Filip Krag Knop

Filip Krag Knop

Clinical Professor

Member of:

  • Internal Medicine: Endocrinology


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  1. Published

    Cardiovascular safety and benefits of GLP-1 receptor agonists

    Dalsgaard, N. B., Brønden, A., Vilsbøll, Tina & Knop, Filip Krag, 2017, In: Expert Opinion on Drug Safety. 16, 3, p. 351-363 13 p.

    Research output: Contribution to journal › Review › Research › peer-review

  2. Published

    Cephalic phase secretion of insulin and other enteropancreatic hormones in humans

    Veedfald, Simon, Plamboeck, A., Deacon, Carolyn F., Hartmann, Bolette, Knop, Filip Krag, Vilsbøll, Tina & Holst, Jens Juul, 1 Jan 2016, In: American Journal of Physiology: Gastrointestinal and Liver Physiology. 310, 1, p. G43-51

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Changes in oxidative RNA and DNA modifications following one-week treatment with sevelamer: two randomized, placebo-controlled trials

    Larsen, E. L., Brønden, A., Karstoft, K., Henriksen, T., Vilsbøll, Tina, Poulsen, Henrik Enghusen & Knop, Filip Krag, 2018, In: Free Radical Biology and Medicine. 128, p. S118 280.

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  4. Published

    Changes in oxidative nucleic acid modifications and inflammation following one-week treatment with the bile acid sequestrant sevelamer: Two randomised, placebo-controlled trials

    Brønden, A., Larsen, E. L., Karstoft, K., Henriksen, T., Vilsbøll, Tina, Poulsen, Henrik Enghusen & Knop, Filip Krag, Feb 2020, In: Journal of Diabetes and its Complications. 34, 2, 8 p., 107446.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Changes in urinary excretion of oxidative nucleic acid modifications in the week following Copenhagen Marathon 2018, Denmark

    Larsen, E. L., Kjær, L. K., Michaelsen, C., Andersen, E., Lyngbæk, M., Petersen-bønding, C., Henriksen, T., Vilsbøll, Tina, Knop, Filip Krag, Ploug, Thorkil, Poulsen, Henrik Enghusen & Karstoft, K., 2018, In: Free Radical Biology and Medicine. 128, S1, p. S54

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  6. Published

    Characterization of Postprandial Bile Acid Profiles and Glucose Metabolism in Cerebrotendinous Xanthomatosis

    Majait, S., Meessen, E. C. E., Vaz, F. M., Kemper, E. M., Nierop, S. V., Olde Damink, S. W., Schaap, F. G., Romijn, J. A., Nieuwdorp, M., Verrips, A., Knop, Filip Krag & Soeters, M. R., 2023, In: Nutrients. 15, 21, 12 p., 4625.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Characterization of oral and intravenous glucose handling in truncally vagotomised subjects with pyloroplasty

    Plamboeck, A., Veedfald, Simon, Deacon, Carolyn F., Hartmann, Bolette, Wettergren, A., Svendsen, Lars Bo, Meisner, S., Hovendal, C., Knop, Filip Krag, Vilsbøll, Tina & Holst, Jens Juul, 23 May 2013, In: European Journal of Endocrinology. 169, p. 187-201 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Cholecystokinin secretion is suppressed by glucagon-like peptide-1: clue to the mechanism of the adverse gallbladder events of GLP-1-derived drugs

    Rehfeld, Jens Frederik, Knop, Filip Krag, Asmar, A., Madsbad, Sten, Holst, Jens Juul & Asmar, M., 2018, In: Scandinavian Journal of Gastroenterology. 53, 12, p. 1429-1432

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Cholecystokinin-Induced Gallbladder Emptying and Single-Dose Metformin Elicit Additive Glucagon-Like Peptide-1 Responses

    Rohde, U., Sonne, D. P., Christensen, M., Hansen, M., Brønden, A., Toräng, S., Rehfeld, Jens Frederik, Holst, Jens Juul, Vilsbøll, Tina & Knop, Filip Krag, 1 May 2016, In: The Journal of clinical endocrinology and metabolism. 101, 5, p. 2076-2083

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Circulating Glucagon 1-61 Regulates Blood Glucose by Increasing Insulin Secretion and Hepatic Glucose Production

