Filip Krag Knop

Filip Krag Knop

Clinical Professor

Member of:

  • Internal Medicine: Endocrinology


  1. Published

    The Glucagon Receptor Antagonist LY2409021 has No Effect on Postprandial Glucose in Type 2 Diabetes

    Hædersdal, S., Lund, A., Maagensen, H., Nielsen-Hannerup, E., Gasbjerg, Lærke Smidt, Rosenkilde, Mette, Forman, Julie Lyng, van Hall, Gerrit, Holst, Jens Juul, Knop, Filip Krag & Vilsbøll, Tina, 2022, In: European Journal of Endocrinology. 186, 2, p. 207-221 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    Revisiting the role of glucagon in health, diabetes mellitus and other metabolic diseases

    Hædersdal, S., Andersen, A., Knop, Filip Krag & Vilsbøll, Tina, 2023, In: Nature Reviews Endocrinology. 19, 6, p. 321-335

    Research output: Contribution to journalReviewResearchpeer-review

  3. Published

    The role of glucagon in the acute therapeutic effects of SGLT2 inhibition

    Hædersdal, S., Lund, A., Nielsen-Hannerup, E., Maagensen, H., van Hall, Gerrit, Holst, Jens Juul, Knop, Filip Krag & Vilsbøll, Tina, 2020, In: Diabetes. 69, 12, p. 2619-2629 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    The Role of Glucagon in the Pathophysiology and Treatment of Type 2 Diabetes

    Hædersdal, S., Lund, A., Knop, Filip Krag & Vilsbøll, Tina, 2018, In: Mayo Clinic Proceedings. 93, 2, p. 217-239

    Research output: Contribution to journalReviewResearchpeer-review

  5. Published

    Management of dyslipidaemia in individuals with severe mental illness: a population-based study in the Greater Copenhagen Area

    Høgnason Mohr, G., Barcella, C. A., Grand, Mia Klinten, Kriegbaum, Margit, Siersma, Volkert Dirk, Hahn, M. K., Agarwal, S. M., Bakkedal, Catrine, Baandrup, Lone, Knop, Filip Krag, Andersen, C. L. & Ebdrup, Bjørn, 2023, In: Therapeutic Advances in Psychopharmacology. 13, 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Four weeks of near-normalization of blood glucose has no effect on postprandial GLP-1 and GIP secretion, but augments pancreatic B-cell responsiveness to a meal in patients with Type 2 diabetes

    Højberg, P. V., Vilsbøll, Tina, Zander, P. M., Knop, Filip Krag, Krarup, T., Vølund, A., Holst, J. M. & Madsbad, Sten, 1 Nov 2008, In: Diabetic Medicine. 25, 11, p. 1268-75 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Four weeks of near-normalization of blood glucose has no effect on postprandial GLP-1 and GIP secretion, but augments pancreatic B-cell responsiveness to a meal in patients with Type 2 diabetes

    Højberg, P. V., Vilsbøll, T., Zander, M., Knop, Filip Krag, Krarup, T., Vølund, A., Holst, Jens Juul & Madsbad, Sten, Nov 2008, In: Diabetic Medicine Online. 25, 11, p. 1268-75 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Four weeks of near-normalisation of blood glucose improves the insulin response to glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide in patients with type 2 diabetes

    Højberg, P. V., Vilsbøll, Tina, Rabøl, R., Knop, Filip Krag, Bache, M., Krarup, T., Holst, Jens Juul & Madsbad, Sten, 2008, In: Diabetologia. 52, 2, p. 199-207 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Near normalisation of blood glucose improves the potentiating effect of GLP-1 on glucose-induced insulin secretion in patients with type 2 diabetes

    Højberg, P. V., Zander, M., Vilsbøll, T., Knop, Filip Krag, Krarup, T., Vølund, A., Holst, Jens Juul & Madsbad, Sten, 1 Apr 2008, In: Diabetologia. 51, 4, p. 632-640 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Safety and efficacy of liraglutide in patients with type 2 diabetes and end-stage renal disease: an investigator-initiated, randomised, placebo-controlled trial

    Idorn, T., Knop, Filip Krag, Jorgensen, M. B., Jensen, T., Resuli, M., Hansen, P. M., Christensen, Karl Bang, Holst, Jens Juul, Hornum, M. & Feldt-Rasmussen, B., Sep 2014, In: Diabetologia. 57, 1 supplement, p. S370-S371 909.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  11. Published

