Filip Krag Knop

Filip Krag Knop

Clinical Professor

Member of:

  • Internal Medicine: Endocrinology


  1. 2024
  2. Published

    Empagliflozin to elderly and obese patients with increased risk of developing heart failure: Study protocol for the Empire Prevent trial program

    Andersen, Camilla, Larsen, J. H., Jensen, J., Omar, M., Nouhravesh, N., Kistorp, Caroline Michaela Nervil, Tuxen, C., Gustafsson, Finn, Knop, Filip Krag, Forman, Julie Lyng, Davidovski, Filip Søskov, Jensen, Lars Thorbjørn, Højlund, K., Køber, Lars Valeur, Antonsen, L., Poulsen, M. K., Schou, Morten & Møller, J. E., 2024, In: American Heart Journal. 271, p. 84-96 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Empagliflozin Normalizes Fasting Hyperglycemia and Improves Postprandial Glucose Tolerance in Totally Pancreatectomized Patients: A Randomized, Double-Blind, Placebo-Controlled Crossover Study

    Baekdal, M., Nielsen, S. W., Hansen, C. P., Storkholm, J. H., van Hall, Gerrit, Hartmann, Bolette, Holst, Jens Juul, Vilsbøll, Tina, Lund, A. & Knop, Filip Krag, 2024, In: Diabetes Care. 47, 1, p. 71-80 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Weight Loss for Patients With Gout and Concomitant Obesity: A Proof-of-Concept Randomized Trial

    Christensen, R., Zobbe, K., Nielsen, S. M., Stamp, L. K., Henriksen, Marius, Overgaard, A. F., Dreyer, L., Knop, Filip Krag, Singh, J. A., Doherty, M., Richette, P., Astrup, A., Ellegaard, K., Bartels, E. M., Boesen, Mikael Ploug, Gudbergsen, Henrik Rindel, Bliddal, Henning & Kristensen, L. E., 2024, In: Arthritis & rheumatology (Hoboken, N.J.). 766, 5, p. 806-812 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Metformin treatment is associated with reduced risk of hypoglycaemia, major adverse cardiovascular events, and all-cause mortality in patients with post-pancreatitis diabetes mellitus: a nationwide cohort study

    Davidsen, L., Jensen, M. H., Cook, M. E., Vestergaard, P., Knop, Filip Krag, Drewes, A. M. & Olesen, S. S., 2024, In: European Journal of Endocrinology. 190, 1, p. 44-53 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Author Response to Letter to the Editor regarding “the Epidemiology of Bile Acid Diarrhea in Denmark” [Response to Letter]

    Ellegaard, A. M., Kårhus, M. L., Knop, Filip Krag & Kårhus, L. L., 2024, In: Clinical Epidemiology. 16, p. 5-6 2 p.

    Research output: Contribution to journalLetterResearchpeer-review

  7. Published

    Intestinal expression profiles and hepatic expression of LEAP2, ghrelin and their common receptor, GHSR, in humans

    Englund, A., Gilliam-Vigh, H., Suppli, M. P., Gasbjerg, Lærke Smidt, Vilsbøll, Tina & Knop, Filip Krag, 2024, In: Peptides. 177, 7 p., 171227.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Colesevelam has no acute effect on postprandial GLP-1 levels but abolishes gallbladder refilling

    Gether, I. M., Bahne, E., Nerild, H. H., Rehfeld, Jens Frederik, Hartmann, Bolette, Holst, Jens Juul, Vilsbøll, Tina, Sonne, David Peick & Knop, Filip Krag, 2024, In: European Journal of Endocrinology. 190, 4, p. 314-326 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    The effect of exogenous glucagon on circulating amino acids in individuals with and without type 2 diabetes and obesity

    Grøndahl, M. F. G., Bagger, J. I., Suppli, M. P., van Hall, Gerrit, Albrechtsen, Nicolai Jacob Wewer, Holst, Jens Juul, Vilsbøll, Tina, Christensen, Mikkel Bring, Lund, A. B. & Knop, Filip Krag, 2024, In: Endocrine Connections. 13, 3, 7 p., e230516.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Accepted/In press

    Effects of oral roflumilast therapy on body weight and cardiometabolic parameters in patients with psoriasis – results from a randomized controlled trial (PSORRO)

    Gyldenløve, Mette, Sørensen, J. A., Fage, S., Meteran, H., Skov, Lone, Zachariae, Claus, Knop, Filip Krag, Nielsen, M. L. & Egeberg, Alexander, 2024, (Accepted/In press) In: Journal of the American Academy of Dermatology.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. E-pub ahead of print

