Filip Krag Knop

Filip Krag Knop

Clinical Professor

Member of:

  • Internal Medicine: Endocrinology


  1. 2021
  2. Published

    Response to letter to the editor from McKee and McGill: “Glycemic control and variability of diabetes secondary to total pancreatectomy assessed by continuous glucose monitoring”

    Juel, C. T. B., Dejgaard, T. F., Hansen, C. P., Storkholm, J. H., Vilsbøll, Tina, Lund, A. & Knop, Filip Krag, 2021, In: Journal of Clinical Endocrinology and Metabolism. 106, 10, p. E4307-E4308

    Research output: Contribution to journalComment/debateResearch

  3. Published

    Arginine-vasopressin mediates counter-regulatory glucagon release and is diminished in type 1 diabetes

    Kim, A., Knudsen, J. G., Madara, J. C., Benrick, A., Hill, T. G., Kadir, L. A., Kellard, J. A., Mellander, L., Miranda, C., Lin, H., James, T., Suba, K., Spigelman, A. F., Wu, Y., Macdonald, P. E., Asterholm, I. W., Magnussen, T., Christensen, M., Vilsbøll, T., Salem, V. & 4 others, Knop, Filip Krag, Rorsman, P., Lowell, B. B. & Briant, L. J. B., 2021, In: eLife. 10, 29 p., e72919.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Glycemic, maternal and neonatal outcomes in women with type 1 diabetes using continuous glucose monitoring during pregnancy – Pump vs multiple daily injections, a secondary analysis of an observational cohort study

    Kjölhede, K., Berntorp, K., Kristensen, K., Katsarou, A., Shaat, N., Wiberg, N., Knop, Filip Krag, Kristensen, L., Dotevall, A., Elfvin, A., Sandgren, U., Sengpiel, V. & Englund-Ögge, L., 2021, In: Acta Obstetricia et Gynecologica Scandinavica. 100, 5, p. 927-933 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Time spent in glycaemic control after initiating treatment with oral semaglutide vs empagliflozin: an exploratory analysis of the PIONEER 2 trial

    Knop, Filip Krag, Cariou, B., Christiansen, E., Davies, A. L., Montanya, E., Abildlund, M. T. & Rosenstock, J., 2021, In: Diabetologia. 64, SUPPL 1, p. 249-250 2 p.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  6. Published
  7. Published

    The altered serum lipidome and its diagnostic potential for Non-Alcoholic Fatty Liver (NAFL)-associated hepatocellular carcinoma: Diagnosis of NAFLD-HCC utilising serum lipidomics

    Lewinska, M., Santos-Laso, A., Arretxe, E., Alonso, C., Zhuravleva, E., Jimenez-Agüero, R., Eizaguirre, E., Pareja, M. J., Romero-Gómez, M., Jimenez, M. A., Suppli, M. P., Knop, F. K., Oversoe, S. K., Villadsen, G. E., Decaens, T., Carrilho, F. J., de Oliveira, C. PMS., Sangro, B., Macias, R. I. R., Banales, J. M. & 1 others, Andersen, Jesper Bøje, 2021, In: EBioMedicine. 73, 103661.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Amylin and Calcitonin: Potential Therapeutic Strategies to Reduce Body Weight and Liver Fat

    Mathiesen, D. S., Lund, A., Vilsbøll, Tina, Knop, Filip Krag & Bagger, J. I., 2021, In: Frontiers in Endocrinology. 11, 617400.

    Research output: Contribution to journalReviewResearchpeer-review

  9. Published

    Predictors of Improvement in Quality of Life When Treating Hypothyroidism

    Medici, B. B., Lerche la Cour, J., Knop, Filip Krag, Krakauer, M., Michaelsson, L. F., Faber, Jens, Watt, Torquil & Nygaard, Birte, 2021, In: Journal of Thyroid Research. 2021, 7 p., 5577217.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Parenteral nutrition impairs plasma bile acid and gut hormone responses to mixed meal testing in lean healthy men

    Meessen, E. C. E., Bakker, G. J., Nieuwdorp, M., Dallinga-Thie, G. M., Kemper, E. M., Olde Damink, S. W., Romijn, J. A., Hartmann, Bolette, Holst, Jens Juul, Knop, Filip Krag, Groen, A. K., Schaap, F. G. & Soeters, M. R., 2021, In: Clinical Nutrition. 40, 3, p. 1013-1021

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    The glucose-lowering effect of the bile acid sequestrant sevelamer in patients with type 2 diabetes is not mediated by glucagon-like peptide 1

    Nerild, H. H., Brønden, Andreas, Haddouchi, A. E., Holst, Jens Juul, Sonne, D. P., Vilsbøll, Tina & Knop, Filip Krag, 2021, In: Diabetologia. 64, SUPPL 1, p. 217-217 422.

