Filip Krag Knop
Clinical Professor
Department of Clinical Medicine
Borgmester Ib Juuls Vej 1, 2730 Herlev
Member of:
Internal Medicine: Endocrinology
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Women with prior gestational diabetes mellitus and prediabetes are characterised by a decreased incretin effect
Foghsgaard, S., Vedtofte, L., Andreasen, C., Andersen, E. S., Bahne, E., Bagger, J. I., Svare, J. A., Holst, Jens Juul, Clausen, Tine Dalsgaard, Mathiesen, Elisabeth, Damm, Peter, Knop, Filip Krag & Vilsbøll, Tina, Jul 2017, In: Diabetologia. 60, 7, p. 1344-1353 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Why diversity among participants in clinical studies is not always preferable: the case for small, exploratory studies
Ellegaard, A. M. & Knop, Filip Krag, 2023, In: BMC Medicine. 21, 1, 3 p., 462.Research output: Contribution to journal › Comment/debate › Research › peer-review
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What is on the horizon for type 2 diabetes pharmacotherapy? - An overview of the antidiabetic drug development pipeline
Johansson, K. S., Sonne, D., Knop, Filip Krag & Christensen, Mikkel Bring, 2020, In: Expert Opinion on Drug Discovery. 15, 11, p. 1253-1265Research output: Contribution to journal › Review › Research › peer-review
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Weight loss for overweight and obese individuals with gout: a systematic review of longitudinal studies
Nielsen, S. M., Bartels, E. M., Henriksen, Marius, Wæhrens, E. E., Gudbergsen, Henrik Rindel, Bliddal, Henning, Astrup, A., Knop, Filip Krag, Carmona, L., Taylor, W. J., Singh, J. A., Perez-Ruiz, F., Kristensen, L. E. & Christensen, R., 2017, In: Annals of the Rheumatic Diseases. 76, 11, p. 1870-1882 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Weight gain on antipsychotics – A perfect storm of complex pathophysiology and psychopharmacology
Ebdrup, Bjørn & Knop, Filip Krag, 2021, In: Acta Psychiatrica Scandinavica. 144, 6, p. 521-523 3 p.Research output: Contribution to journal › Letter › Research › peer-review
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Weight Loss for Patients With Gout and Concomitant Obesity: A Proof-of-Concept Randomized Trial
Christensen, R., Zobbe, K., Nielsen, S. M., Stamp, L. K., Henriksen, Marius, Overgaard, A. F., Dreyer, L., Knop, Filip Krag, Singh, J. A., Doherty, M., Richette, P., Astrup, A., Ellegaard, K., Bartels, E. M., Boesen, Mikael Ploug, Gudbergsen, Henrik Rindel, Bliddal, Henning & Kristensen, L. E., 2024, In: Arthritis & rheumatology (Hoboken, N.J.). 766, 5, p. 806-812 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Vitamin D Supplementation Improves Fasting Insulin Levels and HDL Cholesterol in Infertile Men
Holt, R., Petersen, Jørgen Holm, Dinsdale, E., Knop, Filip Krag, Juul, Anders, Jørgensen, N. & Jensen, M. B., 2022, In: Journal of Clinical Endocrinology & Metabolism. 107, 1, p. 98-108Research output: Contribution to journal › Journal article › Research › peer-review
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Value of gym-based group exercise versus usual care for young adults receiving antipsychotic medication: study protocol for the multicenter randomized controlled Vega trial
Rafn, B. S., Andersen, M. F., Sørensen, V., Bjerre, E. D., Baandrup, Lone, Vernal, D. L., Mors, O., Knop, Filip Krag, Wolf, R. T., Tolver, Anders, Firth, J., Nøhr, N., Skou, S. T., Ebdrup, Bjørn & Midtgaard, Julie, 2023, In: BMC Psychiatry. 23, 1, 13 p., 634.Research output: Contribution to journal › Journal article › Research › peer-review
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Vagotomy and subsequent development of diabetes: A nested case-control study
Starup-Linde, J., Gejl, M., Borghammer, P., Knop, Filip Krag, Gregersen, S., Rungby, Jørgen & Vestergaard, P., Jul 2016, In: Metabolism. 65, 7, p. 954-960 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Vaerdien af billeddiagnostiske undersøgelser ordineret i almen praksis
Knop, Filip Krag & Stauning, J. A., 20 Feb 2006, In: Ugeskrift for Laeger. 168, 8, p. 794-8 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Use of inhaled corticosteroids and the risk of developing type 2 diabetes in patients with chronic obstructive pulmonary disease
Saeed, M. I., Eklof, J., Achir, I., Sivapalan, P., Meteran, Howraman, Lokke, A., Biering-Sørensen, Tor, Knop, Filip Krag & Jensen , Jens-Ulrik Stæhr , 2020, In: Diabetes, Obesity and Metabolism. 22, 8, p. 1348-1356 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Use of exenatide and liraglutide in Denmark: A drug utilization study
Pottegård, A., Bjerregaard, B. K., Larsen, M. D., Larsen, K. S., Hallas, J., Knop, Filip Krag & Moreno, S. I., Feb 2014, In: European Journal of Clinical Pharmacology. 70, 2, p. 205-214 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Use of antibiotics in childhood and risk of Type 1 diabetes: a population-based case-control study