    Hemostatic Effects of Exercise-Related Hypoglycemia in Male Persons With Type 1 Diabetes

    Hagelqvist, P. G., Andersen, A., Maytham, K., Andreasen, C. R., Engberg, S., Pedersen-Bjergaard, Ulrik, Forman, Julie Lyng, Jo­hans­son, Pär In­ge­mar , Lykkesfeldt, Jens, Knop, Filip Krag & Vilsbøll, Tina, 2024, (E-pub ahead of print) In: The Journal of clinical endocrinology and metabolism.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Signs of a Glucose- and Insulin-Independent Gut-Bone Axis and Aberrant Bone Homeostasis in Type 1 Diabetes

    Hartmann, Bolette, Longo, M., Mathiesen, D. S., Hare, Kristine Juul, Jørgensen, Niklas Rye, Esposito, K., Deacon, Carolyn F., Vilsbøll, Tina, Holst, Jens Juul & Knop, Filip Krag, 2024, In: Journal of Clinical Endocrinology and Metabolism. 109, 1, p. e259-e265 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Safety of native glucose-dependent insulinotropic polypeptide in humans

    Helsted, M. M., Schaltz, N. L., Gasbjerg, Lærke Smidt, Christensen, Mikkel Bring, Vilsbøll, Tina & Knop, Filip Krag, 2024, In: Peptides. 177, 14 p., 171214.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. E-pub ahead of print

    Transcutaneous vagal nerve stimulation for treating gastrointestinal symptoms in individuals with diabetes: a randomised, double-blind, sham-controlled, multicentre trial

    Kornum, D. S., Bertoli, D., Kufaishi, H., Wegeberg, A. M., Okdahl, T., Mark, E. B., Høyer, K. L., Frøkjær, J. B., Brock, Birgitte, Krogh, K., Hansen, C. S., Knop, Filip Krag, Brock, C. & Drewes, A. M., 2024, (E-pub ahead of print) In: Diabetologia.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    The Epidemiology of Bile Acid Diarrhea in Denmark [Response to Letter]

    Kårhus, M. L., Ellegaard, A. M., Knop, Filip Krag & Kårhus, L. L., 2024, In: Clinical Epidemiology. 16, p. 7-8 2 p.

    Research output: Contribution to journalComment/debateResearchpeer-review

  16. Published

    The bile-gut axis and metabolic consequences of cholecystectomy

    Lange, A. H., Pedersen, M. G., Ellegaard, A. M., Nerild, H. H., Brønden, Andreas, Sonne, David Peick & Knop, Filip Krag, 2024, In: European Journal of Endocrinology. 190, 4, p. R1-R9 9 p.

    Research output: Contribution to journalReviewResearchpeer-review

  17. Published

    Bifidobacterium breve Bif195 ameliorates aspirin-induced gastric mucosal damage: A randomised, double blind, placebo-controlled crossover trial

    Løn, N., Engel, S., Damholt, A., Mortensen, B., Haaber, A. B., Wellejus, A. & Knop, Filip Krag, 2024, In: Alimentary Pharmacology and Therapeutics. 59, 3, p. 341-349 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Editorial: The microbiome and gastric mucosal protection in aspirin users—Authors' reply

    Løn, N., Engel, S., Damholt, A., Wellejus, A. & Knop, Filip Krag, 2024, In: Alimentary Pharmacology and Therapeutics. 59, 4, p. 577-578 2 p.

    Research output: Contribution to journalEditorialResearchpeer-review

  19. Published

    Letter: Bif195 for aspirin-induced gastric mucosal damage – More to do in further research. Authors' reply

    Løn, N., Engel, S., Damholt, A., Wellejus, A. & Knop, Filip Krag, 2024, In: Alimentary Pharmacology and Therapeutics. 59, 10, p. 1306-1307 2 p.