    Safety and efficacy of liraglutide in patients with type 2 diabetes and end-stage renal disease: protocol for an investigator-initiated prospective, randomised, placebo-controlled, double-blinded, parallel intervention study

    Idorn, T., Knop, Filip Krag, Jørgensen, M., Jensen, T., Resuli, M., Hansen, P. M., Christensen, Karl Bang, Holst, Jens Juul, Hornum, Mads & Feldt-Rasmussen, Bo, 26 Apr 2013, In: B M J Open. 3, 4, p. 1-10 11 p., e002764.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Elimination and degradation of glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide in patients with end-stage renal disease

    Idorn, T., Knop, Filip Krag, Jørgensen, M. B., Christensen, Mikkel Bring, Holst, Jens Juul, Hornum, Mads & Feldt-Rasmussen, Bo, 8 Apr 2014, In: The Journal of clinical endocrinology and metabolism. 99, 7, p. 2457-66 10 p., jc20133809.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Postprandial responses of incretin and pancreatic hormones in non-diabetic patients with end-stage renal disease

    Idorn, T., Knop, Filip Krag, Jørgensen, M., Holst, Jens Juul, Hornum, Mads & Feldt-Rasmussen, Bo, Jan 2014, In: Nephrology, Dialysis, Transplantation. 29, 1, p. 119-27 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    The authors reply

    Idorn, T., Knop, Filip Krag, Jørgensen, M., Holst, Jens Juul, Hornum, Mads & Feldt-Rasmussen, Bo, Jan 2014, In: Kidney International. 85, 1, p. 212-3 2 p.

    Research output: Contribution to journalLetterResearchpeer-review

  15. Published

    Gastrointestinal factors contribute to glucometabolic disturbances in nondiabetic patients with end-stage renal disease

    Idorn, T., Knop, Filip Krag, Jørgensen, M., Holst, Jens Juul, Hornum, Mads & Feldt-Rasmussen, Bo, May 2013, In: Kidney International. 83, 5, p. 915-23 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Safety and Efficacy of Liraglutide in Patients With Type 2 Diabetes and End-Stage Renal Disease: An Investigator-Initiated, Placebo-Controlled, Double-Blinded, Parallel Group, Randomized Trial

    Idorn, T., Knop, Filip Krag, Jørgensen, M. B., Jensen, T., Resuli, M., Hansen, P. M., Christensen, Karl Bang, Holst, Jens Juul, Hornum, Mads & Feldt-Rasmussen, Bo, Feb 2016, In: Diabetes Care. 39, 2, p. 206-13 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    No cognitive-enhancing effect of GLP-1 receptor agonism in antipsychotic-treated, obese patients with schizophrenia

    Ishøy, P. L., Fagerlund, Birgitte, Broberg, B. V., Bak, N., Knop, Filip Krag, Glenthøj, Birte Yding & Ebdrup, Bjørn, Jul 2017, In: Acta Psychiatrica Scandinavica. 136, 1, p. 52-62

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Effect of GLP-1 Receptor Agonist Treatment on Body weight in Obese Antipsychotic-treated Patients with Schizophrenia: a Randomized, Placebo-controlled Trial Byline

    Ishøy, P. L., Knop, Filip Krag, Broberg, B. V., Bak, N., Andersen, U. B., Jørgensen, N. R., Holst, Jens Juul, Glenthøj, Birte Yding & Ebdrup, Bjørn, Feb 2017, In: Diabetes, Obesity and Metabolism. 19, 2, p. 162-171

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Sustained weight loss after treatment with a glucagon-like Peptide-1 receptor agonist in an obese patient with schizophrenia and type 2 diabetes

    Ishøy, P. L., Knop, Filip Krag, Vilsbøll, Tina, Glenthøj, Birte Yding & Ebdrup, Bjørn, 1 Jun 2013, In: American Journal of Psychiatry. 170, 6, p. 681-682 2 p.

    Research output: Contribution to journalComment/debateCommunication

  20. Published
  21. Published

    Glucagon Receptor Signaling and Glucagon Resistance

    Janah, L., Kjeldsen, Sasha Alexandra Sampson, Galsgaard, Katrine Douglas, Winther-Sørensen, Marie, Stojanovska, E., Pedersen, Jens, Knop, Filip Krag, Holst, Jens Juul & Albrechtsen, Nicolai Jacob Wewer, 2019, In: International Journal of Molecular Sciences. 20, 13, 27 p., 3314.

