Filip Krag Knop
Clinical Professor
Department of Clinical Medicine
Borgmester Ib Juuls Vej 1, 2730 Herlev
Member of:
Internal Medicine: Endocrinology
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Gluco-metabolic response to exogenous oxytocin in totally pancreatectomized patients and healthy individuals
Kliim-Hansen, V., Gether, I. M., Juel, C. T., Ellegaard, A., Pedersen, M. G., Hartmann, Bolette, Albrechtsen, Nicolai Jacob Wewer, Holst, Jens Juul, Lund, Asger Bach, Gasbjerg, Lærke Smidt & Knop, Filip Krag, 2024, In: Peptides. 179, 5 p., 171242.Research output: Contribution to journal › Journal article › Research › peer-review
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The impact of type 2 diabetes and glycaemic control on mortality and clinical outcomes in hospitalized patients with COVID-19 in the capital region of Denmark
Kliim-Hansen, V., Johansson, K. S., Gasbjerg, Lærke Smidt, Solem, Espen Victor Jimenez, Petersen, Tonny Studsgaard, Nyeland, M. E., Winther-Jensen, M., Ankarfeldt, Mikkel Zöllner, Pedersen, M. G., Ellegaard, A. M., Knop, Filip Krag & Christensen, Mikkel Bring, 2023, In: Diabetes, Obesity and Metabolism. 26, 1, p. 160-168 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Protocol for a 30-day randomised, parallel-group, non-inferiority, controlled trial investigating the effects of discontinuing renin-angiotensin system inhibitors in patients with and without COVID-19: The RASCOVID-19 trial
Kliim-Hansen, V., Gasbjerg, Lærke Smidt, Ellegaard, A. M., Lorentsson, H. J. N., Lynggaard, M. B., Hagemann, C. A., Legart, C., Mathiesen, D. S., Sivapalan, P., Jensen , Jens-Ulrik Stæhr , Vilsbøll, Tina, Christensen, Mikkel Bring & Knop, Filip Krag, 2022, In: BMJ Open. 12, 11, e062895.Research output: Contribution to journal › Journal article › Research › peer-review
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Inappropriate suppression of glucagon during OGTT but not during isoglycaemic i.v. glucose infusion contributes to the reduced incretin effect in type 2 diabetes mellitus
Knop, Filip Krag, Vilsbøll, T., Madsbad, Sten, Holst, Jens Juul & Krarup, T., Apr 2007, In: Diabetologia. 50, 4, p. 797-805 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Glucagon suppression during OGTT worsens while suppression during IVGTT sustains alongside development of glucose intolerance in patients with chronic pancreatitis
Knop, Filip Krag, Vilsbøll, Tina, Larsen, S., Madsbad, Sten, Holst, Jens Juul & Krarup, T. M., 24 Sep 2010, In: Regulatory Peptides. 164, 2-3, p. 144-50 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Thirty days of resveratrol supplementation does not affect postprandial incretin hormone responses, but suppresses postprandial glucagon in obese subjects
Knop, Filip Krag, Konings, E., Timmers, S., Schrauwen, P., Holst, Jens Juul & Blaak, E. E., 11 May 2013, In: Diabetic Medicine. 30, 10, p. 1214-1218 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Time spent in glycaemic control after initiating treatment with oral semaglutide vs empagliflozin: an exploratory analysis of the PIONEER 2 trial
Knop, Filip Krag, Cariou, B., Christiansen, E., Davies, A. L., Montanya, E., Abildlund, M. T. & Rosenstock, J., 2021, In: Diabetologia. 64, SUPPL 1, p. 249-250 2 p.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
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Inappropriate suppression of glucagon during OGTT but not during isoglycaemic i.v. glucose infusion contributes to the reduced incretin effect in type 2 diabetes mellitus
Knop, F. K., Vilsbøll, Tina, Madsbad, Sten, Holst, Jens Juul, Krarup, T., Knop, Filip Krag, Vilsbøll, Tina, Madsbad, Sten, Holst, J. M. & Krarup, T., 1 Apr 2007, In: Diabetologia. 50, 4, p. 797-805 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Replacing SUs with incretin-based therapies for type 2 diabetes mellitus: challenges and feasibility
Knop, Filip Krag, Holst, Jens Juul & Vilsbøll, T., Jul 2008, In: I Drugs: the Investigational Drugs Journal. 11, 7, p. 497-501 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Incretin-based therapy of type 2 diabetes mellitus
Knop, Filip Krag, Vilsbøll, Tina & Holst, Jens Juul, 2009, In: Current Protein and Peptide Science. 10, 1, p. 46-55 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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No hypoglycemia after subcutaneous administration of glucagon-like peptide-1 in lean type 2 diabetic patients and in patients with diabetes secondary to chronic pancreatitis.