    Research output: Contribution to journalComment/debateResearchpeer-review

  20. Published

    Accuracy of continuous glucose monitoring during exercise-related hypoglycemia in individuals with type 1 diabetes

    Maytham, K., Hagelqvist, P. G., Engberg, S., Forman, Julie Lyng, Pedersen-Bjergaard, Ulrik, Knop, Filip Krag, Vilsbøll, Tina & Andersen, A., 2024, In: Frontiers in Endocrinology. 15, 9 p., 1352829.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. E-pub ahead of print

    Expression of bile acid receptors and transporters along the intestine of patients with type 2 diabetes and controls

    Nerild, H. H., Gilliam-Vigh, H., Ellegaard, A., Forman, Julie Lyng, Vilsbøll, Tina, Sonne, David Peick, Brønden, Andreas & Knop, Filip Krag, 2024, (E-pub ahead of print) In: The Journal of clinical endocrinology and metabolism.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Elucidating the glucose-lowering effect of the bile acid sequestrant sevelamer

    Nerild, H. H., Brønden, A., Haddouchi, A. E., Ellegaard, A., Hartmann, Bolette, Rehfeld, Jens Frederik, Holst, Jens Juul, Sonne, David Peick, Vilsbøll, Tina & Knop, Filip Krag, 2024, In: Diabetes, Obesity and Metabolism. 26, 4, p. 1252-1263

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Targeting the GLP-2 receptor in the management of obesity

    Pálsson, T. G., Gilliam-Vigh, Hannah, Jensen, Benjamin Anderschou Holbech, Jeppesen, Palle Bekker, Lund, Asger Bach, Knop, Filip Krag & Nielsen, C. K., 2024, In: Peptides. 177, 9 p., 171210.

    Research output: Contribution to journalReviewResearchpeer-review

  24. Published

    Greater time spent with HbA1c less than 7.0% with oral semaglutide versus oral comparators: An exploratory analysis of the PIONEER studies

    Rosenstock, J., Cariou, B., Eliasson, J., Frappin, G., Kaltoft, M. S., Montanya, E. & Knop, Filip Krag, 2024, In: Diabetes, Obesity and Metabolism. 26, 2, p. 532-539 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    An Extended Minimal Model of OGTT: estimation of α- and β-cell dysfunction, insulin resistance, and the incretin effect

    Subramanian, V., Bagger, J. I., Harihar, V., Holst, Jens Juul, Knop, Filip Krag & Vilsbøll, Tina, 2024, In: American Journal of Physiology - Endocrinology and Metabolism. 326, 2, p. E182-E205

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    Signs of Glucagon Resistance After a Two-Week Hypercaloric Diet Intervention

    Suppli, M. P., Høgedal, A., Bagger, J. I., Chabanova, E., van Hall, Gerrit, Forman, Julie Lyng, Christensen, Mikkel Bring, Albrechtsen, Nicolai Jacob Wewer, Holst, Jens Juul & Knop, Filip Krag, 2024, In: Journal of Clinical Endocrinology and Metabolism. 109, 4, p. 955–967 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. E-pub ahead of print
  28. 2023
  29. Published

    Hepatic Fibrosis Evaluated in Patients with Type 2 Diabetes with and without Chronic Kidney Disease

    Adrian, T., Hornum, Mads, Knop, Filip Krag, Christensen, Karl Bang, Almdal, Thomas Peter, Rossing, Peter, Lídaa, L. Í., Heinrich, N. S., Boer, V. O., Marsman, A., Petersen, E. T., Siebner, Hartwig Roman & Feldt-Rasmussen, Bo, 2023, In: Nephron. 147, 11, p. 673–684 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Nonalcoholic Fatty Liver Disease in Patients with Type 2 Diabetes and Chronic Kidney Disease

    Adrian, T., Hornum, Mads, Knop, Filip Krag, Almdal, Thomas Peter, Rossing, Peter, Lida, L., Heinrich, N. S., Boer, V. O., Marsman, A., Petersen, E. T., Siebner, Hartwig Roman & Feldt-Rasmussen, Bo, 2023, In: Nephron. 147, 6, p. 317–328

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Sustained heart rate-corrected QT prolongation during recovery from hypoglycaemia in people with type 1 diabetes, independently of recovery to hyperglycaemia or euglycaemia

    Andreasen, C. R., Andersen, A., Hagelqvist, P. G., Maytham, K., Lauritsen, J. V., Engberg, S., Faber, Jens, Pedersen-Bjergaard, Ulrik, Knop, Filip Krag & Vilsbøll, Tina, 2023, In: Diabetes, Obesity and Metabolism. 25, 6, p. 1566-1575 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    Efficacy and safety of once-daily oral semaglutide 25 mg and 50 mg compared with 14 mg in adults with type 2 diabetes (PIONEER PLUS): a multicentre, randomised, phase 3b trial

    Aroda, V. R., Aberle, J., Bardtrum, L., Christiansen, E., Knop, Filip Krag, Gabery, S., Pedersen, S. D. & Buse, J. B., 2023, In: The Lancet. 402, 10403, p. 693-704 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Call for prospective studies of continuous glucose monitoring to define the glycaemic response to bariatric surgery

    Bally, L., Khoo, B., Knop, Filip Krag, Madsbad, Sten, Patti, M. & Tan, T., 2023, In: The Lancet Diabetes and Endocrinology. 11, 10, p. 712-714 3 p.

