Filip Krag Knop

Filip Krag Knop

Clinical Professor

Member of:

  • Internal Medicine: Endocrinology


  1. 2022
  2. Published

    Bile acid-farnesoid X receptor-fibroblast growth factor 19 axis in patients with short bowel syndrome: The randomized, glepaglutide phase 2 trial

    Hvistendahl, M. K., Naimi, R. M., Hansen, S. H., Rehfeld, Jens Frederik, Kissow, Hannelouise, Pedersen, Jens, Dragsted, Lars Ove, Sonne, D. P., Knop, Filip Krag & Jeppesen, Palle Bekker, 2022, In: Journal of Parenteral and Enteral Nutrition. 46, 4, p. 923-935 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    The Glucagon Receptor Antagonist LY2409021 has No Effect on Postprandial Glucose in Type 2 Diabetes

    Hædersdal, S., Lund, A., Maagensen, H., Nielsen-Hannerup, E., Gasbjerg, Lærke Smidt, Rosenkilde, Mette, Forman, Julie Lyng, van Hall, Gerrit, Holst, Jens Juul, Knop, Filip Krag & Vilsbøll, Tina, 2022, In: European Journal of Endocrinology. 186, 2, p. 207-221 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    The glucagon receptor antagonist LY2409021 does not affect gastrointestinal-mediated glucose disposal or the incretin effect in individuals with and without type 2 diabetes

    Hædersdal, S., Lund, A., Nielsen-Hannerup, E., Maagensen, H., Forman, Julie Lyng, Holst, Jens Juul, Knop, Filip Krag & Vilsbøll, Tina, 2022, In: European Journal of Endocrinology. 187, 4, p. 507-518 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Effects of short-acting exenatide added three times daily to insulin therapy on bone metabolism in type 1 diabetes

    Johansen, N. J., Dejgaard, T. F., Lund, A., Schlüntz, Camilla, Hartmann, Bolette, Holst, Jens Juul, Vilsbøll, Tina, Andersen, H. U. & Knop, Filip Krag, 2022, In: Diabetes, Obesity and Metabolism. 24, 2, p. 221-227

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Protocol for a 30-day randomised, parallel-group, non-inferiority, controlled trial investigating the effects of discontinuing renin-angiotensin system inhibitors in patients with and without COVID-19: The RASCOVID-19 trial

    Kliim-Hansen, V., Gasbjerg, Lærke Smidt, Ellegaard, A. M., Lorentsson, H. J. N., Lynggaard, M. B., Hagemann, C. A., Legart, C., Mathiesen, D. S., Sivapalan, P., Jensen , Jens-Ulrik Stæhr , Vilsbøll, Tina, Christensen, Mikkel Bring & Knop, Filip Krag, 2022, In: BMJ Open. 12, 11, e062895.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Safety and efficacy of liraglutide versus colesevelam for the treatment of bile acid diarrhoea: A randomised, double-blind, active-comparator, non-inferiority clinical trial

    Kårhus, M. L., Brønden, A., Forman, Julie Lyng, Haaber, A., Knudsen, E., Langholz, Ebbe, Dragsted, Lars Ove, Hansen, S. H., Krakauer, M., Vilsbøll, Tina, Sonne, David Peick & Knop, Filip Krag, 2022, In: The Lancet Gastroenterology and Hepatology. 7, 10, p. 922-931 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Liraglutide versus colesevelam for treating bile acid diarrhoea – Authors' reply

    Kårhus, M. L. & Knop, Filip Krag, 2022, In: The Lancet Gastroenterology and Hepatology. 7, 12, p. 1075-1076 2 p.

    Research output: Contribution to journalComment/debateResearchpeer-review

  9. Published

    Enterohepatic, gluco-metabolic, and gut microbial characterization of individuals with bile acid malabsorption

    Kårhus, M. L., Sonne, David Peick, Thomasen, M., Ellegaard, A., Holst, Jens Juul, Rehfeld, Jens Frederik, Chávez-Talavera, O., Tailleux, A., Staels, B., Nielsen, Dennis Sandris, Dragsted, Lars Ove, Vilsbøll, Tina, Brønden, A. & Knop, Filip Krag, 2022, In: Gastro Hep Advances. 1, 3, p. 299-312 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Fibroblast growth factor 21 is the main alcohol responsive peptide hormone in humans and individuals with alcohol use disorder exihibit increased plasma concentrations after alcohol intake

    Lanng, A., Gasbjerg, Lærke Smidt, Sucksdorff, A., Svenningsen, J., Trammell, Sam, Vilsbøll, Tina, Gillum, M. & Knop, Filip Krag, 2022, In: Journal of Hepatology. 77, S1, p. S121-S121 1 p., THU006.