Mikkelsen, K. H., Knop, Filip Krag, Vilsbøll, Tina, Frost, M., Hallas, J. & Pottegård, A., Feb 2017, In: Diabetic Medicine. 34, 2, p. 272–277Research output: Contribution to journal › Journal article › Research › peer-review
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Use of Antibiotics and Risk of Type 2 Diabetes: A Population-Based Case-Control Study
Mikkelsen, K. H., Knop, Filip Krag, Frost, M., Hallas, J. & Pottegård, A., 2015, In: Journal of Clinical Endocrinology and Metabolism. 100, 10, p. 3633-40 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Unprecedented high insulin secretion in a healthy human subject after intravenous glucagon-like peptide-1: a case report
Knop, Filip Krag, Lund, Asger Bach, Madsbad, Sten, Holst, Jens Juul, Krarup, T. & Vilsbøll, T., 2014, In: BMC Research Notes. 7, p. 1-6 6 p., 326.Research output: Contribution to journal › Journal article › Research › peer-review
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Understanding the place for GLP-1RA therapy: Translating guidelines for treatment of type 2 diabetes into everyday clinical practice and patient selection
Andreasen, C. R., Andersen, A., Knop, Filip Krag & Vilsbøll, Tina, 2021, In: Diabetes, Obesity and Metabolism. 23, S3, p. 40-52 13 p.Research output: Contribution to journal › Review › Research › peer-review
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Twelve weeks treatment with the DPP-4 inhibitor, sitagliptin, prevents degradation of peptide YY and improves glucose- and non-glucose-induced insulin secretion in patients with type 2 diabetes mellitus
Aaboe, K., Knop, Filip Krag, Vilsbøll, Tina, Deacon, Carolyn F., Holst, Jens Juul, Madsbad, Sten & Krarup, T., 2010, In: Diabetes, Obesity and Metabolism. 12, 4, p. 323-333 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Twelve weeks treatment with the DPP-4 inhibitor, sitagliptin, prevents degradation of peptide YY and improves glucose and non-glucose induced insulin secretion in patients with type 2 diabetes mellitus
Aaboe, K., Knop, Filip Krag, Vilsbøll, T., Deacon, Carolyn F., Holst, Jens Juul, Madsbad, S. & Krarup, T. M., 1 Apr 2010, In: Diabetes, Obesity and Metabolism. 12, 4, p. 323-33 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Tværsektorielt samarbejde ved behandling af patienter med type 2-diabetes
Munch, L., Røder, M. E., Rasmussen, I. H., Middelfart, H., Kaarsberg, N., Bennich, B., Knop, Filip Krag & Vilsbøll, Tina, 2018, In: Ugeskrift for Laeger. 180, 8, p. 690-693Research output: Contribution to journal › Journal article › Research › peer-review
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Treatment of type 2 diabetes with glucagon-like peptide-1 receptor agonists
Hansen, K. B., Knop, Filip Krag, Holst, Jens Juul & Vilsbøll, Tina, 2009, In: International Journal of Clinical Practice. 63, 8, p. 1154-60 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Treatment of type 2 diabetes in children: what are the specific considerations?
Grondahl, M. F. G., Johannesen, Jesper, Kristensen, K. & Knop, Filip Krag, 2021, In: Expert Opinion on Pharmacotherapy. 22, 16, p. 2127-2141 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Treatment of antipsychotic-associated obesity with a GLP-1 receptor agonist-protocol for an investigator-initiated prospective, randomised, placebo-controlled, double-blinded intervention study: The TAO study protocol
Ishøy, P. L., Knop, Filip Krag, Broberg, B. V., Baandrup, Lone, Fagerlund, Birgitte, Jørgensen, Niklas Rye, Andersen, U. B., Rostrup, Egill, Glenthøj, Birte Yding & Ebdrup, Bjørn, 2014, In: BMJ Open. 4, 1, e004158.Research output: Contribution to journal › Journal article › Research › peer-review
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Transfer of liraglutide from blood to cerebrospinal fluid is minimal in patients with type 2 diabetes
Christensen, M., wbf943, wbf943, Hartmann, Bolette, Grevstad, U., Rosenkilde, Mette, Holst, Jens Juul, Vilsbøll, T. & Knop, Filip Krag, Nov 2015, In: International journal of obesity (2005). 39, 11, p. 1651-1654 4 p.Research output: Contribution to journal › Letter › Research › peer-review
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Transcutaneous vagal nerve stimulation for treating gastrointestinal symptoms in individuals with diabetes: a randomised, double-blind, sham-controlled, multicentre trial
Kornum, D. S., Bertoli, D., Kufaishi, H., Wegeberg, A., Okdahl, T., Mark, E. B., Høyer, K. L., Frøkjær, J. B., Brock, Birgitte, Krogh, K., Hansen, C. S., Knop, Filip Krag, Brock, C. & Drewes, A. M., 2024, In: Diabetologia. 67, 6, p. 1122-1137Research output: Contribution to journal › Journal article › Research › peer-review
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Time spent in glycaemic control after initiating treatment with oral semaglutide vs empagliflozin: an exploratory analysis of the PIONEER 2 trial
Knop, Filip Krag, Cariou, B., Christiansen, E., Davies, A. L., Montanya, E., Abildlund, M. T. & Rosenstock, J., 2021, In: Diabetologia. 64, SUPPL 1, p. 249-250 2 p.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