    Research output: Contribution to journalComment/debateResearchpeer-review

  34. Published

    Semaglutide for the treatment of overweight and obesity: A review

    Bergmann, N. C., Davies, M. J., Lingvay, I. & Knop, Filip Krag, 2023, In: Diabetes, Obesity and Metabolism. 25, 1, p. 18-35

    Research output: Contribution to journalReviewResearchpeer-review

  35. Published

    MRI-Based Quantification of Pan-Alimentary Function and Motility in Subjects with Diabetes and Gastrointestinal Symptoms

    Bertoli, D., Mark, E. B., Liao, D., Okdahl, T., Nauser, S., Daugberg, L. H., Brock, C., Brock, Birgitte, Knop, Filip Krag, Krogh, K., Brøndum Frøkjær, J. & Drewes, A. M., 2023, In: Journal of Clinical Medicine. 12, 18, 16 p., 5968.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    Pan-alimentary assessment of motility, luminal content, and structures: an MRI-based framework

    Bertoli, D., Mark, E. B., Liao, D., Brock, C., Brock, Birgitte, Knop, Filip Krag, Krogh, K., Frøkjær, J. B. & Drewes, A. M., 2023, In: Scandinavian Journal of Gastroenterology. 58, 12, p. 1378–1390 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    Glucose variability in maintenance hemodialysis patients with type 2 diabetes: Comparison of dialysis and nondialysis days

    Bomholt, T., Rix, M., Almdal, T., Knop, Filip Krag, Rosthøj, Susanne, Jørgensen, M. B., Feldt-Rasmussen, Bo & Hornum, Mads, 2023, In: Hemodialysis International. 27, 2, p. 126-133 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    Acarbose diminishes postprandial suppression of bone resorption in patients with type 2 diabetes

    Dalsgaard, N. B., Gasbjerg, Lærke Smidt, Helsted, M. M., Hansen, L. S., Hansen, N. L., Skov-Jeppesen, Kirsa, Hartmann, Bolette, Holst, Jens Juul, Vilsbøll, Tina & Knop, Filip Krag, 2023, In: Bone. 170, 116687.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    Promising translatable pharmacological interventions for body weight management in individuals with severe mental illness - a narrative review

    De, R., Prasad, F., Stogios, N., Burin, L., Ebdrup, Bjørn, Knop, Filip Krag, Hahn, M. K. & Agarwal, S. M., 2023, In: Expert Opinion on Pharmacotherapy. 24, 16, p. 1823-1832 10 p.

    Research output: Contribution to journalReviewResearchpeer-review

  40. Published

    Why diversity among participants in clinical studies is not always preferable: the case for small, exploratory studies

    Ellegaard, A. M. & Knop, Filip Krag, 2023, In: BMC Medicine. 21, 1, 3 p., 462.

    Research output: Contribution to journalComment/debateResearchpeer-review

  41. Published

    Risk of first-time major cardiovascular event among individuals with newly diagnosed type 2 diabetes: data from Danish registers

    Falkentoft, A. C., Gerds, Thomas Alexander, Zareini, B., Knop, Filip Krag, Køber, Lars Valeur, Torp-Pedersen, Christian, Schou, Morten, Bruun, Niels Eske & Ruwald, A. C., 2023, In: Diabetologia. 66, p. 2017–2029 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Liraglutide treatment for the prevention of glucose tolerance deterioration in women with prior gestational diabetes mellitus: A 52-week randomized controlled clinical trial

    Foghsgaard, S., Vedtofte, L., Andersen, E. S., Bahne, E., Andreasen, C., Sørensen, A. L., Forman, Julie Lyng, Mathiesen, Elisabeth, Svare, J. A., Clausen, Tine Dalsgaard, Damm, Peter, Holst, Jens Juul, Knop, Filip Krag & Vilsbøll, Tina, 2023, In: Diabetes, Obesity and Metabolism. 26, 1, p. 201-214 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    Efficacy and safety of co-administered once-weekly cagrilintide 2·4 mg with once-weekly semaglutide 2·4 mg in type 2 diabetes: a multicentre, randomised, double-blind, active-controlled, phase 2 trial

    Frias, J. P., Deenadayalan, S., Erichsen, L., Knop, Filip Krag, Lingvay, I., Macura, S., Mathieu, C., Pedersen, S. D. & Davies, M., 2023, In: The Lancet. 402, 10403, p. 720-730 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    The importance of glucose-dependent insulinotropic polypeptide receptor activation for the effects of tirzepatide