    Research output: Contribution to journalConference abstract in journalResearch

  11. Published

    Long-acting amylin analogues for the management of obesity

    Mathiesen, D. S., Bagger, J. I. & Knop, Filip Krag, 2022, In: Current Opinion in Endocrinology, Diabetes and Obesity. 29, 2, p. 183-190 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    THERAPY OF ENDOCRINE DISEASE: Amylin and calcitonin - physiology and pharmacology

    Mathiesen, D. S., Lund, A., Holst, Jens Juul, Knop, Filip Krag, Lutz, T. A. & Bagger, J. I., 2022, In: European Journal of Endocrinology. 186, 6, p. R93-R111

    Research output: Contribution to journalReviewResearchpeer-review

  13. Published

    Dyslipidæmi ved psykisk lidelse

    Mohr, G. H., Barcella, C. A., Coello, K., Baandrup, Lone & Knop, Filip Krag, 2022, In: Ugeskrift for Laeger. 184, 10, 10 p., V05210439.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Dasiglucagon Effectively Mitigates Postbariatric Postprandial Hypoglycemia: A Randomized, Double-Blind, Placebo-Controlled, Crossover Trial

    Nielsen, C. K., Øhrstrøm, C. C., Kielgast, U. L., Hansen, D. L., Hartmann, Bolette, Holst, Jens Juul, Lund, Asger Bach, Vilsbøll, Tina & Knop, Filip Krag, 2022, In: Diabetes Care. 45, 6, p. 1476–1481

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    The Liver-Alpha Cell Axis in Health and in Disease

    Richter, Michael Martin, Galsgaard, Katrine Douglas, Elmelund, E., Knop, Filip Krag, Suppli, M. P., Holst, Jens Juul, Winther-Sørensen, Marie, Kjeldsen, Sasha Alexandra Sampson & Albrechtsen, Nicolai Jacob Wewer, 2022, In: Diabetes. 71, +, p. 1852–1861

    Research output: Contribution to journalReviewResearchpeer-review

  16. Published

    Azithromycin and hydroxychloroquine in hospitalised patients with confirmed COVID-19: a randomised double-blinded placebo-controlled trial

    Sivapalan, P. & ProPAC-COVID writing group on behalf of the ProPAC-COVID Study Group, P. W. G. O. B. O. T. P. S. G., 2022, In: European Respiratory Journal. 59, 1, 2100752.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published
  18. Published
  19. Published

    A glucose-insulin-glucagon coupled model of the isoglycemic intravenous glucose infusion experiment

    Subramanian, V., Bagger, J. I., Holst, Jens Juul, Knop, Filip Krag & Vilsbøll, Tina, 2022, In: Frontiers in Physiology. 13, 20 p., 911616.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Neurotensin secretion after Roux-en-Y gastric bypass, sleeve gastrectomy, and truncal vagotomy with pyloroplasty

    Svane, M. S., Øhrstrøm, C. C., Plamboeck, A., Jørgensen, Nils Bruun, Bojsen-Møller, K. N., Dirksen, C., Martinussen, C., Vilsbøll, Tina, Hartmann, Bolette, Deacon, Carolyn F., Kristiansen, V. B., Knop, Filip Krag, Svendsen, Lars Bo, Madsbad, Sten, Holst, Jens Juul & Veedfald, Simon, 2022, In: Neurogastroenterology and Motility. 34, 1, e14210.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. 2021
  22. Published

    Associations of hypoglycaemia and glycaemic variability with cardiac arrhythmias using a long-term monitoring approach in insulin-treated patients with type 2 diabetes

    Andersen, A., Bagger, J. I., Sorensen, S. K., Baldassarre, M. P. A., Pedersen-Bjergaard, Ulrik, Forman, Julie Lyng, Gislason, Gunnar Hilmar, Lindhardt, T. B., Knop, Filip Krag & Vilsbøll, Tina, 2021, In: Diabetologia. 64, SUPPL 1, p. 135-135 257.

    Research output: Contribution to journalConference abstract in journalResearch

  23. Published

    A Pharmacological and Clinical Overview of Oral Semaglutide for the Treatment of Type 2 Diabetes

    Andersen, A., Knop, Filip Krag & Vilsbøll, Tina, 2021, In: Drugs. 81, p. 1003-1030 28 p.

