria for primary hyperhidrosis. / Henning, Mattias A.S.; Al-Rahimi, Hajer I.; Jemec, Gregor B.E.; Pedersen, Ole B.
In: Acta Dermatovenerologica Alpina, Pannonica et Adriatica, Vol. 33, No. 1, 2024, p. 17-22.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Diagnostic accuracy of a short-form version of the diagnostic criteria for primary hyperhidrosis
AU - Henning, Mattias A.S.
AU - Al-Rahimi, Hajer I.
AU - Jemec, Gregor B.E.
AU - Pedersen, Ole B.
N1 - Publisher Copyright: © 2024, Slovene Medical Society. All rights reserved.
PY - 2024
Y1 - 2024
N2 - Introduction: The gold standard method for diagnosing primary hyperhidrosis (PHH) is based on seven patient-reported criteria. By determining an individual criterion’s diagnostic accuracy, one can identify short-version classification models. Methods: In this cross-sectional study, data were collected from Danish blood donors in 2021. Cohen’s kappa and diagnostic accuracy were determined by comparing each criterion with the gold standard method. Results: The study included 1,039 participants. Of them, 59 (5.7%) had PHH and 980 (94.3%) were classified as control individuals. The PHH major criterion “focal visible excessive sweating for at least 6 months without an apparent cause” had the highest prevalence in the participants with PHH compared to the control individuals (100% vs. 0.6%; p < 0.0001). The agreement between this criterion and PHH was Cohen’s kappa = 0.95 (95% confidence interval [CI] 0.91–0.99), and its sensitivity was 1.00 (95% CI 0.94–1.00) and specificity 0.99 (95% CI 0.99–1.00). The other criteria showed lower agreement and diagnostic accuracy. Conclusions: The PHH major criterion showed near-perfect agreement and near-equal diagnostic accuracy compared with the gold standard method. This single criterion can be used as a short-form version to screen for PHH. Determination of reproducibility in independent populations is warranted.
AB - Introduction: The gold standard method for diagnosing primary hyperhidrosis (PHH) is based on seven patient-reported criteria. By determining an individual criterion’s diagnostic accuracy, one can identify short-version classification models. Methods: In this cross-sectional study, data were collected from Danish blood donors in 2021. Cohen’s kappa and diagnostic accuracy were determined by comparing each criterion with the gold standard method. Results: The study included 1,039 participants. Of them, 59 (5.7%) had PHH and 980 (94.3%) were classified as control individuals. The PHH major criterion “focal visible excessive sweating for at least 6 months without an apparent cause” had the highest prevalence in the participants with PHH compared to the control individuals (100% vs. 0.6%; p < 0.0001). The agreement between this criterion and PHH was Cohen’s kappa = 0.95 (95% confidence interval [CI] 0.91–0.99), and its sensitivity was 1.00 (95% CI 0.94–1.00) and specificity 0.99 (95% CI 0.99–1.00). The other criteria showed lower agreement and diagnostic accuracy. Conclusions: The PHH major criterion showed near-perfect agreement and near-equal diagnostic accuracy compared with the gold standard method. This single criterion can be used as a short-form version to screen for PHH. Determination of reproducibility in independent populations is warranted.
KW - diagnostic accuracy
KW - primary hyperhidrosis
KW - sensitivity
KW - short-form version
KW - specificity
U2 - 10.15570/actaapa.2024.7
DO - 10.15570/actaapa.2024.7
M3 - Journal article
C2 - 38532656
AN - SCOPUS:85189090151
VL - 33
SP - 17
EP - 22
JO - Acta Dermatovenerologica Alpina, Panonica et Adriatica
JF - Acta Dermatovenerologica Alpina, Panonica et Adriatica
SN - 1318-4458
IS - 1
ER -
ID: 388021491