The Lectin Pathway of Complement and Biocompatibility

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

Standard

The Lectin Pathway of Complement and Biocompatibility. / Hein, Estrid; Garred, Peter.

Immune Responses to Biosurfaces: Mechanisms and Therapeutic Interventions. Vol. 865 Springer, 2015. p. 77-92 (Advances in Experimental Medicine and Biology).

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

Harvard

Hein, E & Garred, P 2015, The Lectin Pathway of Complement and Biocompatibility. in Immune Responses to Biosurfaces: Mechanisms and Therapeutic Interventions. vol. 865, Springer, Advances in Experimental Medicine and Biology, pp. 77-92. https://doi.org/10.1007/978-3-319-18603-0_5

APA

Hein, E., & Garred, P. (2015). The Lectin Pathway of Complement and Biocompatibility. In Immune Responses to Biosurfaces: Mechanisms and Therapeutic Interventions (Vol. 865, pp. 77-92). Springer. Advances in Experimental Medicine and Biology https://doi.org/10.1007/978-3-319-18603-0_5

Vancouver

Hein E, Garred P. The Lectin Pathway of Complement and Biocompatibility. In Immune Responses to Biosurfaces: Mechanisms and Therapeutic Interventions. Vol. 865. Springer. 2015. p. 77-92. (Advances in Experimental Medicine and Biology). https://doi.org/10.1007/978-3-319-18603-0_5

Author

Hein, Estrid ; Garred, Peter. / The Lectin Pathway of Complement and Biocompatibility. Immune Responses to Biosurfaces: Mechanisms and Therapeutic Interventions. Vol. 865 Springer, 2015. pp. 77-92 (Advances in Experimental Medicine and Biology).

Bibtex

@inbook{e121797042b64e3999293e13cdc2b5eb,
title = "The Lectin Pathway of Complement and Biocompatibility",
abstract = "In modern health technologies the use of biomaterials in the form of stents, haemodialysis tubes, artificial implants, bypass circuits etc. is rapidly expanding. The exposure of synthetic, foreign surfaces to the blood and tissue of the host, calls for strict biocompatibility in respect to contact activation, the coagulation system and the complement system. The complement system is an important part of the initial immune response and consists of fluid phase molecules in the blood stream. Three different activation pathways can initiate the complement system, the lectin, the classical and the alternative pathway, all converging in an amplification loop of the cascade system and downstream reactions. Thus, when exposed to foreign substances complement components will be activated and lead to a powerful inflammatory response. Biosurface induced complement activation is a recognised issue that has been broadly documented. However, the specific role of lectin pathway and the pattern recognition molecules initiating the pathway has only been transiently investigated. Here we review the current data on the field.",
keywords = "Biocompatible Materials, Blood Coagulation, Blood Coagulation Factors, Collectins, Complement Activation, Complement Pathway, Mannose-Binding Lectin, Extracorporeal Circulation, Gene Expression Regulation, Humans, Lectins, Mannose-Binding Protein-Associated Serine Proteases, Protein Binding, Receptors, Pattern Recognition, Signal Transduction, Surface Properties",
author = "Estrid Hein and Peter Garred",
year = "2015",
doi = "10.1007/978-3-319-18603-0_5",
language = "English",
isbn = "978-3-319-18602-3",
volume = "865",
series = "Advances in Experimental Medicine and Biology",
publisher = "Springer",
pages = "77--92",
booktitle = "Immune Responses to Biosurfaces",
address = "Switzerland",

}

RIS

TY - CHAP

T1 - The Lectin Pathway of Complement and Biocompatibility

AU - Hein, Estrid

AU - Garred, Peter

PY - 2015

Y1 - 2015

N2 - In modern health technologies the use of biomaterials in the form of stents, haemodialysis tubes, artificial implants, bypass circuits etc. is rapidly expanding. The exposure of synthetic, foreign surfaces to the blood and tissue of the host, calls for strict biocompatibility in respect to contact activation, the coagulation system and the complement system. The complement system is an important part of the initial immune response and consists of fluid phase molecules in the blood stream. Three different activation pathways can initiate the complement system, the lectin, the classical and the alternative pathway, all converging in an amplification loop of the cascade system and downstream reactions. Thus, when exposed to foreign substances complement components will be activated and lead to a powerful inflammatory response. Biosurface induced complement activation is a recognised issue that has been broadly documented. However, the specific role of lectin pathway and the pattern recognition molecules initiating the pathway has only been transiently investigated. Here we review the current data on the field.

AB - In modern health technologies the use of biomaterials in the form of stents, haemodialysis tubes, artificial implants, bypass circuits etc. is rapidly expanding. The exposure of synthetic, foreign surfaces to the blood and tissue of the host, calls for strict biocompatibility in respect to contact activation, the coagulation system and the complement system. The complement system is an important part of the initial immune response and consists of fluid phase molecules in the blood stream. Three different activation pathways can initiate the complement system, the lectin, the classical and the alternative pathway, all converging in an amplification loop of the cascade system and downstream reactions. Thus, when exposed to foreign substances complement components will be activated and lead to a powerful inflammatory response. Biosurface induced complement activation is a recognised issue that has been broadly documented. However, the specific role of lectin pathway and the pattern recognition molecules initiating the pathway has only been transiently investigated. Here we review the current data on the field.

KW - Biocompatible Materials

KW - Blood Coagulation

KW - Blood Coagulation Factors

KW - Collectins

KW - Complement Activation

KW - Complement Pathway, Mannose-Binding Lectin

KW - Extracorporeal Circulation

KW - Gene Expression Regulation

KW - Humans

KW - Lectins

KW - Mannose-Binding Protein-Associated Serine Proteases

KW - Protein Binding

KW - Receptors, Pattern Recognition

KW - Signal Transduction

KW - Surface Properties

U2 - 10.1007/978-3-319-18603-0_5

DO - 10.1007/978-3-319-18603-0_5

M3 - Book chapter

C2 - 26306444

SN - 978-3-319-18602-3

VL - 865

T3 - Advances in Experimental Medicine and Biology

SP - 77

EP - 92

BT - Immune Responses to Biosurfaces

PB - Springer

ER -

ID: 162872200