Low ficolin-3 levels in early follow-up serum samples are associated with the severity and unfavorable outcome of acute ischemic stroke
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Low ficolin-3 levels in early follow-up serum samples are associated with the severity and unfavorable outcome of acute ischemic stroke. / Fust, George; Fog, Lea Munthe; Illes, Zsolt; Szeplaki, Gabor; Molnar, Tihamer; Pusch, Gabriella; Hirschberg, Kristof; Szegedi, Robert; Szeplaki, Zoltan; Prohaszka, Zoltan; Skjoedt, Mikkel-Ole; Garred, Peter.
In: Journal of Neuroinflammation, Vol. 8, No. 1, 2011, p. 185.Research output: Contribution to journal › Journal article › Research › peer-review
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T1 - Low ficolin-3 levels in early follow-up serum samples are associated with the severity and unfavorable outcome of acute ischemic stroke
AU - Fust, George
AU - Fog, Lea Munthe
AU - Illes, Zsolt
AU - Szeplaki, Gabor
AU - Molnar, Tihamer
AU - Pusch, Gabriella
AU - Hirschberg, Kristof
AU - Szegedi, Robert
AU - Szeplaki, Zoltan
AU - Prohaszka, Zoltan
AU - Skjoedt, Mikkel-Ole
AU - Garred, Peter
PY - 2011
Y1 - 2011
N2 - ABSTRACT: BACKGROUND: A number of data indicate that the lectin pathway of complement activation contributes to the pathophysiology of ischemic stroke. The lectin pathway may be triggered by the binding of mannose-binding lectin (MBL), ficolin-2 or ficolin-3 to different ligands. Although several papers demonstrated the significance of MBL in ischemic stroke, the role of ficolins has not been examined. METHODS: Sera were obtained within 12 hours after the onset of ischemic stroke (admission samples) and 3-4 days later (follow-up samples) from 65 patients. The control group comprised 100 healthy individuals and 135 patients with significant carotid stenosis (patient controls). The concentrations of ficolin-2 and ficolin-3, initiator molecules of the lectin complement pathway, were measured by ELISA methods. Concentration of C-reactive protein (CRP) was also determined by a particle-enhanced immunturbidimetric assay. RESULTS: Concentrations of both ficolin-2 and ficolin-3 were significantly (p
AB - ABSTRACT: BACKGROUND: A number of data indicate that the lectin pathway of complement activation contributes to the pathophysiology of ischemic stroke. The lectin pathway may be triggered by the binding of mannose-binding lectin (MBL), ficolin-2 or ficolin-3 to different ligands. Although several papers demonstrated the significance of MBL in ischemic stroke, the role of ficolins has not been examined. METHODS: Sera were obtained within 12 hours after the onset of ischemic stroke (admission samples) and 3-4 days later (follow-up samples) from 65 patients. The control group comprised 100 healthy individuals and 135 patients with significant carotid stenosis (patient controls). The concentrations of ficolin-2 and ficolin-3, initiator molecules of the lectin complement pathway, were measured by ELISA methods. Concentration of C-reactive protein (CRP) was also determined by a particle-enhanced immunturbidimetric assay. RESULTS: Concentrations of both ficolin-2 and ficolin-3 were significantly (p
U2 - http://dx.doi.org/10.1186/1742-2094-8-185
DO - http://dx.doi.org/10.1186/1742-2094-8-185
M3 - Journal article
VL - 8
SP - 185
JO - Journal of Neuroinflammation
JF - Journal of Neuroinflammation
SN - 1742-2094
IS - 1
ER -
ID: 40152912