Flemming Pociot
Clinical Professor
Department of Clinical Medicine
Blegdamsvej 3
2200 København N.
Member of:
Internal Medicine: Endocrinology
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25-Hydroxyvitamin D and Peripheral Immune Mediators: Results from Two Nationwide Danish Pediatric Cohorts
Thorsen, S., Pipper, C., Skogstrand, K., Pociot, Flemming & Svensson, Jannet, Apr 2017, In: Nutrients. 9, 4, 10 p., 365.Research output: Contribution to journal › Journal article › Research › peer-review
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25-hydroxyvitamin D, autoantigenic and total antibody concentrations: Results from a Danish case-control study of newly diagnosed patients with childhood type 1 diabetes and their healthy siblings
Thorsen, S. U., Pipper, C. B., Johannesen, Jesper, Mortensen, H. B., Pociot, Flemming & Svensson, Jannet, 2018, In: Scandinavian Journal of Immunology. 87, 1, p. 46-53 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Skap2, a candidate gene for type 1 diabetes, regulates b-cell apoptosis and glycemic control in newly diagnosed patients
Fløyel, T., Meyerovich, K., Prause, Michala Cecilie Burstein, Kaur, S., Frørup, C., Mortensen, H. B., Nielsen, L. B., Pociot, Flemming, Cardozo, A. K. & Størling, Joachim, 2021, In: Diabetes. 70, 2, p. 464-476 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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TYK2, a Candidate Gene for Type 1 Diabetes, Modulates Apoptosis and the Innate Immune Response in Human Pancreatic β-Cells
Marroqui, L., Dos Santos, R. S., Fløyel, T., Grieco, F. A., Santin, I., Op de Beeck, A., Marselli, L., Marchetti, P., Pociot, Flemming & Eizirik, D. L., Nov 2015, In: Diabetes. 64, 11, p. 3808-17 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A Dual Systems Genetics Approach Identifies Common Genes, Networks, and Pathways for Type 1 and 2 Diabetes in Human Islets
Kaur, S., Mirza, A. H., Overgaard, A. J., Pociot, Flemming & Størling, Joachim, 2021, In: Frontiers in Genetics. 12, 630109.Research output: Contribution to journal › Journal article › Research › peer-review
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A Gluten-Free Diet during Pregnancy and Early Life Increases Short Chain Fatty Acid-Producing Bacteria and Regulatory T Cells in Prediabetic NOD Mice
Johansen, Valdemar Brimnes Ingemann, Færø, D., Buschard, K., Kristiansen, Karsten, Pociot, Flemming, Kiilerich, P., Josefsen, K., Haupt-jorgensen, M. & Antvorskov, J. C., 2023, In: Cells. 12, 12, 15 p., 1567.Research output: Contribution to journal › Journal article › Research › peer-review
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A Systematic Comparison of Purification and Normalization Protocols for Quantitative MicroRNA Expressional Profiling in Insulin-Producing Cells
Vestergaard, A. L., Blankestijn, M., Stahl, J. L., Pallesen, E. M. H., Bang-Berthelsen, C. H., Pociot, Flemming, Novotny, G. W., Lundh, M. & Mandrup-Poulsen, Thomas, 2016, In: International Journal of Molecular Sciences (Online). 17, 6, 8 p., 896.Research output: Contribution to journal › Comment/debate › Research › peer-review
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A human phenome-interactome network of protein complexes implicated in genetic disorders
Lage, K., Karlberg, E. O., Størling, Z. M., Olason, P. I., Pedersen, A. G., Rigina, O., Hinsby, A. M., Tümer, Asuman Zeynep, Pociot, Flemming, Tommerup, Niels, Moreau, Y. & Brunak, S., 2007, In: Nature Biotechnology. 25, 3, p. 309-16 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A human type 1 diabetes susceptibility locus maps to chromosome 21q22.3
Concannon, P., Onengut-Gumuscu, S., Todd, J. A., Smyth, D. J., Pociot, Flemming, Bergholdt, R., Akolkar, B., Erlich, H. A., Hilner, J. E., Julier, C., Morahan, G., Nerup, J., Nierras, C. R., Chen, W. M. & Rich, S. S., 2008, In: Diabetes. 57, 10, p. 2858-2861 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A non-synonymous variant in SLC30A8 is not associated with type 1 diabetes in the Danish population
Brorsson, C., Bergholdt, R., Sjogren, M., Eising, S., Sorensen, K. M., Hougaard, D. M., Orho-Melander, M., Groop, L. & Pociot, Flemming, 2008, In: Molecular Genetics and Metabolism. 94, 3, p. 386-388 2 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A possible association between a dysfunctional skin barrier (filaggrin null-mutation status) and diabetes: a cross-sectional study
Thyssen, Jacob Pontoppidan, Linneberg, Allan René, Carlsen, B. C., Johansen, Jeanne Duus, Engkilde, K., Hansen, Torben, Pociot, Flemming, Pedersen, Oluf Borbye, Meldgaard, M., Szecsi, P. B., Stender, Steen & Menné, T., 1 Jan 2011, In: BMJ Open. 1, 1, p. e000062 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A20 Inhibits β-Cell Apoptosis by Multiple Mechanisms and Predicts Residual β-Cell Function in Type 1 Diabetes
Fukaya, M., Brorsson, C. A., Meyerovich, K., Catrysse, L., Delaroche, D., Vanzela, E. C., Ortis, F., Beyaert, R., Nielsen, L. B., Andersen, M. L. M., Mortensen, H. B., Pociot, Flemming, van Loo, G., Størling, J. & Cardozo, A. K., Jan 2016, In: Molecular endocrinology (Baltimore, Md.). 30, 1, p. 48-61 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Abnormal islet sphingolipid metabolism in type 1 diabetes
Holm, L. J., Krogvold, L., Hasselby, Jane Preuss, Kaur, S., Claessens, L. A., Russell, M. A., Mathews, C. E., Hanssen, K. F., Morgan, N. G., Koeleman, B. P. C., Roep, B. O., Gerling, I. C., Pociot, Flemming, Dahl-Jørgensen, K. & Buschard, K., 2018, In: Diabetologia. 61, 7, p. 1650-1661 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Alu Elements as Novel Regulators of Gene Expression in Type 1 Diabetes Susceptibility Genes?