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Thirty days of resveratrol supplementation does not affect postprandial incretin hormone responses, but suppresses postprandial glucagon in obese subjects
Knop, Filip Krag, Konings, E., Timmers, S., Schrauwen, P., Holst, Jens Juul & Blaak, E. E., 11 May 2013, In: Diabetic Medicine. 30, 10, p. 1214-1218 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Therapy for obesity based on gastrointestinal hormones
Bagger, J. I., Christensen, M., Knop, Filip Krag & Vilsbøll, Tina, 2011, In: Review of Diabetic Studies. 8, 3, p. 339-47 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The use of double-balloon enteroscopy in retrieving mucosal biopsies from the entire human gastrointestinal tract
Rhee, N. A., Vilmann, Peter, Hassan, H., Hendel, J. W., Holst, Jens Juul, Vilsbøll, T. & Knop, Filip Krag, Sep 2014, In: Scandinavian Journal of Gastroenterology. 49, 9, p. 1143-1149 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The spectrum of antidiabetic actions of GLP-1 in patients with diabetes
Vilsbøll, Tina, Holst, Jens Juul & Knop, Filip Krag, 2009, In: Best Practice & Research: Clinical Endocrinology & Metabolism. 23, 4, p. 453-62 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The separate and combined impact of the intestinal hormones, GIP, GLP-1, and GLP-2, on glucagon secretion in type 2 diabetes
Lund, Asger Bach, Vilsbøll, Tina, Bagger, J. I., Holst, Jens Juul & Knop, Filip Krag, 2011, In: American Journal of Physiology: Endocrinology and Metabolism. 300, 6, p. E1038-E1046 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The role of the incretins in the postprandial bone remodelling
Helsted, M. M., Gasbjerg, Lærke Smidt, Lanng, A. R., Stensen, S., Hartmann, Bolette, Christensen, Mikkel Bring, Holst, Jens Juul, Vilsbøll, Tina, Rosenkilde, M. M. & Knop, Filip Krag, 2018, In: Diabetologia. 61, S1, p. S221-S221 449.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
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The role of glucagon in the acute therapeutic effects of SGLT2 inhibition
Hædersdal, S., Lund, A., Nielsen-Hannerup, E., Maagensen, H., van Hall, Gerrit, Holst, Jens Juul, Knop, Filip Krag & Vilsbøll, Tina, 2020, In: Diabetes. 69, 12, p. 2619-2629 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The role of endogenous GIP and GLP-1 in postprandial bone homeostasis
Helsted, M. M., Gasbjerg, Lærke Smidt, Lanng, A. R., Bergmann, N. C., Stensen, S., Hartmann, Bolette, Christensen, Mikkel Bring, Holst, Jens Juul, Vilsbøll, Tina, Rosenkilde, Mette & Knop, Filip Krag, 2020, In: Bone. 140, 7 p., 115553.Research output: Contribution to journal › Journal article › Research › peer-review
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The role of efferent cholinergic transmission for the insulinotropic and glucagonostatic effects of GLP-1
Plamboeck, A., Veedfald, Simon, Deacon, Carolyn F., Hartmann, Bolette, Vilsbøll, T., Knop, Filip Krag & Holst, Jens Juul, Sep 2015, In: American Journal of Physiology: Regulatory, Integrative and Comparative Physiology. 309, 5, p. R544-51 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The role of GLP-1 in the postprandial effects of acarbose in type 2 diabetes
Dalsgaard, N. B., Gasbjerg, Lærke Smidt, Hansen, L. S., Hansen, N. L., Stensen, S., Hartmann, Bolette, Rehfeld, Jens Frederik, Holst, Jens Juul, Vilsbøll, Tina & Knop, Filip Krag, 2021, In: European Journal of Endocrinology. 184, 3, p. 387-398 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The potential of colchicine for lowering the risk of cardiovascular events in type 1 diabetes
Johansen, N. J. & Knop, Filip Krag, 2023, In: European Heart Journal - Cardiovascular Pharmacotherapy. 9, 4, p. 311-317Research output: Contribution to journal › Journal article › Research › peer-review
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The pathophysiology of diabetes involves a defective amplification of the late-phase insulin response to glucose by glucose-dependent insulinotropic polypeptide-regardless of etiology and phenotype
Vilsbøll, Tina, Knop, Filip Krag, Krarup, T., Johansen, A., Madsbad, Sten, Larsen, S., Hansen, T., Pedersen, O., Holst, J. M. & Johansen, A., 1 Oct 2003, In: Journal of Clinical Endocrinology and Metabolism. 88, 10, p. 4897-903 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The naturally occurring GIP(1-30)NH2 is a GIP receptor agonist in humans
Krogh, L. S. L., Henriksen, K., Stensen, S., Skov-Jeppesen, Kirsa, Bergmann, N. C., Størling, Joachim, Rosenkilde, Mette, Hartmann, Bolette, Holst, Jens Juul, Gasbjerg, Lærke Smidt & Knop, Filip Krag, 2023, In: European Journal of Endocrinology. 188, 1, lvac015.Research output: Contribution to journal › Journal article › Research › peer-review
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The liver-alpha cell axis and type 2 diabetes