    Research output: Contribution to journalReviewResearchpeer-review

  22. Published

    GLP-1 agonists for type 2 diabetes: pharmacokinetic and toxicological considerations

    Jespersen, M. J., Knop, Filip Krag & Christensen, Mikkel Bring, 2013, In: Expert Opinion on Drug Metabolism & Toxicology. 9, 1, p. 17-29 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Dulaglutide, a long-acting GLP-1 analog fused with an Fc antibody fragment for the potential treatment of type 2 diabetes

    Solem, Espen Victor Jimenez, Rasmussen, M. H., Christensen, M. & Knop, Filip Krag, 1 Dec 2010, In: Current Opinion in Molecular Therapeutics. 12, 6, p. 790-7 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Efficacy and safety of meal-time administration of short-acting exenatide for glycaemic control in type 1 diabetes (MAG1C): a randomised, double-blind, placebo-controlled trial

    Johansen, N. J., Dejgaard, T. F., Lund, A., Schluntz, C., Frandsen, C. S., Forman, Julie Lyng, Albrechtsen, Nicolai Jacob Wewer, Holst, Jens Juul, Pedersen-Bjergaard, Ulrik, Madsbad, Sten, Vilsbøll, Tina, Andersen, H. U. & Knop, Filip Krag, 2020, In: The Lancet Diabetes & Endocrinology. 8, 4, p. 313-324 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Effect of short-acting exenatide administered three times daily on markers of cardiovascular disease in type 1 diabetes: A randomized double-blind placebo-controlled trial

    Johansen, N. J., Dejgaard, T. F., Lund, A., Schluentz, C., Larsen, E. L., Poulsen, Henrik Enghusen, Goetze, Jens P. , Møller, H. J., Vilsbøll, Tina, Andersen, H. U. & Knop, Filip Krag, 2020, In: Diabetes, Obesity and Metabolism. 22, 9, p. 1639-1647

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    Effects of short-acting exenatide added three times daily to insulin therapy on bone metabolism in type 1 diabetes

    Johansen, N. J., Dejgaard, T. F., Lund, A., Schlüntz, Camilla, Hartmann, Bolette, Holst, Jens Juul, Vilsbøll, Tina, Andersen, H. U. & Knop, Filip Krag, 2022, In: Diabetes, Obesity and Metabolism. 24, 2, p. 221-227

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    The potential of colchicine for lowering the risk of cardiovascular events in type 1 diabetes

    Johansen, N. J. & Knop, Filip Krag, 2023, In: European Heart Journal - Cardiovascular Pharmacotherapy. 9, 4, p. 311-317

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Protocol for Meal-time Administration of Exenatide for Glycaemic Control in Type 1 Diabetes Cases (The MAG1C trial): A randomised, double-blinded, placebo-controlled trial

    Johansen, N. J., Dejgaard, T. F., Lund, A., Vilsbøll, Tina, Andersen, H. U. & Knop, Filip Krag, 2018, In: BMJ Open. 8, 6, 8 p., 021861.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Clinical pharmacology of imeglimin for the treatment of type 2 diabetes

    Johansson, K. S., Brønden, A., Knop, Filip Krag & Christensen, Mikkel Bring, May 2020, In: Expert Opinion on Pharmacotherapy. 21, 8, p. 871-882

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    What is on the horizon for type 2 diabetes pharmacotherapy? - An overview of the antidiabetic drug development pipeline

    Johansson, K. S., Sonne, D., Knop, Filip Krag & Christensen, Mikkel Bring, 2020, In: Expert Opinion on Drug Discovery. 15, 11, p. 1253-1265

    Research output: Contribution to journalReviewResearchpeer-review

  31. Published

    GLP-1 and Amylin in the Treatment of Obesity

    Jorsal, T., Rungby, Jørgen, Knop, Filip Krag & Vilsbøll, Tina, Jan 2016, In: Current Diabetes Reports. 16, 1.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    Investigating Intestinal Glucagon after Roux-en-Y Gastric Bypass Surgery