    Research output: Contribution to journalConference abstract in journalResearch

  12. Published
  13. Published

    Systemic corticosteroids and the risk of venous thromboembolism in patients with severe copd: A nationwide study of 30, 473 outpatients

    Rastoder, E., Sivapalan, P., Eklöf, J., Saeed, M. I., Jordan, A. S., Meteran, H., Tønnesen, L., Biering-Sørensen, T., Løkke, A., Seersholm, N., Nielsen, T. L., Carlsen, J., Janner, J., Godtfredsen, N., Bodtger, U., Laursen, C. B., Hilberg, O., Knop, F. K., Priemé, H., Ingebrigtsen, T. S. & 3 others, Gottlieb, V., Wilcke, Jon Torgny Rostrup & Jensen , Jens-Ulrik Stæhr , 2021, In: Biomedicines. 9, 8, 874.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Increased glucagon sensitivity in totally pancreatectomised patients

    Rix, I., Lund, A., Garvey, Lene Heise, Owen, K., Hansen, C., van Hall, Gerrit, Holst, Jens Juul, Vilsbøll, Tina & Knop, Filip Krag, 2021, In: Diabetologia. 64, SUPPL 1, p. 118-119 226.

    Research output: Contribution to journalConference abstract in journalResearch

  15. Published

    Glucose-dependent insulinotropic polypeptide (GIP) contributes to sitagliptin-mediated improvement of beta cell function in patients with type 2 diabetes

    Stensen, S., Gasbjerg, Lærke Smidt, Rosenkilde, Mette, Hartmann, Bolette, Vilsbøll, Tina, Holst, Jens Juul, Christensen, M. B. & Knop, Filip Krag, 2021, In: Diabetologia. 64, SUPPL 1, p. 95-95 179.

    Research output: Contribution to journalConference abstract in journalResearch

  16. Published

    Effects of endogenous GIP in patients with type 2 diabetes

    Stensen, S., Gasbjerg, Lærke Smidt, Krogh, L. L., Skov-Jeppesen, Kirsa, wbf943, wbf943, Jensen, M. H., Dela, Flemming, Hartmann, Bolette, Vilsbøll, Tina, Holst, Jens Juul, Rosenkilde, Mette, Christensen, Mikkel Bring & Knop, Filip Krag, Apr 2021, In: European Journal of Endocrinology. 185, 1, p. 33-45

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Hepatic microbiome in healthy lean and obese humans

    Suppli, M. P., Bagger, J. I., Lelouvier, B., Broha, A., Demant, M., Kønig, M. J., Strandberg, C., Lund, A., Vilsbøll, Tina & Knop, Filip Krag, Aug 2021, In: JHEP Reports. 3, 4, 100299.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    An overview of obesity mechanisms in humans: Endocrine regulation of food intake, eating behaviour and common determinants of body weight

    Theilade, Karen Simone, Christensen, Mikkel Bring, Vilsbøll, Tina & Knop, Filip Krag, 2021, In: Diabetes, Obesity and Metabolism. 23, S1, p. 17-35 19 p.

    Research output: Contribution to journalReviewResearchpeer-review

  19. Published

    Pancreatic polypeptide: A potential biomarker of glucose-dependent insulinotropic polypeptide receptor activation in vivo

    Veedfald, Simon, Bergmann, N. C., Vilsbøll, Tina, Christensen, Mikkel Bring, Holst, Jens Juul & Knop, Filip Krag, May 2021, In: Diabetic Medicine Online. 38, 8, e14592.

    Research output: Contribution to journalLetterResearchpeer-review

  20. Published

    Prediabetes Defined by First Measured HbA1c Predicts Higher Cardiovascular Risk Compared With HbA1c in the Diabetes Range: A Cohort Study of Nationwide Registries

    Yahyavi, S. K., Snorgaard, O., Knop, Filip Krag, Schou, Morten, Lee, C., Selmer, C., Gislason, Gunnar Hilmar, Torp-Pedersen, Christian, Blomberg Jensen, M. & Nissen Bonde, A., 2021, In: Diabetes Care. 44, 12, p. 2767-2774 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    INPP4B protects from metabolic syndrome and associated disorders

    Zhang, M., Ceyhan, Y., Kaftanovskaya, E. M., Vasquez, J. L., Vacher, J., Knop, Filip Krag, Nathanson, L., Agoulnik, A. I., Ittmann, M. M. & Agoulnik, I. U., 2021, In: Communications Biology . 4, 1, 416.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. 2020
  23. Published

