Do chorionic villus samplings (CVS) or amniocenteses (AC) induce RhD immunisation? An evaluation of a large Danish cohort with no routine administration of anti-D after invasive prenatal testing

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Do chorionic villus samplings (CVS) or amniocenteses (AC) induce RhD immunisation? An evaluation of a large Danish cohort with no routine administration of anti-D after invasive prenatal testing. / Kristensen, S.S.; Nørgaard, L. N.; Tabor, A.; Sundberg, K.; Dziegiel, M.H.; Hedegaard, M.; Ekelund, C K.

In: B J O G, Vol. 126, No. 12, 2019, p. 1476-1480.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Kristensen, SS, Nørgaard, LN, Tabor, A, Sundberg, K, Dziegiel, MH, Hedegaard, M & Ekelund, CK 2019, 'Do chorionic villus samplings (CVS) or amniocenteses (AC) induce RhD immunisation? An evaluation of a large Danish cohort with no routine administration of anti-D after invasive prenatal testing', B J O G, vol. 126, no. 12, pp. 1476-1480. https://doi.org/10.1111/1471-0528.15861

APA

Kristensen, S. S., Nørgaard, L. N., Tabor, A., Sundberg, K., Dziegiel, M. H., Hedegaard, M., & Ekelund, C. K. (2019). Do chorionic villus samplings (CVS) or amniocenteses (AC) induce RhD immunisation? An evaluation of a large Danish cohort with no routine administration of anti-D after invasive prenatal testing. B J O G, 126(12), 1476-1480. https://doi.org/10.1111/1471-0528.15861

Vancouver

Kristensen SS, Nørgaard LN, Tabor A, Sundberg K, Dziegiel MH, Hedegaard M et al. Do chorionic villus samplings (CVS) or amniocenteses (AC) induce RhD immunisation? An evaluation of a large Danish cohort with no routine administration of anti-D after invasive prenatal testing. B J O G. 2019;126(12):1476-1480. https://doi.org/10.1111/1471-0528.15861

Author

Kristensen, S.S. ; Nørgaard, L. N. ; Tabor, A. ; Sundberg, K. ; Dziegiel, M.H. ; Hedegaard, M. ; Ekelund, C K. / Do chorionic villus samplings (CVS) or amniocenteses (AC) induce RhD immunisation? An evaluation of a large Danish cohort with no routine administration of anti-D after invasive prenatal testing. In: B J O G. 2019 ; Vol. 126, No. 12. pp. 1476-1480.

Bibtex

@article{c3bb1e2fa22f4941b987aa012aa5eda2,
title = "Do chorionic villus samplings (CVS) or amniocenteses (AC) induce RhD immunisation?: An evaluation of a large Danish cohort with no routine administration of anti-D after invasive prenatal testing",
abstract = "OBJECTIVE: To evaluate the risk of inducing RhD immunisation in pregnancies of RhD-negative mothers with an RhD-positive fetus undergoing chorionic villus samplings (CVS) or amniocenteses (AC).DESIGN, SETTING AND POPULATION: Registry-based study in a Danish cohort which has not been given rhesus prophylaxis.METHODS: Data were retrieved from the Department of Clinical Immunology at Rigshospitalet. All RhD-negative women carrying an RhD-positive fetus with screen test results from weeks 8-12 and weeks 25-29 were linked to data from the Danish Fetal Medicine Database. Data were divided into cases where no invasive prenatal diagnostic procedure was performed, cases that had AC performed, and cases that had CVS performed.MAIN OUTCOME MEASURES: A comparison of the proportion of women who developed RhD immunisation between the two screen tests.RESULTS: The cohort consisted of 10 085 women: 9353 had no invasive procedures performed, 189 had AC and 543 had CVS performed. No women were immunised spontaneously or due to the procedure between the first and second screen test in the group with no procedure performed, or in the AC group. One woman was immunised in the CVS group. When comparing the proportion of women who was immunised in the CVS group with the no invasive test group a non-significant difference was found (P = 0.055).CONCLUSION: The RhD immunisation rate before gestational weeks 25-29 in RhD-negative women carrying an RhD-positive fetus is very low, even in women undergoing prenatal invasive testing without rhesus prophylaxis.TWEETABLE ABSTRACT: The RhD immunisation rate during pregnancy is very low even in women undergoing prenatal invasive testing.",
author = "S.S. Kristensen and N{\o}rgaard, {L. N.} and A. Tabor and K. Sundberg and M.H. Dziegiel and M. Hedegaard and Ekelund, {C K}",
note = "{\textcopyright} 2019 Royal College of Obstetricians and Gynaecologists.",
year = "2019",
doi = "10.1111/1471-0528.15861",
language = "English",
volume = "126",
pages = "1476--1480",
journal = "BJOG: An International Journal of Obstetrics and Gynaecology",
issn = "0140-7686",
publisher = "Wiley-Blackwell",
number = "12",

}

RIS

TY - JOUR

T1 - Do chorionic villus samplings (CVS) or amniocenteses (AC) induce RhD immunisation?