    Research output: Contribution to journalReviewResearchpeer-review

  24. Published

    Acute hypoglycemia and risk of cardiac arrhythmias in insulin-treated type 2 diabetes and controls

    Andersen, A., Bagger, J. I., Baldassarre, M. P., Christensen, Mikkel Bring, Abelin, K. U., Faber, Jens, Pedersen-Bjerregaard, U., Holst, Jens Juul, Lindhardt, T. B., Gislason, Gunnar Hilmar, Knop, Filip Krag & Vilsbøll, Tina, 2021, In: European Journal of Endocrinology. 185, 2, p. 343-353 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Associations of hypoglycemia, glycemic variability and risk of cardiac arrhythmias in insulin-treated patients with type 2 diabetes: a prospective, observational study

    Andersen, A., Bagger, J. I., Sørensen, S. K., Baldassarre, M. P. A., Pedersen-Bjergaard, Ulrik, Forman, Julie Lyng, Gislason, Gunnar Hilmar, Lindhardt, T. B., Knop, Filip Krag & Vilsbøll, Tina, 2021, In: Cardiovascular Diabetology. 20, 1, 10 p., 241.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    MECHANISMS IN ENDOCRINOLOGY: The physiology of neuronostatin

    Andersen, M. R., Suppli, M. P., Bagger, J. I., Christensen, Mikkel Bring, Yosten, G. L. C., Knop, Filip Krag & Lund, A., 2021, In: European Journal of Endocrinology. 185, 4, p. R93-R101

    Research output: Contribution to journalReviewResearchpeer-review

  27. Published

    The impact of acute fluctuations in plasma glucose on echocardiographic derived measures of systolic function in patients with type 1 diabetes

    Andreasen, C. R., Andersen, A., Haqelqvist, P. G., Abelin, K., Lauritsen, J. V., Jorgensen, P. G., Engberg, S., Faber, Jens, Holst, Jens Juul, Pedersen-Bjergaard, Ulrik, Knop, Filip Krag & Vilsbøll, Tina, 2021, In: Diabetologia. 64, SUPPL 1, p. 135-136 2 p.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  28. Published

    How glucagon-like peptide 1 receptor agonists work

    Andreasen, C. R., Andersen, A., Knop, Filip Krag & Vilsbøll, Tina, 2021, In: Endocrine Connections. 10, 7, p. R200-R212 13 p.

    Research output: Contribution to journalReviewResearchpeer-review

  29. Published

    Understanding the place for GLP-1RA therapy: Translating guidelines for treatment of type 2 diabetes into everyday clinical practice and patient selection

    Andreasen, C. R., Andersen, A., Knop, Filip Krag & Vilsbøll, Tina, 2021, In: Diabetes, Obesity and Metabolism. 23, S3, p. 40-52 13 p.

    Research output: Contribution to journalReviewResearchpeer-review

  30. Published

    Glucagonostatic Potency of GLP-1 in Patients with Type 2 Diabetes, in Patients with Type 1 Diabetes, and Healthy Control Subjects

    Bagger, J. I., Grøndahl, M., Lund, Asger Bach, Holst, Jens Juul, Vilsbøll, Tina & Knop, Filip Krag, 2021, In: Diabetes. 70, 4, p. 1347-1356

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Exogenous secretin decreases ad libitum food intake and exhibits a biphasic effect on supraclavicular brown adipose tissue activity in healthy men

    Bentzen, M. J., Heimburger, S. M. N., Hartmann, Bolette, Holst, Jens Juul, Christensen, Mikkel Bring & Knop, Filip Krag, 2021, In: Diabetologia. 64, SUPPL 1, p. 211-211 1 p.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  32. Published

    GLYCAEMIC MARKERS IN PATIENTS WITH TYPE 2 DIABETES UNDERGOING HAEMODIALYSIS EVALUATED BY LONG-TERM CONTINUOUS GLUCOSE MONITORING

    Bomholt, T., Rix, M., Almdal, Thomas Peter, Knop, Filip Krag, Rosthøj, Susanne, Heinrich, N. S., Jørgensen, M., Larsson, A., Hilsted, L., Feldt-Rasmussen, Bo & Hornum, Mads, 2021, In: Nephrology Dialysis Transplantation. 36, Supplement 1, p. 371 1 p., MO633.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  33. Published

    Reduced erythrocyte lifespan measured by chromium-51 in patients with type 2 diabetes undergoing long-term hemodialysis

    Bomholt, T., Oturai, P., Rix, M., Almdal, Thomas Peter, Knop, Filip Krag, Rosthøj, Susanne, Feldt-Rasmussen, Bo & Hornum, M., 2021, In: Hemodialysis International. 25, 2, p. 198-204 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    The Glycemic Effect of Liraglutide Evaluated by Continuous Glucose Monitoring in Persons with Type 2 Diabetes Receiving Dialysis

