Preoperative methylprednisolone increases plasma Pentraxin 3 early after total knee arthroplasty: a randomized, double-blind, placebo-controlled trial

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Standard

Preoperative methylprednisolone increases plasma Pentraxin 3 early after total knee arthroplasty : a randomized, double-blind, placebo-controlled trial. / Lindberg-Larsen, V.; Kehlet, H.; Pilely, K.; Bagger, J.; Rovsing, M. L.; Garred, P.

In: Clinical and Experimental Immunology, Vol. 191, No. 3, 2018, p. 356-362.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Lindberg-Larsen, V, Kehlet, H, Pilely, K, Bagger, J, Rovsing, ML & Garred, P 2018, 'Preoperative methylprednisolone increases plasma Pentraxin 3 early after total knee arthroplasty: a randomized, double-blind, placebo-controlled trial', Clinical and Experimental Immunology, vol. 191, no. 3, pp. 356-362. https://doi.org/10.1111/cei.13071

APA

Lindberg-Larsen, V., Kehlet, H., Pilely, K., Bagger, J., Rovsing, M. L., & Garred, P. (2018). Preoperative methylprednisolone increases plasma Pentraxin 3 early after total knee arthroplasty: a randomized, double-blind, placebo-controlled trial. Clinical and Experimental Immunology, 191(3), 356-362. https://doi.org/10.1111/cei.13071

Vancouver

Lindberg-Larsen V, Kehlet H, Pilely K, Bagger J, Rovsing ML, Garred P. Preoperative methylprednisolone increases plasma Pentraxin 3 early after total knee arthroplasty: a randomized, double-blind, placebo-controlled trial. Clinical and Experimental Immunology. 2018;191(3):356-362. https://doi.org/10.1111/cei.13071

Author

Lindberg-Larsen, V. ; Kehlet, H. ; Pilely, K. ; Bagger, J. ; Rovsing, M. L. ; Garred, P. / Preoperative methylprednisolone increases plasma Pentraxin 3 early after total knee arthroplasty : a randomized, double-blind, placebo-controlled trial. In: Clinical and Experimental Immunology. 2018 ; Vol. 191, No. 3. pp. 356-362.

Bibtex

@article{66d7c7b007024d898c779ec21d781cc3,
title = "Preoperative methylprednisolone increases plasma Pentraxin 3 early after total knee arthroplasty: a randomized, double-blind, placebo-controlled trial",
abstract = "Preoperative glucocorticoid administration reduces the systemic inflammatory response. Pentraxin 3 (PTX3) is a novel inflammatory marker belonging to the humoral arm of innate immunity exerting a potentially protective host response. This study evaluated PTX3 and other complement marker changes after preoperative methylprednisolone (MP) early after total knee arthroplasty (TKA). Seventy patients were randomized (1 : 1) to preoperative intravenous (i.v.) MP 125 mg (group MP) or isotonic saline i.v. (group C). The outcomes included change in plasma PTX3, mannose‐binding lectin (MBL), ficolins (ficolin‐1, −2 and −3), complement components (C4 and C3), terminal complement complex (TCC) and C‐reactive protein (CRP) concentrations. Blood samples were analysed at baseline and 2, 6, 24 and 48 h after surgery with complete sampling from 63 patients for analyses. MP resulted in an increase in circulating PTX3 compared to saline from baseline to 24 h postoperatively (P < 0·001), while MP reduced the systemic inflammatory response (CRP) 24 and 48 h postoperatively (P < 0·001). However, the small postoperative changes in MBL, ficolin‐1, −2 and −3, C4, C3 and TCC concentrations did not differ between groups (P > 0·05). In conclusion, preoperative MP 125 mg increased circulating PTX3 and reduced the general inflammatory response (CRP) early after TKA, but did not affect other complement markers.",
keywords = "acute-phase proteins, arthroplasty, complement, glucocorticoids, inflammation",
author = "V. Lindberg-Larsen and H. Kehlet and K. Pilely and J. Bagger and Rovsing, {M. L.} and P. Garred",
year = "2018",
doi = "10.1111/cei.13071",
language = "English",
volume = "191",
pages = "356--362",
journal = "Clinical and Experimental Immunology, Supplement",
issn = "0964-2536",
publisher = "Wiley-Blackwell",
number = "3",

}

RIS

TY - JOUR

T1 - Preoperative methylprednisolone increases plasma Pentraxin 3 early after total knee arthroplasty

T2 - a randomized, double-blind, placebo-controlled trial

AU - Lindberg-Larsen, V.