    Albrechtsen, N. J. W., Kuhre, R. E., Hornburg, D., Jensen, C. Z., Hornum, M., Dirksen, C., Svane, M., Gasbjerg, L. S., Jorgensen, N. B., Gabe, M. N., Balk-Moller, E., Albrechtsen, R., Winther-Sorensen, M., Galsgaard, K. D., Meissner, F., Jorsal, T., Lund, A., Vilsboll, T., Eliasen, R., Bojsen-Moller, K. N. & 9 others, Idorn, T., Deacon, Carolyn F., Knop, Filip Krag, Rosenkilde, Mette, Hartmann, Bolette, Feldt-Rasmussen, Bo, Mann, Matthias, Madsbad, Sten & Holst, Jens Juul, Nov 2017, In: Cell Reports. 21, 6, p. 1452-1460

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Circulating Levels of the Soluble Receptor for AGE (sRAGE) during Escalating Oral Glucose Dosages and Corresponding Isoglycaemic i.v. Glucose Infusions in Individuals with and without Type 2 Diabetes

    Fotheringham, A. K., Bagger, J. I., Borg, D. J., McCarthy, D. A., Holst, Jens Juul, Vilsbøll, Tina, Knop, Filip Krag & Forbes, J. M., 2020, In: Nutrients. 12, 10, 12 p., 2928.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Circulating levels of endothelial progenitor cells are associated with better cognitive function in older adults with glucagon-like peptide 1 receptor agonist-treated type 2 diabetes

    Longo, M., Di Meo, I., Caruso, P., Muscio, M. F., Scappaticcio, L., Maio, A., Maiorino, M. I., Bellastella, G., Signoriello, G., Knop, Filip Krag, Rizzo, M. R. & Esposito, K., 2023, In: Diabetes Research and Clinical Practice. 200, 7 p., 110688.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Clearance of glucoregulatory peptide hormones during haemodialysis and haemodiafiltration in non-diabetic end-stage renal disease patients

    Jørgensen, M. B., Idorn, T., Knop, Filip Krag, Holst, Jens Juul, Hornum, Mads & Feldt-Rasmussen, Bo, Mar 2015, In: Nephrology, Dialysis, Transplantation. 30, 3, p. 513-20 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Clinical Pharmacokinetics and Pharmacodynamics of Albiglutide

    Brønden, A., Knop, Filip Krag & Christensen, Mikkel Bring, 2017, In: Clinical Pharmacokinetics. 56, 7, p. 719-731

    Research output: Contribution to journal › Review › Research › peer-review

  15. Published

    Clinical characteristics and glucose-lowering drug utilization among patients initiating liraglutide in Denmark: a routine clinical care prescription study

    Knudsen, J. S., Thomsen, R. W., Pottegard, A., Knop, Filip Krag & Sørensen, H. T., 2019, In: Journal of Diabetes. 11, 8, p. 690-694

    Research output: Contribution to journal › Letter › Research › peer-review

  16. Published

    Clinical pharmacology of imeglimin for the treatment of type 2 diabetes

    Johansson, K. S., Brønden, A., Knop, Filip Krag & Christensen, Mikkel Bring, May 2020, In: Expert Opinion on Pharmacotherapy. 21, 8, p. 871-882

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Clinical relevance of the bile acid receptor TGR5 in metabolism

    van Nierop, F. S., Scheltema, M. J., Eggink, H. M., Pols, T. W., Sonne, David Peick, Knop, Filip Krag & Soeters, M. R., Mar 2017, In: The Lancet Diabetes and Endocrinology. 5, 3, p. 224–233

    Research output: Contribution to journal › Review › Research › peer-review

  18. Published

    Clinical translatability of a diet-induced obese mouse model of non-alcoholic steatohepatitis

    Rigbolt, K., Veidal, S., Suppli, M., Eriksen, P. L., Feigh, M., Knop, Filip Krag, Gronbaek, H., Thomsen, K. L., Jelsing, J. & Vrang, N., 2019, In: Journal of Hepatology. 70, 1, p. E544 1 p.

    Research output: Contribution to journal › Conference abstract in journal › Research

  19. Published

    Colesevelam has no acute effect on postprandial GLP-1 levels but abolishes gallbladder refilling

    Gether, I. M., Bahne, E., Nerild, H. H., Rehfeld, Jens Frederik, Hartmann, Bolette, Holst, Jens Juul, Vilsbøll, Tina, Sonne, David Peick & Knop, Filip Krag, 2024, In: European Journal of Endocrinology. 190, 4, p. 314-326 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Combined N-terminal and C-terminal truncations of Glucose dependent Insulinotropic Polypeptide (GIP) are potent and efficient GIP receptor antagonists

    Hansen, L. S., wbf943, wbf943, Svendsen, B., Christensen, M., Hartmann, Bolette, Knop, Filip Krag, Holst, Jens Juul & Rosenkilde, Mette, Sep 2015, In: Diabetologia. 58, 1 supplement, p. S276-S277 2 p., 569.