Kaur, S. & Pociot, Flemming, 2015, In: Genes. 6, 3, p. 577-91 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Anti-diabetic potential of Urtica Dioica: current knowledge and future direction
Chehri, A., Yarani, R., Yousefi, Z., Novin Bahador, T., Shakouri, S. K., Ostadrahimi, A., Mobasseri, M., Pociot, Flemming & Araj-Khodaei, M., 2022, In: Journal of Diabetes and Metabolic Disorders. 21, 1, p. 931-940 10 p.Research output: Contribution to journal › Review › Research › peer-review
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Anti-diabetic potential of plant alkaloids: Revisiting current findings and future perspectives
Rasouli, H., Yarani, R., Pociot, Flemming & Popović-Djordjević, J., May 2020, In: Pharmacological Research. 155, 15 p., 104723.Research output: Contribution to journal › Review › Research › peer-review
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Assisting the implementation of screening for type 1 diabetes by using artificial intelligence on publicly available data
Teixeira, P. F., Battelino, T., Carlsson, A., Gudbjörnsdottir, S., Hannelius, U., von Herrath, M., Knip, M., Korsgren, O., Elding Larsson, H., Lindqvist, A., Ludvigsson, J., Lundgren, M., Nowak, C., Pettersson, P., Pociot, Flemming, Sundberg, F., Åkesson, K., Lernmark, Å. & Forsander, G., 2024, In: Diabetologia. 67, 6, p. 985-994Research output: Contribution to journal › Journal article › Research › peer-review
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Association between Neonatal Whole Blood Iron Content and Cytokines, Adipokines, and Other Immune Response Proteins
Thorsen, S. U., Pipper, C. B., Ellervik, Christina, Pociot, Flemming, Kyvsgaard, J. N. & Svensson, Jannet, 2019, In: Nutrients. 11, 3, 12 p., 543.Research output: Contribution to journal › Journal article › Research › peer-review
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Association of a functional 17beta-estradiol sensitive IL6-174G/C promoter polymorphism with early-onset type 1 diabetes in females
Kristiansen, O. P., Nolsøe, R. L., Larsen, L., Gjesing, A. M. P., Johannesen, J., Larsen, Z. M. E., Lykkesfeldt, A. E., Karlsen, A. E., Pociot, Flemming, Mandrup-Poulsen, Thomas & DIEGG, D., 15 May 2003, In: Human Molecular Genetics. 12, 10, p. 1101-10 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Bone Mineral Density Is Increased in 276 Danish Children and Adolescents with Type-1-Diabetes
Madsen, J. O. B., Herskin, C. W., Zerahn, B., Olsen, B. S., Pociot, Flemming & Johannesen, Jesper, 2018, ESPE Abstracts. Bioscientifica, Vol. 89. p. 113 (Hormone Research in Paediatrics).Research output: Chapter in Book/Report/Conference proceeding › Article in proceedings › Research › peer-review
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Bone turnover markers during the remission phase in children and adolescents with type 1 diabetes
Madsen, J. O. B., Herskin, C. W., Zerahn, B., Jensen, Andreas Kryger, Jørgensen, Niklas Rye, Olsen, B. S., Svensson, Jannet, Pociot, Flemming & Johannesen, Jesper, 2020, In: Pediatric Diabetes. 21, 2, p. 366-376 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Bone turnover markers in children and adolescents with type 1 diabetes
Madsen, J. O. B., Jørgensen, N. R., Pociot, Flemming & Johannesen, Jesper, 2019, In: Pediatric Diabetes. 20, 5, p. 510-522Research output: Contribution to journal › Review › Research › peer-review
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Breast Milk-Derived Extracellular Vesicles Enriched in Exosomes From Mothers With Type 1 Diabetes Contain Aberrant Levels of microRNAs
Mirza, A. H., Kaur, S., Nielsen, L. B., Størling, J., Yarani, R., Roursgaard, Martin, Mathiesen, Elisabeth, Damm, Peter, Svare, J., Mortensen, H. B. & Pociot, Flemming, 2019, In: Frontiers in Immunology. 10, p. 2543Research output: Contribution to journal › Journal article › Research › peer-review
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CTSH regulates β-cell function and disease progression in newly diagnosed type 1 diabetes patients
Fløyel, T., Brorsson, C., Nielsen, L. B., Miani, M., Bang-Berthelsen, C. H., Friedrichsen, M., Overgaard, A. J., Berchtold, L. A., Wiberg, A., Poulsen, P., Hansen, L., Rosinger, S., Boehm, B. O., Ram, R., Nguyen, Q., Mehta, M., Morahan, G., Concannon, P., Bergholdt, R., Nielsen, J. H. & 7 others, , 15 Jul 2014, In: Proceedings of the National Academy of Sciences of the United States of America. 111, 28, p. 10305-10310 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Capturing residual beta cell function in type 1 diabetes
Pociot, Flemming, 2019, In: Diabetologia. 62, 1, p. 28-32 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Cathepsin c regulates cytokine-induced apoptosis in β-cell model systems
Fløyel, T., Frørup, C., Størling, Joachim & Pociot, Flemming, 2021, In: Genes. 12, 11, 1694.Research output: Contribution to journal › Journal article › Research › peer-review