Knop, Filip Krag, Vilsbøll, Tina, Larsen, S., Madsbad, Sten, Holst, J. J. & Krarup, T., 2003, In: Diabetes Care. 26, 9, p. 2581-7 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The impact of pancreatic enzyme supplementation on postprandial responses of glucagon-like Peptide-2 in patients with chronic pancreatitis and pancreatic exocrine insufficiency
Knop, Filip Krag, Vilsbøll, Tina, Lund, A., Krarup, T., Holst, Jens Juul & Hornum, Mads, 6 Sep 2010, In: Journal of the Pancreas. 11, 5, p. 489-91 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Unprecedented high insulin secretion in a healthy human subject after intravenous glucagon-like peptide-1: a case report
Knop, Filip Krag, Lund, Asger Bach, Madsbad, Sten, Holst, Jens Juul, Krarup, T. & Vilsbøll, T., 2014, In: BMC Research Notes. 7, p. 1-6 6 p., 326.Research output: Contribution to journal › Journal article › Research › peer-review
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Impaired incretin effect and fasting hyperglucagonaemia characterizing type 2 diabetic subjects are early signs of dysmetabolism in obesity
Knop, Filip Krag, Aaboe, K., Vilsbøll, Tina, Vølund, A., Holst, Jens Juul, Krarup, T. & Madsbad, Sten, 2012, In: Diabetes, Obesity and Metabolism. 14, 6, p. 500-510 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A gut feeling about glucagon: Eje Prize 2018
Knop, Filip Krag, 2018, In: European Journal of Endocrinology. 178, 6, p. R267-R280 14 p.Research output: Contribution to journal › Review › Research › peer-review
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Exenatide: pharmacokinetics, clinical use, and future directions
Knop, Filip Krag, Bronden, A. & Vilsbøll, Tina, 2017, In: Expert Opinion on Pharmacotherapy. 18, 6, p. 555-571 17 p.Research output: Contribution to journal › Review › Research › peer-review
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Oral semaglutide 50 mg taken once per day in adults with overweight or obesity (OASIS 1): a randomised, double-blind, placebo-controlled, phase 3 trial
OASIS 1 Investigators, O. 1. I., 2023, In: The Lancet. 402, 10403, p. 705-719 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Bile-induced secretion of glucagon-like peptide-1: pathophysiological implications in type 2 diabetes?
Knop, Filip Krag, 1 Jul 2010, In: American Journal of Physiology: Endocrinology and Metabolism. 299, 1, p. E10-3Research output: Contribution to journal › Journal article › Research › peer-review
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Small-bowel hemangiosarcoma and capsule endoscopy
Knop, Filip Krag, Hansen, M. B. & Meisner, S., 1 Jul 2003, In: Endoscopy. 35, 7, p. 637Research output: Contribution to journal › Journal article › Research › peer-review
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Comment on: Villareal et al. (2009) TCF7L2 variant rs7903146 affects the risk of type 2 diabetes by modulating incretin action. Diabetes;59:479-485
Knop, Filip Krag, 1 Jun 2010, In: Diabetes. 59, 6, p. e4; author reply e5-6Research output: Contribution to journal › Letter › Research › peer-review
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Glucagon-like peptide 1-baseret behandling af type 2-diabetes mellitus
Knop, Filip Krag & Vilsbøll, Tina, 28 May 2007, In: Ugeskrift for Laeger. 169, 22, p. 2095-9 5 p.Research output: Contribution to journal › Review › Research › peer-review
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Comment on: Chen et al. Utilizing the Second-Meal Effect in Type 2 Diabetes: Practical Use of a Soya-Yogurt Snack. Diabetes Care 2010;33:2552-2554
Knop, Filip Krag, 1 Apr 2011, In: Diabetes Care. 34, 4, p. e44Research output: Contribution to journal › Letter › Research › peer-review
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Delayed ischemic cecal perforation despite optimal decompression after placement of a self-expanding metal stent: report of a case
Knop, Filip Krag, Pilsgaard, B., Meisner, S. & Wille-Jørgensen, P., 1 Nov 2004, In: Diseases of the Colon and Rectum. 47, 11, p. 1970-3 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Resolution of type 2 diabetes following gastric bypass surgery: involvement of gut-derived glucagon and glucagonotropic signalling?
Knop, Filip Krag, 2009, In: Diabetologia. 52, 11, p. 2270-6 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Vaerdien af billeddiagnostiske undersøgelser ordineret i almen praksis
Knop, Filip Krag & Stauning, J. A., 20 Feb 2006, In: Ugeskrift for Laeger. 168, 8, p. 794-8 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Incretin hormones and beta cell function in chronic pancreatitis
Knop, Filip Krag, 1 Jul 2010, In: Danish Medical Bulletin (Online). 57, 7, p. B4163Research output: Contribution to journal › Review › Research › peer-review
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Clinical characteristics and glucose-lowering drug utilization among patients initiating liraglutide in Denmark: a routine clinical care prescription study
Knudsen, J. S., Thomsen, R. W., Pottegard, A., Knop, Filip Krag & Sørensen, H. T., 2019, In: Journal of Diabetes. 11, 8, p. 690-694Research output: Contribution to journal › Letter › Research › peer-review
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Differences Between Randomized Clinical Trial Patients and Real-World Initiators of the Glucagon-Like Peptide 1 Receptor Agonist Liraglutide