T2 - An evaluation of a large Danish cohort with no routine administration of anti-D after invasive prenatal testing

AU - Kristensen, S.S.

AU - Nørgaard, L. N.

AU - Tabor, A.

AU - Sundberg, K.

AU - Dziegiel, M.H.

AU - Hedegaard, M.

AU - Ekelund, C K

N1 - © 2019 Royal College of Obstetricians and Gynaecologists.

PY - 2019

Y1 - 2019

N2 - OBJECTIVE: To evaluate the risk of inducing RhD immunisation in pregnancies of RhD-negative mothers with an RhD-positive fetus undergoing chorionic villus samplings (CVS) or amniocenteses (AC).DESIGN, SETTING AND POPULATION: Registry-based study in a Danish cohort which has not been given rhesus prophylaxis.METHODS: Data were retrieved from the Department of Clinical Immunology at Rigshospitalet. All RhD-negative women carrying an RhD-positive fetus with screen test results from weeks 8-12 and weeks 25-29 were linked to data from the Danish Fetal Medicine Database. Data were divided into cases where no invasive prenatal diagnostic procedure was performed, cases that had AC performed, and cases that had CVS performed.MAIN OUTCOME MEASURES: A comparison of the proportion of women who developed RhD immunisation between the two screen tests.RESULTS: The cohort consisted of 10 085 women: 9353 had no invasive procedures performed, 189 had AC and 543 had CVS performed. No women were immunised spontaneously or due to the procedure between the first and second screen test in the group with no procedure performed, or in the AC group. One woman was immunised in the CVS group. When comparing the proportion of women who was immunised in the CVS group with the no invasive test group a non-significant difference was found (P = 0.055).CONCLUSION: The RhD immunisation rate before gestational weeks 25-29 in RhD-negative women carrying an RhD-positive fetus is very low, even in women undergoing prenatal invasive testing without rhesus prophylaxis.TWEETABLE ABSTRACT: The RhD immunisation rate during pregnancy is very low even in women undergoing prenatal invasive testing.

AB - OBJECTIVE: To evaluate the risk of inducing RhD immunisation in pregnancies of RhD-negative mothers with an RhD-positive fetus undergoing chorionic villus samplings (CVS) or amniocenteses (AC).DESIGN, SETTING AND POPULATION: Registry-based study in a Danish cohort which has not been given rhesus prophylaxis.METHODS: Data were retrieved from the Department of Clinical Immunology at Rigshospitalet. All RhD-negative women carrying an RhD-positive fetus with screen test results from weeks 8-12 and weeks 25-29 were linked to data from the Danish Fetal Medicine Database. Data were divided into cases where no invasive prenatal diagnostic procedure was performed, cases that had AC performed, and cases that had CVS performed.MAIN OUTCOME MEASURES: A comparison of the proportion of women who developed RhD immunisation between the two screen tests.RESULTS: The cohort consisted of 10 085 women: 9353 had no invasive procedures performed, 189 had AC and 543 had CVS performed. No women were immunised spontaneously or due to the procedure between the first and second screen test in the group with no procedure performed, or in the AC group. One woman was immunised in the CVS group. When comparing the proportion of women who was immunised in the CVS group with the no invasive test group a non-significant difference was found (P = 0.055).CONCLUSION: The RhD immunisation rate before gestational weeks 25-29 in RhD-negative women carrying an RhD-positive fetus is very low, even in women undergoing prenatal invasive testing without rhesus prophylaxis.TWEETABLE ABSTRACT: The RhD immunisation rate during pregnancy is very low even in women undergoing prenatal invasive testing.

U2 - 10.1111/1471-0528.15861

DO - 10.1111/1471-0528.15861

M3 - Journal article

C2 - 31283084

VL - 126

SP - 1476

EP - 1480

JO - BJOG: An International Journal of Obstetrics and Gynaecology

JF - BJOG: An International Journal of Obstetrics and Gynaecology

SN - 0140-7686

IS - 12

ER -

ID: 228407707