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Cell Type-Selective Expression of Circular RNAs in Human Pancreatic Islets
Kaur, S., Mirza, A. H. & Pociot, Flemming, 2018, In: Non-coding RNA. 4, 4, 20 p., 38.Research output: Contribution to journal › Journal article › Research › peer-review
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Changes in the lipidome in type 1 diabetes following low carbohydrate diet: Post-hoc analysis of a randomized crossover trial
Al-Sari, N., Schmidt, S., Suvitaival, T., Kim, M., Trošt, K., Ranjan, A. G., Christensen, M. B., Overgaard, A. J., Pociot, Flemming, Nørgaard, Kirsten & Legido-Quigley, C., 2021, In: Endocrinology, Diabetes and Metabolism. 4, 2, e00213.Research output: Contribution to journal › Journal article › Research › peer-review
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Characterization of plasma lipidomics in adolescent subjects with increased risk for type 1 diabetes in the DiPiS cohort
Andersson Svärd, A., Kaur, S., Trôst, K., Suvitaival, T., Lernmark, Å., Maziarz, M., Pociot, Flemming, Overgaard, A. J. & DiPiS Study Group, D. S. G., 2020, In: Metabolomics : Official journal of the Metabolomic Society. 16, 10, 14 p., 10.Research output: Contribution to journal › Journal article › Research › peer-review
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Characterization of the functional and transcriptomic effects of pro-inflammatory cytokines on human EndoC-βH5 beta cells
Frørup, C., Gerwig, R., Svane, C. A. S., Mendes Lopes de Melo, J., Henriksen, K., Fløyel, T., Pociot, Flemming, Kaur, S. & Størling, Joachim, 2023, In: Frontiers in Endocrinology. 14, 15 p., 1128523.Research output: Contribution to journal › Journal article › Research › peer-review
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Children at onset of type 1 diabetes show altered N-glycosylation of plasma proteins and IgG
Rudman, N., Kifer, D., Kaur, S., Simunović, V., Cvetko, A., Pociot, Flemming, Morahan, G. & Gornik, O., 2022, In: Diabetologia. 65, 8, p. 1315-1327 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Circulating Inflammatory Markers Are Inversely Associated with Heart Rate Variability Measures in Type 1 Diabetes
Wegeberg, A. L., Okdahl, T., Fløyel, T., Brock, C., Ejskjaer, N., Riahi, S., Pociot, Flemming, Størling, Joachim & Brock, Birgitte, 2020, In: Mediators of Inflammation. 2020, 10 p., 3590389.Research output: Contribution to journal › Journal article › Research › peer-review
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Circulating MicroRNAs in Plasma of Hepatitis B e Antigen Positive Children Reveal Liver-Specific Target Genes
Winther, T. N., Jacobsen, K. S., Mirza, A. H., Heiberg, I. L., Bang-Berthelsen, C. H., Pociot, Flemming & Høgh, Birthe, 2014, In: International Journal of Hepatology. 2014, p. 791045Research output: Contribution to journal › Journal article › Research › peer-review
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Circulating microRNA levels predict residual beta cell function and glycaemic control in children with type 1 diabetes mellitus
Samandari, N., Mirza, A. H., Nielsen, L. B., Kaur, S., Hougaard, P., Fredheim, S., Mortensen, H. B. & Pociot, Flemming, 2017, In: Diabetologia. 60, 2, p. 354-363Research output: Contribution to journal › Journal article › Research › peer-review
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Cross-species high-resolution transcriptome profiling suggests biomarkers and therapeutic targets for ulcerative colitis
Yarani, R., Palasca, Oana, Doncheva, Nadezhda Tsankova, Anthon, Christian, Pilecki, B., Svane, C. A. S., Mirza, A. H., Litman, Thomas, Holmskov, U., Bang-Berthelsen, C. H., Vilien, M., Jensen, Lars Juhl, Gorodkin, Jan & Pociot, Flemming, 2023, In: Frontiers in Molecular Biosciences. 9, 1081176.Research output: Contribution to journal › Journal article › Research › peer-review
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Decreased markers of bone turnover in children and adolescents with type 1 diabetes
Madsen, J. O. B., Herskin, C. W., Zerahn, B., Jørgensen, Niklas Rye, Olsen, B. S., Pociot, Flemming & Johannesen, Jesper, 2020, In: Pediatric Diabetes. 21, 3, p. 505-514Research output: Contribution to journal › Journal article › Research › peer-review
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Diabetes complications and extracellular vesicle therapy
Soltani, S., Mansouri, K., Parvaneh, S., Thakor, A. S., Pociot, Flemming & Yarani, R., 2022, In: Reviews in Endocrine and Metabolic Disorders. 23, p. 357–385Research output: Contribution to journal › Review › Research › peer-review
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Differences in insulin sensitivity in the partial remission phase of childhood type 1 diabetes: a longitudinal cohort study