Albrechtsen, Nicolai Jacob Wewer, Pedersen, Jens, Galsgaard, Katrine Douglas, Winther-Sørensen, Marie, Suppli, M. P., Janah, L., Gromada, J., Vilstrup, H., Knop, Filip Krag & Holst, Jens Juul, 2019, In: Endocrine Reviews. 40, 5, p. 1353-1366Research output: Contribution to journal › Review › Research › peer-review
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The incretin effect in patients with maturity onset diabetes of the young
Ostoft, S. H., Bagger, J. I., Hansen, T., Pedersen, O., Holst, Jens Juul, Knop, Filip Krag & Vilsboll, T., 2012, In: Diabetologia. 55, p. S144-S144Research output: Contribution to journal › Journal article › Research › peer-review
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The importance of glucose-dependent insulinotropic polypeptide receptor activation for the effects of tirzepatide
Gasbjerg, Lærke Smidt, Rosenkilde, Mette, Meier, J. J., Holst, Jens Juul & Knop, Filip Krag, 2023, In: Diabetes, Obesity and Metabolism. 25, 11, p. 3079-3092Research output: Contribution to journal › Review › Research › peer-review
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The impact of type 2 diabetes and glycaemic control on mortality and clinical outcomes in hospitalized patients with COVID-19 in the capital region of Denmark
Kliim-Hansen, V., Johansson, K. S., Gasbjerg, Lærke Smidt, Solem, Espen Victor Jimenez, Petersen, Tonny Studsgaard, Nyeland, M. E., Winther-Jensen, M., Ankarfeldt, Mikkel Zöllner, Pedersen, M. G., Ellegaard, A. M., Knop, Filip Krag & Christensen, Mikkel Bring, 2023, In: Diabetes, Obesity and Metabolism. 26, 1, p. 160-168 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The impact of statins and RAS inhibitors on the association between delayed antidiabetic treatment and the risk of cardiovascular event in patients with a first HbAlc between 48-57 mmol/mol
Falkentoft, A. C., Gerds, Thomas Alexander, Knop, Filip Krag, Fosbøl, E., Køber, Lars Valeur, Torp-Pedersen, Christian, Schou, M., Bruun, Niels Eske & Ruwald, A. C., 2022, In: European Heart Journal. 43, Supplement 1, p. 2419 1 p.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
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The impact of pancreatic enzyme supplementation on postprandial responses of glucagon-like Peptide-2 in patients with chronic pancreatitis and pancreatic exocrine insufficiency
Knop, Filip Krag, Vilsbøll, Tina, Lund, A., Krarup, T., Holst, Jens Juul & Hornum, Mads, 6 Sep 2010, In: Journal of the Pancreas. 11, 5, p. 489-91 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The impact of dipeptidyl peptidase 4 inhibition on incretin effect, glucose tolerance, and gastrointestinal-mediated glucose disposal in healthy subjects
Rhee, N. A., Østoft, S. H., Holst, Jens Juul, Deacon, Carolyn F., Vilsbøll, T. & Knop, Filip Krag, 16 Jun 2014, In: European Journal of Endocrinology. 171, 3, p. 353-362 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The impact of acute glycaemic fluctuations on left ventricular systolic function in insulin-treated type 2 diabetes
Andersen, A., Jorgensen, P. G., Bagger, J. I., Baldassarre, M. P. A., Christensen, M., Abelin, K. U., Faber, Jens, Pedersen-Bjergaard, Ulrik, Holst, Jens Juul, Lindhardt, T., Gislason, Gunnar Hilmar, Knop, Filip Krag & Vilsbøll, Tina, 2020, In: Diabetologia. 63, SUPPL 1, p. S429-S429 897.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
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The impact of acute fluctuations in plasma glucose on echocardiographic derived measures of systolic function in patients with type 1 diabetes
Andreasen, C. R., Andersen, A., Haqelqvist, P. G., Abelin, K., Lauritsen, J. V., Jorgensen, P. G., Engberg, S., Faber, Jens, Holst, Jens Juul, Pedersen-Bjergaard, Ulrik, Knop, Filip Krag & Vilsbøll, Tina, 2021, In: Diabetologia. 64, SUPPL 1, p. 135-136 2 p.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
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The impact of EndoBarrier gastrointestinal liner in obese patients with normal glucose tolerance and in patients with type 2 diabetes
Rohde, U., Federspiel, C. A., Vilmann, Peter, Langholz, Ebbe, Friis, S. U., Krakauer, M., Rehfeld, Jens Frederik, Holst, Jens Juul, Vilsbøll, Tina & Knop, Filip Krag, Feb 2017, In: Diabetes, Obesity and Metabolism. 19, 2, p. 189-199 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The glucose-lowering effect of the bile acid sequestrant sevelamer in patients with type 2 diabetes is not mediated by glucagon-like peptide 1
Nerild, H. H., Brønden, Andreas, Haddouchi, A. E., Holst, Jens Juul, Sonne, D. P., Vilsbøll, Tina & Knop, Filip Krag, 2021, In: Diabetologia. 64, SUPPL 1, p. 217-217 422.Research output: Contribution to journal › Conference abstract in journal › Research
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The glucagonostatic and insulinotropic effects of glucagon-like peptide 1 contribute equally to its glucose-lowering action