    Bomholt, T., Idorn, T., Knop, Filip Krag, Jørgensen, M. B., Ranjan, A. G., Resuli, M., Hansen, P. M., Borg, Rikke, Persson, F., Feldt-Rasmussen, Bo & Hornum, Mads, 2021, In: Nephron. 145, 1, p. 27-34

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    Prognostic factors of 90-day mortality in patients hospitalised with covid-19

    Brieghel, C., Ellekvist, P., Lund, M. L., Søborg, C., Walsted, E. S., Thomsen, J. J., Biering-Sørensen, Tor, Mohr, T., Knop, Filip Krag & Ravn, Pernille, 2021, In: Danish Medical Journal. 68, 3, p. 1-9 9 p., A09200705.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    Liraglutide decreases postprandial fibroblast growth factor 19 and glucagon-like peptide 2, and increases postprandial cholecystokinin in individuals with obesity

    Bronden, A., Nerild, H. H., Nexoe-Larsen, C. C., Hellmann, P. H., Baekdal, M., Gether, I. M., Gillum, M. P., Hartmann, Bolette, Knudsen, L. B., Jacobsen, L. V., Rehfeld, Jens Frederik, Holst, Jens Juul, Vilsbøll, Tina, Sonne, D. P. & Knop, Filip Krag, 2021, In: Diabetologia. 64, SUPPL 1, p. 94-94 177.

    Research output: Contribution to journalConference abstract in journalResearch

  37. Published

    Prototype of an evidence-based tool to aid individualized treatment for type 2 diabetes

    Buse, J. B., Holst, I., Knop, Filip Krag, Kvist, K., Thielke, D. & Pratley, R., 2021, In: Diabetes, Obesity and Metabolism. 23, 7, p. 1666-1671

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    The role of GLP-1 in the postprandial effects of acarbose in type 2 diabetes

    Dalsgaard, N. B., Gasbjerg, Lærke Smidt, Hansen, L. S., Hansen, N. L., Stensen, S., Hartmann, Bolette, Rehfeld, Jens Frederik, Holst, Jens Juul, Vilsbøll, Tina & Knop, Filip Krag, 2021, In: European Journal of Endocrinology. 184, 3, p. 387-398 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    Metabolic effects of one-week binge drinking and fast food intake during Roskilde Festival in young healthy male adults

    Demant, Mia Grønlund, Suppli, M. P., Foghsgaard, S., Gether, L., Grøndahl, M. F. G., Dalsgaard, N. B., Bergmann, S. S., Lanng, A. R., Gasbjerg, Lærke Smidt, Thomasen, M., Bagger, J. I., Strandberg, C., Kønig, M. J., Grønbæk, H., Becker, U., Holst, Jens Juul, Knop, J., Gillum, M. P., Vilsbøll, Tina & Knop, Filip Krag, Apr 2021, In: European Journal of Endocrinology. 185, 1, p. 23-32

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    Weight gain on antipsychotics – A perfect storm of complex pathophysiology and psychopharmacology

    Ebdrup, Bjørn & Knop, Filip Krag, 2021, In: Acta Psychiatrica Scandinavica. 144, 6, p. 521-523 3 p.

    Research output: Contribution to journalLetterResearchpeer-review

  41. Published

    Editorial: Proglucagon-Derived Peptides

    Flatt, P. R., Knop, Filip Krag & Tarasov, A. I., Nov 2021, In: Frontiers in Endocrinology. 12, 776871.

    Research output: Contribution to journalEditorialResearch

  42. Published

    Dose-dependent efficacy of the glucose-dependent insulinotropic polypeptide (GIP)receptor antagonistGIP(3-30)NH2 on GIP actions in humans

    Gasbjerg, Lærke Smidt, Bari, E. J., Stensen, S., Hoe, B., Lanng, A. R., Mathiesen, D. S., Christensen, Mikkel Bring, Hartmann, Bolette, Holst, Jens Juul, Rosenkilde, Mette & Knop, Filip Krag, 2021, In: Diabetes, Obesity and Metabolism. 23, 1, p. 68-74

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    Exendin(9-39)NH2: Recommendations for clinical use based on a systematic literature review

    Gasbjerg, Lærke Smidt, Bari, E. J., Christensen, Mikkel Bring & Knop, Filip Krag, 2021, In: Diabetes, Obesity and Metabolism. 23, 11, p. 2419-2436

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    Expression of Cholecystokinin and its Receptors in the Intestinal Tract of Type 2 Diabetes Patients and Healthy Controls

    Gilliam-Vigh, H., Jorsal, T., Rehfeld, Jens Frederik, Pedersen, Jens, Poulsen, Steen Seier, Vilsbøll, Tina & Knop, Filip Krag, 2021, In: Journal of Clinical Endocrinology and Metabolism. 106, 8, p. 2164-2170 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    Treatment of type 2 diabetes in children: what are the specific considerations?