    Gasbjerg, Lærke Smidt, Rosenkilde, Mette, Meier, J. J., Holst, Jens Juul & Knop, Filip Krag, 2023, In: Diabetes, Obesity and Metabolism. 25, 11, p. 3079-3092

    Research output: Contribution to journalReviewResearchpeer-review

  45. Published

    Effects of topical corticosteroid vs. tacrolimus on insulin sensitivity and bone homeostasis in adults with atopic dermatitis - a randomized controlled study

    Gether, L., Storgaard, H., Kezic, S., Jakasa, I., Hartmann, Bolette, Skov-Jeppesen, Kirsa, Holst, Jens Juul, Pedersen, A. J., Forman, Julie Lyng, van Hall, Gerrit, Sørensen, O. E., Skov, Lone, Røpke, Mads Almose, Knop, Filip Krag & Thyssen, Jacob Pontoppidan, 2023, In: Allergy. 78, 7, p. 1964-1979 16 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    Expression of Neurotensin and Its Receptors Along the Intestinal Tract in Type 2 Diabetes Patients and Healthy Controls

    Gilliam-Vigh, H., Jorsal, T., Nielsen, S. W., Forman, Julie Lyng, Pedersen, Jens, Poulsen, Steen Seier, Vilsbøll, Tina & Knop, Filip Krag, 2023, In: Journal of Clinical Endocrinology & Metabolism. p. 2211–2216 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    Expression of Secretin and its Receptor Along the Intestinal Tract in Type 2 Diabetes Patients and Healthy Controls

    Gilliam-Vigh, H., Jorsal, T., Nielsen, S. W., Forman, Julie Lyng, Pedersen, Jens, Poulsen, Steen Seier, Vilsbøll, Tina & Knop, Filip Krag, 2023, In: Journal of Clinical Endocrinology and Metabolism. 108, 12, p. e1597–e1602 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    Exercise-related hypoglycaemia induces QTc-interval prolongation in individuals with type 1 diabetes

    Hagelqvist, P. G., Andersen, A., Maytham, K. B., Andreasen, C. R., Engberg, S., Lindhardt, T. B., Faber, Jens, Holst, Jens Juul, Forman, Julie Lyng, Pedersen-Bjergaard, Ulrik, Knop, Filip Krag & Vilsbøll, Tina, 2023, In: Diabetes, Obesity and Metabolism. 25, 5, p. 1186-1195 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    Glycaemia and cardiac arrhythmias in people with type 1 diabetes: A prospective observational study

    Hagelqvist, P. G., Andersen, A., Maytham, K., Andreasen, C. R., Engberg, S., Lindhardt, T. B., Forman, Julie Lyng, Pedersen-Bjergaard, Ulrik, Knop, Filip Krag & Vilsbøll, Tina, 2023, In: Diabetes, Obesity and Metabolism. 25, 8, p. 2300-2309

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    Protocol for assessing the effects of exogenous hormone administration on human postprandial glucose metabolism, appetite sensations, and food intake

    Hagemann, C. A., Gasbjerg, Lærke Smidt, Christensen, Mikkel Bring & Knop, Filip Krag, 2023, In: STAR Protocols. 4, 1, 10 p., 102070.

    Research output: Contribution to journalJournal articleResearchpeer-review

  51. Published

    Liraglutide treatment is associated with progression of coronary artery fibrous plaque: a prospective 1-year follow-up study in asymptomatic patients with type 2 diabetes

    Heinsen, L. J., Pararajasingam, G., Andersen, T. R., Auscher, S., Sheta, H. M., Precht, H., Engdam, K. B., Hangaard, J., Lambrechtsen, J., Knop, Filip Krag & Egstrup, K., 2023, In: BMC Cardiovascular Disorders. 23, 1, 8 p., 214.

    Research output: Contribution to journalJournal articleResearchpeer-review

  52. Published

    No effect of the turmeric root phenol curcumin on prednisolone-induced gluco-metabolic perturbations in men with overweight or obesity

    Hellmann, P. H., Bagger, J. I., Carlander, K. R., Hansen, K. B., Forman, Julie Lyng, Størling, Joachim, Chabanova, E., Holst, Jens Juul, Vilsbøll, Tina & Knop, Filip Krag, 2023, In: Endocrine Connections. 12, 4, e220334.

    Research output: Contribution to journalJournal articleResearchpeer-review

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