    The impact of acute glycaemic fluctuations on left ventricular systolic function in insulin-treated type 2 diabetes

    Andersen, A., Jorgensen, P. G., Bagger, J. I., Baldassarre, M. P. A., Christensen, M., Abelin, K. U., Faber, Jens, Pedersen-Bjergaard, Ulrik, Holst, Jens Juul, Lindhardt, T., Gislason, Gunnar Hilmar, Knop, Filip Krag & Vilsbøll, Tina, 2020, In: Diabetologia. 63, SUPPL 1, p. S429-S429 897.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  24. Published

    Hypoglycaemia and cardiac arrhythmias in diabetes

    Andersen, A., Jørgensen, P. G., Knop, Filip Krag & Vilsbøll, Tina, 2020, In: Therapeutic Advances in Endocrinology and Metabolism. 11, 11 p., 2042018820911803.

    Research output: Contribution to journalReviewResearchpeer-review

  25. Published

    Counterregulatory responses to hypoglycaemia in totally pancreatectomised patients

    Baekdal, M., Lund, A., Baldassare, M. P. A., Rose, K., Egholk, J., Christensen, M. B., Hansen, C. P., Storkholm, J. H., Faber, Jens, Hartmann, Bolette, Holst, Jens Juul, Vilsbøll, Tina & Knop, Filip Krag, 2020, In: Diabetologia. 63, SUPPL 1, p. S95-S95

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  26. Published

    Experience of family function, family involvement, and self-management in adult patients with type 2 diabetes: A thematic analysis

    Bennich, B. B., Munch, L., Overgaard, D., Konradsen, Hanne, Knop, Filip Krag, Roder, M., Vilsbøll, Tina & Egerod, Ingrid Eugenie, 2020, In: Journal of Advanced Nursing. 76, 2, p. 621-631

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published
  28. Published

    Gluco-Metabolic Effects of Pharmacotherapy-Induced Modulation of Bile Acid Physiology

    Bronden, A. & Knop, Filip Krag, 2020, In: Journal of Clinical Endocrinology & Metabolism. 105, 1, p. 362-373

    Research output: Contribution to journalReviewResearchpeer-review

  29. Published

    Changes in oxidative nucleic acid modifications and inflammation following one-week treatment with the bile acid sequestrant sevelamer: Two randomised, placebo-controlled trials

    Brønden, A., Larsen, E. L., Karstoft, K., Henriksen, T., Vilsbøll, Tina, Poulsen, Henrik Enghusen & Knop, Filip Krag, Feb 2020, In: Journal of Diabetes and its Complications. 34, 2, 8 p., 107446.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Efficacy and Safety of Glimepiride With or Without Linagliptin Treatment in Patients With HNF1A Diabetes (Maturity-Onset Diabetes of the Young Type 3): A Randomized, Double-Blinded, Placebo-Controlled, Crossover Trial (GLIMLINA)

    Christensen, A. S., Haedersdal, S., Stoy, J., Storgaard, H., Kampmann, U., Forman, Julie Lyng, Seghieri, M., Holst, Jens Juul, Hansen, Torben, Knop, Filip Krag & Vilsbøll, Tina, 2020, In: Diabetes Care. 43, 9, p. 2025-2033 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    GIP and GLP-1 Potentiate Sulfonylurea-Induced Insulin Secretion in Hepatocyte Nuclear Factor 1 alpha Mutation Carriers

    Christensen, A. S., Haedersdal, S., Storgaard, H., Rose, K., Hansen, N. L., Holst, Jens Juul, Hansen, Torben, Knop, Filip Krag & Vilsbøll, Tina, 2020, In: Diabetes. 69, 9, p. 1989-2002 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    GIP's involvement in the pathophysiology of type 2 diabetes

    Christensen, Mikkel Bring, Gasbjerg, Lærke Smidt, Heimbürger, S. M., Stensen, S., Vilsbøll, Tina & Knop, Filip Krag, Mar 2020, In: Peptides. 125, 10 p., 170178.

