Diphyllin, a novel and naturally potent V-ATPase inhibitor, abrogates acidification of the osteoclastic resorption lacunae and bone resorption
Research output: Contribution to journal › Journal article › Research › peer-review
Dissolution of the inorganic phase of bone by the osteoclasts mediated by V-ATPase and ClC-7 is a prerequisite for bone resorption. Inhibitors of osteoclastic V-ATPase or ClC-7 are novel approaches for inhibition of osteoclastic bone resorption. By testing natural compounds in acidification assays, diphyllin was identified. We characterized diphyllin with respect to the pharmacological effects on osteoclasts.
| Original language | English |
|---|---|
| Journal | Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research |
| Volume | 22 |
| Issue number | 10 |
| Pages (from-to) | 1640-8 |
| Number of pages | 9 |
| ISSN | 0884-0431 |
| DOIs | |
| Publication status | Published - Oct 2007 |
- Acids, Adrenal Medulla, Animals, Biological Transport, Bone Resorption, Cattle, Cell Survival, Cells, Cultured, Dioxolanes, Enzyme Inhibitors, Humans, Hydrogen-Ion Concentration, Lignans, Molecular Structure, Osteoclasts, Vacuolar Proton-Translocating ATPases
Research areas
ID: 47555975