Knudsen, J. S., Thomsen, R. W., Pottegård, A., Knop, Filip Krag & Sørensen, H. T., 2018, In: Diabetes Care. 41, 9, p. e133-e135 3 p.Research output: Contribution to journal › Letter › Research › peer-review
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Improvement of Insulin Sensitivity after Lean Donor Feces in Metabolic Syndrome Is Driven by Baseline Intestinal Microbiota Composition
Kootte, R. S., Levin, E., Salojärvi, J., Smits, L. P., Hartstra, A. V., Udayappan, S. D., Hermes, G., Bouter, K. E., Koopen, A. M., Holst, J. J., Knop, F. K., Blaak, E. E., Zhao, J., Smidt, H., Harms, A. C., Hankemeijer, T., Bergman, J. J. G. H. M., Romijn, H. A., Schaap, F. G., Olde Damink, S. W. M. & 8 others, , Oct 2017, In: Cell Metabolism. 26, 4, p. 611-619.e6 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Transcutaneous vagal nerve stimulation for treating gastrointestinal symptoms in individuals with diabetes: a randomised, double-blind, sham-controlled, multicentre trial
Kornum, D. S., Bertoli, D., Kufaishi, H., Wegeberg, A., Okdahl, T., Mark, E. B., Høyer, K. L., Frøkjær, J. B., Brock, Birgitte, Krogh, K., Hansen, C. S., Knop, Filip Krag, Brock, C. & Drewes, A. M., 2024, In: Diabetologia. 67, 6, p. 1122-1137Research output: Contribution to journal › Journal article › Research › peer-review
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Continuous glucose monitoring in pregnant women with type 1 diabetes: an observational cohort study of 186 pregnancies
Kristensen, K., Ögge, L. E., Sengpiel, V., Kjölhede, K., Dotevall, A., Elfvin, A., Knop, Filip Krag, Wiberg, N., Katsarou, A., Shaat, N., Kristensen, L. & Berntorp, K., 2019, In: Diabetologia. 62, 7, p. 1143-1153 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The naturally occurring GIP(1-30)NH2 is a GIP receptor agonist in humans
Krogh, L. S. L., Henriksen, K., Stensen, S., Skov-Jeppesen, Kirsa, Bergmann, N. C., Størling, Joachim, Rosenkilde, Mette, Hartmann, Bolette, Holst, Jens Juul, Gasbjerg, Lærke Smidt & Knop, Filip Krag, 2023, In: European Journal of Endocrinology. 188, 1, lvac015.Research output: Contribution to journal › Journal article › Research › peer-review
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Biomarkører for kardiovaskulær sygdom ved type 2-diabetes
Krogh, S. K., Andersen, A., Knop, Filip Krag & Vilsbøll, Tina, 2019, In: Ugeskrift for Laeger. 181, 6 p., V10180711.Research output: Contribution to journal › Journal article › Research › peer-review
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Evidence connecting old, new and neglected glucose-lowering drugs to bile acid-induced GLP-1 secretion: a review
Kårhus, M. L., Brønden, A., Sonne, D. P., Vilsbøll, Tina & Knop, Filip Krag, Sep 2017, In: Diabetes, Obesity and Metabolism. 19, 9, p. 1214-1222Research output: Contribution to journal › Review › Research › peer-review
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Safety and efficacy of liraglutide versus colesevelam for the treatment of bile acid diarrhoea: A randomised, double-blind, active-comparator, non-inferiority clinical trial
Kårhus, M. L., Brønden, A., Forman, Julie Lyng, Haaber, A., Knudsen, E., Langholz, Ebbe, Dragsted, Lars Ove, Hansen, S. H., Krakauer, M., Vilsbøll, Tina, Sonne, David Peick & Knop, Filip Krag, 2022, In: The Lancet Gastroenterology and Hepatology. 7, 10, p. 922-931 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Remission of Bile Acid Malabsorption Symptoms Following Treatment With the Glucagon-Like Peptide 1 Receptor Agonist Liraglutide
Kårhus, M. L., Brønden, A., Roder, M. E., Leotta, S., Sonnet, D. P. & Knop, Filip Krag, 2019, In: Gastroenterology. 157, 2, p. 569-571Research output: Contribution to journal › Journal article › Research › peer-review
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Liraglutide versus colesevelam for treating bile acid diarrhoea – Authors' reply
Kårhus, M. L. & Knop, Filip Krag, 2022, In: The Lancet Gastroenterology and Hepatology. 7, 12, p. 1075-1076 2 p.Research output: Contribution to journal › Comment/debate › Research › peer-review
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The Epidemiology of Bile Acid Diarrhea in Denmark
Kårhus, M. L., Ellegaard, A. M., Winther-Jensen, M., Hansen, S., Knop, Filip Krag & Kårhus, L. L., 2023, In: Clinical Epidemiology. 15, p. 1173-1181 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The Epidemiology of Bile Acid Diarrhea in Denmark [Response to Letter]
Kårhus, M. L., Ellegaard, A. M., Knop, Filip Krag & Kårhus, L. L., 2024, In: Clinical Epidemiology. 16, p. 7-8 2 p.Research output: Contribution to journal › Comment/debate › Research › peer-review
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Different Effects of Once-weekly and Once-daily Administered GLP-1RA Semaglutide and Liraglutide on Bile Acid Diarrhea
Kårhus, M. L., Knudsen, E. & Knop, Filip Krag, 2023, In: JCEM case reports. 1, 1, 3 p., luac004.Research output: Contribution to journal › Journal article › Research › peer-review
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Enterohepatic, gluco-metabolic, and gut microbial characterization of individuals with bile acid malabsorption
