Plasma levels of mannose-binding lectin and future risk of venous thromboembolism

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Plasma levels of mannose-binding lectin and future risk of venous thromboembolism. / Liang, Robin A.; Høiland, Ina I.; Ueland, Thor; Aukrust, Pål; Snir, Omri; Hindberg, Kristian; Brækkan, Sigrid K.; Garred, Peter; Mollnes, Tom E.; Hansen, John Bjarne.

In: Journal of Thrombosis and Haemostasis, Vol. 17, No. 10, 2019, p. 1661-1669.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Liang, RA, Høiland, II, Ueland, T, Aukrust, P, Snir, O, Hindberg, K, Brækkan, SK, Garred, P, Mollnes, TE & Hansen, JB 2019, 'Plasma levels of mannose-binding lectin and future risk of venous thromboembolism', Journal of Thrombosis and Haemostasis, vol. 17, no. 10, pp. 1661-1669. https://doi.org/10.1111/jth.14539

APA

Liang, R. A., Høiland, I. I., Ueland, T., Aukrust, P., Snir, O., Hindberg, K., Brækkan, S. K., Garred, P., Mollnes, T. E., & Hansen, J. B. (2019). Plasma levels of mannose-binding lectin and future risk of venous thromboembolism. Journal of Thrombosis and Haemostasis, 17(10), 1661-1669. https://doi.org/10.1111/jth.14539

Vancouver

Liang RA, Høiland II, Ueland T, Aukrust P, Snir O, Hindberg K et al. Plasma levels of mannose-binding lectin and future risk of venous thromboembolism. Journal of Thrombosis and Haemostasis. 2019;17(10):1661-1669. https://doi.org/10.1111/jth.14539

Author

Liang, Robin A. ; Høiland, Ina I. ; Ueland, Thor ; Aukrust, Pål ; Snir, Omri ; Hindberg, Kristian ; Brækkan, Sigrid K. ; Garred, Peter ; Mollnes, Tom E. ; Hansen, John Bjarne. / Plasma levels of mannose-binding lectin and future risk of venous thromboembolism. In: Journal of Thrombosis and Haemostasis. 2019 ; Vol. 17, No. 10. pp. 1661-1669.

Bibtex

@article{1573a78a37a6417b999328db4fd5628e,
title = "Plasma levels of mannose-binding lectin and future risk of venous thromboembolism",
abstract = "Background: Animal and observational studies have suggested a pathophysiological role for complement in venous thromboembolism (VTE), but the initiating mechanisms are unknown. Mannose-binding lectin (MBL) bound to altered host cells leads to activation of the lectin complement pathway, and both high and low MBL levels have been implicated in the pathophysiology of cardiovascular disease. Objectives: To investigate the association between plasma MBL levels and future risk of incident VTE. Methods: We conducted a nested case-control study in 417 VTE patients and 849 age-matched and sex-matched controls derived from the general population (Troms{\o} Study). Plasma MBL levels were measured using enzyme-linked immunosorbent assay. Logistic regression models were used to estimate odds ratio (OR) for VTE across quartiles of plasma MBL levels. Results: Subjects with plasma MBL levels in the lowest quartile (<435 ng/mL) had a reduced OR for overall VTE (OR 0.79, 95% confidence interval [CI]: 0.56-1.10) and for DVT (OR 0.70, 95% CI: 0.47-1.04) compared to those with MBL in the highest quartile (≥2423 ng/mL) after multivariable adjustments. For VTE, DVT, and pulmonary embolism (PE) the ORs decreased substantially with decreasing time between blood sampling and VTE event. Conclusions: Our findings suggest that low plasma MBL levels are associated with reduced risk of VTE, and DVT in particular.",
keywords = "complement, deep vein thrombosis, mannose-binding lectin, pulmonary embolism, venous thromboembolism",
author = "Liang, {Robin A.} and H{\o}iland, {Ina I.} and Thor Ueland and P{\aa}l Aukrust and Omri Snir and Kristian Hindberg and Br{\ae}kkan, {Sigrid K.} and Peter Garred and Mollnes, {Tom E.} and Hansen, {John Bjarne}",
year = "2019",
doi = "10.1111/jth.14539",
language = "English",
volume = "17",
pages = "1661--1669",
journal = "Journal of Thrombosis and Haemostasis",
issn = "1538-7933",
publisher = "Wiley-Blackwell",
number = "10",

}

RIS

TY - JOUR

T1 - Plasma levels of mannose-binding lectin and future risk of venous thromboembolism

AU - Liang, Robin A.

