Filip Krag Knop

Filip Krag Knop

Clinical Professor

Member of:

  • Internal Medicine: Endocrinology


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  1. Published

    The impact of acute glycaemic fluctuations on left ventricular systolic function in insulin-treated type 2 diabetes

    Andersen, A., Jorgensen, P. G., Bagger, J. I., Baldassarre, M. P. A., Christensen, M., Abelin, K. U., Faber, Jens, Pedersen-Bjergaard, Ulrik, Holst, Jens Juul, Lindhardt, T., Gislason, Gunnar Hilmar, Knop, Filip Krag & Vilsbøll, Tina, 2020, In: Diabetologia. 63, SUPPL 1, p. S429-S429 897.

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  2. Published

    The impact of dipeptidyl peptidase 4 inhibition on incretin effect, glucose tolerance, and gastrointestinal-mediated glucose disposal in healthy subjects

    Rhee, N. A., Østoft, S. H., Holst, Jens Juul, Deacon, Carolyn F., Vilsbøll, T. & Knop, Filip Krag, 16 Jun 2014, In: European Journal of Endocrinology. 171, 3, p. 353-362 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    The impact of pancreatic enzyme supplementation on postprandial responses of glucagon-like Peptide-2 in patients with chronic pancreatitis and pancreatic exocrine insufficiency

    Knop, Filip Krag, Vilsbøll, Tina, Lund, A., Krarup, T., Holst, Jens Juul & Hornum, Mads, 6 Sep 2010, In: Journal of the Pancreas. 11, 5, p. 489-91 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    The impact of statins and RAS inhibitors on the association between delayed antidiabetic treatment and the risk of cardiovascular event in patients with a first HbAlc between 48-57 mmol/mol

    Falkentoft, A. C., Gerds, Thomas Alexander, Knop, Filip Krag, Fosbøl, E., Køber, Lars Valeur, Torp-Pedersen, Christian, Schou, M., Bruun, Niels Eske & Ruwald, A. C., 2022, In: European Heart Journal. 43, Supplement 1, p. 2419 1 p.

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  5. Published

    The impact of type 2 diabetes and glycaemic control on mortality and clinical outcomes in hospitalized patients with COVID-19 in the capital region of Denmark

    Kliim-Hansen, V., Johansson, K. S., Gasbjerg, Lærke Smidt, Solem, Espen Victor Jimenez, Petersen, Tonny Studsgaard, Nyeland, M. E., Winther-Jensen, M., Ankarfeldt, Mikkel Zöllner, Pedersen, M. G., Ellegaard, A. M., Knop, Filip Krag & Christensen, Mikkel Bring, 2023, In: Diabetes, Obesity and Metabolism. 26, 1, p. 160-168 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    The importance of glucose-dependent insulinotropic polypeptide receptor activation for the effects of tirzepatide

    Gasbjerg, Lærke Smidt, Rosenkilde, Mette, Meier, J. J., Holst, Jens Juul & Knop, Filip Krag, 2023, In: Diabetes, Obesity and Metabolism. 25, 11, p. 3079-3092

    Research output: Contribution to journal › Review › Research › peer-review

  7. Published

    The incretin effect in patients with maturity onset diabetes of the young

    Ostoft, S. H., Bagger, J. I., Hansen, T., Pedersen, O., Holst, Jens Juul, Knop, Filip Krag & Vilsboll, T., 2012, In: Diabetologia. 55, p. S144-S144

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    The liver-alpha cell axis and type 2 diabetes

    Albrechtsen, Nicolai Jacob Wewer, Pedersen, Jens, Galsgaard, Katrine Douglas, Winther-Sørensen, Marie, Suppli, M. P., Janah, L., Gromada, J., Vilstrup, H., Knop, Filip Krag & Holst, Jens Juul, 2019, In: Endocrine Reviews. 40, 5, p. 1353-1366

    Research output: Contribution to journal › Review › Research › peer-review

  9. Published

    The naturally occurring GIP(1-30)NH2 is a GIP receptor agonist in humans

    Krogh, L. S. L., Henriksen, K., Stensen, S., Skov-Jeppesen, Kirsa, Bergmann, N. C., Størling, Joachim, Rosenkilde, Mette, Hartmann, Bolette, Holst, Jens Juul, Gasbjerg, Lærke Smidt & Knop, Filip Krag, 2023, In: European Journal of Endocrinology. 188, 1, lvac015.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    The pathophysiology of diabetes involves a defective amplification of the late-phase insulin response to glucose by glucose-dependent insulinotropic polypeptide-regardless of etiology and phenotype

    Vilsbøll, Tina, Knop, Filip Krag, Krarup, T., Johansen, A., Madsbad, Sten, Larsen, S., Hansen, T., Pedersen, O., Holst, J. M. & Johansen, A., 1 Oct 2003, In: Journal of Clinical Endocrinology and Metabolism. 88, 10, p. 4897-903 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    The potential of colchicine for lowering the risk of cardiovascular events in type 1 diabetes

