Surveillance of OXA-244-producing Escherichia coli and epidemiologic investigation of cases, Denmark, January 2016 to August 2019

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Standard

Surveillance of OXA-244-producing Escherichia coli and epidemiologic investigation of cases, Denmark, January 2016 to August 2019. / Hammerum, Anette M.; Porsbo, Lone Jannok; Hansen, Frank; Roer, Louise; Kaya, Hülya; Henius, Anna; Møller, Karina Lauenborg; Justesen, Ulrik S.; Søes, Lillian; Røder, Bent L.; Thomsen, Philip K.; Wang, Mikala; Søndergaard, Turid Snekloth; Holzknecht, Barbara Juliane; Østergaard, Claus; Kjerulf, Anne; Kristensen, Brian; Hasman, Henrik.

In: Eurosurveillance, Vol. 25, No. 18, 2020, p. 1-9.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Hammerum, AM, Porsbo, LJ, Hansen, F, Roer, L, Kaya, H, Henius, A, Møller, KL, Justesen, US, Søes, L, Røder, BL, Thomsen, PK, Wang, M, Søndergaard, TS, Holzknecht, BJ, Østergaard, C, Kjerulf, A, Kristensen, B & Hasman, H 2020, 'Surveillance of OXA-244-producing Escherichia coli and epidemiologic investigation of cases, Denmark, January 2016 to August 2019', Eurosurveillance, vol. 25, no. 18, pp. 1-9. https://doi.org/10.2807/1560-7917.ES.2020.25.18.1900742

APA

Hammerum, A. M., Porsbo, L. J., Hansen, F., Roer, L., Kaya, H., Henius, A., Møller, K. L., Justesen, U. S., Søes, L., Røder, B. L., Thomsen, P. K., Wang, M., Søndergaard, T. S., Holzknecht, B. J., Østergaard, C., Kjerulf, A., Kristensen, B., & Hasman, H. (2020). Surveillance of OXA-244-producing Escherichia coli and epidemiologic investigation of cases, Denmark, January 2016 to August 2019. Eurosurveillance, 25(18), 1-9. https://doi.org/10.2807/1560-7917.ES.2020.25.18.1900742

Vancouver

Hammerum AM, Porsbo LJ, Hansen F, Roer L, Kaya H, Henius A et al. Surveillance of OXA-244-producing Escherichia coli and epidemiologic investigation of cases, Denmark, January 2016 to August 2019. Eurosurveillance. 2020;25(18):1-9. https://doi.org/10.2807/1560-7917.ES.2020.25.18.1900742

Author

Hammerum, Anette M. ; Porsbo, Lone Jannok ; Hansen, Frank ; Roer, Louise ; Kaya, Hülya ; Henius, Anna ; Møller, Karina Lauenborg ; Justesen, Ulrik S. ; Søes, Lillian ; Røder, Bent L. ; Thomsen, Philip K. ; Wang, Mikala ; Søndergaard, Turid Snekloth ; Holzknecht, Barbara Juliane ; Østergaard, Claus ; Kjerulf, Anne ; Kristensen, Brian ; Hasman, Henrik. / Surveillance of OXA-244-producing Escherichia coli and epidemiologic investigation of cases, Denmark, January 2016 to August 2019. In: Eurosurveillance. 2020 ; Vol. 25, No. 18. pp. 1-9.

Bibtex

@article{cf7f49bd41744bf5b8f5de7696242c4f,
title = "Surveillance of OXA-244-producing Escherichia coli and epidemiologic investigation of cases, Denmark, January 2016 to August 2019",
abstract = "Background: Carbapenemase-producing Escherichia coli are increasing worldwide. In recent years, an increase in OXA-244-producing E. coli isolates has been seen in the national surveillance of carbapenemase-producing organisms in Denmark. Aim: Molecular characterisation and epidemiological investigation of OXA-244-producing E. coli isolates from January 2016 to August 2019. Methods: For the epidemiological investigation, data from the Danish National Patient Registry and the Danish register of civil registration were used together with data from phone interviews with patients. Isolates were characterised by analysing whole genome sequences for resistance genes, MLST and core genome MLST (cgMLST). Results: In total, 24 OXA-244-producing E. coli isolates were obtained from 23 patients. Among the 23 patients, 13 reported travelling before detection of the E. coli isolates, with seven having visited countries in Northern Africa. Fifteen isolates also carried an extended-spectrum beta-lactamase gene and one had a plasmid-encoded AmpC gene. The most common detected sequence type (ST) was ST38, followed by ST69, ST167, ST10, ST361 and ST3268. Three clonal clusters were detected by cgMLST, but none of these clusters seemed to reflect nosocomial transmission in Denmark. Conclusion: Import of OXA-244 E. coli isolates from travelling abroad seems likely for the majority of cases. Community sources were also possible, as many of the patients had no history of hospitalisation and many of the E. coli isolates belonged to STs that are present in the community. It was not possible to point at a single country or a community source as risk factor for acquiring OXA-244-producing E. coli.",
author = "Hammerum, {Anette M.} and Porsbo, {Lone Jannok} and Frank Hansen and Louise Roer and H{\"u}lya Kaya and Anna Henius and M{\o}ller, {Karina Lauenborg} and Justesen, {Ulrik S.} and Lillian S{\o}es and R{\o}der, {Bent L.} and Thomsen, {Philip K.} and Mikala Wang and S{\o}ndergaard, {Turid Snekloth} and Holzknecht, {Barbara Juliane} and Claus {\O}stergaard and Anne Kjerulf and Brian Kristensen and Henrik Hasman",
year = "2020",
doi = "10.2807/1560-7917.ES.2020.25.18.1900742",
language = "English",
volume = "25",
pages = "1--9",
journal = "Eurosurveillance",
issn = "1025-496X",
publisher = "Centre Europeen pour la Surveillance Epidemiologique du SIDA",
number = "18",

