Assessment of a new model of glucagon action with glucagon receptor dynamics

Research output: Contribution to journal › Conference article › Research › peer-review

Standard

Assessment of a new model of glucagon action with glucagon receptor dynamics. / Furió-Novejarque, Clara; Sanz, Ricardo; Reenberg, Asbjørn Thode; Ritschel, Tobias K.S.; Ranjan, Ajenthen G.; Nørgaard, Kirsten; Díez, Jose Luis; Jørgensen, John Bagterp; Bondia, Jorge.

In: IFAC-PapersOnLine, Vol. 55, No. 20, 2022, p. 647-652.

Research output: Contribution to journal › Conference article › Research › peer-review

Harvard

Furió-Novejarque, C, Sanz, R, Reenberg, AT, Ritschel, TKS, Ranjan, AG, Nørgaard, K, Díez, JL, Jørgensen, JB & Bondia, J 2022, 'Assessment of a new model of glucagon action with glucagon receptor dynamics', IFAC-PapersOnLine, vol. 55, no. 20, pp. 647-652. https://doi.org/10.1016/j.ifacol.2022.09.169

APA

Furió-Novejarque, C., Sanz, R., Reenberg, A. T., Ritschel, T. K. S., Ranjan, A. G., Nørgaard, K., Díez, J. L., Jørgensen, J. B., & Bondia, J. (2022). Assessment of a new model of glucagon action with glucagon receptor dynamics. IFAC-PapersOnLine, 55(20), 647-652. https://doi.org/10.1016/j.ifacol.2022.09.169

Vancouver

Furió-Novejarque C, Sanz R, Reenberg AT, Ritschel TKS, Ranjan AG, Nørgaard K et al. Assessment of a new model of glucagon action with glucagon receptor dynamics. IFAC-PapersOnLine. 2022;55(20):647-652. https://doi.org/10.1016/j.ifacol.2022.09.169

Author

Furió-Novejarque, Clara ; Sanz, Ricardo ; Reenberg, Asbjørn Thode ; Ritschel, Tobias K.S. ; Ranjan, Ajenthen G. ; Nørgaard, Kirsten ; Díez, Jose Luis ; Jørgensen, John Bagterp ; Bondia, Jorge. / Assessment of a new model of glucagon action with glucagon receptor dynamics. In: IFAC-PapersOnLine. 2022 ; Vol. 55, No. 20. pp. 647-652.

Bibtex

@inproceedings{1abfabef188041b4a1be74aeefd4dd71,

title = "Assessment of a new model of glucagon action with glucagon receptor dynamics",

abstract = "In this work, a novel insulin-glucagon-glucose model is proposed, where the glucagon effect on the endogenous glucose production (EGP) is described by the dynamics of the glucagon receptors. In order to assess the quality of the model, its parameters are fitted in such a way that the influence of glucagon on EGP is isolated. Experimental data is used to validate the model structure and show that the receptor dynamics allow to explain some of the glucagon-related phenomena observed in the clinical data. This physiology-focused model will be useful in the development of artificial pancreas algorithms both for more realistic in silico validations and in the development of model-based control strategies.",

keywords = "clinical data, Diabetes, glucagon receptors, parameter estimation, PK-PD model",

author = "Clara Furi{\'o}-Novejarque and Ricardo Sanz and Reenberg, {Asbj{\o}rn Thode} and Ritschel, {Tobias K.S.} and Ranjan, {Ajenthen G.} and Kirsten N{\o}rgaard and D{\'i}ez, {Jose Luis} and J{\o}rgensen, {John Bagterp} and Jorge Bondia",

note = "Publisher Copyright: {\textcopyright} 2022 The Authors.; 10th Vienna International Conference on Mathematical Modelling, MATHMOD 2022 ; Conference date: 27-07-2022 Through 29-07-2022",

year = "2022",

doi = "10.1016/j.ifacol.2022.09.169",

language = "English",

volume = "55",

pages = "647--652",

journal = "IFAC-PapersOnLine",

issn = "2405-8963",

publisher = "IFAC Secretariat",

number = "20",

}

RIS

TY - GEN

T1 - Assessment of a new model of glucagon action with glucagon receptor dynamics

AU - Furió-Novejarque, Clara

AU - Sanz, Ricardo

AU - Reenberg, Asbjørn Thode

AU - Ritschel, Tobias K.S.

AU - Ranjan, Ajenthen G.

AU - Nørgaard, Kirsten

AU - Díez, Jose Luis

AU - Jørgensen, John Bagterp

AU - Bondia, Jorge

PY - 2022

Y1 - 2022

N2 - In this work, a novel insulin-glucagon-glucose model is proposed, where the glucagon effect on the endogenous glucose production (EGP) is described by the dynamics of the glucagon receptors. In order to assess the quality of the model, its parameters are fitted in such a way that the influence of glucagon on EGP is isolated. Experimental data is used to validate the model structure and show that the receptor dynamics allow to explain some of the glucagon-related phenomena observed in the clinical data. This physiology-focused model will be useful in the development of artificial pancreas algorithms both for more realistic in silico validations and in the development of model-based control strategies.

AB - In this work, a novel insulin-glucagon-glucose model is proposed, where the glucagon effect on the endogenous glucose production (EGP) is described by the dynamics of the glucagon receptors. In order to assess the quality of the model, its parameters are fitted in such a way that the influence of glucagon on EGP is isolated. Experimental data is used to validate the model structure and show that the receptor dynamics allow to explain some of the glucagon-related phenomena observed in the clinical data. This physiology-focused model will be useful in the development of artificial pancreas algorithms both for more realistic in silico validations and in the development of model-based control strategies.

KW - clinical data

KW - Diabetes

KW - glucagon receptors

KW - parameter estimation

KW - PK-PD model

U2 - 10.1016/j.ifacol.2022.09.169

DO - 10.1016/j.ifacol.2022.09.169

M3 - Conference article

AN - SCOPUS:85142216875

VL - 55

SP - 647

EP - 652

JO - IFAC-PapersOnLine

JF - IFAC-PapersOnLine

SN - 2405-8963

IS - 20

T2 - 10th Vienna International Conference on Mathematical Modelling, MATHMOD 2022

Y2 - 27 July 2022 through 29 July 2022

ER -

ID: 335684190

Department of Clinical Medicine