Within-patient horizontal transfer of pOXA-48 from a hypervirulent Klebsiella pneumoniae SL218 to Serratia marcescens following spread of the K. pneumoniae isolate among hospitalised patients, Denmark, 2021
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A hypervirulent Klebsiella pneumoniae SL218 (ST23-KL57), phylogenetically distinct from the classical hypervirulent SL23 (ST23-KL1) lineage, was transmitted between hospitalised patients in Denmark in 2021. The isolate carried a hybrid resistance and virulence plasmid containing blaNDM-1 and a plasmid containing blaOXA-48 (pOXA-48); the latter plasmid was horizontally transferred within-patient to Serratia marcescens. The convergence of drug resistance and virulence factors in single plasmids and in different lineages of K. pneumoniae is concerning and requires surveillance.
| Original language | English |
|---|---|
| Journal | Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin |
| Volume | 28 |
| Issue number | 17 |
| Number of pages | 7 |
| ISSN | 1025-496X |
| DOIs | |
| Publication status | Published - 2023 |
- antimicrobial resistance, Hospital-acquired infections, hypervirulent K. pneumoniae, OXA-48, within-patient plasmid transfer
Research areas
ID: 366496701