    Research output: Contribution to journalReviewResearchpeer-review

  33. Published

    Glucose-Dependent Insulinotropic Polypeptide (GIP) Reduces Bone Resorption in Patients With Type 2 Diabetes

    Christensen, Mikkel Bring, Lund, A. B., Jørgensen, Niklas Rye, Holst, Jens Juul, Vilsbøll, Tina & Knop, Filip Krag, 2020, In: Journal of the endocrine society. 4, 9, 9 p., 097.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Pregnancy loss is associated with type 2 diabetes: a nationwide case-control study

    Egerup, P., Mikkelsen, A. P., Kolte, A. M., Westergaard, D., Rasmussen, S., Knop, Filip Krag, Lidegaard, Øjvind & Nielsen, Henriette Svarre, 2020, In: Diabetologia. 63, 8, p. 1521-1529

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    Circulating Levels of the Soluble Receptor for AGE (sRAGE) during Escalating Oral Glucose Dosages and Corresponding Isoglycaemic i.v. Glucose Infusions in Individuals with and without Type 2 Diabetes

    Fotheringham, A. K., Bagger, J. I., Borg, D. J., McCarthy, D. A., Holst, Jens Juul, Vilsbøll, Tina, Knop, Filip Krag & Forbes, J. M., 2020, In: Nutrients. 12, 10, 12 p., 2928.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published
  37. Published

    Evaluation of the incretin effect in humans using GIP and GLP-1 receptor antagonists

    Gasbjerg, Lærke Smidt, Bergmann, N. C., Stensen, S., Christensen, Mikkel Bring, Rosenkilde, Mette, Holst, Jens Juul, Nauck, M. & Knop, Filip Krag, 2020, In: Peptides. 125, 10 p., 170183.

    Research output: Contribution to journalReviewResearchpeer-review

  38. Published

    GIP and GLP-1 Receptor Antagonism During a Meal in Healthy Individuals

    Gasbjerg, Lærke Smidt, Helsted, M. M., Hartmann, Bolette, wbf943, wbf943, Veedfald, Simon, Stensen, S., Lanng, A. R., Bergmann, N. C., Christensen, Mikkel Bring, Vilsbøll, Tina, Holst, Jens Juul, Rosenkilde, Mette & Knop, Filip Krag, 2020, In: Journal of Clinical Endocrinology and Metabolism. 105, 3, p. e725-e738 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    Normal insulin sensitivity, glucose tolerance, gut incretin and pancreatic hormone responses in adults with atopic dermatitis

    Gether, L., Thyssen, Jacob Pontoppidan, Gyldenlove, M., Hartmann, Bolette, Holst, Jens Juul, Foghsgaard, S., Vilsbøll, Tina & Knop, Filip Krag, 2020, In: Diabetes, Obesity and Metabolism. 22, 11, p. 2161-2169 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    Human translatability of the GAN diet-induced obese mouse model of non-alcoholic steatohepatitis

    Hansen, H. H., Aegidius, H. M., Oro, D., Evers, S. S., Heeboll, S., Eriksen, P. L., Thomsen, K. L., Bengtsson, A., Veidal, S. S., Feigh, M., Suppli, M. P., Knop, Filip Krag, Gronbaek, H., Miranda, D., Trevaskis, J. L., Vrang, N., Jelsing, J. & Rigbolt, K. T. G., 2020, In: B M C Gastroenterology. 20, 12 p., 210.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    Glucagon-Like Peptide 2 Inhibits Postprandial Gallbladder Emptying in Man: A Randomized, Double-Blinded, Crossover Study

    Hansen, N. L., Brønden, Andreas, Nexoe-Larsen, C. C., Christensen, A. S., Sonne, D. P., Rehfeld, Jens Frederik, Albrechtsen, Nicolai Jacob Wewer, Hartmann, Bolette, Vilsbøll, Tina, Holst, Jens Juul & Knop, Filip Krag, 2020, In: Clinical and Translational Gastroenterology. 11, 12, 9 p., e00257.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Six-day subcutaneous GIP infusion increases glycaemic time in range in patients with type 1 diabetes

    Heimbuerger, S. M. N., Hoe, B., Nielsen, C. N., Bergmann, N. C., Hartmann, Bolette, Holst, Jens Juul, Størling, Joachim, Vilsbøll, Tina, Dejgaard, T. F., Christensen, Mikkel Bring & Knop, Filip Krag, 2020, In: Diabetologia. 63, SUPPL 1, p. S73 1 p., 145.

    Research output: Contribution to journalConference abstract in journalResearch

  43. Published

    Glucose-dependent insulinotropic polypeptide (GIP) and cardiovascular disease

    Heimbürger, S. M., Bergmann, N. C., Augustin, R., Gasbjerg, Lærke Smidt, Christensen, Mikkel Bring & Knop, Filip Krag, 2020, In: Peptides. 125, 8 p., 170174.