    Johansen, N. J. & Knop, Filip Krag, 2023, In: European Heart Journal - Cardiovascular Pharmacotherapy. 9, 4, p. 311-317

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    The role of GLP-1 in the postprandial effects of acarbose in type 2 diabetes

    Dalsgaard, N. B., Gasbjerg, Lærke Smidt, Hansen, L. S., Hansen, N. L., Stensen, S., Hartmann, Bolette, Rehfeld, Jens Frederik, Holst, Jens Juul, Vilsbøll, Tina & Knop, Filip Krag, 2021, In: European Journal of Endocrinology. 184, 3, p. 387-398 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    The role of efferent cholinergic transmission for the insulinotropic and glucagonostatic effects of GLP-1

    Plamboeck, A., Veedfald, Simon, Deacon, Carolyn F., Hartmann, Bolette, Vilsbøll, T., Knop, Filip Krag & Holst, Jens Juul, Sep 2015, In: American Journal of Physiology: Regulatory, Integrative and Comparative Physiology. 309, 5, p. R544-51 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    The role of endogenous GIP and GLP-1 in postprandial bone homeostasis

    Helsted, M. M., Gasbjerg, Lærke Smidt, Lanng, A. R., Bergmann, N. C., Stensen, S., Hartmann, Bolette, Christensen, Mikkel Bring, Holst, Jens Juul, Vilsbøll, Tina, Rosenkilde, Mette & Knop, Filip Krag, 2020, In: Bone. 140, 7 p., 115553.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    The role of glucagon in the acute therapeutic effects of SGLT2 inhibition

    Hædersdal, S., Lund, A., Nielsen-Hannerup, E., Maagensen, H., van Hall, Gerrit, Holst, Jens Juul, Knop, Filip Krag & Vilsbøll, Tina, 2020, In: Diabetes. 69, 12, p. 2619-2629 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    The role of the incretins in the postprandial bone remodelling

    Helsted, M. M., Gasbjerg, Lærke Smidt, Lanng, A. R., Stensen, S., Hartmann, Bolette, Christensen, Mikkel Bring, Holst, Jens Juul, Vilsbøll, Tina, Rosenkilde, M. M. & Knop, Filip Krag, 2018, In: Diabetologia. 61, S1, p. S221-S221 449.

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  17. Published

    The separate and combined impact of the intestinal hormones, GIP, GLP-1, and GLP-2, on glucagon secretion in type 2 diabetes

    Lund, Asger Bach, Vilsbøll, Tina, Bagger, J. I., Holst, Jens Juul & Knop, Filip Krag, 2011, In: American Journal of Physiology: Endocrinology and Metabolism. 300, 6, p. E1038-E1046 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    The spectrum of antidiabetic actions of GLP-1 in patients with diabetes

    Vilsbøll, Tina, Holst, Jens Juul & Knop, Filip Krag, 2009, In: Best Practice & Research: Clinical Endocrinology & Metabolism. 23, 4, p. 453-62 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    The use of double-balloon enteroscopy in retrieving mucosal biopsies from the entire human gastrointestinal tract

    Rhee, N. A., Vilmann, Peter, Hassan, H., Hendel, J. W., Holst, Jens Juul, Vilsbøll, T. & Knop, Filip Krag, Sep 2014, In: Scandinavian Journal of Gastroenterology. 49, 9, p. 1143-1149 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Therapy for obesity based on gastrointestinal hormones

    Bagger, J. I., Christensen, M., Knop, Filip Krag & Vilsbøll, Tina, 2011, In: Review of Diabetic Studies. 8, 3, p. 339-47 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Thirty days of resveratrol supplementation does not affect postprandial incretin hormone responses, but suppresses postprandial glucagon in obese subjects

    Knop, Filip Krag, Konings, E., Timmers, S., Schrauwen, P., Holst, Jens Juul & Blaak, E. E., 11 May 2013, In: Diabetic Medicine. 30, 10, p. 1214-1218 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Time spent in glycaemic control after initiating treatment with oral semaglutide vs empagliflozin: an exploratory analysis of the PIONEER 2 trial

    Knop, Filip Krag, Cariou, B., Christiansen, E., Davies, A. L., Montanya, E., Abildlund, M. T. & Rosenstock, J., 2021, In: Diabetologia. 64, SUPPL 1, p. 249-250 2 p.

