Waning humoral and cellular immunity after COVID-19 vaccination in patients with psoriasis treated with methotrexate and biologics: A cohort study
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Waning humoral and cellular immunity after COVID-19 vaccination in patients with psoriasis treated with methotrexate and biologics : A cohort study. / Kvist-Hansen, Amanda; Pérez-Alós, Laura; Al-Sofi, Rownaq Fares; Heftdal, Line Dam; Hamm, Sebastian Rask; Møller, Dina Leth; Pries-Heje, Mia Marie; Fogh, Kamille; Bo Hansen, Cecilie; Bo Hasselbalch, Rasmus; Madsen, Johannes Roth; Armenteros, Jose Juan Almagro; Frikke-Schmidt, Ruth; Hilsted, Linda; Sørensen, Erik; Ostrowski, Sisse Rye; Bundgaard, Henning; Nielsen, Susanne Dam; Iversen, Kasper; Zachariae, Claus; Garred, Peter; Skov, Lone.
In: British Journal of Dermatology, Vol. 188, No. 5, 2023, p. 661-669.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Waning humoral and cellular immunity after COVID-19 vaccination in patients with psoriasis treated with methotrexate and biologics
T2 - A cohort study
AU - Kvist-Hansen, Amanda
AU - Pérez-Alós, Laura
AU - Al-Sofi, Rownaq Fares
AU - Heftdal, Line Dam
AU - Hamm, Sebastian Rask
AU - Møller, Dina Leth
AU - Pries-Heje, Mia Marie
AU - Fogh, Kamille
AU - Bo Hansen, Cecilie
AU - Bo Hasselbalch, Rasmus
AU - Madsen, Johannes Roth
AU - Armenteros, Jose Juan Almagro
AU - Frikke-Schmidt, Ruth
AU - Hilsted, Linda
AU - Sørensen, Erik
AU - Ostrowski, Sisse Rye
AU - Bundgaard, Henning
AU - Nielsen, Susanne Dam
AU - Iversen, Kasper
AU - Zachariae, Claus
AU - Garred, Peter
AU - Skov, Lone
N1 - Publisher Copyright: © 2023 The Author(s). Published by Oxford University Press on behalf of British Association of Dermatologists. All rights reserved.
PY - 2023
Y1 - 2023
N2 - Background: mRNA-based COVID-19 vaccines have short- and long-term efficacy in healthy individuals, but their efficacy in patients with psoriasis receiving immunomodulatory therapy is less studied. Objectives: To investigate long-term immunity after COVID-19 vaccination in patients with psoriasis receiving immunomodulatory therapy. Methods: A prospective cohort study including patients (n = 123) with psoriasis receiving methotrexate (MTX) or biologics and controls (n = 226). Only mRNA-based COVID-19 vaccines administered with standard intervals between doses were investigated. Markers of immunity included SARS-CoV-2 spike glycoprotein-specific IgG and IgA, neutralizing capacity, and interferon-γrelease from T cells stimulated with peptides of the SARS-CoV-2 spike glycoprotein. Results: The proportion of IgG responders was lower 6 months after vaccination in patients receiving anti-tumour necrosis factor (TNF) treatment compared with controls. Anti-TNF treatment was associated with lower IgG levels (β = -0.82, 95% confidence interval -1.38 to -0.25; P = 0.001). The median neutralizing index was lower in the anti-TNF group [50% inhibition (interquartile range [IQR] 37-89)] compared with controls [98% inhibition (IQR 96-99)]; P < 0.001. Cellular responses were numerically lowest in the anti-TNF group. Conclusions: Treatment with anti-TNF has an impact on the immunity elicited by mRNA-based COVID-19 vaccination in patients with psoriasis, resulting in a faster waning of humoral and cellular markers of immunity; however, the clinical implications are unknown.
AB - Background: mRNA-based COVID-19 vaccines have short- and long-term efficacy in healthy individuals, but their efficacy in patients with psoriasis receiving immunomodulatory therapy is less studied. Objectives: To investigate long-term immunity after COVID-19 vaccination in patients with psoriasis receiving immunomodulatory therapy. Methods: A prospective cohort study including patients (n = 123) with psoriasis receiving methotrexate (MTX) or biologics and controls (n = 226). Only mRNA-based COVID-19 vaccines administered with standard intervals between doses were investigated. Markers of immunity included SARS-CoV-2 spike glycoprotein-specific IgG and IgA, neutralizing capacity, and interferon-γrelease from T cells stimulated with peptides of the SARS-CoV-2 spike glycoprotein. Results: The proportion of IgG responders was lower 6 months after vaccination in patients receiving anti-tumour necrosis factor (TNF) treatment compared with controls. Anti-TNF treatment was associated with lower IgG levels (β = -0.82, 95% confidence interval -1.38 to -0.25; P = 0.001). The median neutralizing index was lower in the anti-TNF group [50% inhibition (interquartile range [IQR] 37-89)] compared with controls [98% inhibition (IQR 96-99)]; P < 0.001. Cellular responses were numerically lowest in the anti-TNF group. Conclusions: Treatment with anti-TNF has an impact on the immunity elicited by mRNA-based COVID-19 vaccination in patients with psoriasis, resulting in a faster waning of humoral and cellular markers of immunity; however, the clinical implications are unknown.
U2 - 10.1093/bjd/ljad023
DO - 10.1093/bjd/ljad023
M3 - Journal article
C2 - 36703193
AN - SCOPUS:85174418797
VL - 188
SP - 661
EP - 669
JO - British Journal of Dermatology
JF - British Journal of Dermatology
SN - 0007-0963
IS - 5
ER -
ID: 386606762