Mørk, F. C. B., Madsen, J. O. B., Jensen, Andreas Kryger, van Hall, Gerrit, Pilgaard, Kasper Ascanius, Pociot, Flemming & Johannesen, Jesper, 2022, In: Diabetic Medicine. 39, 2, 9 p., 14702.Research output: Contribution to journal › Journal article › Research › peer-review
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Differential plasma microRNA profiles in HBeAg positive and HBeAg negative children with chronic hepatitis B
Winther, T. N., Bang-Berthelsen, C. H., Heiberg, I. L., Pociot, Flemming & Høgh, Birthe, 2013, In: PLOS ONE. 8, 3, p. e58236Research output: Contribution to journal › Journal article › Research › peer-review
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Differentially Expressed miRNAs in Ulcerative Colitis and Crohn's Disease
Yarani, R., Shojaeian, A., Palasca, Oana, Doncheva, Nadezhda Tsankova, Jensen, Lars Juhl, Gorodkin, Jan & Pociot, Flemming, 2022, In: Frontiers in Immunology. 13, 21 p., 865777.Research output: Contribution to journal › Review › Research › peer-review
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Divalent metal transporter 1 regulates iron-mediated ROS and pancreatic ß cell fate in response to cytokines
Hansen, J. B., Tonnesen, M. F., Madsen, A. N., Hagedorn, P., Friberg, J., Grunnet, L. G., Heller, R. S., Nielsen, A. Ø., Størling, J., Baeyens, L., Anker-Kitai, L., Qvortrup, K., Bouwens, L., Efrat, S., Aalund, M., Andrews, N. C., Billestrup, N., Karlsen, A. E., Holst, B., Pociot, F. & 1 others, , 2012, In: Cell Metabolism. 16, 4, p. 449-61 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Does rapid sequence divergence preclude RNA structure conservation in vertebrates?
Seemann, Ernst Stefan, Mirza, A. H., Bang-Berthelsen, C. H., Garde, C., Christensen-Dalsgaard, M., Workman, C. T., Pociot, Flemming, Tommerup, Niels, Gorodkin, Jan & Ruzzo, W. L., 2022, In: Nucleic Acids Research. 50, 5, p. 2452-2463 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Effects of the genome on immune regulation in type 1 diabetes
Pociot, Flemming, Kaur, S. & Nielsen, L. B., Jul 2016, In: Pediatric Diabetes. 17 , S22, p. 37-42 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Elevated levels of interleukin-12/23p40 may serve as a potential indicator of dysfunctional heart rate variability in type 2 diabetes
Wegeberg, A. M., Okdahl, T., Riahi, S., Ejskjaer, N., Pociot, Flemming, Størling, Joachim, Brock, Birgitte & Brock, C., 2022, In: Cardiovascular Diabetology. 21, 1, 10 p., 5.Research output: Contribution to journal › Journal article › Research › peer-review
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Expression profiling of human genetic and protein interaction networks in type 1 diabetes
Bergholdt, R., Brorsson, C., Lage, K., Nielsen, Jens Høiriis, Brunak, S. & Pociot, Flemming, 2009, In: PLoS ONE. 4, 7, p. e6250Research output: Contribution to journal › Journal article › Research › peer-review
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Extracellular Vesicle Therapy for Type 1 Diabetes
Soltani, S., Mansouri, K., Emami Aleagha, M. S., Moasefi, N., Yavari, Niloofar, Shakouri, S. K., Notararigo, S., Shojaeian, A., Pociot, Flemming & Yarani, R., 2022, In: Frontiers in Immunology. 13, 865782.Research output: Contribution to journal › Review › Research › peer-review
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Finding diabetic nephropathy biomarkers in the plasma peptidome by high-throughput magnetic bead processing and MALDI-TOF-MS analysis
Hansen, H. G., Overgaard, J., Lajer, M., Hubalek, F., Højrup, P., Pedersen, L., Tarnow, L., Rossing, Peter, Pociot, Flemming & McGuire, J. N., 1 Sep 2010, In: Proteomics - Clinical Applications. 4, 8-9, p. 697-705 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Fine-mapping, trans-ancestral and genomic analyses identify causal variants, cells, genes and drug targets for type 1 diabetes
Robertson, C. C. & Type 1 Diabetes Genetics Consortium, T. 1. D. G. C., 2021, In: Nature Genetics. 53, 7, p. 962-971 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Functional SOCS1 polymorphisms are associated with variation in obesity in whites
Gylvin, T., Ek, J., Nolsøe, R., Albrechtsen, A., Andersen, G., Bergholdt, R., Brorsson, C., Bang-Berthelsen, C. H., Hansen, T., Karlsen, A. E., Billestrup, N., Borch-Johnsen, K., Jørgensen, T., Pedersen, Oluf Borbye, Mandrup-Poulsen, Thomas, Nerup, J. & Pociot, Flemming, 2009, In: Diabetes, Obesity and Metabolism. 11, 3, p. 196-203 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Functional promoter haplotypes of the human FAS gene are associated with the phenotype of SLE characterized by thrombocytopenia
Nolsøe, R. L., Kelly, J. A., Pociot, Flemming, Moser, K., Kristiansen, O. P., Mandrup-Poulsen, Thomas & Harley, J. B., 1 Dec 2005, In: Genes and Immunity. 6, 8, p. 699-706 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Further evidence that mutations in INS can be a rare cause of Maturity-Onset Diabetes of the Young (MODY)