Kårhus, M. L., Sonne, David Peick, Thomasen, M., Ellegaard, A., Holst, Jens Juul, Rehfeld, Jens Frederik, Chávez-Talavera, O., Tailleux, A., Staels, B., Nielsen, Dennis Sandris, Dragsted, Lars Ove, Vilsbøll, Tina, Brønden, A. & Knop, Filip Krag, 2022, In: Gastro Hep Advances. 1, 3, p. 299-312 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Protocol for a randomised, double-blinded, placebo-controlled, double-dummy 6-week clinical trial comparing the treatment effects of the glucagon-like peptide 1 receptor agonist liraglutide versus the bile acid sequestrant colesevelam on bile acid malabsorption
Kårhus, M. L., Brønden, A., Forman, Julie Lyng, Haaber, A., Vilsbøll, Tina, Sonne, D. P. & Knop, Filip Krag, 2021, In: BMJ Open. 11, 2, e044711.Research output: Contribution to journal › Comment/debate › Research › peer-review
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The bile-gut axis and metabolic consequences of cholecystectomy
Lange, A. H., Pedersen, M. G., Ellegaard, A. M., Nerild, H. H., Brønden, Andreas, Sonne, David Peick & Knop, Filip Krag, 2024, In: European Journal of Endocrinology. 190, 4, p. R1-R9 9 p.Research output: Contribution to journal › Review › Research › peer-review
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Fibroblast growth factor 21 is the main alcohol responsive peptide hormone in humans and individuals with alcohol use disorder exihibit increased plasma concentrations after alcohol intake
Lanng, A., Gasbjerg, Lærke Smidt, Sucksdorff, A., Svenningsen, J., Trammell, Sam, Vilsbøll, Tina, Gillum, M. & Knop, Filip Krag, 2022, In: Journal of Hepatology. 77, S1, p. S121-S121 1 p., THU006.Research output: Contribution to journal › Conference abstract in journal › Research
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The effect of acute intragastric vs. intravenous alcohol administration on inflammation markers, blood lipids and gallbladder motility in healthy men
Lanng, A. R., Gasbjerg, Lærke Smidt, Bergmann, N. C., Gillum, M. P., Rehfeld, Jens Frederik, Helsted, M. M., Møller, H. J., Grønbæk, H., Vilsbøll, Tina & Knop, Filip Krag, 2020, In: Alcohol. 87, p. 29-37 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The Effect of Ethanol on Inflammation Markers and FGF-21 in Healthy Individuals
Lanng, A. R., Gasbjerg, Lærke Smidt, Bergmann, N. C., Møller, H., Gillum, M., Gronbaek, H., Vilsbøll, Tina & Knop, Filip Krag, 2018, In: Diabetes. 67, Supplement 1, 2415-PUB.Research output: Contribution to journal › Journal article › Research › peer-review
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Gluco-metabolic effects of oral and intravenous alcohol administration in men
Lanng, A. R., Gasbjerg, Lærke Smidt, Bergmann, N. C., Bergmann, S., Heisted, M. M., Gillum, M. P., Hartmann, Bolette, Holst, Jens Juul, Vilsbøll, Tina & Knop, Filip Krag, 2019, In: Endocrine Connections. 8, 10, p. 1372-1382Research output: Contribution to journal › Journal article › Research › peer-review
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Julefrokostdilemmaet
Lanng, A. R., Gasbjerg, L. S. & Knop, Filip Krag, 11 Dec 2017, In: Ugeskrift for Laeger. 179, 25, p. 2212-15 4 p., V69590.Research output: Contribution to journal › Journal article › Research › peer-review
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Changes in oxidative RNA and DNA modifications following one-week treatment with sevelamer: two randomized, placebo-controlled trials
Larsen, E. L., Brønden, A., Karstoft, K., Henriksen, T., Vilsbøll, Tina, Poulsen, Henrik Enghusen & Knop, Filip Krag, 2018, In: Free Radical Biology and Medicine. 128, p. S118 280.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
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The effect of empagliflozin on oxidative nucleic acid modifications in patients with type 2 diabetes: Protocol for a randomised, double-blinded, placebo-controlled trial
Larsen, E. L., Cejvanovic, V., Kjær, L. K., Vilsbøll, Tina, Knop, Filip Krag, Rungby, Jørgen & Poulsen, Henrik Enghusen, May 2017, In: BMJ Open. 7, 5, 6 p., e014728.Research output: Contribution to journal › Journal article › Research › peer-review
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Differential time responses in inflammatory and oxidative stress markers after a marathon: An observational study
Larsen, E. L., Poulsen, Henrik Enghusen, Michaelsen, C., Kjær, L. K., Lyngbæk, M., Andersen, Emilie Skytte, Petersen-Bønding, C., Lemoine, C., Gillum, M., Jørgensen, Niklas Rye, Ploug, Thorkil, Vilsbøll, Tina, Knop, Filip Krag & Karstoft, K., 2020, In: Journal of Sports Sciences. 38, 18, p. 2080-2091Research output: Contribution to journal › Journal article › Research › peer-review
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Changes in urinary excretion of oxidative nucleic acid modifications in the week following Copenhagen Marathon 2018, Denmark
Larsen, E. L., Kjær, L. K., Michaelsen, C., Andersen, E., Lyngbæk, M., Petersen-bønding, C., Henriksen, T., Vilsbøll, Tina, Knop, Filip Krag, Ploug, Thorkil, Poulsen, Henrik Enghusen & Karstoft, K., 2018, In: Free Radical Biology and Medicine. 128, S1, p. S54Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
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Effects of two- and twelve-weeks sodium-glucose cotransporter 2 inhibition on DNA and RNA oxidation: two randomized, placebo-controlled trials
