Noninvasive antenatal screening for fetal RHD in RhD negative women to guide targeted anti-D prophylaxis
Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Noninvasive antenatal screening for fetal RHD in RhD negative women to guide targeted anti-D prophylaxis. / Clausen, Frederik Banch; Rieneck, Klaus; Krog, Grethe Risum; Bundgaard, Birgitte Suhr; Dziegiel, Morten Hanefeld.
Prenatal Diagnosis. ed. / Brynn Levy. Humana Press, 2019. p. 347-359 (Methods in Molecular Biology, Vol. 1885).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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TY - CHAP
T1 - Noninvasive antenatal screening for fetal RHD in RhD negative women to guide targeted anti-D prophylaxis
AU - Clausen, Frederik Banch
AU - Rieneck, Klaus
AU - Krog, Grethe Risum
AU - Bundgaard, Birgitte Suhr
AU - Dziegiel, Morten Hanefeld
PY - 2019
Y1 - 2019
N2 - RhD negative pregnant women who carry an RhD positive fetus are at risk of immunization against the D antigen, which may result in hemolytic disease of the fetus and the newborn. Predicting the fetal RhD status by noninvasive antenatal screening for the fetal RhD gene (RHD) can guide targeted use of antenatal anti-D prophylaxis. Cell-free fetal DNA is extracted from maternal plasma from RhD negative pregnant women at a gestational age of 25 weeks. A real-time PCR-based detection of two RHD exons enables reliable prediction of the fetal RhD status to determine the administration of antenatal prophylaxis, as well as postnatal prophylaxis.
AB - RhD negative pregnant women who carry an RhD positive fetus are at risk of immunization against the D antigen, which may result in hemolytic disease of the fetus and the newborn. Predicting the fetal RhD status by noninvasive antenatal screening for the fetal RhD gene (RHD) can guide targeted use of antenatal anti-D prophylaxis. Cell-free fetal DNA is extracted from maternal plasma from RhD negative pregnant women at a gestational age of 25 weeks. A real-time PCR-based detection of two RHD exons enables reliable prediction of the fetal RhD status to determine the administration of antenatal prophylaxis, as well as postnatal prophylaxis.
KW - Antenatal prophylaxis
KW - Anti-D
KW - Cell-free fetal DNA
KW - Hemolytic disease of the fetus and newborn
KW - Noninvasive RHD typing
KW - Real-time PCR
U2 - 10.1007/978-1-4939-8889-1_23
DO - 10.1007/978-1-4939-8889-1_23
M3 - Book chapter
C2 - 30506209
AN - SCOPUS:85058170091
SN - 978-1-4939-8887-7
T3 - Methods in Molecular Biology
SP - 347
EP - 359
BT - Prenatal Diagnosis
A2 - Levy, Brynn
PB - Humana Press
ER -
ID: 223453130