Boesgaard, T. W., Pruhova, S., Andersson, E. A., Cinek, O., Obermannova, B., Lauenborg, J., Damm, Peter, Bergholdt, R., Pociot, Flemming, Pisinger, C., Barbetti, F., Lebl, J., Pedersen, Oluf Borbye & Hansen, Torben, 1 Jan 2010, In: B M C Medical Genetics. 11, p. 42Research output: Contribution to journal › Journal article › Research › peer-review
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GLP-1 Induces Barrier Protective Expression in Brunner's Glands and Regulates Colonic Inflammation
Bang-Berthelsen, C. H., Holm, T. L., Pyke, C., Simonsen, L., Søkilde, R., Pociot, Flemming, Heller, R. S., Folkersen, L., Kvist, P. H., Jackerott, M., Fleckner, J., Vilien, M., Knudsen, L. B., Heding, A. & Frederiksen, K. S., Sep 2016, In: Inflammatory Bowel Diseases. 22, 9, p. 2078-97 20 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Gene expression signature predicts rate of type 1 diabetes progression
Suomi, T., Starskaia, I., Kalim, U. U., Rasool, O., Jaakkola, M. K., Grönroos, T., Välikangas, T., Brorsson, C., Mazzoni, G., Bruggraber, S., Overbergh, L., Dunger, D., Peakman, M., Chmura, P., Brunak, S., Schulte, A. M., Mathieu, C., Knip, M., Lahesmaa, R., Elo, L. L. & 4 others, , 2023, In: EBioMedicine. 92, 18 p., 104625.Research output: Contribution to journal › Journal article › Research › peer-review
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Genes affecting β-cell function in type 1 diabetes
Fløyel, T., Kaur, S. & Pociot, Flemming, Nov 2015, In: Current Diabetes Reports. 15, 11, p. 1-11 15-97.Research output: Contribution to journal › Journal article › Research › peer-review
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Genetic Determinants of Enterovirus Infections: Polymorphisms in Type 1 Diabetes and Innate Immune Genes in the MIDIA Study
Witsø, E., Cinek, O., Tapia, G., Brorsson, C. A., Stene, L. C., Gjessing, H. K., Rasmussen, T., Bergholdt, R., Pociot, Flemming & Rønningen, K. S., Dec 2015, In: Viral Immunology. 28, 10, p. 556-63 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Genetic Risk Score Modelling for Disease Progression in New-Onset Type 1 Diabetes Patients: Increased Genetic Load of Islet-Expressed and Cytokine-Regulated Candidate Genes Predicts Poorer Glycemic Control
Brorsson, C. A., Nielsen, L. B., Andersen, M., Kaur, S., Bergholdt, R., Hansen, L., Mortensen, H. B., Pociot, Flemming, Størling, J. & Hvidoere Study Group On Childhood Diabetes, H. S. G. O. C. D., 2016, In: Journal of Diabetes Research. 2016, 8 p., 9570424.Research output: Contribution to journal › Journal article › Research › peer-review
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Genetic Variants Associated with Neuropeptide Y Autoantibody Levels in Newly Diagnosed Individuals with Type 1 Diabetes
Mansachs, S. J., Villumsen, S. O., Johannesen, Jesper, Lind, A., Kaur, S. & Pociot, Flemming, 2022, In: Genes. 13, 5, 869.Research output: Contribution to journal › Journal article › Research › peer-review
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Genetic association study in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) identifies several potential risk loci
Hajdarevic, R., Lande, A., Mehlsen, J., Rydland, A., Sosa, D. D., Strand, E. B., Mella, O., Pociot, Flemming, Fluge, Ø., Lie, B. A. & Viken, M. K., 2022, In: Brain, Behavior, and Immunity. 102, p. 362-369 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Genetic predisposition in the 2′-5′A pathway in the development of type 1 diabetes: potential contribution to dysregulation of innate antiviral immunity
Pedersen, K., Haupt-Jorgensen, M., Krogvold, L., Kaur, S., Gerling, I. C., Pociot, Flemming, Dahl-Jørgensen, K. & Buschard, K., Aug 2021, In: Diabetologia. 64, 8, p. 1805-1815 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Genetic risk factors for type 1 diabetes
Pociot, Flemming & Lernmark, Å., Jun 2016, In: The Lancet. 387, 10035, p. 2331-9 9 p.Research output: Contribution to journal › Review › Research › peer-review
Genetic versus Non-Genetic Regulation of miR-103, miR-143 and miR-483-3p Expression in Adipose Tissue and Their Metabolic Implications-A Twin Study
Bork-Jensen, J., Thuesen, A. C. B., Bang-Bertelsen, C. H., Grunnet, Louise Groth, Pociot, Flemming, Beck-Nielsen, H., Ozanne, S. E., Poulsen, P. & Vaag, A., 2014, In: Genes. 5, 3, p. 508-17 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes
Barrett, J. C., Clayton, D. G., Concannon, P., Akolkar, B., Cooper, J. D., Erlich, H. A., Julier, C., Morahan, G., Nerup, J., Nierras, C., Plagnol, V., Pociot, Flemming, Schuilenburg, H., Smyth, D. J., Stevens, H., Todd, J. A., Walker, N. M., Rich, S. S. & The Type 1 Diabetes Genetics Consortium, T. T. 1. D. G. C., 2009, In: Nature Genetics.Research output: Contribution to journal › Journal article › Research › peer-review
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Genome-wide scan for linkage to type 1 diabetes in 2,496 multiplex families from the type 1 diabetes genetics consortium