Larsen, E. L., Andersen, A., Kjær, L. K., Eickhoff, M. K., Frimodt-Møller, M., Persson, F., Rossing, Peter, Lykkesfeldt, Jens, Knop, Filip Krag, Vilsbøll, Tina, Rungby, Jørgen & Poulsen, Henrik Enghusen, 2023, In: Free Radical Research. 57, 2, p. 140-151Research output: Contribution to journal › Journal article › Research › peer-review
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Echocardiographic abnormalities and predictors of mortality in hospitalized COVID-19 patients: the ECHOVID-19 study
Lassen, M. C. H., Skaarup, K. G., Lind, J. N., Alhakak, A. S., Sengeløv, M., Nielsen, A. B., Espersen, C., Ravnkilde, K., Hauser, R., Schöps, L. B., Holt, E., Johansen, N. D., Modin, D., Djernæs, K., Graff, C., Bundgaard, H., Hassager, C., Jabbari, R., Carlsen, J., Lebech, A-M. & 28 others, , 2020, In: ESC heart failure. 7, 6, p. 4189-4197Research output: Contribution to journal › Journal article › Research › peer-review
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Oral glucose has little or no effect on appetite and satiety sensations despite a significant gastrointestinal response
Lauritsen, J. V., Bergmann, N., Junker, A. E., Gyldenløve, Mette, Skov, Lone, Gluud, Lise Lotte, Hartmann, Bolette, Holst, Jens Juul, Vilsbøll, Tina & Knop, Filip Krag, 2023, In: European Journal of Endocrinology. 189, 6, p. 619-626 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Bariatric surgery in patients with non-alcoholic fatty liver disease from pathophysiology to clinical effects
Laursen, T. L., Hagemann, C. A., Wei, C., Kazankov, K., Thomsen, K. L., Knop, Filip Krag & Gronbaek, H., 2019, In: World Journal of Hepatology. 11, 2, p. 138-149Research output: Contribution to journal › Review › Research › peer-review
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Adaptive changes in pancreas post Roux-en-Y gastric bypass induced weight loss
Lautenbach, A., Wernecke, M., Riedel, N., Veigel, J., Yamamura, J., Keller, S., Jung, R., Busch, P., Mann, O., Knop, Filip Krag, Holst, Jens Juul, Meier, J. J. & Aberle, J., Oct 2018, In: Diabetes - Metabolism: Research and Reviews (Print Edition). 34, 7, p. 1-8 e3025.Research output: Contribution to journal › Journal article › Research › peer-review
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Serum lipidome unravels a diagnostic potential in bile acid diarrhoea
Lewinska, M., Kårhus, M. L., Ellegaard, A. G., Romero-Gómez, M., Macias, R. I. R., Andersen, Jesper Bøje & Knop, Filip Krag, 2023, In: Gut. 72, 9, p. 1698-1708Research output: Contribution to journal › Journal article › Research › peer-review
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The altered serum lipidome and its diagnostic potential for Non-Alcoholic Fatty Liver (NAFL)-associated hepatocellular carcinoma: Diagnosis of NAFLD-HCC utilising serum lipidomics
Lewinska, M., Santos-Laso, A., Arretxe, E., Alonso, C., Zhuravleva, E., Jimenez-Agüero, R., Eizaguirre, E., Pareja, M. J., Romero-Gómez, M., Jimenez, M. A., Suppli, M. P., Knop, F. K., Oversoe, S. K., Villadsen, G. E., Decaens, T., Carrilho, F. J., de Oliveira, C. PMS., Sangro, B., Macias, R. I. R., Banales, J. M. & 1 others, , 2021, In: EBioMedicine. 73, 103661.Research output: Contribution to journal › Journal article › Research › peer-review
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Genetic variation in the two-pore domain potassium channel, TASK-1, may contribute to an atrial substrate for arrhythmogenesis
Liang, B., Soka, M., Christensen, Alex Hørby, Olesen, Morten Steen Salling, Larsen, A. P., Knop, Filip Krag, Wang, F., Nielsen, J. B., Andersen, M. N., Humphreys, D., Mann, S. A., Huttner, I. G., Vandenberg, J. I., Svendsen, Jesper Hastrup, Haunsø, Stig, Preiss, T., Seebohm, G., Olesen, Søren-Peter, Schmitt, Nicole & Fatkin, D., 27 Dec 2013, In: Journal of Molecular and Cellular Cardiology. 67, p. 69-76 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Circulating levels of endothelial progenitor cells are associated with better cognitive function in older adults with glucagon-like peptide 1 receptor agonist-treated type 2 diabetes
Longo, M., Di Meo, I., Caruso, P., Muscio, M. F., Scappaticcio, L., Maio, A., Maiorino, M. I., Bellastella, G., Signoriello, G., Knop, Filip Krag, Rizzo, M. R. & Esposito, K., 2023, In: Diabetes Research and Clinical Practice. 200, 7 p., 110688.Research output: Contribution to journal › Journal article › Research › peer-review
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Empagliflozin decreases fasting and postprandial hyperglycaemia in totally pancreatectomised patients: a randomised, double-blinded, placebo-controlled study
Lund, A., Baekdal, M., Nielsen, S. W., Hansen, C. P., Storkholm, J. H., Hartmann, Bolette, Holst, Jens Juul, Vilsbøll, Tina & Knop, Filip Krag, 2020, In: Diabetologia. 63, Suppl. 1, p. S276 1 p., 574.Research output: Contribution to journal › Conference abstract in journal › Research
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Glucagon elimination is increased in patients with type 2 diabetes
Lund, A. B., Grøndahl, M. F., Bagger, J. I., Holst, Jens Juul, Christensen, M., Vilsbøll, Tina & Knop, Filip Krag, 2017, In: Diabetologia. 60, p. S240-S240Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
- Published
