Primary structure and localization of a conserved immunogenic Plasmodium falciparum glutamate rich protein (GLURP) expressed in both the preerythrocytic and erythrocytic stages of the vertebrate life cycle

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A gene coding for a 220-kDa glutamate rich protein (GLURP), an exoantigen of Plasmodium falciparum, was isolated and its nucleotide sequence was determined. The deduced amino acid sequence contains 2 repeat regions. The sequence of one of these was shown to be conserved among geographically dispersed isolates, and a fusion protein containing that sequence was able to stimulate B- and T-cells. Antibodies against GLURP stained erythrocytic stages of the parasite as well as the hepatic stage as detected by electron microscopy.
Original languageEnglish
JournalMolecular and Biochemical Parasitology
Issue number1
Pages (from-to)119-31
Number of pages12
Publication statusPublished - 1991

Bibliographical note

Keywords: Amino Acid Sequence; Animals; Antigens, Protozoan; Base Sequence; Chromosome Mapping; DNA, Protozoan; Erythrocytes; Microscopy, Immunoelectron; Molecular Sequence Data; Plasmodium falciparum; Protozoan Proteins

ID: 18177925