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  21. Published

    Comment on Xu et al. Effects of Metformin on Metabolite Profiles and LDL Cholesterol in Patients With Type 2 Diabetes

    Sonne, David Peick & Knop, Filip Krag, Dec 2015, In: Diabetes Care. 38, 12, p. e215 1 p.

    Research output: Contribution to journal › Comment/debate › Research › peer-review

  22. Published

    Comment on: Chen et al. Utilizing the Second-Meal Effect in Type 2 Diabetes: Practical Use of a Soya-Yogurt Snack. Diabetes Care 2010;33:2552-2554

    Knop, Filip Krag, 1 Apr 2011, In: Diabetes Care. 34, 4, p. e44

    Research output: Contribution to journal › Letter › Research › peer-review

  23. Published

    Comment on: Villareal et al. (2009) TCF7L2 variant rs7903146 affects the risk of type 2 diabetes by modulating incretin action. Diabetes;59:479-485

    Knop, Filip Krag, 1 Jun 2010, In: Diabetes. 59, 6, p. e4; author reply e5-6

    Research output: Contribution to journal › Letter › Research › peer-review

  24. Published

    Comparing olive oil and C4-dietary oil, a prodrug for the GPR119 agonist, 2-oleoyl glycerol, less energy intake of the latter is needed to stimulate incretin hormone secretion in overweight subjects with type 2 diabetes

    Mandøe, M. J., Hansen, K. B., Windeløv, Johanne Agerlin, Knop, Filip Krag, Rehfeld, Jens Frederik, Rosenkilde, Mette, Holst, Jens Juul & Hansen, Harald S., 2018, In: Nutrition and Diabetes. 8, 1, p. 1-10 2.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Continuous glucose monitoring in pregnant women with type 1 diabetes: an observational cohort study of 186 pregnancies

    Kristensen, K., Ögge, L. E., Sengpiel, V., Kjölhede, K., Dotevall, A., Elfvin, A., Knop, Filip Krag, Wiberg, N., Katsarou, A., Shaat, N., Kristensen, Lars Erik Vølund & Berntorp, K., 2019, In: Diabetologia. 62, 7, p. 1143-1153 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Counterregulatory responses to hypoglycaemia in totally pancreatectomised patients

    Baekdal, M., Lund, A., Baldassare, M. P. A., Rose, K., Egholk, J., Christensen, M. B., Hansen, C. P., Storkholm, J. H., Faber, Jens, Hartmann, Bolette, Holst, Jens Juul, Vilsbøll, Tina & Knop, Filip Krag, 2020, In: Diabetologia. 63, SUPPL 1, p. S95-S95

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  27. Published

    Current Therapies That Modify Glucagon Secretion: What Is the Therapeutic Effect of Such Modifications?

    Grøndahl, M. F., Keating, D. J., Vilsbøll, Tina & Knop, Filip Krag, 2017, In: Current Diabetes Reports. 17, 12, 10 p., 128.

    Research output: Contribution to journal › Review › Research › peer-review

  28. Published

    Current evidence for a role of GLP-1 in Roux-en-Y gastric bypass-induced remission of type 2 diabetes

    Rhee, N. A., Vilsbøll, Tina & Knop, Filip Krag, 2012, In: Diabetes, Obesity and Metabolism. 14, 4, p. 291-298

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Dasiglucagon Effectively Mitigates Postbariatric Postprandial Hypoglycemia: A Randomized, Double-Blind, Placebo-Controlled, Crossover Trial

    Nielsen, C. K., Øhrstrøm, C. C., Kielgast, U. L., Hansen, D. L., Hartmann, Bolette, Holst, Jens Juul, Lund, Asger Bach, Vilsbøll, Tina & Knop, Filip Krag, 2022, In: Diabetes Care. 45, 6, p. 1476–1481

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    Dasiglucagon Treatment for Postprandial Hypoglycemia After Gastric Bypass: A Randomized, Double-Blind, Placebo-Controlled Trial