Emerging GLP-1 receptor agonists
Lund, A., Knop, Filip Krag & Vilsbøll, Tina, 2011, In: Expert Opinion on Emerging Drugs. 16, 4, p. 607-18 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Higher Endogenous Glucose Production during OGTT vs Isoglycemic Intravenous Glucose Infusion
Lund, Asger Bach, Bagger, J. I., Christensen, Mikkel Bring, Grøndahl, M., van Hall, Gerrit, Holst, Jens Juul, Vilsbøll, Tina & Knop, Filip Krag, Nov 2016, In: The Journal of Clinical Endocrinology & Metabolism. 101, 11, p. 4377-4384Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Extrapancreatic glucagon: Present status
Lund, A. & Knop, Filip Krag, 2019, In: Diabetes Research and Clinical Practice. 147, p. 19-28Research output: Contribution to journal › Review › Research › peer-review
- Published
Evidence of Extrapancreatic Glucagon Secretion in Man
Lund, Asger Bach, Bagger, J. I., Albrechtsen, Nicolai Jacob Wewer, Christensen, M., Grøndahl, M., Hartmann, Bolette, Mathiesen, Elisabeth, Hansen, C. P., Storkholm, J. H., van Hall, Gerrit, Rehfeld, Jens Frederik, Hornburg, D., Meissner, F., Mann, Matthias, Larsen, S., Holst, Jens Juul, Vilsbøll, Tina & Knop, Filip Krag, Mar 2016, In: Diabetes. 65, 3, p. 585-597 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The separate and combined impact of the intestinal hormones, GIP, GLP-1, and GLP-2, on glucagon secretion in type 2 diabetes
Lund, Asger Bach, Vilsbøll, Tina, Bagger, J. I., Holst, Jens Juul & Knop, Filip Krag, 2011, In: American Journal of Physiology: Endocrinology and Metabolism. 300, 6, p. E1038-E1046 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Erratum: Evidence of extrapancreatic glucagon secretion in man. Diabetes 2016;65:585-597
Lund, Asger Bach, Bagger, J. I., Albrechtsen, Nicolai Jacob Wewer, Christensen, M., Grøndahl, M., Hartmann, Bolette, Mathiesen, Elisabeth, Hansen, C. P., Storkholm, J. H., van Hall, Gerrit, Rehfeld, Jens Frederik, Hornburg, D., Meissner, F., Mann, Matthias, Larsen, S., Holst, Jens Juul, Vilsbøll, Tina & Knop, Filip Krag, 1 Jun 2016, In: Diabetes. 65, 6, p. 1752 1 p.Research output: Contribution to journal › Comment/debate › Research › peer-review
- Published
Glucagon and type 2 diabetes: the return of the alpha cell
Lund, Asger Bach, Bagger, J. I., Christensen, M., Knop, Filip Krag & Vilsbøll, T., Dec 2014, In: Current Diabetes Reports. 14, 12, p. 1-7 7 p., 555.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
L-cell Differentiation Is Induced by Bile Acids Through GPBAR1 and Paracrine GLP-1 and Serotonin Signaling
Lund, M. L., Sorrentino, G., Egerod, Kristoffer Lihme, Kroone, C., Mortensen, B., Knop, Filip Krag, Reimann, F., Gribble, F. M., Drucker, D. J., De Koning, E. J. P., Schoonjans, K., Bäckhed, F., Schwartz, Thue W. & Petersen, N., Apr 2020, In: Diabetes. 69, 4, p. 614-623 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GIP(3-30)NH2 – a tool for the study of GIP physiology
Lynggaard, M. B., Gasbjerg, Lærke Smidt, Christensen, Mikkel Bring & Knop, Filip Krag, 2020, In: Current Opinion in Pharmacology. 55, p. 31-40 10 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Bifidobacterium breve Bif195 ameliorates aspirin-induced gastric mucosal damage: A randomised, double blind, placebo-controlled crossover trial
Løn, N., Engel, S., Damholt, A., Mortensen, B., Haaber, A. B., Wellejus, A. & Knop, Filip Krag, 2024, In: Alimentary Pharmacology and Therapeutics. 59, 3, p. 341-349 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Editorial: The microbiome and gastric mucosal protection in aspirin users—Authors' reply
Løn, N., Engel, S., Damholt, A., Wellejus, A. & Knop, Filip Krag, 2024, In: Alimentary Pharmacology and Therapeutics. 59, 4, p. 577-578 2 p.Research output: Contribution to journal › Editorial › Research › peer-review
- Published
Letter: Bif195 for aspirin-induced gastric mucosal damage – More to do in further research. Authors' reply
Løn, N., Engel, S., Damholt, A., Wellejus, A. & Knop, Filip Krag, 2024, In: Alimentary Pharmacology and Therapeutics. 59, 10, p. 1306-1307 2 p.Research output: Contribution to journal › Comment/debate › Research › peer-review
- Published
Individual and combined glucose-lowering effects of glucagon receptor antagonism and dipeptidyl peptidase-4 inhibition
Maagensen, H., Haedersdal, S., Lund, A., Nielsen-Hannerup, E., Holst, Jens Juul, Knop, Filip Krag & Vilsbøll, Tina, 2018, In: Diabetologia. 61, p. S246-S247Research output: Contribution to journal › Conference abstract in journal › Research
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Bone Turnover Markers in Patients With Nonalcoholic Fatty Liver Disease and/or Type 2 Diabetes During Oral Glucose and Isoglycemic Intravenous Glucose
Maagensen, H., Junker, A. E., Jorgensen, N. R., Gluud, Lise Lotte, Knop, Filip Krag & Vilsbøll, Tina, 2018, In: Journal of Clinical Endocrinology & Metabolism. 103, 5, p. 2042-2049 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The Gut-Bone Axis in Diabetes
Maagensen, H., Helsted, M. M., Gasbjerg, Lærke Smidt, Vilsbøll, Tina & Knop, Filip Krag, 2023, In: Current Osteoporosis Reports. 21, p. 21–31 11 p.Research output: Contribution to journal › Review › Research › peer-review
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Does glucose lowering restore GIP's effect on insulin secretion?