    Jorsal, T., Wewer Albrechtsen, N. J., Christensen, M. M., Mortensen, B., Wandall, E., Langholz, E., Friis, S., Worm, D., Ørskov, C., Støving, R. K., Andries, A., Juhl, C. B., Sørensen, F., Forman, J. L., Falkenhahn, M., Musholt, P. B., Theis, S., Larsen, P. J., Holst, J. J., Vrang, N. & 3 others, Jelsing, J., Vilsbøll, Tina & Knop, Filip Krag, 2019, In: Journal of Clinical Endocrinology and Metabolism. 104, 12, p. 6403–6416 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Gut Mucosal Gene Expression and Metabolic Changes After Roux-en-Y Gastric Bypass Surgery

    Jorsal, T., Christensen, M. M., Mortensen, B., Nygaard, E. B., Zhang, C., Rigbolt, K., Wandall, E., Langholz, E., Friis, S., Worm, D., Floyd, A., Helgstrand, F., Støving, R. K., Aldries, A. R., Juhl, C. B., Østergaard, T., Rydborg, T., Forman, J. L., Sørensen, F., Schmidt, T. & 9 others, Falkenhahn, M., Musholt, P. B., Theis, S., Larsen, P. J., Rehfeld, Jens Frederik, Vrang, N., Jelsing, J., Vilsbøll, Tina & Knop, Filip Krag, 2020, In: Obesity. 28, 11, p. 2163-2174 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Enteroendocrine K and L cells in healthy and type 2 diabetic individuals

    Jorsal, T., Rhee, N. A., Pedersen, Jens, Wahlgren, C. D., Mortensen, B., Jepsen, Sara Lind, Jelsing, J., Dalbøge, L. S., Vilmann, Peter, Hassan, H., Hendel, J. W., Poulsen, Steen Seier, Holst, Jens Juul, Vilsbøll, Tina & Knop, Filip Krag, 1 Feb 2018, In: Diabetologia. 61, 2, p. 284-294 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    Glycemic Control and Variability of Diabetes Secondary to Total Pancreatectomy Assessed by Continuous Glucose Monitoring

    Juel, C. T. B., Dejgaard, T. F., Hansen, C. P., Storkholm, J. H., Vilsbøll, Tina, Lund, A. & Knop, Filip Krag, 2021, In: The Journal of clinical endocrinology and metabolism. 106, 1, p. 168-173 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    Response to letter to the editor from McKee and McGill: “Glycemic control and variability of diabetes secondary to total pancreatectomy assessed by continuous glucose monitoring”

    Juel, C. T. B., Dejgaard, T. F., Hansen, C. P., Storkholm, J. H., Vilsbøll, Tina, Lund, A. & Knop, Filip Krag, 2021, In: Journal of Clinical Endocrinology and Metabolism. 106, 10, p. E4307-E4308

    Research output: Contribution to journalComment/debateResearch

  37. Published

    The GLP-1 receptor agonist lixisenatide reduces postprandial glucose in patients with diabetes secondary to total pancreatectomy: a randomised, placebo-controlled, double-blinded crossover trial

    Juel, C. T. B., Lund, A., Andersen, M. M., Hansen, C. P., Storkholm, J. H., Rehfeld, Jens Frederik, van Hall, G., Hartmann, Bolette, Albrechtsen, Nicolai Jacob Wewer, Holst, Jens Juul, Vilsbøll, Tina & Knop, Filip Krag, Jul 2020, In: Diabetologia. 63, p. 1285-1298

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    Diabetic and nondiabetic patients with nonalcoholic fatty liver disease have an impaired incretin effect and fasting hyperglucagonaemia

    Junker, A. E., Gluud, Lise Lotte, Holst, Jens Juul, Knop, Filip Krag & Vilsbøll, Tina, May 2016, In: Journal of Internal Medicine. 279, 5, p. 485–493 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    Effects of glucagon-like peptide-1 on glucagon secretion in patients with non-alcoholic fatty liver disease

    Junker, A. E., Gluud, Lise Lotte, van Hall, Gerrit, Holst, Jens Juul, Knop, Filip Krag & Vilsbøll, Tina, Apr 2016, In: Journal of Hepatology. 64, 4, p. 908–915

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    Influence of gastrointestinal factors on glucose metabolism in patients with cirrhosis

    Junker, A. E., Gluud, Lise Lotte, Holst, Jens Juul, Knop, Filip Krag & Vilsbøll, Tina, Oct 2015, In: Journal of Gastroenterology and Hepatology. 30, 10, p. 1522-8 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    A 25-year-old woman with type 2 diabetes and liver disease

