Real-world evidence to guide healthcare policies in oncology
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Randomized controlled clinical trials (RCTs) in oncology enroll patients who meet strict protocol-specified criteria. Many of these criteria overlap across multiple RCTs. A vast proportion of patients with metastatic cancer do not meet such criteria. Hence, patient populations encountered in clinical practice are essentially different from RCT-populations, questioning the representativeness of these trials. A real-world evidence approach, using data from clinical practice, is increasingly employed to complement the information on drug safety and efficacy obtained from traditional clinical trials.
Original language | English |
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Journal | OncoTarget |
Volume | 10 |
Issue number | 44 |
Pages (from-to) | 4513-4515 |
ISSN | 1949-2553 |
DOIs | |
Publication status | Published - 2019 |
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