Humoral and T-cell response 12 months after the first BNT162b2 vaccination in solid organ transplant recipients and controls: Kinetics, associated factors, and role of SARS-CoV-2 infection
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Humoral and T-cell response 12 months after the first BNT162b2 vaccination in solid organ transplant recipients and controls : Kinetics, associated factors, and role of SARS-CoV-2 infection. / Rezahosseini, Omid; Hamm, Sebastian Rask; Heftdal, Line Dam; Pérez-Alós, Laura; Møller, Dina Leth; Perch, Michael; Madsen, Johannes Roth; Hald, Annemette; Hansen, Cecilie Bo; Armenteros, Jose Juan Almagro; Pries-Heje, Mia Marie; Hasselbalch, Rasmus Bo; Fogh, Kamille; Frikke-Schmidt, Ruth; Hilsted, Linda Maria; Sørensen, Erik; Ostrowski, Sisse Rye; Harboe, Zitta Barrella; Iversen, Kasper; Bundgaard, Henning; Sørensen, Søren Schwartz; Rasmussen, Allan; Garred, Peter; Nielsen, Susanne Dam.
In: Frontiers in Immunology, Vol. 13, 1075423, 2023.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Humoral and T-cell response 12 months after the first BNT162b2 vaccination in solid organ transplant recipients and controls
T2 - Kinetics, associated factors, and role of SARS-CoV-2 infection
AU - Rezahosseini, Omid
AU - Hamm, Sebastian Rask
AU - Heftdal, Line Dam
AU - Pérez-Alós, Laura
AU - Møller, Dina Leth
AU - Perch, Michael
AU - Madsen, Johannes Roth
AU - Hald, Annemette
AU - Hansen, Cecilie Bo
AU - Armenteros, Jose Juan Almagro
AU - Pries-Heje, Mia Marie
AU - Hasselbalch, Rasmus Bo
AU - Fogh, Kamille
AU - Frikke-Schmidt, Ruth
AU - Hilsted, Linda Maria
AU - Sørensen, Erik
AU - Ostrowski, Sisse Rye
AU - Harboe, Zitta Barrella
AU - Iversen, Kasper
AU - Bundgaard, Henning
AU - Sørensen, Søren Schwartz
AU - Rasmussen, Allan
AU - Garred, Peter
AU - Nielsen, Susanne Dam
N1 - Publisher Copyright: Copyright © 2023 Rezahosseini, Hamm, Heftdal, Pérez-Alós, Møller, Perch, Madsen, Hald, Hansen, Armenteros, Pries-Heje, Hasselbalch, Fogh, Frikke-Schmidt, Hilsted, Sørensen, Ostrowski, Harboe, Iversen, Bundgaard, Sørensen, Rasmussen, Garred and Nielsen.
PY - 2023
Y1 - 2023
N2 - Introduction: We investigated humoral and T-cell responses within 12 months after first BNT162b2 vaccine in solid organ transplant (SOT) recipients and controls who had received at least three vaccine doses. Furthermore, we compared the immune response in participants with and without previous SARS-CoV-2 infection. Methods: We included adult liver, lung, and kidney transplant recipients, and controls were selected from a parallel cohort of healthcare workers. Results: At 12th-month, the IgG geometric mean concentrations (GMCs) (P<0.001), IgA GMCs (P=0.003), and median IFN-γ (P<0.001) were lower in SOT recipients than in controls. However, in SOT recipients and controls with previous infection, the neutralizing index was 99%, and the IgG, and IgA responses were comparable. After adjustment, female-sex (aOR: 3.6, P<0.009), kidney (aOR: 7.0, P= 0.008) or lung transplantation (aOR: 7.5, P= 0.014), and use of mycophenolate (aOR: 5.2, P=0.03) were associated with low IgG non response. Age (OR:1.4, P=0.038), time from transplantation to first vaccine (OR: 0.45, P<0.035), and previous SARS-CoV-2 infection (OR: 0.14, P<0.001), were associated with low IgA non response. Diabetes (OR:2.4, P=0.044) was associated with T-cell non response. Conclusion: In conclusion, humoral and T-cell responses were inferior in SOT recipients without previous SARS-CoV-2 infection but comparable to controls in SOT recipients with previous infection.
AB - Introduction: We investigated humoral and T-cell responses within 12 months after first BNT162b2 vaccine in solid organ transplant (SOT) recipients and controls who had received at least three vaccine doses. Furthermore, we compared the immune response in participants with and without previous SARS-CoV-2 infection. Methods: We included adult liver, lung, and kidney transplant recipients, and controls were selected from a parallel cohort of healthcare workers. Results: At 12th-month, the IgG geometric mean concentrations (GMCs) (P<0.001), IgA GMCs (P=0.003), and median IFN-γ (P<0.001) were lower in SOT recipients than in controls. However, in SOT recipients and controls with previous infection, the neutralizing index was 99%, and the IgG, and IgA responses were comparable. After adjustment, female-sex (aOR: 3.6, P<0.009), kidney (aOR: 7.0, P= 0.008) or lung transplantation (aOR: 7.5, P= 0.014), and use of mycophenolate (aOR: 5.2, P=0.03) were associated with low IgG non response. Age (OR:1.4, P=0.038), time from transplantation to first vaccine (OR: 0.45, P<0.035), and previous SARS-CoV-2 infection (OR: 0.14, P<0.001), were associated with low IgA non response. Diabetes (OR:2.4, P=0.044) was associated with T-cell non response. Conclusion: In conclusion, humoral and T-cell responses were inferior in SOT recipients without previous SARS-CoV-2 infection but comparable to controls in SOT recipients with previous infection.
KW - BNT162 vaccine
KW - cellular immune response
KW - humoral immune responses
KW - mRNA vaccine
KW - organ transplantation
KW - SARS-CoV-2
U2 - 10.3389/fimmu.2022.1075423
DO - 10.3389/fimmu.2022.1075423
M3 - Journal article
C2 - 36713395
AN - SCOPUS:85147075495
VL - 13
JO - Frontiers in Immunology
JF - Frontiers in Immunology
SN - 1664-3224
M1 - 1075423
ER -
ID: 335964856