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  23. Published

    Transcutaneous vagal nerve stimulation for treating gastrointestinal symptoms in individuals with diabetes: a randomised, double-blind, sham-controlled, multicentre trial

    Kornum, D. S., Bertoli, D., Kufaishi, H., Wegeberg, A., Okdahl, T., Mark, E. B., Høyer, K. L., Frøkjær, J. B., Brock, Birgitte, Krogh, K., Hansen, C. S., Knop, Filip Krag, Brock, C. & Drewes, A. M., 2024, In: Diabetologia. 67, 6, p. 1122-1137

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Transfer of liraglutide from blood to cerebrospinal fluid is minimal in patients with type 2 diabetes

    Christensen, M., wbf943, wbf943, Hartmann, Bolette, Grevstad, U., Rosenkilde, Mette, Holst, Jens Juul, Vilsbøll, T. & Knop, Filip Krag, Nov 2015, In: International journal of obesity (2005). 39, 11, p. 1651-1654 4 p.

    Research output: Contribution to journal › Letter › Research › peer-review

  25. Published

    Treatment of antipsychotic-associated obesity with a GLP-1 receptor agonist-protocol for an investigator-initiated prospective, randomised, placebo-controlled, double-blinded intervention study: The TAO study protocol

    Ishøy, P. L., Knop, Filip Krag, Broberg, B. V., Baandrup, Lone, Fagerlund, Birgitte, Jørgensen, Niklas Rye, Andersen, U. B., Rostrup, Egill, Glenthøj, Birte Yding & Ebdrup, Bjørn, 2014, In: BMJ Open. 4, 1, e004158.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Treatment of type 2 diabetes in children: what are the specific considerations?

    Grondahl, M. F. G., Johannesen, Jesper, Kristensen, K. & Knop, Filip Krag, 2021, In: Expert Opinion on Pharmacotherapy. 22, 16, p. 2127-2141 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    Treatment of type 2 diabetes with glucagon-like peptide-1 receptor agonists

    Hansen, K. B., Knop, Filip Krag, Holst, Jens Juul & Vilsbøll, Tina, 2009, In: International Journal of Clinical Practice. 63, 8, p. 1154-60 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Tværsektorielt samarbejde ved behandling af patienter med type 2-diabetes

    Munch, L., Røder, M. E., Rasmussen, I. H., Middelfart, H., Kaarsberg, N., Bennich, B., Knop, Filip Krag & Vilsbøll, Tina, 2018, In: Ugeskrift for Laeger. 180, 8, p. 690-693

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Twelve weeks treatment with the DPP-4 inhibitor, sitagliptin, prevents degradation of peptide YY and improves glucose and non-glucose induced insulin secretion in patients with type 2 diabetes mellitus

    Aaboe, K., Knop, Filip Krag, Vilsbøll, T., Deacon, Carolyn F., Holst, Jens Juul, Madsbad, S. & Krarup, T. M., 1 Apr 2010, In: Diabetes, Obesity and Metabolism. 12, 4, p. 323-33 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    Twelve weeks treatment with the DPP-4 inhibitor, sitagliptin, prevents degradation of peptide YY and improves glucose- and non-glucose-induced insulin secretion in patients with type 2 diabetes mellitus

    Aaboe, K., Knop, Filip Krag, Vilsbøll, Tina, Deacon, Carolyn F., Holst, Jens Juul, Madsbad, Sten & Krarup, T., 2010, In: Diabetes, Obesity and Metabolism. 12, 4, p. 323-333 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    Understanding the place for GLP-1RA therapy: Translating guidelines for treatment of type 2 diabetes into everyday clinical practice and patient selection

    Andreasen, C. R., Andersen, A., Knop, Filip Krag & Vilsbøll, Tina, 2021, In: Diabetes, Obesity and Metabolism. 23, S3, p. 40-52 13 p.

    Research output: Contribution to journal › Review › Research › peer-review

  32. Published

    Unprecedented high insulin secretion in a healthy human subject after intravenous glucagon-like peptide-1: a case report

    Knop, Filip Krag, Lund, Asger Bach, Madsbad, Sten, Holst, Jens Juul, Krarup, T. & Vilsbøll, T., 2014, In: BMC Research Notes. 7, p. 1-6 6 p., 326.

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    Use of Antibiotics and Risk of Type 2 Diabetes: A Population-Based Case-Control Study

    Mikkelsen, K. H., Knop, Filip Krag, Frost, M., Hallas, J. & Pottegård, A., 2015, In: Journal of Clinical Endocrinology and Metabolism. 100, 10, p. 3633-40 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. Published

    Use of antibiotics in childhood and risk of Type 1 diabetes: a population-based case-control study

    Mikkelsen, K. H., Knop, Filip Krag, Vilsbøll, Tina, Frost, M., Hallas, J. & Pottegård, A., Feb 2017, In: Diabetic Medicine. 34, 2, p. 272–277

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Published

    Use of exenatide and liraglutide in Denmark: A drug utilization study

    Pottegård, A., Bjerregaard, B. K., Larsen, M. D., Larsen, K. S., Hallas, J., Knop, Filip Krag & Moreno, S. I., Feb 2014, In: European Journal of Clinical Pharmacology. 70, 2, p. 205-214 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    Use of inhaled corticosteroids and the risk of developing type 2 diabetes in patients with chronic obstructive pulmonary disease