    Research output: Contribution to journalReviewResearchpeer-review

  44. Published

    The role of endogenous GIP and GLP-1 in postprandial bone homeostasis

    Helsted, M. M., Gasbjerg, Lærke Smidt, Lanng, A. R., Bergmann, N. C., Stensen, S., Hartmann, Bolette, Christensen, Mikkel Bring, Holst, Jens Juul, Vilsbøll, Tina, Rosenkilde, Mette & Knop, Filip Krag, 2020, In: Bone. 140, 7 p., 115553.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    GIP infusion in patients with type 1 diabetes seems to attenuate post-prandial glucose excursions after prandial insulin over-dose and physical activity

    Hoe, B., Heimburger, S. M. N., Gasbjerg, L. S., Lanng, A. R., Lynggaard, M. B., Hartmann, Bolette, Holst, Jens Juul, Vilsbøll, Tina, Lund, A., Engberg, S., Dejgaard, T. F., Christensen, Mikkel Bring & Knop, Filip Krag, 2020, In: Diabetologia. 63, Suppl. 1, p. S117 1 p., 232.

    Research output: Contribution to journalConference abstract in journalResearch

  46. Published

    The role of glucagon in the acute therapeutic effects of SGLT2 inhibition

    Hædersdal, S., Lund, A., Nielsen-Hannerup, E., Maagensen, H., van Hall, Gerrit, Holst, Jens Juul, Knop, Filip Krag & Vilsbøll, Tina, 2020, In: Diabetes. 69, 12, p. 2619-2629 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    Effect of short-acting exenatide administered three times daily on markers of cardiovascular disease in type 1 diabetes: A randomized double-blind placebo-controlled trial

    Johansen, N. J., Dejgaard, T. F., Lund, A., Schluentz, C., Larsen, E. L., Poulsen, Henrik Enghusen, Goetze, Jens P. , Møller, H. J., Vilsbøll, Tina, Andersen, H. U. & Knop, Filip Krag, 2020, In: Diabetes, Obesity and Metabolism. 22, 9, p. 1639-1647

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    Efficacy and safety of meal-time administration of short-acting exenatide for glycaemic control in type 1 diabetes (MAG1C): a randomised, double-blind, placebo-controlled trial

    Johansen, N. J., Dejgaard, T. F., Lund, A., Schluntz, C., Frandsen, C. S., Forman, Julie Lyng, Albrechtsen, Nicolai Jacob Wewer, Holst, Jens Juul, Pedersen-Bjergaard, Ulrik, Madsbad, Sten, Vilsbøll, Tina, Andersen, H. U. & Knop, Filip Krag, 2020, In: The Lancet Diabetes & Endocrinology. 8, 4, p. 313-324 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    Clinical pharmacology of imeglimin for the treatment of type 2 diabetes

    Johansson, K. S., Brønden, A., Knop, Filip Krag & Christensen, Mikkel Bring, May 2020, In: Expert Opinion on Pharmacotherapy. 21, 8, p. 871-882

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    What is on the horizon for type 2 diabetes pharmacotherapy? - An overview of the antidiabetic drug development pipeline

    Johansson, K. S., Sonne, D., Knop, Filip Krag & Christensen, Mikkel Bring, 2020, In: Expert Opinion on Drug Discovery. 15, 11, p. 1253-1265

    Research output: Contribution to journalReviewResearchpeer-review

  51. Published

    Gut Mucosal Gene Expression and Metabolic Changes After Roux-en-Y Gastric Bypass Surgery

    Jorsal, T., Christensen, M. M., Mortensen, B., Nygaard, E. B., Zhang, C., Rigbolt, K., Wandall, E., Langholz, E., Friis, S., Worm, D., Floyd, A., Helgstrand, F., Støving, R. K., Aldries, A. R., Juhl, C. B., Østergaard, T., Rydborg, T., Forman, J. L., Sørensen, F., Schmidt, T. & 9 others, Falkenhahn, M., Musholt, P. B., Theis, S., Larsen, P. J., Rehfeld, Jens Frederik, Vrang, N., Jelsing, J., Vilsbøll, Tina & Knop, Filip Krag, 2020, In: Obesity. 28, 11, p. 2163-2174 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  52. Published

    The GLP-1 receptor agonist lixisenatide reduces postprandial glucose in patients with diabetes secondary to total pancreatectomy: a randomised, placebo-controlled, double-blinded crossover trial

    Juel, C. T. B., Lund, A., Andersen, M. M., Hansen, C. P., Storkholm, J. H., Rehfeld, Jens Frederik, van Hall, G., Hartmann, Bolette, Albrechtsen, Nicolai Jacob Wewer, Holst, Jens Juul, Vilsbøll, Tina & Knop, Filip Krag, Jul 2020, In: Diabetologia. 63, p. 1285-1298

    Research output: Contribution to journalJournal articleResearchpeer-review

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