Immunoglobulin M and G antibody responses to Plasmodium falciparum glutamate-rich protein: correlation with clinical immunity in Gambian children
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Immunoglobulin M and G antibody responses to Plasmodium falciparum glutamate-rich protein : correlation with clinical immunity in Gambian children. / Dziegiel, Morten Hanefeld; Rowe, P; Bennett, S; Allen, S J; Olerup, O; Gottschau, A; Borre, M; Riley, E M.
In: Infection and Immunity, Vol. 61, No. 1, 01.1993, p. 103-8.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Immunoglobulin M and G antibody responses to Plasmodium falciparum glutamate-rich protein
T2 - correlation with clinical immunity in Gambian children
AU - Dziegiel, Morten Hanefeld
AU - Rowe, P
AU - Bennett, S
AU - Allen, S J
AU - Olerup, O
AU - Gottschau, A
AU - Borre, M
AU - Riley, E M
PY - 1993/1
Y1 - 1993/1
N2 - The aims of the present study were to describe the age-related immunoglobulin M (IgM) and IgG response to part of a 220-kDa glutamate-rich protein (GLURP) from Plasmodium falciparum and to determine possible correlations of possession of these antibodies with malaria morbidity. IgM and IgG levels were measured with a recombinant fusion protein consisting of the carboxy-terminal 783 amino acids of the GLURP. Samples for the study were obtained during a longitudinal malaria morbidity survey performed in The Gambia; cross-sectional surveys were performed at the beginning of the transmission season in May and in October. Seropositivity rates increased with age to a maximum of 77% for IgM and 95% for IgG in adults. High prevalences of seropositivity were associated with certain human leukocyte antigen class II alleles (DRw8, DR9, DR7, DR4, DQw7, and DQw2) or haplotypes. The relationship between anti-GLURP489-1271 antibodies and clinical immunity is not clear; asymptomatically infected children aged 5 to 8 years had significantly higher levels of IgG than clinically ill children of the same age, suggesting that antibodies to the carboxy-terminal part of the GLURP may contribute to immunity to P. falciparum. However, this was not significant for younger children.
AB - The aims of the present study were to describe the age-related immunoglobulin M (IgM) and IgG response to part of a 220-kDa glutamate-rich protein (GLURP) from Plasmodium falciparum and to determine possible correlations of possession of these antibodies with malaria morbidity. IgM and IgG levels were measured with a recombinant fusion protein consisting of the carboxy-terminal 783 amino acids of the GLURP. Samples for the study were obtained during a longitudinal malaria morbidity survey performed in The Gambia; cross-sectional surveys were performed at the beginning of the transmission season in May and in October. Seropositivity rates increased with age to a maximum of 77% for IgM and 95% for IgG in adults. High prevalences of seropositivity were associated with certain human leukocyte antigen class II alleles (DRw8, DR9, DR7, DR4, DQw7, and DQw2) or haplotypes. The relationship between anti-GLURP489-1271 antibodies and clinical immunity is not clear; asymptomatically infected children aged 5 to 8 years had significantly higher levels of IgG than clinically ill children of the same age, suggesting that antibodies to the carboxy-terminal part of the GLURP may contribute to immunity to P. falciparum. However, this was not significant for younger children.
KW - Adolescent
KW - Adult
KW - Age Factors
KW - Aged
KW - Aged, 80 and over
KW - Animals
KW - Antigens, Surface
KW - Child
KW - Child, Preschool
KW - Cross Reactions
KW - Cross-Sectional Studies
KW - Enzyme-Linked Immunosorbent Assay
KW - Female
KW - Gambia
KW - HLA-DQ Antigens
KW - HLA-DR Antigens
KW - Humans
KW - Immunity
KW - Immunoglobulin G
KW - Immunoglobulin M
KW - Malaria, Falciparum
KW - Male
KW - Middle Aged
KW - Morbidity
KW - Protozoan Proteins
KW - Recombinant Fusion Proteins
KW - Sex Factors
M3 - Journal article
C2 - 8418032
VL - 61
SP - 103
EP - 108
JO - Infection and Immunity
JF - Infection and Immunity
SN - 0019-9567
IS - 1
ER -
ID: 47556947