Concannon, P., Chen, W. M., Julier, C., Morahan, G., Akolkar, B., Erlich, H. A., Hilner, J. E., Nerup, J., Nierras, C., Pociot, Flemming, Todd, J. A. & Rich, S. S., 2009, In: Diabetes. 58, 4, p. 1018-1022 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Hepatitis B surface antigen quantity positively correlates with plasma levels of microRNAs differentially expressed in immunological phases of chronic hepatitis B in children
Winther, T. N., Heiberg, I. L., Bang-Berthelsen, C. H., Pociot, Flemming & Høgh, Birthe, 2013, In: PLoS ONE. 8, 11, p. e80384Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Hepatitis B virus suppresses the secretion of insulin-like growth factor binding protein 1 to facilitate anti-apoptotic IGF-1 effects in HepG2 cells
Nielsen, K. O., Mirza, A. H., Kaur, S., Jacobsen, K. S., Winther, T. N., Glebe, D., Pociot, Flemming, Høgh, Birthe & Størling, J., 15 Sep 2018, In: Experimental Cell Research. 370, 2, p. 399-408 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Hepatitis B virus upregulates host microRNAs that target apoptosis-regulatory genes in an in vitro cell model
Nielsen, K. O., Jacobsen, K. S., Mirza, A. H., Winther, T. N., Størling, J., Glebe, D., Pociot, Flemming & Høgh, Birthe, 2018, In: Experimental Cell Research. 371, 1, p. 92-103Research output: Contribution to journal › Journal article › Research › peer-review
- Published
High neonatal blood iron content is associated with the risk of childhood type 1 diabetes mellitus
Kyvsgaard, J. N., Overgaard, A. J., Thorsen, S. U., Hansen, Thomas Hesselhøj, Pipper, C. B., Mortensen, H. B., Pociot, Flemming & Svensson, Jannet, 2017, In: Nutrients. 9, 11, 10 p., 1221.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
High-Throughput Human Complement C3 N-Glycoprofiling Identifies Markers of Early Onset Type 1 Diabetes Mellitus in Children
Šoić, D., Keser, T., Štambuk, J., Kifer, D., Pociot, Flemming, Lauc, G., Morahan, G., Novokmet, M. & Gornik, O., 2022, In: Molecular and Cellular Proteomics. 21, 10, 100407.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Home capillary sampling and screening for type 1 diabetes, celiac disease, and autoimmune thyroid disease in a Swedish general pediatric population: the TRIAD study
Naredi Scherman, M., Lind, A., Hamdan, S., Lundgren, M., Svensson, J., Pociot, Flemming & Agardh, D., 2024, In: Frontiers in Pediatrics. 12, 10 p., 1386513.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Human pathways in animal models: possibilities and limitations
Doncheva, Nadezhda Tsankova, Palasca, Oana, Yarani, R., Litman, Thomas, Anthon, Christian, Groenen, M. A. M., Stadler, P. F., Pociot, Flemming, Jensen, Lars Juhl & Gorodkin, Jan, 2021, In: Nucleic Acids Research. 49, 4, p. 1859-1871 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Huntingtin-interacting protein 14 is a type 1 diabetes candidate protein regulating insulin secretion and beta-cell apoptosis
Berchtold, L. A., Størling, Z. M., Ortis, F., Lage, K., Bang-Berthelsen, C., Bergholdt, R., Hald, J., Brorsson, C. A., Eizirik, D. L., Pociot, Flemming, Brunak, Søren & Størling, Joachim, 2011, In: PNAS Early Edition. 108, 37, p. E681-8Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Hypoglycemia, S-ACE and ACE genotypes in a Danish nationwide population of children and adolescents with type 1 diabetes
Johannesen, Jesper, Svensson, Jannet, Bergholdt, R., Eising, S., Gramstrup, H., Frandsen, E., Dick-Nielsen, J., Hansen, L., Pociot, Flemming, Mortensen, H. B. & Danish Society for Diabetes in Childhood and Adolescence, D. S. F. D. I. C. A. A., Mar 2011, In: Pediatric Diabetes Online. 12, 2, p. 100-6 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Identification of T1D susceptibility genes within the MHC region by combining protein interaction networks and SNP genotyping data
Brorsson, C., Hansen, N. T., Lage, K., Bergholdt, R., Brunak, Søren, Pociot, Flemming & Diabetes Genetics Consortium, D. G. C., Feb 2009, In: Diabetes, Obesity and Metabolism Online. 11, SUPPL. 1, p. 60-6 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Identification of a type 1 diabetes-associated CD4 promoter haplotype with high constitutive activity
Kristiansen, O. P., Karlsen, A. E., Larsen, Z. M., Johannesen, Jesper, Pociot, Flemming, Mandrup-Poulsen, Thomas & Danish IDDM Epidemiology and Genetics Group and Danish Study Group of IDDM in Childhood, D. I. E. A. G. G. A. D. S. G. O. I. I. C., 1 Jun 2004, In: Scandinavian Journal of Immunology. 59, 6, p. 582-91 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Identification of valid reference genes for microRNA expression studies in a hepatitis B virus replicating liver cell line
Jacobsen, K. S., Nielsen, K. O., Nordmann Winther, T., Glebe, D., Pociot, Flemming & Høgh, Birthe, 22 Jan 2016, In: BMC Research Notes. 9, p. 1-7 7 p., 38.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Increased levels of inflammatory factors are associated with severity of polyneuropathy in type 1 diabetes