Hare, K. J., Vilsbøll, Tina, Asmar, M., Deacon, Carolyn F., Knop, Filip Krag & Holst, Jens Juul, 1 Jul 2010, In: Diabetes. 59, 7, p. 1765-70 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The glucagon receptor antagonist LY2409021 does not affect gastrointestinal-mediated glucose disposal or the incretin effect in individuals with and without type 2 diabetes
Hædersdal, S., Lund, A., Nielsen-Hannerup, E., Maagensen, H., Forman, Julie Lyng, Holst, Jens Juul, Knop, Filip Krag & Vilsbøll, Tina, 2022, In: European Journal of Endocrinology. 187, 4, p. 507-518 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The efficacy and safety of exenatide once weekly in patients with type 2 diabetes
Heimburger, S. M., Brønden, Andreas, Johansen, N. J., Dejgaard, T. F., Vilsbøll, Tina & Knop, Filip Krag, 2019, In: Expert Opinion on Pharmacotherapy. 20, 5, p. 501-510Research output: Contribution to journal › Journal article › Research › peer-review
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The effects of sodium-glucose co-transporter 2 inhibitors in patients with type 2 diabetes: protocol for a systematic review with meta-analysis of randomised trials
Storgaard, H., Gluud, Lise Lotte, Christensen, Mikkel Bring, Knop, Filip Krag & Vilsbøll, T., 2014, In: B M J Open. 4, 8, p. 1-5 5 p., e005378.Research output: Contribution to journal › Journal article › Research › peer-review
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The effects of dual GLP-1/GIP receptor agonism on glucagon secretion: a review
Mathiesen, D. S., Bagger, J. I., Bergmann, N. C., Lund, A., Christensen, Mikkel Bring, Vilsbøll, Tina & Knop, Filip Krag, 2019, In: International Journal of Molecular Sciences. 20, 17, 18 p., 4092.Research output: Contribution to journal › Review › Research › peer-review
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The effect of exogenous glucagon on circulating amino acids in individuals with and without type 2 diabetes and obesity
Grøndahl, M. F. G., Bagger, J. I., Suppli, M. P., van Hall, Gerrit, Albrechtsen, Nicolai Jacob Wewer, Holst, Jens Juul, Vilsbøll, Tina, Christensen, Mikkel Bring, Lund, A. B. & Knop, Filip Krag, 2024, In: Endocrine Connections. 13, 3, 7 p., e230516.Research output: Contribution to journal › Journal article › Research › peer-review
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The effect of empagliflozin on oxidative nucleic acid modifications in patients with type 2 diabetes: Protocol for a randomised, double-blinded, placebo-controlled trial
Larsen, E. L., Cejvanovic, V., Kjær, L. K., Vilsbøll, Tina, Knop, Filip Krag, Rungby, Jørgen & Poulsen, Henrik Enghusen, May 2017, In: BMJ Open. 7, 5, 6 p., e014728.Research output: Contribution to journal › Journal article › Research › peer-review
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The effect of curcumin on hepatic fat content in individuals with obesity
Hellmann, P. H., Bagger, J. I., Carlander, K. R., Forman, Julie Lyng, Chabanova, E., Svenningsen, J. S., Holst, Jens Juul, Gillum, M. P., Vilsbøll, Tina & Knop, Filip Krag, 2022, In: Diabetes, Obesity and Metabolism. 24, 11, p. 2192-2202 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The effect of acute intragastric vs. intravenous alcohol administration on inflammation markers, blood lipids and gallbladder motility in healthy men
Lanng, A. R., Gasbjerg, Lærke Smidt, Bergmann, N. C., Gillum, M. P., Rehfeld, Jens Frederik, Helsted, M. M., Møller, H. J., Grønbæk, H., Vilsbøll, Tina & Knop, Filip Krag, 2020, In: Alcohol. 87, p. 29-37 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The effect of a glucagon-like peptide-1 receptor agonist on glucose tolerance in women with previous gestational diabetes mellitus: protocol for an investigator-initiated, randomised, placebo-controlled, double-blinded, parallel intervention trial
Foghsgaard, S., Vedtofte, L., Mathiesen, Elisabeth, Svare, J. A., Gluud, Lise Lotte, Holst, Jens Juul, Damm, Peter, Knop, Filip Krag & Vilsbøll, T., 2013, In: B M J Open. 3, 10, p. 1-8 9 p., e003834.Research output: Contribution to journal › Journal article › Research › peer-review
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The effect of 6-day subcutaneous glucose-dependent insulinotropic polypeptide infusion on time in glycaemic range in patients with type 1 diabetes: a randomised, double-blind, placebo-controlled crossover trial
Heimbürger, S. M. N., Hoe, B., Nielsen, C. N., Bergmann, N. C., Hartmann, Bolette, Holst, Jens Juul, Vilsbøll, Tina, Dejgaard, T. F., Christensen, Mikkel Bring & Knop, Filip Krag, 2021, In: Diabetologia. 64, p. 2425-2431Research output: Contribution to journal › Journal article › Research › peer-review
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The design and discovery of lixisenatide for the treatment of type 2 diabetes mellitus
Christensen, M., Miossec, P., Larsen, B. D., Werner, U. & Knop, Filip Krag, 2014, In: Expert Opinion on Drug Discovery. 9, 10, p. 1223-1251 29 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The biology of glucagon and the consequences of hyperglucagonemia