    Junker, A. E., Gluud, Lise Lotte, Pedersen, J., Langhoff, J. L., Holst, Jens Juul, Knop, Filip Krag & Vilsbøll, T., 2014, In: Case Reports in Gastroenterology. 8, 3, p. 398-403 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Clearance of glucoregulatory peptide hormones during haemodialysis and haemodiafiltration in non-diabetic end-stage renal disease patients

    Jørgensen, M. B., Idorn, T., Knop, Filip Krag, Holst, Jens Juul, Hornum, Mads & Feldt-Rasmussen, Bo, Mar 2015, In: Nephrology, Dialysis, Transplantation. 30, 3, p. 513-20 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    Effect of the Incretin Hormones on the Endocrine Pancreas in End-Stage Renal Disease

    Jørgensen, M. B., Idorn, T., Rydahl, C., Hansen, H. P., Bressendorff, I., Brandi, Lisbet, Wewer Albrechtsen, N. J., van Hall, Gerrit, Hartmann, Bolette, Holst, Jens Juul, Knop, Filip Krag, Hornum, Mads & Feldt-Rasmussen, Bo, Jan 2020, In: Journal of Clinical Endocrinology and Metabolism. 105, 3, p. e564-e574

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    Effect of exercise combined with glucagon-like peptide-1 receptor agonist treatment on cardiac function: A randomized double-blind placebo-controlled clinical trial

    Jørgensen, P. G., Jensen, M. T., Mensberg, P., Storgaard, H., Nyby, S., Jensen, J. S., Knop, Filip Krag & Vilsbøll, Tina, 2017, In: Diabetes, Obesity and Metabolism. 19, 7, p. 1040-1044

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    Effect of 10-Day Treatment with 50 mg Prednisolone Once-Daily on Haemostasis in Healthy Men—A Randomised Placebo-Controlled Trial

    Kamstrup, P., Rastoder, E., Hellmann, P. H., Sivapalan, P., Larsen, E. L., Vestbo, J., Ulrik, Charlotte Suppli, Goetze, Jens P. , Knop, Filip Krag & Jensen , Jens-Ulrik Stæhr , 2023, In: Biomedicines. 11, 7, p. 1-14 2052.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    Electroretinography in healthy subjects in relation to systemic glucocorticoid intake

    Kappelgaard, P., Hansen, K. B., Vilsbøll, Tina, Knop, Filip Krag & Larsen, Michael, 2012, In: Documenta Ophthalmologica. 124, 1, p. 49-57 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    Antidiabetes Agents and Incident Depression: A Nationwide Population-Based Study

    Kessing, Lars Vedel, Rytgaard, Helene Charlotte Wiese, Ekstrøm, Claus Thorn, Knop, Filip Krag, Berk, M. & Gerds, Thomas Alexander, 2020, In: Diabetes Care. 43, 12, p. 3050-3060

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    Arginine-vasopressin mediates counter-regulatory glucagon release and is diminished in type 1 diabetes

    Kim, A., Knudsen, J. G., Madara, J. C., Benrick, A., Hill, T. G., Kadir, L. A., Kellard, J. A., Mellander, L., Miranda, C., Lin, H., James, T., Suba, K., Spigelman, A. F., Wu, Y., Macdonald, P. E., Asterholm, I. W., Magnussen, T., Christensen, M., Vilsbøll, T., Salem, V. & 4 others, Knop, Filip Krag, Rorsman, P., Lowell, B. B. & Briant, L. J. B., 2021, In: eLife. 10, 29 p., e72919.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    Glycemic, maternal and neonatal outcomes in women with type 1 diabetes using continuous glucose monitoring during pregnancy – Pump vs multiple daily injections, a secondary analysis of an observational cohort study

    Kjölhede, K., Berntorp, K., Kristensen, K., Katsarou, A., Shaat, N., Wiberg, N., Knop, Filip Krag, Kristensen, Lars Erik Vølund, Dotevall, A., Elfvin, A., Sandgren, U., Sengpiel, V. & Englund-Ögge, L., 2021, In: Acta Obstetricia et Gynecologica Scandinavica. 100, 5, p. 927-933 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    Retinal vascular and structural dynamics during acute hyperglycaemia

    Klefter, O. N., Vilsbøll, Tina, Knop, Filip Krag & Larsen, Michael, Dec 2015, In: Acta Ophthalmologica. 93, 8, p. 697-705 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

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