Okdahl, T., Brock, C., Floyel, T., Wegeberg, A. L., Jakobsen, P. E., Ejskjaer, N., Pociot, Flemming, Brock, Birgitte & Størling, Joachim, 2020, In: Clinical Endocrinology. 93, 4, p. 419-428Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Increased mortality in a Danish cohort of young people with Type 1 diabetes mellitus followed for 24 years
Sandahl, K., Nielsen, L. B., Svensson, Jannet, Johannesen, Jesper, Pociot, Flemming, Mortensen, H. B., Hougaard, P., Broe, R., Rasmussen, M. L., Grauslund, J., Peto, T. & Olsen, B. S., Mar 2017, In: Diabetic Medicine. 34, 3, p. 380–386Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Influence of Disease Duration on Circulating Levels of miRNAs in Children and Adolescents with New Onset Type 1 Diabetes
Samandari, N., Mirza, A. H., Kaur, S., Hougaard, P., Nielsen, L. B., Fredheim, S., Mortensen, H. B. & Pociot, Flemming, 2018, In: Non-coding RNA. 4, 4, 12 p., 35.Research output: Contribution to journal › Journal article › Research › peer-review
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Integrated glycomics and genetics analyses reveal a potential role for N-glycosylation of plasma proteins and IgGs, as well as the complement system, in the development of type 1 diabetes
Rudman, N., Kaur, S., Simunović, V., Kifer, D., Šoić, D., Keser, T., Štambuk, T., Klarić, L., Pociot, Flemming, Morahan, G. & Gornik, O., 2023, In: Diabetologia. 66, 6, p. 1071-1083 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Integrative analysis for finding genes and networks involved in diabetes and other complex diseases
Bergholdt, R., Størling, Z. M., Lage, K., Karlberg, E. O., Olason, P. I., Aalund, M., Nerup, J., Brunak, Søren, Workman, C. & Pociot, Flemming, 2007, In: Genome Biology (Online Edition). 8, 11, p. R253Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Levels of soluble TREM-1 in children with newly diagnosed type 1 diabetes and their siblings without type 1 diabetes: a Danish case-control study
Thorsen, S. U., Pipper, C. B., Mortensen, H. B., Skogstrand, K., Pociot, Flemming, Johannesen, Jesper, Svensson, Jannet & the Danish Childhood Diabetes Register, T. D. C. D. R., Dec 2017, In: Pediatric Diabetes. 18, 8, p. 749–754Research output: Contribution to journal › Journal article › Research › peer-review
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Linking glycemic dysregulation in diabetes to symptoms, comorbidities, and genetics through EHR data mining
Kirk, I. K., Simon, C., Banasik, K., Holm, P. C., Haue, A. D., Jensen, P. B., Jensen, L. J., Rodriguez, C. L., Pedersen, M. K., Eriksson, R., Andersen, H. U., Almdal, T., Bork-Jensen, J., Grarup, N., Borch-Johnsen, K., Pedersen, O., Pociot, F., Hansen, T., Bergholdt, R., Rossing, P. & 1 others, , 2019, In: eLife. 8, 19 p., e44941.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Lipidomic and metabolomic characterization of a genetically modified mouse model of the early stages of human type 1 diabetes pathogenesis
Overgaard, A. J., Weir, J. M., De Souza, D. P., Tull, D., Haase, C., Meikle, P. J. & Pociot, Flemming, Jan 2016, In: Metabolomics. 12, p. 1-9 9 p., 13.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Lipidomics of human adipose tissue reveals diversity between body areas
Al-Sari, N., Suvitaival, T., Mattila, I., Ali, A., Ahonen, L., Trost, K., Henriksen, T. F., Pociot, Flemming, Dragsted, Lars Ove & Legido-Quigley, C., 2020, In: P L o S One. 15, 6, 15 p., e0228521.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Long Noncoding RNAs in Diabetes and β-Cell Regulation
Kaur, S., Frørup, C., Jensen, V. H., Mirza, A. H., de Melo, J. M. L., Yarani, R., Overgaard, A. J., Størling, J. & Pociot, Flemming, 2020, The Chemical Biology of Long Noncoding RNAs: RNA Technologies. Jurga, S. & Barciszewski, J. (eds.). Springer, Vol. 11. p. 523-544Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Long non-coding RNAs as novel players in β cell function and type 1 diabetes
Mirza, A. H., Kaur, S. & Pociot, Flemming, 24 Jul 2017, In: Human Genomics (Online). 11, 10 p., 17.Research output: Contribution to journal › Review › Research › peer-review
- Published
Low perinatal zinc status is not associated with the risk of type 1 diabetes in children
Kyvsgaard, J. N., Overgaard, A. J., Jacobsen, L. D., Thorsen, S. U., Pipper, C. B., Hansen, Thomas Hesselhøj, Husted, Søren, Mortensen, H. B., Pociot, Flemming & Svensson, Jannet, 2017, In: Pediatric Diabetes. 18, 7, p. 637–642 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Low-grade inflammation in type 2 diabetes: A cross-sectional study from a Danish diabetes outpatient clinic
Okdahl, T., Wegeberg, A. M., Pociot, Flemming, Brock, Birgitte, Størling, Joachim & Brock, C., 2022, In: BMJ Open. 12, 12, 10 p., e062188.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mass spectrometry is only one piece of the puzzle in clinical proteomics
