Heterozygosity for a deletion in the CKR-5 gene leads to prolonged AIDS-free survival and slower CD4 T-cell decline in a cohort of HIV-seropositive individuals

Research output: Contribution to journalJournal articleResearchpeer-review

  • J Eugen-Olsen
  • Anton Iversen
  • Garred, Peter
  • Uffe Koppelhus
  • C Pedersen
  • Thomas Benfield
  • A M Sorensen
  • T Katzenstein
  • E Dickmeiss
  • Gerstoft, Jan
  • P Skinhøj
  • A Svejgaard
  • J O Nielsen
  • B Hofmann
Recently, it has been shown that a homozygous 32 base-pair deletion in the gene encoding CKR-5, a major coreceptor for HIV-1, leads to resistance to infection with HIV-1. We have investigated whether HIV-seropositive individuals who were heterozygous for the CKR-5 deletion had a different course of the disease.
Original languageEnglish
JournalAIDS
Volume11
Issue number3
Pages (from-to)305-10
Number of pages6
ISSN0269-9370
Publication statusPublished - 1997

ID: 40148459