Albrechtsen, Nicolai Jacob Wewer, Kuhre, Rune Ehrenreich, Pedersen, Jens, Knop, Filip Krag & Holst, Jens Juul, 9 Sep 2016, In: Biomarkers in Medicine. 10, 11, p. 1141-1151 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The bile-gut axis and metabolic consequences of cholecystectomy
Lange, A. H., Pedersen, M. G., Ellegaard, A. M., Nerild, H. H., Brønden, Andreas, Sonne, David Peick & Knop, Filip Krag, 2024, In: European Journal of Endocrinology. 190, 4, p. R1-R9 9 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
The bile acid-sequestering resin sevelamer eliminates the acute GLP-1 stimulatory effect of endogenously released bile acids in patients with type 2 diabetes
Brønden, A., Albér, A., Rohde, U., Gasbjerg, Lærke Smidt, Rehfeld, Jens Frederik, Holst, Jens Juul, Vilsbøll, Tina & Knop, Filip Krag, 1 Feb 2018, In: Diabetes, Obesity and Metabolism. 20, 2, p. 362-369Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The authors reply
Idorn, T., Knop, Filip Krag, Jørgensen, M., Holst, Jens Juul, Hornum, Mads & Feldt-Rasmussen, Bo, Jan 2014, In: Kidney International. 85, 1, p. 212-3 2 p.Research output: Contribution to journal › Letter › Research › peer-review
- Published
The altered serum lipidome and its diagnostic potential for Non-Alcoholic Fatty Liver (NAFL)-associated hepatocellular carcinoma: Diagnosis of NAFLD-HCC utilising serum lipidomics
Lewinska, M., Santos-Laso, A., Arretxe, E., Alonso, C., Zhuravleva, E., Jimenez-Agüero, R., Eizaguirre, E., Pareja, M. J., Romero-Gómez, M., Jimenez, M. A., Suppli, M. P., Knop, F. K., Oversoe, S. K., Villadsen, G. E., Decaens, T., Carrilho, F. J., de Oliveira, C. PMS., Sangro, B., Macias, R. I. R., Banales, J. M. & 1 others, , 2021, In: EBioMedicine. 73, 103661.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The alpha-cell as target for type 2 diabetes therapy
Christensen, M., Bagger, J. I., Vilsbøll, Tina & Knop, Filip Krag, 2011, In: Review of Diabetic Studies. 8, 3, p. 369-81 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The Role of Glucagon in the Pathophysiology and Treatment of Type 2 Diabetes
Hædersdal, S., Lund, A., Knop, Filip Krag & Vilsbøll, Tina, 2018, In: Mayo Clinic Proceedings. 93, 2, p. 217-239Research output: Contribution to journal › Review › Research › peer-review
- Published
The Nkx6.1 homeodomain transcription factor suppresses glucagon expression and regulates glucose-stimulated insulin secretion in islet beta cells
Schisler, J. C., Jensen, P. B., Harper, D. A. T., Becker, T., Knop, Filip Krag, Takekawa, S., German, M., Weir, G. C., Lu, D., Mirmira, R. G. & Newgard, C. B., 17 May 2005, In: Proceedings of the National Academy of Sciences of the United States of America. 102, 20, p. 7297-302 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The Liver-Alpha Cell Axis in Health and in Disease
Richter, Michael Martin, Galsgaard, Katrine Douglas, Elmelund, E., Knop, Filip Krag, Suppli, M. P., Holst, Jens Juul, Winther-Sørensen, Marie, Kjeldsen, Sasha Alexandra Sampson & Albrechtsen, Nicolai Jacob Wewer, 2022, In: Diabetes. 71, +, p. 1852–1861Research output: Contribution to journal › Review › Research › peer-review
- Published
The Gut-Bone Axis in Diabetes
Maagensen, H., Helsted, M. M., Gasbjerg, Lærke Smidt, Vilsbøll, Tina & Knop, Filip Krag, 2023, In: Current Osteoporosis Reports. 21, p. 21–31 11 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
The Gut: A Key to the Pathogenesis of Type 2 Diabetes?
Holst, Jens Juul, Pedersen, Jens, Albrechtsen, Nicolai Jacob Wewer & Knop, Filip Krag, Aug 2017, In: Metabolic Syndrome and Related Disorders. 15, 6, p. 259-262 4 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
The Glycemic Effect of Liraglutide Evaluated by Continuous Glucose Monitoring in Persons with Type 2 Diabetes Receiving Dialysis
Bomholt, T., Idorn, T., Knop, Filip Krag, Jørgensen, M. B., Ranjan, A. G., Resuli, M., Hansen, P. M., Borg, Rikke, Persson, F., Feldt-Rasmussen, Bo & Hornum, Mads, 2021, In: Nephron. 145, 1, p. 27-34Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The Glucagon Receptor Antagonist LY2409021 has No Effect on Postprandial Glucose in Type 2 Diabetes
Hædersdal, S., Lund, A., Maagensen, H., Nielsen-Hannerup, E., Gasbjerg, Lærke Smidt, Rosenkilde, Mette, Forman, Julie Lyng, van Hall, Gerrit, Holst, Jens Juul, Knop, Filip Krag & Vilsbøll, Tina, 2022, In: European Journal of Endocrinology. 186, 2, p. 207-221 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The GLP-1 receptor agonist lixisenatide reduces postprandial glucose in patients with diabetes secondary to total pancreatectomy: a randomised, placebo-controlled, double-blinded crossover trial