Madsbad, Sten, Knop, Filip Krag & Holst, Jens Juul, 2023, In: Nutrition, Metabolism & Cardiovascular Diseases. 33, 9, p. 1817-1818Research output: Contribution to journal › Comment/debate › Research
- Published
Characterization of Postprandial Bile Acid Profiles and Glucose Metabolism in Cerebrotendinous Xanthomatosis
Majait, S., Meessen, E. C. E., Vaz, F. M., Kemper, E. M., Nierop, S. V., Olde Damink, S. W., Schaap, F. G., Romijn, J. A., Nieuwdorp, M., Verrips, A., Knop, Filip Krag & Soeters, M. R., 2023, In: Nutrients. 15, 21, 12 p., 4625.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Incretin hormones in patients with type 2 diabetes are increased by diet-oil, a pro-drug for the GPR 119 receptor agonist, 2-oleoyl-glycerol
Mandoe, M. J., Hansen, K. B., Knop, Filip Krag, Holst, Jens Juul & Hansen, Harald S., Oct 2012, In: Diabetologia. 55, p. S340-S340Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
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Comparing olive oil and C4-dietary oil, a prodrug for the GPR119 agonist, 2-oleoyl glycerol, less energy intake of the latter is needed to stimulate incretin hormone secretion in overweight subjects with type 2 diabetes
Mandøe, M. J., Hansen, K. B., Windeløv, Johanne Agerlin, Knop, Filip Krag, Rehfeld, Jens Frederik, Rosenkilde, Mette, Holst, Jens Juul & Hansen, Harald S., 2018, In: Nutrition and Diabetes. 8, 1, p. 1-10 2.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mechanisms of the incretin effect in subjects with normal glucose tolerance and patients with type 2 diabetes
Mari, A., Bagger, J. I., Ferrannini, E., Holst, Jens Juul, Knop, Filip Krag & Vilsbøll, T., 2013, In: PLOS ONE. 8, 9, p. e73154Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Amylin and Calcitonin: Potential Therapeutic Strategies to Reduce Body Weight and Liver Fat
Mathiesen, D. S., Lund, A., Vilsbøll, Tina, Knop, Filip Krag & Bagger, J. I., 2021, In: Frontiers in Endocrinology. 11, 617400.Research output: Contribution to journal › Review › Research › peer-review
- Published
Long-acting amylin analogues for the management of obesity
Mathiesen, D. S., Bagger, J. I. & Knop, Filip Krag, 2022, In: Current Opinion in Endocrinology, Diabetes and Obesity. 29, 2, p. 183-190 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
THERAPY OF ENDOCRINE DISEASE: Amylin and calcitonin - physiology and pharmacology
Mathiesen, D. S., Lund, A., Holst, Jens Juul, Knop, Filip Krag, Lutz, T. A. & Bagger, J. I., 2022, In: European Journal of Endocrinology. 186, 6, p. R93-R111Research output: Contribution to journal › Review › Research › peer-review
- Published
The effects of dual GLP-1/GIP receptor agonism on glucagon secretion: a review
Mathiesen, D. S., Bagger, J. I., Bergmann, N. C., Lund, A., Christensen, Mikkel Bring, Vilsbøll, Tina & Knop, Filip Krag, 2019, In: International Journal of Molecular Sciences. 20, 17, 18 p., 4092.Research output: Contribution to journal › Review › Research › peer-review
- Published
No detectable effect of a type 2 diabetes-associated TCF7L2 genotype on the incretin effect
Mathiesen, D. S., Bagger, J., Hansen, K. B., Junker, A. E., Plamboeck, A., Harring, S., Idorn, T., Hornum, M., Holst, Jens Juul, Jonsson, Anna Elisabet, Hansen, Torben, Vilsbøll, Tina, Lund, Asger Bach & Knop, Filip Krag, 2020, In: Endocrine Connections. 9, 12, p. 1221-1232 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Accuracy of continuous glucose monitoring during exercise-related hypoglycemia in individuals with type 1 diabetes
Maytham, K., Hagelqvist, P. G., Engberg, S., Forman, Julie Lyng, Pedersen-Bjergaard, Ulrik, Knop, Filip Krag, Vilsbøll, Tina & Andersen, A., 2024, In: Frontiers in Endocrinology. 15, 9 p., 1352829.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Predictors of Improvement in Quality of Life When Treating Hypothyroidism
Medici, B. B., Lerche la Cour, J., Knop, Filip Krag, Krakauer, M., Michaelsson, L. F., Faber, Jens, Watt, Torquil & Nygaard, Birte, 2021, In: Journal of Thyroid Research. 2021, 7 p., 5577217.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effects of levothyroxine substitution therapy on hunger and food intake in individuals with hypothyroidism