McGuire, J. N., Overgaard, J. & Pociot, Flemming, 2008, In: Briefings in Functional Genomics and Proteomics. 7, 1, p. 74-83 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Metabolomic Biomarkers in the Progression to Type 1 Diabetes
Overgaard, A. J., Kaur, S. & Pociot, Flemming, Dec 2016, In: Current Diabetes Reports. 16, 5 p., 127.Research output: Contribution to journal › Review › Research › peer-review
- Published
MicroRNAs and histone deacetylase inhibition-mediated protection against inflammatory β-cell damage
Vestergaard, A. L., Bang-Berthelsen, C. H., Floyel, T., Stahl, J. L., Christen, L., Sotudeh, F. T., Horskjaer, P. D. H., Frederiksen, K. S., Kofod, F. G., Bruun, C., Berchtold, L. A., Storling, J., Regazzi, R., Kaur, S., Pociot, Flemming & Mandrup-Poulsen, Thomas, 27 Sep 2018, In: PLOS ONE. 13, 9, p. 1-22 22 p., e0203713 .Research output: Contribution to journal › Journal article › Research › peer-review
- Published
MicroRNAs as regulators of beta-cell function and dysfunction
Osmai, M., Osmai, Y., Bang-Berthelsen, C. H., Pallesen, E. M. H., Vestergaard, A. L., Novotny, G. W., Pociot, Flemming & Mandrup-Poulsen, Thomas, May 2016, In: Diabetes - Metabolism: Research and Reviews (Print Edition). 32, 4, p. 334–349 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mutation analysis of suppressor of cytokine signalling 3, a candidate gene in Type 1 diabetes and insulin sensitivity
Gylvin, T., Nolsøe, R., Hansen, Torben, Nielsen, E. M. D., Bergholdt, R., Karlsen, A. E., Billestrup, Nils, Borch-Johnsen, K., Pedersen, O., Mandrup-Poulsen, Thomas, Nerup, J. & Pociot, Flemming, 1 Jul 2004, In: Diabetologia. 47, 7, p. 1273-7 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Neonatal levels of adiponectin, interleukin-10 and interleukin-12 are associated with the risk of developing type 1 diabetes in childhood and adolescence: A nationwide Danish case-control study
Thorsen, S. U., Pipper, C. B., Eising, S., Skogstrand, K., Hougaard, D. M., Svensson, Jannet & Pociot, Flemming, Jan 2017, In: Clinical Immunology. 174, p. 18–23 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Neonatal vitamin D status is not associated with later risk of type 1 diabetes: results from two large Danish population-based studies
Jacobsen, Ramune, Thorsen, S. U., Cohen, A. S., Lundqvist, M., Frederiksen, P., Pipper, C. B., Pociot, Flemming, Thygesen, L. C., Ascherio, A., Svensson, Jannet & Heitmann, Berit, Sep 2016, In: Diabetologia. 59, 9, p. 1871-1881 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
No Contribution of GAD-65 and IA-2 Autoantibodies around Time of Diagnosis to the Increasing Incidence of Juvenile Type 1 Diabetes: A 9-Year Nationwide Danish Study
Thorsen, S. U., Pipper, C. B., Mortensen, H. B., Pociot, Flemming, Johannesen, Jesper & Svensson, Jannet, 2016, In: International Journal of Endocrinology. 2016, 7 p., 8350158.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
No association between type 1 diabetes and genetic variation in vitamin D metabolism genes: a Danish study
Thorsen, S. U., Mortensen, H. B., Carstensen, Bendix, Fenger, M., Thuesen, B. H., Husemoen, L., Bergholdt, R., Brorsson, C., Pociot, Flemming, Linneberg, Allan René & Svensson, Jannet, Sep 2014, In: Pediatric Diabetes. 15, 6, p. 416-421 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
No association of the IRS1 and PAX4 genes with type I diabetes
Bergholdt, R., Brorsson, C., Boehm, B., Morahan, G. & Pociot, Flemming, 2009, In: Genes and Immunity. 10, p. S49-S53 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
No difference in vitamin d levels between children newly diagnosed with type 1 diabetes and their healthy siblings
Thorsen, S. U., Mortensen, H. B., Carstensen, Bendix, Fenger, M., Thuesen, B. H., Husemoen, L. L., Bergholdt, R., Brorsson, C., Pociot, Flemming, Linneberg, Allan René & Svensson, Jannet, 2013, In: Diabetes Care. 36, 9, p. e157-e158Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Novel Association Between Immune-Mediated Susceptibility Loci and Persistent Autoantibody Positivity in Type 1 Diabetes
Brorsson, C. A., Onengut, S., Chen, W., Wenzlau, J., Yu, L., Baker, P., Williams, A. J. K., Bingley, P. J., Hutton, J. C., Eisenbarth, G. S., Concannon, P., Rich, S. S., Pociot, Flemming & Type 1 Diabetes Genetics Consortium, T. 1. D. G. C., Aug 2015, In: Diabetes. 64, 8, p. 3017-27 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 922065
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Transcriptomic landscape of lncRNAs in inflammatory bowel disease
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Plasma proteome analysis of patients with type 1 diabetes with diabetic nephropathy
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Long non-coding RNAs as novel players in β cell function and type 1 diabetes
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