Pre-Analytical Conditions in Non-Invasive Prenatal Testing of Cell-Free Fetal RHD
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Pre-Analytical Conditions in Non-Invasive Prenatal Testing of Cell-Free Fetal RHD. / Clausen, Frederik Banch; Jakobsen, Tanja Roien; Rieneck, Klaus; Krog, Grethe Risum; Nielsen, Leif Kofoed; Tabor, Ann; Dziegiel, Morten Hanefeld.
In: PloS one, Vol. 8, No. 10, 2013, p. e76990.Research output: Contribution to journal › Journal article › Research
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TY - JOUR
T1 - Pre-Analytical Conditions in Non-Invasive Prenatal Testing of Cell-Free Fetal RHD
AU - Clausen, Frederik Banch
AU - Jakobsen, Tanja Roien
AU - Rieneck, Klaus
AU - Krog, Grethe Risum
AU - Nielsen, Leif Kofoed
AU - Tabor, Ann
AU - Dziegiel, Morten Hanefeld
PY - 2013
Y1 - 2013
N2 - Non-invasive prenatal testing of cell-free fetal DNA (cffDNA) in maternal plasma can predict the fetal RhD type in D negative pregnant women. In Denmark, routine antenatal screening for the fetal RhD gene (RHD) directs the administration of antenatal anti-D prophylaxis only to women who carry an RhD positive fetus. Prophylaxis reduces the risk of immunization that may lead to hemolytic disease of the fetus and the newborn. The reliability of predicting the fetal RhD type depends on pre-analytical factors and assay sensitivity. We evaluated the testing setup in the Capital Region of Denmark, based on data from routine antenatal RHD screening.
AB - Non-invasive prenatal testing of cell-free fetal DNA (cffDNA) in maternal plasma can predict the fetal RhD type in D negative pregnant women. In Denmark, routine antenatal screening for the fetal RhD gene (RHD) directs the administration of antenatal anti-D prophylaxis only to women who carry an RhD positive fetus. Prophylaxis reduces the risk of immunization that may lead to hemolytic disease of the fetus and the newborn. The reliability of predicting the fetal RhD type depends on pre-analytical factors and assay sensitivity. We evaluated the testing setup in the Capital Region of Denmark, based on data from routine antenatal RHD screening.
U2 - 10.1371/journal.pone.0076990
DO - 10.1371/journal.pone.0076990
M3 - Journal article
C2 - 24204719
VL - 8
SP - e76990
JO - PLoS ONE
JF - PLoS ONE
SN - 1932-6203
IS - 10
ER -
ID: 94618407