    Nielsen, C. K., Øhrstrøm, C. C., Houji, I. J. K., Helsted, M. M., Krogh, L. S. L., Johansen, N. J., Hartmann, Bolette, Holst, Jens Juul, Vilsbøll, Tina & Knop, Filip Krag, 2023, In: Diabetes Care. 46, 12, p. 2208-2217 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    Decreased plasma chemerin levels in women with gestational diabetes mellitus

    Hare, K. J., Bonde, L., Svare, J. A., Randeva, H. S., Asmar, M., Larsen, S., Vilsbøll, T. & Knop, Filip Krag, Aug 2014, In: Diabetic Medicine. 31, 8, p. 936-40 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    Delayed ischemic cecal perforation despite optimal decompression after placement of a self-expanding metal stent: report of a case

    Knop, Filip Krag, Pilsgaard, B., Meisner, S. & Wille-Jørgensen, P., 1 Nov 2004, In: Diseases of the Colon and Rectum. 47, 11, p. 1970-3 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    Determinants of Fasting Hyperglucagonemia in Patients with Type 2 Diabetes and Nondiabetic Control Subjects

    Demant, M., Bagger, J. I., Suppli, M. P., Lund, A., Gyldenløve, M., Hansen, K. B., Hare, Kristine Juul, Christensen, Mikkel Bring, Sonne, D. P., Holst, Jens Juul, Vilsbøll, Tina & Knop, Filip Krag, Dec 2018, In: Metabolic Syndrome and Related Disorders. 16, 10, p. 530-536 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. E-pub ahead of print

    Determinants of plasma levels of proglucagon and the metabolic impact of glucagon receptor signalling: a UK Biobank study

    Winther-Sørensen, Marie, Garcia, S. L., Bartholdy, Andreas, Ottenheijm, Maud Eline, Banasik, Karina, Brunak, Søren, Sorensen, Charlotte Mehlin, Gluud, Lise Lotte, Knop, Filip Krag, Holst, Jens Juul, Rosenkilde, Mette, Jensen, Majken Karoline & Albrechtsen, Nicolai Jacob Wewer, 6 May 2024, (E-pub ahead of print) In: Diabetologia.

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Published

    Diabetes and obesity treatment based on dual incretin receptor activation: ‘twincretins’

    Skow, M. A., Bergmann, N. C. & Knop, Filip Krag, Sep 2016, In: Diabetes, Obesity and Metabolism. 18, 9, p. 847-54 8 p.

    Research output: Contribution to journal › Review › Research › peer-review

  36. Published

    Diabetic Ketoacidosis in a Patient with Type 2 Diabetes After Initiation of Sodium-Glucose Cotransporter 2 Inhibitor Treatment

    Storgaard, H., Bagger, J. I., Knop, Filip Krag, Vilsbøll, Tina & Rungby, Jørgen, Feb 2016, In: Basic & Clinical Pharmacology & Toxicology. 118, 2, p. 168-170 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Published

    Diabetic and nondiabetic patients with nonalcoholic fatty liver disease have an impaired incretin effect and fasting hyperglucagonaemia

    Junker, A. E., Gluud, Lise Lotte, Holst, Jens Juul, Knop, Filip Krag & Vilsbøll, Tina, May 2016, In: Journal of Internal Medicine. 279, 5, p. 485–493 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    Diagnostik og behandling af maturity onset diabetes of the young type 3

    Rose, K., Christensen, A. S., Storgaard, H., Hædersdal, S., Hansen, Torben, Knop, Filip Krag & Vilsbøll, Tina, 2018, In: Ugeskrift for Laeger. 180, 6 p., V06170502.

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    Differences Between Randomized Clinical Trial Patients and Real-World Initiators of the Glucagon-Like Peptide 1 Receptor Agonist Liraglutide

    Knudsen, J. S., Thomsen, R. W., Pottegård, A., Knop, Filip Krag & Sørensen, H. T., 2018, In: Diabetes Care. 41, 9, p. e133-e135 3 p.

    Research output: Contribution to journal › Letter › Research › peer-review

  40. Published

    Different Effects of Once-weekly and Once-daily Administered GLP-1RA Semaglutide and Liraglutide on Bile Acid Diarrhea

    Kårhus, M. L., Knudsen, E. & Knop, Filip Krag, 2023, In: JCEM case reports. 1, 1, 3 p., luac004.