AU - Kehlet, H.

AU - Pilely, K.

AU - Bagger, J.

AU - Rovsing, M. L.

AU - Garred, P.

PY - 2018

Y1 - 2018

N2 - Preoperative glucocorticoid administration reduces the systemic inflammatory response. Pentraxin 3 (PTX3) is a novel inflammatory marker belonging to the humoral arm of innate immunity exerting a potentially protective host response. This study evaluated PTX3 and other complement marker changes after preoperative methylprednisolone (MP) early after total knee arthroplasty (TKA). Seventy patients were randomized (1 : 1) to preoperative intravenous (i.v.) MP 125 mg (group MP) or isotonic saline i.v. (group C). The outcomes included change in plasma PTX3, mannose‐binding lectin (MBL), ficolins (ficolin‐1, −2 and −3), complement components (C4 and C3), terminal complement complex (TCC) and C‐reactive protein (CRP) concentrations. Blood samples were analysed at baseline and 2, 6, 24 and 48 h after surgery with complete sampling from 63 patients for analyses. MP resulted in an increase in circulating PTX3 compared to saline from baseline to 24 h postoperatively (P < 0·001), while MP reduced the systemic inflammatory response (CRP) 24 and 48 h postoperatively (P < 0·001). However, the small postoperative changes in MBL, ficolin‐1, −2 and −3, C4, C3 and TCC concentrations did not differ between groups (P > 0·05). In conclusion, preoperative MP 125 mg increased circulating PTX3 and reduced the general inflammatory response (CRP) early after TKA, but did not affect other complement markers.

AB - Preoperative glucocorticoid administration reduces the systemic inflammatory response. Pentraxin 3 (PTX3) is a novel inflammatory marker belonging to the humoral arm of innate immunity exerting a potentially protective host response. This study evaluated PTX3 and other complement marker changes after preoperative methylprednisolone (MP) early after total knee arthroplasty (TKA). Seventy patients were randomized (1 : 1) to preoperative intravenous (i.v.) MP 125 mg (group MP) or isotonic saline i.v. (group C). The outcomes included change in plasma PTX3, mannose‐binding lectin (MBL), ficolins (ficolin‐1, −2 and −3), complement components (C4 and C3), terminal complement complex (TCC) and C‐reactive protein (CRP) concentrations. Blood samples were analysed at baseline and 2, 6, 24 and 48 h after surgery with complete sampling from 63 patients for analyses. MP resulted in an increase in circulating PTX3 compared to saline from baseline to 24 h postoperatively (P < 0·001), while MP reduced the systemic inflammatory response (CRP) 24 and 48 h postoperatively (P < 0·001). However, the small postoperative changes in MBL, ficolin‐1, −2 and −3, C4, C3 and TCC concentrations did not differ between groups (P > 0·05). In conclusion, preoperative MP 125 mg increased circulating PTX3 and reduced the general inflammatory response (CRP) early after TKA, but did not affect other complement markers.

KW - acute-phase proteins

KW - arthroplasty

KW - complement

KW - glucocorticoids

KW - inflammation

U2 - 10.1111/cei.13071

DO - 10.1111/cei.13071

M3 - Journal article

C2 - 29119559

VL - 191

SP - 356

EP - 362

JO - Clinical and Experimental Immunology, Supplement

JF - Clinical and Experimental Immunology, Supplement

SN - 0964-2536

IS - 3

ER -

ID: 194527009