    Grondahl, M. F. G., Johannesen, Jesper, Kristensen, K. & Knop, Filip Krag, 2021, In: Expert Opinion on Pharmacotherapy. 22, 16, p. 2127-2141 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    Liraglutide after diet-induced weight loss for pain and weight control in knee osteoarthritis: A randomized controlled trial

    Gudbergsen, Henrik Rindel, Overgaard, A., Henriksen, Marius, Wæhrens, E. E., Bliddal, Henning, Christensen, R., Nielsen, S. M., Boesen, Mikael Ploug, Knop, Filip Krag, Astrup, A., Rasmussen, M. U., Bartholdy, C., Daugaard, C. L., Ellegaard, K., Heitmann, Berit, Bartels, E. M., Danneskiold-Samsøe, B. & Kristensen, L. E., 2021, In: American Journal of Clinical Nutrition. 113, 2, p. 314–323 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    Exogenous LEAP2 improves postprandial glucose tolerance and reduces ad libitum food intake in men

    Hagemann, C. A., Jensen, M. S., Holm, Stephanie Kjærulff, Gasbjerg, Lærke Smidt, Christensen, Mikkel Bring, Heimburger, S. M. N., Dela, Flemming, Vilsbøll, Tina, Holst, Birgitte & Knop, Filip Krag, 2021, In: Diabetologia. 64, SUPPL 1, p. 23-23 1 p.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  48. Published

    Identification and Metabolic Profiling of a Novel Human Gut-derived LEAP2 Fragment

    Hagemann, C. A., Zhang, C., Hansen, H. H., Jorsal, T., Rigbolt, K. T. G., Madsen, M. R., Bergmann, N. C., Heimbürger, S. M. N., Falkenhahn, M., Theis, S., Breitschopf, K., Holm, Stephanie Kjærulff, Hedegaard, M. A., Christensen, Mikkel Bring, Vilsbøll, Tina, Holst, Birgitte, Vrang, N., Jelsing, J. & Knop, Filip Krag, 2021, In: The Journal of clinical endocrinology and metabolism. 106, 2, p. e966-e981

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    Once-weekly subcutaneous semaglutide treatment for persons with type 2 diabetes: Real-world data from a diabetes out-patient clinic

    Hansen, K. B., Svendstrup, M., Lund, A., Knop, Filip Krag, Vilsbøll, Tina & drb459, drb459, 2021, In: Diabetic Medicine. 38, 10, p. e14655

    Research output: Contribution to journalReviewResearchpeer-review

  50. Published

    Six-day sc GIP infusion increases plasma NEFA without altering the adipose tissue transcriptome, GIPR levels or plasma markers of inflammation in patients with type 1 diabetes

    Heimburger, S. M. N., Hoe, B., Nielsen, C. N., Hartmann, Bolette, Holst, Jens Juul, Dela, Flemming, Overgaard, J., Størling, Joachim, Vilsbøll, Tina, Dejgaard, T. F., Pyke, C., Christensen, M. B. & Knop, Filip Krag, 2021, In: Diabetologia. 64, SUPPL 1, p. 258-258 494.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  51. Published

    The effect of 6-day subcutaneous glucose-dependent insulinotropic polypeptide infusion on time in glycaemic range in patients with type 1 diabetes: a randomised, double-blind, placebo-controlled crossover trial

    Heimbürger, S. M. N., Hoe, B., Nielsen, C. N., Bergmann, N. C., Hartmann, Bolette, Holst, Jens Juul, Vilsbøll, Tina, Dejgaard, T. F., Christensen, Mikkel Bring & Knop, Filip Krag, 2021, In: Diabetologia. 64, p. 2425-2431

    Research output: Contribution to journalJournal articleResearchpeer-review

  52. Published

    Glycemic Control and Variability of Diabetes Secondary to Total Pancreatectomy Assessed by Continuous Glucose Monitoring

    Juel, C. T. B., Dejgaard, T. F., Hansen, C. P., Storkholm, J. H., Vilsbøll, Tina, Lund, A. & Knop, Filip Krag, 2021, In: The Journal of clinical endocrinology and metabolism. 106, 1, p. 168-173 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

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