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    Differential time responses in inflammatory and oxidative stress markers after a marathon: An observational study

    Larsen, E. L., Poulsen, Henrik Enghusen, Michaelsen, C., Kjær, L. K., Lyngbæk, M., Andersen, Emilie Skytte, Petersen-Bønding, C., Lemoine, C., Gillum, M., Jørgensen, Niklas Rye, Ploug, Thorkil, Vilsbøll, Tina, Knop, Filip Krag & Karstoft, K., 2020, In: Journal of Sports Sciences. 38, 18, p. 2080-2091

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Published

    Disturbed postprandial glucose metabolism and gut hormone responses in non-diabetic patients with psoriasis

    Gyldenløve, M., Vilsbøll, Tina, Holst, Jens Juul, Zachariae, Claus, Skov, L. & Knop, Filip Krag, Nov 2016, In: British Journal of Dermatology. 175, 5, p. 1085–1088

    Research output: Contribution to journal › Letter › Research › peer-review

  43. Published

    Diverse hepatic microbial DNA fingerprints in healthy lean and obese steatotic humans

    Bagger, J. I., Suppli, M. P., Nielsen, T., Lelouvier, B., Broha, A., Demant, M., Konig, M. J., Strandberg, C., Lund, A., Vilsbøll, Tina & Knop, Filip Krag, 2018, In: Diabetologia. 61, p. S120-S121

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  44. Published

    Do the actions of glucagon-like peptide-1 on gastric emptying, appetite, and food intake involve release of amylin in humans?

    Asmar, M., Bache, M., Knop, Filip Krag, Madsbad, Sten & Holst, Jens Juul, 1 May 2010, In: The Journal of clinical endocrinology and metabolism. 95, 5, p. 2367-75 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    Does glucose lowering restore GIP's effect on insulin secretion?

    Madsbad, Sten, Knop, Filip Krag & Holst, Jens Juul, 2023, In: Nutrition, Metabolism & Cardiovascular Diseases. 33, 9, p. 1817-1818

    Research output: Contribution to journal › Comment/debate › Research

  46. Published

    Dose-dependent efficacy of the glucose-dependent insulinotropic polypeptide (GIP)receptor antagonistGIP(3-30)NH2 on GIP actions in humans

    Gasbjerg, Lærke Smidt, Bari, E. J., Stensen, S., Hoe, B., Lanng, A. R., Mathiesen, D. S., Christensen, Mikkel Bring, Hartmann, Bolette, Holst, Jens Juul, Rosenkilde, Mette & Knop, Filip Krag, 2021, In: Diabetes, Obesity and Metabolism. 23, 1, p. 68-74

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    Dulaglutide, a long-acting GLP-1 analog fused with an Fc antibody fragment for the potential treatment of type 2 diabetes

    Solem, Espen Victor Jimenez, Rasmussen, M. H., Christensen, M. & Knop, Filip Krag, 1 Dec 2010, In: Current Opinion in Molecular Therapeutics. 12, 6, p. 790-7 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    Duodenal L cell density correlates with features of metabolic syndrome and plasma metabolites

    Van Baar, A. C. G., Prodan, A., Wahlgren, C. D., Poulsen, Steen Seier, Knop, Filip Krag, Groen, A. K., Bergman, J. J., Nieuwdorp, M. & Levin, E., 2018, In: Endocrine Connections. 7, 5, p. 673-680

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    Dyslipidæmi ved psykisk lidelse

    Mohr, G. H., Barcella, C. A., Coello, K., Baandrup, Lone & Knop, Filip Krag, 2022, In: Ugeskrift for Laeger. 184, 10, 10 p., V05210439.

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Published

    EFFECT OF LIRAGLUTIDE ON BODY WEIGHT AND PAIN IN THE TREATMENT OF OVERWEIGHT AND KNEE OSTEOARTHRITIS: A RANDOMISED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY

    Gudbergsen, H., Overgaard, A., Henriksen, Marius, Waehrens, E. E., Bliddal, Henning, Christensen, R., Nielsen, S. M., Boesen, Mikael Ploug, Knop, Filip Krag, Astrup, A., Rasmussen, M. U., Bartholdy, C. R., Daugaard, C., Bartels, E. M., Ellegaard, K., Heitmann, Berit & Kristensen, Lars Erik Vølund, 2019, In: Annals of the Rheumatic Diseases. 78, p. 71-72 2 p.

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

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