Heterocomplexes of mannose-binding lectin and the pentraxins PTX3 or serum amyloid P component trigger cross-activation of the complement system

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Heterocomplexes of mannose-binding lectin and the pentraxins PTX3 or serum amyloid P component trigger cross-activation of the complement system. / Ma, Ying Jie; Doni, Andrea; Skjoedt, Mikkel-Ole; Honoré, Christian Le Fèvre; Arendrup, Maiken; Mantovani, Alberto; Garred, Peter.

In: Journal of Biological Chemistry, Vol. 286, No. 5, 04.02.2011, p. 3405-17.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Ma, YJ, Doni, A, Skjoedt, M-O, Honoré, CLF, Arendrup, M, Mantovani, A & Garred, P 2011, 'Heterocomplexes of mannose-binding lectin and the pentraxins PTX3 or serum amyloid P component trigger cross-activation of the complement system', Journal of Biological Chemistry, vol. 286, no. 5, pp. 3405-17. https://doi.org/10.1074/jbc.M110.190637, https://doi.org/10.1074/jbc.M110.190637

APA

Ma, Y. J., Doni, A., Skjoedt, M-O., Honoré, C. L. F., Arendrup, M., Mantovani, A., & Garred, P. (2011). Heterocomplexes of mannose-binding lectin and the pentraxins PTX3 or serum amyloid P component trigger cross-activation of the complement system. Journal of Biological Chemistry, 286(5), 3405-17. https://doi.org/10.1074/jbc.M110.190637, https://doi.org/10.1074/jbc.M110.190637

Vancouver

Ma YJ, Doni A, Skjoedt M-O, Honoré CLF, Arendrup M, Mantovani A et al. Heterocomplexes of mannose-binding lectin and the pentraxins PTX3 or serum amyloid P component trigger cross-activation of the complement system. Journal of Biological Chemistry. 2011 Feb 4;286(5):3405-17. https://doi.org/10.1074/jbc.M110.190637, https://doi.org/10.1074/jbc.M110.190637

Author

Ma, Ying Jie ; Doni, Andrea ; Skjoedt, Mikkel-Ole ; Honoré, Christian Le Fèvre ; Arendrup, Maiken ; Mantovani, Alberto ; Garred, Peter. / Heterocomplexes of mannose-binding lectin and the pentraxins PTX3 or serum amyloid P component trigger cross-activation of the complement system. In: Journal of Biological Chemistry. 2011 ; Vol. 286, No. 5. pp. 3405-17.

Bibtex

@article{3e0145accc004ad3a05c718ac091f434,
title = "Heterocomplexes of mannose-binding lectin and the pentraxins PTX3 or serum amyloid P component trigger cross-activation of the complement system",
abstract = "The long pentraxin 3 (PTX3), serum amyloid P component (SAP), and C-reactive protein belong to the pentraxin family of pattern recognition molecules involved in tissue homeostasis and innate immunity. They interact with C1q from the classical complement pathway. Whether this also occurs via the analogous mannose-binding lectin (MBL) from the lectin complement pathway is unknown. Thus, we investigated the possible interaction between MBL and the pentraxins. We report that MBL bound PTX3 and SAP partly via its collagen-like domain but not C-reactive protein. MBL-PTX3 complex formation resulted in recruitment of C1q, but this was not seen for the MBL-SAP complex. However, both MBL-PTX3 and MBL-SAP complexes enhanced C4 and C3 deposition and opsonophagocytosis of Candida albicans by polymorphonuclear leukocytes. Interaction between MBL and PTX3 led to communication between the lectin and classical complement pathways via recruitment of C1q, whereas SAP-enhanced complement activation occurs via a hitherto unknown mechanism. Taken together, MBL-pentraxin heterocomplexes trigger cross-activation of the complement system.",
author = "Ma, {Ying Jie} and Andrea Doni and Mikkel-Ole Skjoedt and Honor{\'e}, {Christian Le F{\`e}vre} and Maiken Arendrup and Alberto Mantovani and Peter Garred",
year = "2011",
month = feb,
day = "4",
doi = "10.1074/jbc.M110.190637",
language = "English",
volume = "286",
pages = "3405--17",
journal = "Journal of Biological Chemistry",
issn = "0021-9258",
publisher = "American Society for Biochemistry and Molecular Biology, Inc.",
number = "5",

}

RIS

TY - JOUR

T1 - Heterocomplexes of mannose-binding lectin and the pentraxins PTX3 or serum amyloid P component trigger cross-activation of the complement system

AU - Ma, Ying Jie

AU - Doni, Andrea

AU - Skjoedt, Mikkel-Ole

AU - Honoré, Christian Le Fèvre

AU - Arendrup, Maiken

AU - Mantovani, Alberto

AU - Garred, Peter

PY - 2011/2/4

Y1 - 2011/2/4

N2 - The long pentraxin 3 (PTX3), serum amyloid P component (SAP), and C-reactive protein belong to the pentraxin family of pattern recognition molecules involved in tissue homeostasis and innate immunity. They interact with C1q from the classical complement pathway. Whether this also occurs via the analogous mannose-binding lectin (MBL) from the lectin complement pathway is unknown. Thus, we investigated the possible interaction between MBL and the pentraxins. We report that MBL bound PTX3 and SAP partly via its collagen-like domain but not C-reactive protein. MBL-PTX3 complex formation resulted in recruitment of C1q, but this was not seen for the MBL-SAP complex. However, both MBL-PTX3 and MBL-SAP complexes enhanced C4 and C3 deposition and opsonophagocytosis of Candida albicans by polymorphonuclear leukocytes. Interaction between MBL and PTX3 led to communication between the lectin and classical complement pathways via recruitment of C1q, whereas SAP-enhanced complement activation occurs via a hitherto unknown mechanism. Taken together, MBL-pentraxin heterocomplexes trigger cross-activation of the complement system.

AB - The long pentraxin 3 (PTX3), serum amyloid P component (SAP), and C-reactive protein belong to the pentraxin family of pattern recognition molecules involved in tissue homeostasis and innate immunity. They interact with C1q from the classical complement pathway. Whether this also occurs via the analogous mannose-binding lectin (MBL) from the lectin complement pathway is unknown. Thus, we investigated the possible interaction between MBL and the pentraxins. We report that MBL bound PTX3 and SAP partly via its collagen-like domain but not C-reactive protein. MBL-PTX3 complex formation resulted in recruitment of C1q, but this was not seen for the MBL-SAP complex. However, both MBL-PTX3 and MBL-SAP complexes enhanced C4 and C3 deposition and opsonophagocytosis of Candida albicans by polymorphonuclear leukocytes. Interaction between MBL and PTX3 led to communication between the lectin and classical complement pathways via recruitment of C1q, whereas SAP-enhanced complement activation occurs via a hitherto unknown mechanism. Taken together, MBL-pentraxin heterocomplexes trigger cross-activation of the complement system.

U2 - 10.1074/jbc.M110.190637

DO - 10.1074/jbc.M110.190637

M3 - Journal article

C2 - 21106539

VL - 286

SP - 3405

EP - 3417

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

SN - 0021-9258

IS - 5

ER -

ID: 34135851