Medici, B. R., Nygaard, Birte, la Cour, J. L., Krakauer, M., Brønden, Andreas, Sonne, M. P., Holst, Jens Juul, Rehfeld, Jens Frederik, Vilsbøll, Tina, Faber, J. & Knop, Filip Krag, 2023, In: Endocrine Connections. 12, 10, 14 p., e230314.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Parenteral nutrition impairs plasma bile acid and gut hormone responses to mixed meal testing in lean healthy men
Meessen, E. C. E., Bakker, G. J., Nieuwdorp, M., Dallinga-Thie, G. M., Kemper, E. M., Olde Damink, S. W., Romijn, J. A., Hartmann, Bolette, Holst, Jens Juul, Knop, Filip Krag, Groen, A. K., Schaap, F. G. & Soeters, M. R., 2021, In: Clinical Nutrition. 40, 3, p. 1013-1021Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Self-expanding metal stents for colonic obstruction: experiences from 104 procedures in a single center
Meisner, S., Hensler, M., Knop, Filip Krag, West, F. & Wille-Jørgensen, P., 1 Apr 2004, In: Diseases of the Colon and Rectum. 47, 4, p. 444-50 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Rectal sensitivity correlated with gastrointestinal-mediated glucose disposal, but not the incretin effect
Meling, S., Tjora, E., Eichele, H., Nedergaard, R. B., Knop, Filip Krag, Ejskjaer, N., Carlsen, S., Njølstad, P. R., Brock, C. & Søfteland, E., 2023, In: Endocrinology, Diabetes and Metabolism. 7, 1, 13 p., e463.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
High intensity interval training improves insulin sensitivity in individuals with prediabetes
Mensberg, P., Frandsen, C., Espersen, E., Leineweber, T., Storgaard, H., Schlawitz, K. S., Petersen, T. H. D., Poulsen, J. N., Sørensen, F., Forman, Julie Lyng, Knop, Filip Krag & Vilsbøll, Tina, 2018, In: Diabetologia. 61, Supplement 1, p. S217-S218 2 p., 441.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
- Published
Near-normalization of glycaemic control with glucagon-like peptide-1 receptor agonist treatment combined with exercise in patients with type 2 diabetes
Mensberg, P., Nyby, S., Jørgensen, P. G., Storgaard, H., Jensen, M. T., Sivertsen, J., Holst, Jens Juul, Kiens, Bente, Richter, Erik A., Knop, Filip Krag & Vilsbøll, Tina, 2017, In: Diabetes, Obesity and Metabolism. 19, 2, p. 172-180 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effect of Antibiotics on Gut Microbiota, Gut Hormones and Glucose Metabolism
Mikkelsen, K. H., Frost, M., Bahl, M. I., Licht, T. R., Jensen, U. S., Rosenberg, Jacob, Pedersen, Oluf Borbye, Hansen, Torben, Rehfeld, Jens Frederik, Holst, Jens Juul, Vilsbøll, T. & Knop, Filip Krag, 12 Nov 2015, In: PLOS ONE. 10, 11, p. 1-14 e0142352.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
No changes in levels of bone formation and resorption markers following a broad-spectrum antibiotic course
Mikkelsen, K. H., Vilsbøll, Tina, Holst, Jens Juul, Hartmann, Bolette, Knop, Filip Krag & Frost, M., 2018, In: BMC Endocrine Disorders. 18, 6 p., 60.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Response to the letter: "epidemiologic association between antibiotic use with the risk of developing type 2 diabetes" by López-Hernández, D.
Mikkelsen, K. H., Knop, Filip Krag, Frost, M., Hallas, J. & Pottegard, A., 2015, In: Journal of Clinical Endocrinology and Metabolism. 100, 11, 1 p., L121.Research output: Contribution to journal › Letter › Research › peer-review
- Published
Effect of antibiotics on gut microbiota, glucose metabolism and bodyweight regulation: a review of the literature
Mikkelsen, K. H., Allin, K. H. & Knop, Filip Krag, May 2016, In: Diabetes, Obesity and Metabolism. 18, 5, 444–453.Research output: Contribution to journal › Review › Research › peer-review
ID: 40100368
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L-cell Differentiation Is Induced by Bile Acids Through GPBAR1 and Paracrine GLP-1 and Serotonin Signaling
Research output: Contribution to journal › Journal article › Research › peer-review
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Plasma proteome profiling discovers novel proteins associated with non-alcoholic fatty liver disease
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Circulating Glucagon 1-61 Regulates Blood Glucose by Increasing Insulin Secretion and Hepatic Glucose Production
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