Screening of protein kinase inhibitors identifies PKC inhibitors as inhibitors of osteoclastic acid secretion and bone resorption
Research output: Contribution to journal › Journal article › Research › peer-review
Bone resorption is initiated by osteoclastic acidification of the resorption lacunae. This process is mediated by secretion of protons through the V-ATPase and chloride through the chloride antiporter ClC-7. To shed light on the intracellular signalling controlling extracellular acidification, we screened a protein kinase inhibitor library in human osteoclasts.
| Original language | English |
|---|---|
| Journal | B M C Musculoskeletal Disorders |
| Volume | 11 |
| Pages (from-to) | 250 |
| ISSN | 1471-2474 |
| DOIs | |
| Publication status | Published - 1 Jan 2010 |
- Acids, Animals, Bone Resorption, Cattle, Cells, Cultured, Humans, Osteoclasts, Protein Kinase C, Protein Kinase Inhibitors
Research areas
ID: 34240848