Juel, C. T. B., Lund, A., Andersen, M. M., Hansen, C. P., Storkholm, J. H., Rehfeld, Jens Frederik, van Hall, G., Hartmann, Bolette, Albrechtsen, Nicolai Jacob Wewer, Holst, Jens Juul, Vilsbøll, Tina & Knop, Filip Krag, Jul 2020, In: Diabetologia. 63, p. 1285-1298Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The Epidemiology of Bile Acid Diarrhea in Denmark [Response to Letter]
Kårhus, M. L., Ellegaard, A. M., Knop, Filip Krag & Kårhus, L. L., 2024, In: Clinical Epidemiology. 16, p. 7-8 2 p.Research output: Contribution to journal › Comment/debate › Research › peer-review
- Published
The Epidemiology of Bile Acid Diarrhea in Denmark
Kårhus, M. L., Ellegaard, A. M., Winther-Jensen, M., Hansen, S., Knop, Filip Krag & Kårhus, L. L., 2023, In: Clinical Epidemiology. 15, p. 1173-1181 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The Effect of Exogenous GLP-1 on Food Intake is Lost in Male Truncally Vagotomized Subjects with Pyloroplasty
Plamboeck, A., Veedfald, Simon, Deacon, Carolyn F., Hartmann, Bolette, Wettergren, A., Svendsen, Lars Bo, Meisner, S., Hovendahl, C., Vilsbøll, Tina, Knop, Filip Krag & Holst, Jens Juul, 18 Apr 2013, In: American Journal of Physiology: Gastrointestinal and Liver Physiology. 304, p. G1117-G1127 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The Effect of Ethanol on Inflammation Markers and FGF-21 in Healthy Individuals
Lanng, A. R., Gasbjerg, Lærke Smidt, Bergmann, N. C., Møller, H., Gillum, M., Gronbaek, H., Vilsbøll, Tina & Knop, Filip Krag, 2018, In: Diabetes. 67, Supplement 1, 2415-PUB.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The Accuracy of Hemoglobin A1c and Fructosamine Evaluated by Long-Term Continuous Glucose Monitoring in Patients with Type 2 Diabetes Undergoing Hemodialysis
Bomholt, T., Rix, M., Almdal, Thomas Peter, Knop, Filip Krag, Rosthøj, Susanne, Heinrich, N. S., Jørgensen, M. B., Larsson, A., Hilsted, Linda, Feldt-Rasmussen, Bo & Hornum, Mads, 2022, In: Blood Purification. 51, p. 608–616 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Targeting the GLP-2 receptor in the management of obesity
Pálsson, T. G., Gilliam-Vigh, Hannah, Jensen, Benjamin Anderschou Holbech, Jeppesen, Palle Bekker, Lund, Asger Bach, Knop, Filip Krag & Nielsen, C. K., 2024, In: Peptides. 177, 9 p., 171210.Research output: Contribution to journal › Review › Research › peer-review
- Published
THERAPY OF ENDOCRINE DISEASE: Amylin and calcitonin - physiology and pharmacology
Mathiesen, D. S., Lund, A., Holst, Jens Juul, Knop, Filip Krag, Lutz, T. A. & Bagger, J. I., 2022, In: European Journal of Endocrinology. 186, 6, p. R93-R111Research output: Contribution to journal › Review › Research › peer-review
- Published
THERAPY Liraglutide: preventing or postponing T2DM diagnosis?
Vilsbøll, Tina & Knop, Filip Krag, 2017, In: Nature Reviews Endocrinology. 13, p. 320-322Research output: Contribution to journal › Comment/debate › Research › peer-review
- Published
Systemic corticosteroids and the risk of venous thromboembolism in patients with severe copd: A nationwide study of 30, 473 outpatients
Rastoder, E., Sivapalan, P., Eklöf, J., Saeed, M. I., Jordan, A. S., Meteran, H., Tønnesen, L., Biering-Sørensen, T., Løkke, A., Seersholm, N., Nielsen, T. L., Carlsen, J., Janner, J., Godtfredsen, N., Bodtger, U., Laursen, C. B., Hilberg, O., Knop, F. K., Priemé, H., Ingebrigtsen, T. S. & 3 others, , 2021, In: Biomedicines. 9, 8, 874.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Sustained weight loss after treatment with a glucagon-like Peptide-1 receptor agonist in an obese patient with schizophrenia and type 2 diabetes
Ishøy, P. L., Knop, Filip Krag, Vilsbøll, Tina, Glenthøj, Birte Yding & Ebdrup, Bjørn, 1 Jun 2013, In: American Journal of Psychiatry. 170, 6, p. 681-682 2 p.Research output: Contribution to journal › Comment/debate › Communication
- Published
Sustained heart rate-corrected QT prolongation during recovery from hypoglycaemia in people with type 1 diabetes, independently of recovery to hyperglycaemia or euglycaemia
Andreasen, C. R., Andersen, A., Hagelqvist, P. G., Maytham, K., Lauritsen, J. V., Engberg, S., Faber, Jens, Pedersen-Bjergaard, Ulrik, Knop, Filip Krag & Vilsbøll, Tina, 2023, In: Diabetes, Obesity and Metabolism. 25, 6, p. 1566-1575 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Supportive and non-supportive interactions in families with a type 2 diabetes patient: an integrative review
Bennich, B. B., Røder, M. E., Overgaard, D., Egerod, Ingrid Eugenie, Munch, L., Knop, Filip Krag, Vilsbøll, Tina & Konradsen, H., 2017, In: Diabetology & Metabolic Syndrome. 9, 10 p., 57.Research output: Contribution to journal › Review › Research › peer-review
- Published
Study protocol for a multicentre, randomised, parallel group, sham-controlled clinical trial investigating the effect of transcutaneous vagal nerve stimulation on gastrointestinal symptoms in people with diabetes complicated with diabetic autonomic neuropathy: The DAN-VNS Study