AU - Høiland, Ina I.

AU - Ueland, Thor

AU - Aukrust, Pål

AU - Snir, Omri

AU - Hindberg, Kristian

AU - Brækkan, Sigrid K.

AU - Garred, Peter

AU - Mollnes, Tom E.

AU - Hansen, John Bjarne

PY - 2019

Y1 - 2019

N2 - Background: Animal and observational studies have suggested a pathophysiological role for complement in venous thromboembolism (VTE), but the initiating mechanisms are unknown. Mannose-binding lectin (MBL) bound to altered host cells leads to activation of the lectin complement pathway, and both high and low MBL levels have been implicated in the pathophysiology of cardiovascular disease. Objectives: To investigate the association between plasma MBL levels and future risk of incident VTE. Methods: We conducted a nested case-control study in 417 VTE patients and 849 age-matched and sex-matched controls derived from the general population (Tromsø Study). Plasma MBL levels were measured using enzyme-linked immunosorbent assay. Logistic regression models were used to estimate odds ratio (OR) for VTE across quartiles of plasma MBL levels. Results: Subjects with plasma MBL levels in the lowest quartile (<435 ng/mL) had a reduced OR for overall VTE (OR 0.79, 95% confidence interval [CI]: 0.56-1.10) and for DVT (OR 0.70, 95% CI: 0.47-1.04) compared to those with MBL in the highest quartile (≥2423 ng/mL) after multivariable adjustments. For VTE, DVT, and pulmonary embolism (PE) the ORs decreased substantially with decreasing time between blood sampling and VTE event. Conclusions: Our findings suggest that low plasma MBL levels are associated with reduced risk of VTE, and DVT in particular.

AB - Background: Animal and observational studies have suggested a pathophysiological role for complement in venous thromboembolism (VTE), but the initiating mechanisms are unknown. Mannose-binding lectin (MBL) bound to altered host cells leads to activation of the lectin complement pathway, and both high and low MBL levels have been implicated in the pathophysiology of cardiovascular disease. Objectives: To investigate the association between plasma MBL levels and future risk of incident VTE. Methods: We conducted a nested case-control study in 417 VTE patients and 849 age-matched and sex-matched controls derived from the general population (Tromsø Study). Plasma MBL levels were measured using enzyme-linked immunosorbent assay. Logistic regression models were used to estimate odds ratio (OR) for VTE across quartiles of plasma MBL levels. Results: Subjects with plasma MBL levels in the lowest quartile (<435 ng/mL) had a reduced OR for overall VTE (OR 0.79, 95% confidence interval [CI]: 0.56-1.10) and for DVT (OR 0.70, 95% CI: 0.47-1.04) compared to those with MBL in the highest quartile (≥2423 ng/mL) after multivariable adjustments. For VTE, DVT, and pulmonary embolism (PE) the ORs decreased substantially with decreasing time between blood sampling and VTE event. Conclusions: Our findings suggest that low plasma MBL levels are associated with reduced risk of VTE, and DVT in particular.

KW - complement

KW - deep vein thrombosis

KW - mannose-binding lectin

KW - pulmonary embolism

KW - venous thromboembolism

U2 - 10.1111/jth.14539

DO - 10.1111/jth.14539

M3 - Journal article

C2 - 31220397

AN - SCOPUS:85068354624

VL - 17

SP - 1661

EP - 1669

JO - Journal of Thrombosis and Haemostasis

JF - Journal of Thrombosis and Haemostasis

SN - 1538-7933

IS - 10

ER -

ID: 236218638