    Saeed, M. I., Eklof, J., Achir, I., Sivapalan, P., Meteran, Howraman, Lokke, A., Biering-Sørensen, Tor, Knop, Filip Krag & Jensen , Jens-Ulrik Stæhr , 2020, In: Diabetes, Obesity and Metabolism. 22, 8, p. 1348-1356 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Published

    Vaerdien af billeddiagnostiske undersøgelser ordineret i almen praksis

    Knop, Filip Krag & Stauning, J. A., 20 Feb 2006, In: Ugeskrift for Laeger. 168, 8, p. 794-8 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    Vagotomy and subsequent development of diabetes: A nested case-control study

    Starup-Linde, J., Gejl, M., Borghammer, P., Knop, Filip Krag, Gregersen, S., Rungby, Jørgen & Vestergaard, P., Jul 2016, In: Metabolism. 65, 7, p. 954-960 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    Value of gym-based group exercise versus usual care for young adults receiving antipsychotic medication: study protocol for the multicenter randomized controlled Vega trial

    Rafn, B. S., Andersen, M. F., Sørensen, V., Bjerre, E. D., Baandrup, Lone, Vernal, D. L., Mors, O., Knop, Filip Krag, Wolf, R. T., Tolver, Anders, Firth, J., Nøhr, N., Skou, S. T., Ebdrup, Bjørn & Midtgaard, Julie, 2023, In: BMC Psychiatry. 23, 1, 13 p., 634.

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    Vitamin D Supplementation Improves Fasting Insulin Levels and HDL Cholesterol in Infertile Men

    Holt, R., Petersen, Jørgen Holm, Dinsdale, E., Knop, Filip Krag, Juul, Anders, Jørgensen, N. & Jensen, M. B., 2022, In: Journal of Clinical Endocrinology & Metabolism. 107, 1, p. 98-108

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    Weight Loss for Patients With Gout and Concomitant Obesity: A Proof-of-Concept Randomized Trial

    Christensen, R., Zobbe, K., Nielsen, S. M., Stamp, L. K., Henriksen, Marius, Overgaard, A. F., Dreyer, L., Knop, Filip Krag, Singh, J. A., Doherty, M., Richette, P., Astrup, A., Ellegaard, K., Bartels, E. M., Boesen, Mikael Ploug, Gudbergsen, Henrik Rindel, Bliddal, Henning & Kristensen, L. E., 2024, In: Arthritis & rheumatology (Hoboken, N.J.). 766, 5, p. 806-812 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Published

    Weight gain on antipsychotics – A perfect storm of complex pathophysiology and psychopharmacology

    Ebdrup, Bjørn & Knop, Filip Krag, 2021, In: Acta Psychiatrica Scandinavica. 144, 6, p. 521-523 3 p.

    Research output: Contribution to journal › Letter › Research › peer-review

  43. Published

    Weight loss for overweight and obese individuals with gout: a systematic review of longitudinal studies

    Nielsen, S. M., Bartels, E. M., Henriksen, Marius, Wæhrens, E. E., Gudbergsen, Henrik Rindel, Bliddal, Henning, Astrup, A., Knop, Filip Krag, Carmona, L., Taylor, W. J., Singh, J. A., Perez-Ruiz, F., Kristensen, Lars Erik Vølund & Christensen, R., 2017, In: Annals of the Rheumatic Diseases. 76, 11, p. 1870-1882 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Published

    What is on the horizon for type 2 diabetes pharmacotherapy? - An overview of the antidiabetic drug development pipeline

    Johansson, K. S., Sonne, D., Knop, Filip Krag & Christensen, Mikkel Bring, 2020, In: Expert Opinion on Drug Discovery. 15, 11, p. 1253-1265

    Research output: Contribution to journal › Review › Research › peer-review

  45. Published

    Why diversity among participants in clinical studies is not always preferable: the case for small, exploratory studies

    Ellegaard, A. M. & Knop, Filip Krag, 2023, In: BMC Medicine. 21, 1, 3 p., 462.

    Research output: Contribution to journal › Comment/debate › Research › peer-review

  46. Published

    Women with prior gestational diabetes mellitus and prediabetes are characterised by a decreased incretin effect

    Foghsgaard, S., Vedtofte, L., Andreasen, C., Andersen, E. S., Bahne, E., Bagger, J. I., Svare, J. A., Holst, Jens Juul, Clausen, Tine Dalsgaard, Mathiesen, Elisabeth, Damm, Peter, Knop, Filip Krag & Vilsbøll, Tina, Jul 2017, In: Diabetologia. 60, 7, p. 1344-1353 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

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