Okdahl, T., Bertoli, D., Brock, Birgitte, Krogh, K., Knop, Filip Krag, Brock, C. & Drewes, A. M., 2021, In: BMJ Open. 11, 1, e038677.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Specificity and sensitivity of commercially available assays for glucagon-like peptide-1 (GLP-1): Implications for GLP-1 measurements in clinical studies
Bak, M. J., Albrechtsen, Nicolai Jacob Wewer, Pedersen, Jens, Knop, Filip Krag, Vilsbøll, Tina, Jørgensen, N. B., Hartmann, Bolette, Deacon, Carolyn F., Dragsted, Lars Ove & Holst, Jens Juul, 2014, In: Diabetes, Obesity and Metabolism. 16, 11, p. 1155-1164 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Species-specific action of (Pro3)GIP - an efficacious agonist on human GIP receptor, but partial agonist and competitive antagonist on rat and mouse GIP receptors
wbf943, wbf943, Gasbjerg, Lærke Smidt, Svendsen, B., Christensen, M., Knop, Filip Krag, Hartmann, Bolette, Holst, Jens Juul & Rosenkilde, Mette, Jan 2016, In: British Journal of Pharmacology. 173, 1, p. 27-38 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Sodium-glucose cotransporter 2 (SGLT-2) inhibitors for patients with Type 2 diabetes
Røder, M. E., Storgaard, H., Rungby, Jørgen, Knop, Filip Krag & Vilsbøll, Tina, 19 Sep 2016, In: Ugeskrift for Laeger. 178, 38Research output: Contribution to journal › Review › Research › peer-review
- Published
Sodium-glucose cotransporter 2 (SGLT-2) inhibitors for patients with Type 2 diabetes
Røder, M. E., Storgaard, H., Rungby, Jørgen, Knop, Filip Krag & Vilsbøll, Tina, 19 Sep 2016, In: Ugeskrift for Laeger. 178, 38Research output: Contribution to journal › Review › Research › peer-review
- Published
Sodium-glucose cotransporter (SGLT)-2-inhibitorer til patienter med type 2-diabetes
Røder, M. E., Storgaard, H., Rungby, J., Knop, Filip Krag & Vilsbøll, Tina, 26 Dec 2016, In: Ugeskrift for Laeger. 178, 26, p. 2461-64 V05160310.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Small-bowel hemangiosarcoma and capsule endoscopy
Knop, Filip Krag, Hansen, M. B. & Meisner, S., 1 Jul 2003, In: Endoscopy. 35, 7, p. 637Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Six-day subcutaneous GIP infusion increases glycaemic time in range in patients with type 1 diabetes
Heimbuerger, S. M. N., Hoe, B., Nielsen, C. N., Bergmann, N. C., Hartmann, Bolette, Holst, Jens Juul, Størling, Joachim, Vilsbøll, Tina, Dejgaard, T. F., Christensen, Mikkel Bring & Knop, Filip Krag, 2020, In: Diabetologia. 63, SUPPL 1, p. S73 1 p., 145.Research output: Contribution to journal › Conference abstract in journal › Research
- Published
Six-day sc GIP infusion increases plasma NEFA without altering the adipose tissue transcriptome, GIPR levels or plasma markers of inflammation in patients with type 1 diabetes
Heimburger, S. M. N., Hoe, B., Nielsen, C. N., Hartmann, Bolette, Holst, Jens Juul, Dela, Flemming, Overgaard, J., Størling, Joachim, Vilsbøll, Tina, Dejgaard, T. F., Pyke, C., Christensen, M. B. & Knop, Filip Krag, 2021, In: Diabetologia. 64, SUPPL 1, p. 258-258 494.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
- Published
Single-Dose Metformin Enhances Bile Acid-Induced Glucagon-Like Peptide-1 Secretion in Patients With Type 2 Diabetes
Brønden, A., Albér, A., Rohde, U., Rehfeld, Jens Frederik, Holst, Jens Juul, Vilsbøll, Tina & Knop, Filip Krag, Nov 2017, In: The Journal of clinical endocrinology and metabolism. 102, 11, p. 4153-4162 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Signs of a Glucose- and Insulin-Independent Gut-Bone Axis and Aberrant Bone Homeostasis in Type 1 Diabetes
Hartmann, Bolette, Longo, M., Mathiesen, D. S., Hare, Kristine Juul, Jørgensen, Niklas Rye, Esposito, K., Deacon, Carolyn F., Vilsbøll, Tina, Holst, Jens Juul & Knop, Filip Krag, 2024, In: Journal of Clinical Endocrinology and Metabolism. 109, 1, p. e259-e265 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Signs of Glucagon Resistance After a Two-Week Hypercaloric Diet Intervention
Suppli, M. P., Høgedal, A., Bagger, J. I., Chabanova, E., van Hall, Gerrit, Forman, Julie Lyng, Christensen, Mikkel Bring, Albrechtsen, Nicolai Jacob Wewer, Holst, Jens Juul & Knop, Filip Krag, 2024, In: Journal of Clinical Endocrinology and Metabolism. 109, 4, p. 955–967 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Short-acting glucagon-like peptide-1 receptor agonists as add-on to insulin therapy in type 1 diabetes: A review
Albèr, A., Brønden, A. & Knop, Filip Krag, 2017, In: Diabetes, Obesity and Metabolism. 19, 7, p. 915-925Research output: Contribution to journal › Review › Research › peer-review
ID: 40100368
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L-cell Differentiation Is Induced by Bile Acids Through GPBAR1 and Paracrine GLP-1 and Serotonin Signaling
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Plasma proteome profiling discovers novel proteins associated with non-alcoholic fatty liver disease
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Circulating Glucagon 1-61 Regulates Blood Glucose by Increasing Insulin Secretion and Hepatic Glucose Production
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