}

RIS

TY - JOUR

T1 - Surveillance of OXA-244-producing Escherichia coli and epidemiologic investigation of cases, Denmark, January 2016 to August 2019

AU - Hammerum, Anette M.

AU - Porsbo, Lone Jannok

AU - Hansen, Frank

AU - Roer, Louise

AU - Kaya, Hülya

AU - Henius, Anna

AU - Møller, Karina Lauenborg

AU - Justesen, Ulrik S.

AU - Søes, Lillian

AU - Røder, Bent L.

AU - Thomsen, Philip K.

AU - Wang, Mikala

AU - Søndergaard, Turid Snekloth

AU - Holzknecht, Barbara Juliane

AU - Østergaard, Claus

AU - Kjerulf, Anne

AU - Kristensen, Brian

AU - Hasman, Henrik

PY - 2020

Y1 - 2020

N2 - Background: Carbapenemase-producing Escherichia coli are increasing worldwide. In recent years, an increase in OXA-244-producing E. coli isolates has been seen in the national surveillance of carbapenemase-producing organisms in Denmark. Aim: Molecular characterisation and epidemiological investigation of OXA-244-producing E. coli isolates from January 2016 to August 2019. Methods: For the epidemiological investigation, data from the Danish National Patient Registry and the Danish register of civil registration were used together with data from phone interviews with patients. Isolates were characterised by analysing whole genome sequences for resistance genes, MLST and core genome MLST (cgMLST). Results: In total, 24 OXA-244-producing E. coli isolates were obtained from 23 patients. Among the 23 patients, 13 reported travelling before detection of the E. coli isolates, with seven having visited countries in Northern Africa. Fifteen isolates also carried an extended-spectrum beta-lactamase gene and one had a plasmid-encoded AmpC gene. The most common detected sequence type (ST) was ST38, followed by ST69, ST167, ST10, ST361 and ST3268. Three clonal clusters were detected by cgMLST, but none of these clusters seemed to reflect nosocomial transmission in Denmark. Conclusion: Import of OXA-244 E. coli isolates from travelling abroad seems likely for the majority of cases. Community sources were also possible, as many of the patients had no history of hospitalisation and many of the E. coli isolates belonged to STs that are present in the community. It was not possible to point at a single country or a community source as risk factor for acquiring OXA-244-producing E. coli.

AB - Background: Carbapenemase-producing Escherichia coli are increasing worldwide. In recent years, an increase in OXA-244-producing E. coli isolates has been seen in the national surveillance of carbapenemase-producing organisms in Denmark. Aim: Molecular characterisation and epidemiological investigation of OXA-244-producing E. coli isolates from January 2016 to August 2019. Methods: For the epidemiological investigation, data from the Danish National Patient Registry and the Danish register of civil registration were used together with data from phone interviews with patients. Isolates were characterised by analysing whole genome sequences for resistance genes, MLST and core genome MLST (cgMLST). Results: In total, 24 OXA-244-producing E. coli isolates were obtained from 23 patients. Among the 23 patients, 13 reported travelling before detection of the E. coli isolates, with seven having visited countries in Northern Africa. Fifteen isolates also carried an extended-spectrum beta-lactamase gene and one had a plasmid-encoded AmpC gene. The most common detected sequence type (ST) was ST38, followed by ST69, ST167, ST10, ST361 and ST3268. Three clonal clusters were detected by cgMLST, but none of these clusters seemed to reflect nosocomial transmission in Denmark. Conclusion: Import of OXA-244 E. coli isolates from travelling abroad seems likely for the majority of cases. Community sources were also possible, as many of the patients had no history of hospitalisation and many of the E. coli isolates belonged to STs that are present in the community. It was not possible to point at a single country or a community source as risk factor for acquiring OXA-244-producing E. coli.

U2 - 10.2807/1560-7917.ES.2020.25.18.1900742

DO - 10.2807/1560-7917.ES.2020.25.18.1900742

M3 - Journal article

C2 - 32400363

AN - SCOPUS:85084543392

VL - 25

SP - 1

EP - 9

JO - Eurosurveillance

JF - Eurosurveillance

SN - 1025-496X

IS - 18

ER -

ID: 255887392